Research integrity University Affairs

The English science supremacy

England leads the world in science, any fule kno. Meet some more of the star jesters: Nick Lemoine, Peter St George-Hyslop and Xin Lu. They are curing cancer and Alzheimer with Photoshop.

England. A world superpower. Not just in everything else, but also in science, which is world-beating. English spitfire pluckiness destroyed the Huns in two world wars and in Brexit, but also in scientific performance, both impact-factor and money-wise. Brexit Britain will be free of all diseases, because whatever an English scientist does, conclusions remain not affected.

The secret to English science supremacy is not just the limitless capacity of certain English researchers to fabricate exciting results and phony cures, anyone can do that. It is the unique arrogance and corruption of English universities and of British health authorities who regularly decree all data fakeries to be quality science, outside statute of limitations, and verified independently by many citations, while telling whistleblowers to get lost.

It is a game only the crooks can win. And tax payers, charity donors and patients pay the price.

Not matter what you hear from Brexit, it’s not like England is not tolerant and welcoming. Clean of foreign detritus, free Britain can now freely choose what kind of foreigner it will let it. The foreigner must bring the right skill, like Amato Giaccia did, when he arrived to Oxford from Stanford in USA, trailed by a string of questionable research. Brexit and the COVID-19 pandemic showcased what the English ruling elites value most: defrauding and bullshitting the public. Science is just another coffer to plunder in this scam.

I previously celebrated the English science genius, with superior English minds like regenerative medicine enthusiast Martin Birchall, who took over Paolo Macchiarini‘s deadly technology to run some trachea transplants of his own. Birchall was acquitted in full by his own UCL, including for data irregularities, foreign scapegoats were assigned. Also Master of Birkbeck Sir David Latchman, CBE, was saved by UCL from unruly investigators whose reports were overruled by officials to determine no misconduct. Dame Kay Davies, DBE, was defended by her University of Oxford thanks to statute of limitations of 3 years for research misconduct charges, and by the publisher Oxford University Press where she as Editor-in-Chief retaliated against a fraud whistleblower. Paul Workman and Alan Ashworth, current and former director of ICR London, were both absolved in full, nothing at all worth retracting was found, while minor characters (not their protegees though) got the blame. Richard Marais of Cancer Research UK in Manchester weathered a research fraud scandal in his lab and a mountain of bullying accusations, he is still director of the institute.

Now, I shall celebrate more such talents, based on the sleuthing of Clare Francis. Cancer is cured, brain diseases vanquished, all thanks to the English scholars I want you to admire. Please raise, tuck in your shirt and comb your hair. The honour is all yours:

Nick Lemoine, FRCPath FMedSci

We shall start with Nicholas Lemoine. This cancer researcher is professor at the Queen Mary University of London and director of the Cancer Research UK Barts Centre. He is also an extremely high-ranking expert at the MRC (Medical Research Council), which means Dr Nick decides which biomedical researchers in UK gets funded and which don’t:

He has served as Chair of the Clinical Training and Career Development Panel at the Medical Research Council, and as Vice-Chair of the MRC Stratified Medicine Expert Panel. He has previously served as Chair of the MRC Stem Cell Strategic Grant and Fellowship Panels, and has been a member of the MRC’s Molecular & Cellular Medicine Board.

As medical director of NIHR Clinical Research Network, Dr Nick is now in charge of UK’s COVID-19 response:

So what kind of science are you, a humble British scientist seeking to eke out a meagre grant from MRC or NIHR, expected to deliver in order to impress Professor Lemoine? Well, you could study from his own papers, here is one:

Iman El-Hariry, Massimo Pignatelli, Nicholas R. Lemoine FGF-1 and FGF-2 regulate the expression of E-cadherin and catenins in pancreatic adenocarcinoma International Journal of Cancer (2001)  DOI: 10.1002/ijc.1515

As you see, the Figure 4 is fake, it has 3 cloned bands. Which means, the conclusions are not affected. A correction was issued by the publisher Wiley in 2019:

There is an error in the experimental conditions reported for the data presented in Figure 4 panel B. We apologize for these circumstances, which required clarification of the data.”

As it happens, Ashworth’s mentee and first author on a bunch of hilariously fake papers, Sarah Martin, is presently faculty member and Deputy Centre Lead at the Lemoine-ruled Bart’s and, this is really cruel: director of the graduate school. Now you see which qualifications you need to get employed at Barts, plus they probably sack PhD students for refusing to fake data there.

Maybe they use this paper by Limoine and his Barts colleagues to teach the students how to do cancer research properly:

Nothing was done. The Editor-in-Chief of this Nature Research Group journal is another professor in England, Georgios Giamas, owner of his own PubPeer record, and protege of the controversial, yet perfectly safe in his job, Imperial College professor Justin Stebbing. Giamas also holds a visiting professorship at Imperial, and he will definitely never do anything about the following paper by Limoine in Cancer Gene Therapy:

I A McNeish, T Tenev, S Bell, M Marani, G Vassaux, N Lemoine Herpes simplex virus thymidine kinase/ganciclovir–induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells Cancer Gene Therapy (2001) doi: 10.1038/sj.cgt.7700305

In November 2018, the first author and another Imperial College professor Ian McNeish posted on PubPeer the full investigative report by Limoine’s employer, Barts College, which was also approved by Imperial. McNeish, Limoine and the unnamed investigator agree that the raw data doesn’t exist (anymore, they say), that the two papers were submitted and reviewed simultaneously and that the gel bands are indeed duplicated. The investigator’s conclusions, as quoted by McNeish:

None of these issues in my opinion change the conclusions made in the papers. I see no merit in retracting these important publications or publishing an erratum at this late stage, although agree that there have been errors made in producing the figures. […] The investigation stated that the conclusions made from the published studies were valid and important, even accounting for these reporting errors.

This is the standard attitude of all English and in fact British universities. The wording is typical English passive-aggressiveness towards whistleblowers warning them never to waste the university’s time ever again or meet their due fate.

Below some more of Limoine papers, the rest is on PubPeer. The following is 7 years old, when it was posted the raw data was rather fresh, sometimes even piping hot. A key coauthor on all these papers is Yaohe Wang, another professor at Barts.

J R Tysome, A Briat, G Alusi, F Cao, D Gao, J Yu, P Wang, S Yang, Z Dong, S Wang, L Deng, J Francis, T Timiryasova, I Fodor, N R Lemoine, Y Wang Lister strain of vaccinia virus armed with endostatin–angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancer Gene Therapy (2009) doi: 10.1038/gt.2009.74
Yaohe Wang, Rathi Gangeswaran, Xingbo Zhao, Pengju Wang, James Tysome, Vipul Bhakta, Ming Yuan, C.P. Chikkanna-Gowda, Guozhong Jiang, Dongling Gao, Fengyu Cao, Jennelle Francis, Jinxia Yu, Kangdong Liu, Hongyan Yang, Yunhan Zhang, Weidong Zang, Claude Chelala, Ziming Dong, Nick Lemoine CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells The Journal of clinical investigation (2009) doi: 10.1172/jci37905
Emma Spurrell, Rathi Gangeswaran, Pengju Wang, Fengyu Cao, Dongling Gao, Baisui Feng, William Wold, Ann Tollefson, Nicholas R Lemoine, Yaohe Wang STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus Journal of Virology (2014) doi: 10.1128/jvi.02829-13 
Han Hsi Wong, Guozhong Jiang, Rathi Gangeswaran, Pengju Wang, Jiwei Wang, Ming Yuan, Hexiao Wang, Vipul Bhakta, Heike Müller, Nicholas R Lemoine, Yaohe Wang Modification of the early gene enhancer-promoter improves the oncolytic potency of adenovirus 11 Molecular therapy (2012) doi: 10.1038/mt.2011.242

Barts College apparently decided instead to wait until this Photoshop travesty passes the 10 year statute of limitations. Expect another passive-aggressive investigative report in 2025, declaring Limoine and Wang innocent and all conclusions valid and not affected.

Peter St George-Hyslop, OC, FRS, FRSC, FRCPC

I think this name is so impressive, you can’t be more of English upper class, both in science and in society with a name like this. Of course Professor Peter St George-Hyslop is located in Cambridge, where he works on clinical neuroscience, previously he was in Canada where he was proclaimed “one of the most cited authors in the field of Alzheimer’s disease research”.

There are a number of papers coauthored by St George-Hyslop on PubPeer, here is one from his old lab at the University of Toronto:

Fusheng Chen, Gang Yu, Shigeki Arawaka, Masaki Nishimura, Toshitaka Kawarai, Haung Yu, Anurag Tandon, Agnes Supala, You Qiang Song, Ekaterina Rogaeva, Paul Milman, Christine Sato, Cong Yu, Christopher Janus, Julie Lee, Lixin Song, Lili Zhang, Paul E. Fraser, P. H. St George-Hyslop Nicastrin binds to membrane-tethered Notch Nature Cell Biology (2001) doi: 10.1038/35087069 

Cloned gel bands, spotted by Clare Francis. No action at all form that elite Nature-themed journal. Another St George-Hyslop fabrication, also done with Toronto colleagues:

Sonya Brijbassi, Zareen Amtul, Susan Newbigging, David Westaway, Peter St George-Hyslop, Richard F. Rozmahel Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo Neurobiology of Disease (2007) doi: 10.1016/j.nbd.2006.09.013

But the worst ones were done in collaboration with Frederic Checler, professor of neuroscience at CNRS in France. Like this, where the authors shamelessly double-published to increase their publication record:

Julie Dunys, Toshitaka Kawarai, Emilie Giaime, Sherwin Wilk, M. Herrant, P. Auberger, Peter St George-Hyslop, Cristine Alves Da Costa, Frédéric Checler Study on the putative contribution of caspases and the proteasome to the degradation of Aph-1a and Pen-2 Neuro-degenerative diseases (2007) doi: 10.1159/000101840

There was more data recycling, basically that paper in Neurodeg Dis is a copy of the previously published paper Dunys et al Biochemical J 2006, with all other authors the same. Neither journal, one by Portland Press, one by Karger, cares, never mind for research integrity, not even for their own infringed copyright.

Here more by St George-Hylop and his French ally, some gel band copy-pasting:

 

Bruno Vincent, Claire Sunyach, Hans-Dieter Orzechowski, Peter St George-Hyslop, Frédéric Checler p53-Dependent transcriptional control of cellular prion by presenilins The Journal of neuroscience (2009) doi: 10.1523/jneurosci.0789-09.2009
Raphaëlle Pardossi-Piquard, Agnès Petit, Toshitaka Kawarai, Claire Sunyach, Cristine Alves Da Costa, Bruno Vincent, Sabine Ring, Luciano D’Adamio, Jie Shen, Ulrike Müller, Peter St. George-Hyslop, Frédéric Checler Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP Neuron (2005) doi: 10.1016/j.neuron.2005.04.008

Here another interesting collaboration of our esteemed English upper class scientist, this time with Masaya Tohyama in Japan:

Naoya Sato, Kazunori Imaizumi, Takayuki Manabe, Manabu Taniguchi, Junichi Hitomi, Taiichi Katayama, Takunari Yoneda, Takashi Morihara, Yuichi Yasuda, Tsutomu Takagi, Takashi Kudo, Takehide Tsuda, Yasuto Itoyama, Takao Makifuchi, Paul E. Fraser, Peter St George-Hyslop, Masaya Tohyama Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2 The Journal of biological chemistry (2001) doi: 10.1074/jbc.m006886200
Taiichi Katayama, Kazunori Imaizumi, Akiko Honda, Takunari Yoneda, Takashi Kudo, Masatoshi Takeda, Kazutoshi Mori, Richard Rozmahel, Paul Fraser, Peter St. George-Hyslop, Masaya Tohyama Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer’s disease-linked presenilin-1 mutations The Journal of biological chemistry (2001) doi: 10.1074/jbc.m104096200 
Taiichi Katayama, Kazunori Imaizumi, Naoya Sato, Ko Miyoshi, Takashi Kudo, Junichi Hitomi, Takashi Morihara, Takunari Yoneda, Fumi Gomi, Yasutake Mori, Yuka Nakano, Junji Takeda, Takehide Tsuda, Yasuto Itoyama, Ohoshi Murayama, Akihiko Takashima, Peter St George-Hyslop, Masatoshi Takeda, Masaya Tohyama Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response Nature Cell Biology (1999) doi: 10.1038/70265

The evidence is years old, but nothing has happened so far. Yet one St George-Hyslop coauthored publication was retracted in 2020. Its first author Sabine Wislet is professor in Belgium and has a number of other papers questioned on PubPeer, including another retraction.

Sabine Wislet-Gendebien, Cheryl D’Souza, Toshitaka Kawarai, Peter St George-Hyslop, David Westaway, Paul Fraser, Anurag Tandon Cytosolic proteins regulate alpha-synuclein dissociation from presynaptic membranes The Journal of biological chemistry (2006) doi: 10.1074/jbc.m605965200

Now the fun starts. Clare Francis of course notified the University of Cambridge and the Wellcome Trust (which funds St Seorge-Hyslop’s research). This was their decision, as penned to Clare Francis by the Policies & Governance Officer of Wellcome Trust, Lucy Douch, in February 2017:

Further to your email of 17 August 2016, we raised your concerns about Professor Peter St George-Hyslop with the University of Cambridge, the employing institution.

The University conducted an investigation under its Misconduct in Research policy. The investigation concluded that the allegations made are entirely unfounded.”

This is not even passive aggressive, it sounds almost like a legal threat from Wellcome Trust. In fact, this is a proud English Fuck You to every single whistleblower who dares to impugn the greatness of English science genius.

Although, to be fair, I suspect the Cambridge University probably has same statute of limitations on research fraud as Oxford, of 3 years. Because there was nothing for them to investigate in those older paper, they declared the allegations as “entirely unfounded”.

If you enjoyed St George-Hyslop’s aristocratic antics, you should also have a look at the PubPeer record of another Cambridge professor, Dame Carol Mary Black, DBE, FRCP, BSD, Principal of the Newnham College. Here a sample, with the Dame Commander of the Order of the British Empire as last author, Denton et al JBC 2005:

Xin Lu, FRS

Britain is open to foreigners, as we know. Not the lowly kind who don’t know how to get rich quick. If you know how to play the game, you can become part of the English science elite. Xin Lu studied in her home land China, and in UK she eventually arrived to the Ludwig Cancer Centre, first at its London branch and later to take over the directorship of the central seat in Oxford.

Yes, Oxford is the university with 3 year statute of limitation for research misconduct. Nothing to see here at all:

Daniele Bergamaschi, Yardena Samuels, Alexandra Sullivan, Marketa Zvelebil, Hilde Breyssens, Andrea Bisso, Giannino Del Sal, Nelofer Syed, Paul Smith, Milena Gasco, Tim Crook, Xin Lu iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72–polymorphic p53 Nature Genetics (2006) doi: 10.1038/ng1879

So many cloned gel bands, and yes, Clare Francis informed the University of Oxford of this and other masterpieces. The first author on that paper, Daniele Bergamaschi is now lecturer at the Queen Mary University of London, his lab is at Barts. You see again which kind of talents Barts boss Lemoine expects from his principal investigators. Bergamaschi also authored this work of art with Lu:

Daniele Bergamaschi, Yardena Samuels, Boquan Jin, Sai Duraisingham, Tim Crook, Xin Lu ASPP1 and ASPP2: common activators of p53 family members Molecular and Cellular Biology (2004) doi: 10.1128/mcb.24.3.1341-1350.2004

And this one by Bergamaschi and Lu, in Oncogene (remember the Editor-in-Chief Justin Stebbing?):

Daniele Bergamaschi, Yardena Samuels, Shan Zhong, Xin Lu Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation Oncogene (2005) doi: 10.1038/sj.onc.1208535

I hope you are learning from Bergamaschi and Lu how to make career in English science. It’s not that difficult, all you need is the will to succeed. Another common author on all these papers is Yardena Samuels. She went back to Israel where she is now professor at the Weizmann Institute. Here more by Bergamaschi (and Samuels):

 

Daniele Bergamaschi, Yardena Samuels, Nigel J. O’Neil, Giuseppe Trigiante, Tim Crook, Jung-Kuang Hsieh, Daniel J. O’Connor, Shan Zhong, Isabelle Campargue, Matthew L. Tomlinson, Patricia E. Kuwabara, Xin Lu iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human Nature Genetics (2003) doi: 10.1038/ng1070
Caroline Gubser, Daniele Bergamaschi, Michael Hollinshead, Xin Lu, Frank J. M. Van Kuppeveld, Geoffrey L. Smith A new inhibitor of apoptosis from vaccinia virus and eukaryotes PLoS Pathogens (2007) doi: 10.1371/journal.ppat.0030017

The last author on one of those papers is Geoffrey Smith, head of Pathology Department at University of Cambridge and member of all possible learned societies including the German Leopoldina. People of this calibre can’t be associated with bad science, so don’t expect even a correction.

But the next two papers from Lu lab doesn’t have Bergamaschi among its authors. Here one:

Damian B. S. Yap, Jung-Kuang Hsieh, Shan Zhong, Vicky Heath, Barry Gusterson, Tim Crook, Xin Lu Ser392 phosphorylation regulates the oncogenic function of mutant p53 Cancer Research (2004) doi: 10.1158/0008-5472.can-1305-2 

These are two very fraudulent figures, bands were erased in one version by a rascal. But this paper, like others, is too old for anyone to give a toss about. Here something more recent:

Min Lu, Hilde Breyssens, Victoria Salter, Shan Zhong, Ying Hu, Caroline Baer, Indrika Ratnayaka, Alex Sullivan, Nicholas R. Brown, Jane Endicott, Stefan Knapp, Benedikt M. Kessler, Mark R. Middleton, Christian Siebold, E. Yvonne Jones, Elena V. Sviderskaya, Jonathan Cebon, Thomas John, Otavia L. Caballero, Colin R. Goding, Xin Lu Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP Cancer Cell (2013) doi: 10.1016/j.ccr.2013.03.013 

An Erratum was issued by Cell Press in 2016 and declared:

“This error does not affect any of the findings reported in the paper.”

With English research fabrications it is just like with Brexit: get over it, they won. Science is an English colony and the rotten upper classes are busy plundering it.


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122 comments on “The English science supremacy

  1. Nat Cell Biol. 2001 May;3(5):445-52. doi: 10.1038/35074506.

    Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus

    S Llanos 1, P A Clark, J Rowe, G Peters

    Affiliation
    1Imperial Cancer Research Fund, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK.
    PMID: 11331871 DOI: 10.1038/35074506

    Figure 8c. Much more similar than expected.

    Like

  2. Cancer Res. 2001 Nov 1;61(21):8005-13.

    Direct relation between BCR-ABL tyrosine kinase activity and cyclin D2 expression in lymphoblasts

    M W Deininger 1, S A Vieira, Y Parada, L Banerji, E W Lam, G Peters, F X Mahon, T Köhler, J M Goldman, J V Melo

    Affiliation
    1Department of Haematology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom.
    PMID: 11691826

    Figure 3(a). Much more similar than expected.

    https://pubpeer.com/publications/11CD6B394C5CC0B0DD36A3DCB210C9#1

    Figure 3(c). Much more similar than expected.

    https://pubpeer.com/publications/11CD6B394C5CC0B0DD36A3DCB210C9#3

    Like

  3. Oncogene. 2000 Jan 27;19(4):592-8. doi: 10.1038/sj.onc.1203339.

    E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage
    S Jackson 1, A Storey

    1
    ICRF Skin Tumour Laboratory, Centre for Cutaneous Research, London, UK.
    PMID: 10698529 DOI: 10.1038/sj.onc.1203339

    Problematic data figure 1a. Much more similar than expected.

    Problematic data figure 5. Much more similar than expected.

    Like

  4. Mol Cancer Ther. 2008 May;7(5):1319-28. doi: 10.1158/1535-7163.MCT-07-0475.

    Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78

    Minal Kotecha 1, Jerome Kluza, Geoff Wells, C Caroline O’Hare, Claudia Forni, Roberto Mantovani, Philip W Howard, Peter Morris, David E Thurston, John A Hartley, Daniel Hochhauser

    Affiliation1Cancer Research UK Drug-DNA Interac Research Group, UCL Cancer Institute, University College London, London, United Kingdom.

    PMID: 18483319 DOI: 10.1158/1535-7163.MCT-07-0475
    Problematic data figure 6. Splicing in some panels, but not in other panels.

    Like

  5. Hum Mol Genet. 2004 Dec 1;13(23):2937-45. doi: 10.1093/hmg/ddh316. Epub 2004 Sep 30.
    ATM is required for the cellular response to thymidine induced replication fork stress

    Emma Bolderson 1, Jennifer Scorah, Thomas Helleday, Carl Smythe, Mark Meuth

    Affiliation
    1
    Institute for Cancer Studies, School of Medicine, University of Sheffield, UK.

    PMID: 15459181 DOI: 10.1093/hmg/ddh316

    Problematic data figure 2B. Much more similar than expected.

    Like

  6. Hum Mol Genet. 2004 Jan 15;13(2):203-12. doi: 10.1093/hmg/ddh022. Epub 2003 Nov 25.

    A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks

    Atul Mohindra 1, Emma Bolderson, Jason Stone, Michael Wells, Thomas Helleday, Mark Meuth

    Affiliation1Institute for Cancer Studies, University of Sheffield, School of Medicine, Sheffield, UK.

    PMID: 14645207 DOI: 10.1093/hmg/ddh022

    Problematic data figure 1B. Much more similar after vertical stretch than expected.

    Thomas Helleday’s Group | Karolinska Institutet
    https://ki.se/en/onkpat/thomas-helledays-group
    In 2018, Professor Helleday reestablished a laboratory in the UK as founding Director of the Weston Park Cancer Center at the University of Sheffield. Today Prof. Helleday shares his time between KI and Sheffield University. The Helleday team at KI is fully active under the lead of deputy group head Dr Ulrika Warpman Berglund.

    Like

  7. Nucleic Acids Res. 2005; 33(12): 3799–3811.
    Published online 2005 Jul 11. doi: 10.1093/nar/gki681PMCID: PMC1174933PMID: 16009812

    Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks

    Cecilia Lundin,1 Matthew North,2 Klaus Erixon,1 Kevin Walters,3 Dag Jenssen,1 Alastair S. H. Goldman,2 and Thomas Helleday1,4,

    *Author information 

    1 Department of Genetics, Microbiology and Toxicology, Stockholm University, Svante Arrhenius väg 16, S-106 91 Stockholm, Sweden

    2 Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK

    3 Mathematical Modelling and Genetic Epidemiology, University of Sheffield, Sheffield S10 2TN, UK

    4 The Institute for Cancer Studies, Division of Genomic Medicine, University of Sheffield, Sheffield S10 2TN, UK

    *To whom correspondence should be addressed at Department of Genetics, Microbiology and Toxicology, Stockholm University, Svante Arrhenius väg 16, S-106 91 Stockholm, Sweden. Tel: +46 8 16 29 14; Fax: +46 8 16 43 15; Email: helleday@gmt.su.se

    The authors wish it to be known that Dr A. Goldman is considered as joint senior (last) author (contact details: Tel: +44 114 222 2779; Fax: +44 114 272 8697; Email: a.goldman@sheffield.ac.uk

    Problematic data figure 2C.

    Much more similar than expected.

    Corrected 2012. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384354/

    but Oops I did it again!

    See: https://pubpeer.com/search?q=thomas+helleday

    Like

  8. Pingback: Kristian Helin gets the perfect job – For Better Science

  9. Zebedee

    2021 correction for:

    Clin Cancer Res. 2020 Jan 15;26(2):465-476. doi: 10.1158/1078-0432.CCR-19-1395. Epub 2019 Nov 25.

    A Virus-Infected, Reprogrammed Somatic Cell-Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer

    Shuangshuang Lu 1, Zhe Zhang 1, Pan Du 1, Louisa S Chard 2, Wenli Yan 1, Margueritte El Khouri 2, Zhizhong Wang 1, Zhongxian Zhang 1, Yongchao Chu 1, Dongling Gao 1, Qinxian Zhang 3, Lirong Zhang 3, Ai Nagano 2, Jun Wang 2, Claude Chelala 2, Jing Liu 4 5, Jiekai Chen 4 5, Pentao Liu 6, Yunshu Dong 7, Shengdian Wang 7, Xiaozhu Li 7, Jianzeng Dong 8, Nick R Lemoine 1 2, Duanqing Pei 9 5, Yaohe Wang 10 2

    Affiliations
    1National Center for International Research in Cell and Gene Therapy, Sino-British Research Centre for Molecular Oncology, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
    2Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.
    3School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China.
    4CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangzhou, China.
    5Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China.
    6School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
    7CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
    8Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
    9CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangzhou, China. Yaohe.wang@qmul.ac.uk Pei_duanqing@gibh.ac.cn.
    10National Center for International Research in Cell and Gene Therapy, Sino-British Research Centre for Molecular Oncology, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China. Yaohe.wang@qmul.ac.uk Pei_duanqing@gibh.ac.cn.
    PMID: 31767564

    DOI: 10.1158/1078-0432.CCR-19-1395

    2021 correction.
    https://clincancerres.aacrjournals.org/content/27/9/2663

    In the original version of this article (1), five immunofluorescence panels in Fig. 3A were incorrect: DE-KPC-Oct4/DAPI, PPLC-KPC-Nanog/DAPI, PPLC-KPC-Sox17/DAPI, PPLC-WT-KP-Nanog/DAPI, and PPLC-WT-KP-Sox17/DAPI. In addition, the legend for Fig. 2E did not provide clarification about the teratoma section used. These errors have been corrected in the latest online HTML and PDF versions of the article. The authors regret these errors.

    https://pubpeer.com/publications/2CF10357FD9372276AEAA97D7F2C35

    Reference
    1.↵Lu S, Zhang Z, Du P, Chard LS, Yan W, El Khouri M, et al. A virus-infected, reprogrammed somatic cell–derived tumor cell (VIReST) vaccination regime can prevent initiation and progression of pancreatic cancer. Clin Cancer Res 2020;26:465–76.

    Like

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