After misconduct investigation, Irina Stancheva left Edinburgh, in secret

After misconduct investigation, Irina Stancheva left Edinburgh, in secret

A scientist was “dismissed” by the Department of Biological Sciences at the University of Edinburgh, UK. All evidence points towards that it was the cell biologist Irina Stancheva who specialises on the epigenetics and regulatory methylation of DNA, and who departed from the university recently, after a forced leave. She also has an impressive record on PubPeer, where her publications where flagged for suspected data manipulations around 2 years ago. The suspicions were mostly of western blot band re-use and duplication. Around same time, an investigation started about these PubPeer issues, and by now Stancheva’s name does not feature of the Department’s list of academic staff. A archived version from December 2016 does feature Stancheva, but not that of August 2017. Her institutional website was deleted just hours after I sent my email inquiries to her former faculty colleagues. Continue reading “After misconduct investigation, Irina Stancheva left Edinburgh, in secret”

Alexander Seifalian, UCL’s Persian Scapegoat

Alexander Seifalian, UCL’s Persian Scapegoat

The London university UCL has now completed the investigation into the affair around their past honorary professor and now disgraced thoracic surgeon Paolo Macchiarini and the trachea transplants. Subject of the investigation were: the two plastic tracheas UCL produced (one sent to Karolinska Institutet and implanted in patient Andemariam Beyene in Stockholm, another used by UCL laryngologist Martin Birchall to treat Keziah Shorten, who previously received a cadaveric trachea from Macchiarini as requested by UCL) as well as four more cadaveric trachea transplants, namely the very first such intervention organised by Macchiarini and Birchall in Barcelona in 2008, on patient Claudia Castillo, as well as the three trachea transplants which took place under UCL oversight in London, on paediatric patients Ciaran Lynch, Shauna Davison and a 3-year old child who was transplanted just in May 2017 at the same Great Ormond Street Hospital (GOSH). The offhand revelations about the last transplant in this UCL report came as surprise, since it was otherwise kept secret.

No information is provided by the investigative report on how that child is doing now, in fact it seems no evidence like laboratory books, research data or patients’ medical files was ever requested and the committee relied solely on the opinions provided by the very people they were supposed to investigate: Paolo Macchiarini, Martin Birchall and GOSH paediatric surgeon and past director Martin Elliott. In fact, the report seems to become very nebulous or even creative with its use of alternative facts to avoid implicating Birchall in anything unethical at all. The only guilty party in this medical scandal is incidentally also the only non-clinician and the only non-white character in the entire Macchiarini affair: the nuclear physicist Alexander Seifalian, a Persian-Armenian and dual citizen of Iran and UK, whose lab manufactured two plastic tracheas. He was already sacked by UCL in July 2016, accused of bribery. Seifalian is also bowel cancer survivor, which did not prevent UCL of accusing him of failing to oversee the abroad clinical application of his produce just when he was receiving chemotherapy.

These are the results of UCL investigation in the nutshell:

  • All UCL-employed clinicians involved in trachea transplants, in particular UCL’s chief trachea transplanter Martin Birchall, are fully acquitted from any suspicion of misconduct or clinical wrongdoing. Even Macchiarini seems partially exonerated from the gist of the UCL report, because:
  • The maker of the two plastic tracheas, Alexander Seifalian, is to take all the UCL-related blame for the failed  transplants (as well as other plastics implants in India, Iran and Switzerland). His fault is to have manufactured these products though his UCL lab lacked GMP (Good Manufacturing Practice) certificate. Only this lack of GMP-quality seal was what apparently made plastic tracheas too dangerous to implant in humans.
  • All five cadaveric trachea transplants under the scope of investigation were considered ethically, medically and scientifically justified. Deaths of the patients were explained with new discoveries of recurrent cancer, or demands of other patients for the same hospital bed.
  • Birchall’s clinical trials with cadaveric tracheas (phase 1/2a INSPIRE, and by extension, also EU-wide phase 2 TETRA) are to go ahead as planned and to recruit patients. Same positive recommendation for Birchall’s related trial RegenVox on cadaveric larynx, decellurised and “regenerated” with same technology as tracheas.

Continue reading “Alexander Seifalian, UCL’s Persian Scapegoat”

The rise and fall of an antivax paper, by Smut Clyde

The rise and fall of an antivax paper, by Smut Clyde

For the publisher Elsevier, antivax papers are apparently only a problem when they are too heavily manipulated. It took their journal 12 years to retract the notorious paper by Andrew Wakefield, because of data irregularities (details here and here). But the damage was done, an worldwide antivax movement was born, which keeps spreading bizarre and irrational paranoia that vaccines would cause autism in children (most recently supported by the disastrous US president Donald Trump, in tweets and in actual governmental policy). Vaccination rates dropped worldwide, and consequently deadly diseases considered long eradicated are making a comeback. But scholarly publishers and their journals bear here a heavy responsibility, by repeatedly publishing antivax papers and providing the anti-vax movement with the scientific legitimacy.

This was exactly what Elsevier did just now, again. Their Journal of Inorganic Chemistry published a paper by notorious antivax researchers Christopher Shaw, ophthalmology professor in the University of British Columbia, and his postdoc Lucija Tomljenovic. Both scientists enjoy full support of their Canadian university, despite that, together with another antivaxer, Yehuda Schoenfeld, they once had to retract a paper on the alleged neurotoxicity of aluminium adjuvant in vaccines, from the Elsevier journal Vaccine. The authors then simply republished the retracted masterpiece again in another journal, Immunologic Research, published by Springer.

The newly published Shaw paper in Journal of Inorganic Chemistry is again about alleged neurotoxicity of aluminium (or as authors prefer to call it, “aluminum”) , with a bold claim that it would cause autism in mice, as detected by some biomarkers authors saw as appropriate:

Continue reading “The rise and fall of an antivax paper, by Smut Clyde”

Carol Prives, innocent victim of Susana Gonzalez’ data manipulations?

Carol Prives, innocent victim of Susana Gonzalez’ data manipulations?

Recent news brought us yet another retraction of the Spanish zombie scientist Susana Gonzalez, formerly famous for her impactful ERC-funded research into stem cells and ageing. It is her fifth retraction (others here), and meanwhile Gonzalez is not even a zombie scientist anymore. She has no research group in her new Madrid institute, noone in Spain wants to work in the same building with her, in fact though she is still formally employed with the Spanish Consejo Superior de Investigaciones Científicas (CSIC), it seems she stopped coming to work long ago, being on an endless sick leave. Even the European Research Council (ERC), usually most accommodating with research misconduct of their elite grant recipients, didn’t know what to do with Gonzalez suspended €2Mn grant and eventually terminated it.

The recent Gonzalez retraction at the  Molecular and Cellular Biology (MCB) is interesting in two aspects. First, Retraction Watch previously chastised the journal in a headline for allegedly refusing to investigate evidence of data manipulations in papers older than 6 years (read here). No reference is made to that “smear” accusation in the current Retraction Watch article on Gonzalez retraction.  But the second aspect is really much more intriguing. The retracted MCB paper, from Gonzalez period as postdoc at the Memorial Sloan Kettering Cancer Center (MSKCC) in New York, was coauthored by the US researcher Carol Prives, professor at the Columbia University in New York, and specialist for the cell cycle control protein p53: Continue reading “Carol Prives, innocent victim of Susana Gonzalez’ data manipulations?”

John Innes Centre director Dale Sanders rebuffs a non-peer reviewed internet troll

John Innes Centre director Dale Sanders rebuffs a non-peer reviewed internet troll

Regarding the Olivier Voinnet scandal and a recent data integrity case in Germany (marginally featuring a current group leader of the John Innes Centre in Norwich, UK), I had an email exchange with the director of this British plant science research centre, Dale Sanders. It started with Sanders demanding of me to cease-and desist from ever associating the misconduct-tainted cheater professor Voinnet with his John Innes Centre (despite that connection being very well-documented), and ended with Sanders calling me an “internet troll” and decreeing that my Voinnet reporting is not worth ever being read because it has not been peer reviewed.

The whole case revolves around the former star of plant sciences and current ETH professor Voinnet, though it is actually not at all about him or his own data manipulations. In July 2017, I brought an article, where concerns about the data integrity in publications of a very senior and influential German yeast biologist, Roland Lill, were raised on PubPeer. A past member of Lill’s lab, his PhD student Heike Lange, is now tenured researcher at the same CNRS institute in Strasbourg where Voinnet did most of his data manipulations. Lange has a number of papers which contain what clearly looks like duplicated western blot bands, she and LIll went to PubPeer to declare that the bands were never duplicated (details in my article). Yet Lange and Lill never substantiated their claims or showed any original gel scans for their common papers, which lets one wonder if those actually exist.

It turned out somewhat differently with another former PhD student of Lill, Janneke Balk, who is now the above mentioned group leader at Sanders’ John Innes Centre. Two common papers of Balk and Lill were flagged on PubPeer: Balk et al EMBO J 2004 and Balk et al, Mol Cell Biol. 2005.  She has not managed to address the concerns about the former yet (more about it later), but she did reply on PubPeer to the evidence of gel band duplication by admitting the copy-paste, posting the original gels and explaining at length exactly which band was duplicated and why:

Continue reading “John Innes Centre director Dale Sanders rebuffs a non-peer reviewed internet troll”

Voinnet’s CNRS investigator Catherine Jessus with own data integrity issues

Voinnet’s CNRS investigator Catherine Jessus with own data integrity issues

More suspected data manipulations in the papers by the French elite biologists. It was funny enough when the director and several lead figures at the Strasbourg CNRS institute for plant sciences IBMP, former home of the master data manipulator Olivier Voinnet, and even the institute’s evaluators, were found to sport quite a lot of shifty-looking data in their papers. This time, the irony is just too much. Catherine Jessus, developmental biologist specialising on cell cycle research on oocytes and director of CNRS l’Institut des sciences biologiques (INSB) was in charge of two misconduct cases, and now the data integrity of her own papers is called in question. One investigation led by Jessus was about, whom else, Voinnet and his IBMP sidekick Patrice Dunoyer. In summer 2015, Voinnet was barred from CNRS for 2 years (which sounds worse than it is, because his professorship at ETH Zürich in Switzerland remained untouched, read here), and Dunoyer was suspended for one entire month. Jessus’ secret investigation ended with no documents whatsoever but a terse press release made available to outsiders. Both Voinnet and Dunoyer are by now back to publishing papers in prestigious journals.

Jessus was also in charge of dealing with the misconduct evidence against Voinnet’s former postdoc Charles-Henri Lecellier, whom the mighty plant scientist (according to my sources) banned from his Strasbourg lab because he did not trust his research results. It seems Lecellier started to fudge data already during his PhD at CNRS Hôpital Saint-Louis in Paris (PubPeer record here). Imagine how bad it must get that Voinnet expels you for data manipulation! The tenured CNRS researcher was hence moved out of Voinnet’s sight, to work as group leader at the Institut de Génétique Moléculaire de Montpellier, where he continued his own line of data rigging, helped by his trusted friend from IBMP, Guillaume Vetter (see my earlier reporting for a German magazine here and here). Apparently, with full protection from CNRS: in 2013 Jessus actively opposed on behalf of CNRS the impending retraction of a Lecellier co-authored paper, despite earlier misconduct findings against his partner Vetter at the University of Luxembourg (evidence here, especially this letter, example of data manipulations here).

Continue reading “Voinnet’s CNRS investigator Catherine Jessus with own data integrity issues”

Karolinska embarrasses itself to save two professors

Karolinska embarrasses itself to save two professors

The Swedish Karolinska Institutet (KI) is going through turbulent times. The Paolo Macchiarini scandal sensitised the European elite biomedical research centre and home of the Nobel Prize not just to patient abuse, but also to research misconduct and data manipulations, which its past professor Macchiarini was found guilty of. The misconduct and patient abuse investigations are ongoing. In parallel, several non-clinical KI professors were or still are under KI investigation, because of PubPeer evidence against their publications, as I reported before on my site. Two of them, as I wrote in a separate article, were the autophagy researcher Helin Vakifahmetoglu-Norberg and her former PhD supervisor, the apoptosis specialist  Boris Zhivotovsky. Both are now finally and irrevocably acquitted by KI of all suspicions of data manipulations in their common publications. The case is closed, there will be no external investigation.

In a previous decision regarding 9 of her papers, KI performed an amazing show of contortionism to absolve Vakifahmetoglu-Norberg from all suspicions of data manipulation (see this report). In one case, manipulated data was declared as non-existent because the paper containing it (Shen et al, Oncogene 2008) was retracted, and hence non-existent itself. No papers from Vakifahmetoglu-Norberg’s postdoctoral period in the US in the lab of Junying Yuan in Harvard were scrutinised by KI, despite the fact that KI originally based their decision to recruit Vakifahmetoglu-Norberg as assistant professor in no small part on these very publications. For example, western blot images from Vakifahmetoglu-Norberg et al, Genes & Dev 2013 were apparently re-used in her new lab’s paper in KI, Xia et al JCB 2015, see this PubPeer evidence: Continue reading “Karolinska embarrasses itself to save two professors”