The Science and Technology Committee of the British House of Commons opened in November 2017 an inquiry into Research Integrity. This prompted two University of Liverpool academics to submit a letter to the committee, describing the inaccuracies, misrepresentations and blatant lies which incurred in the course of the trachea transplants performed by the surgeons Paolo Macchiarini and Martin Birchall. The two academics were Patricia Murray, professor in stem cell biology and regenerative medicine, previously a nurse on a Head and Neck unit, and Raphael Lévy, senior lecturer in nanotechnology and imaging. The two also notified the relevant UK authorities and Birchall’s employer UCL of their concerns, especially after even suspected data manipulations came to light. UCL representative gave as a reply an oral and written testimony to the parliamentary committee, other stakeholders provided their own written replies. The first Murray-Levy letter was followed by a second one, because UCL needed help recalling correctly what they did to which patient, and how many have died from the very similar trachea replacement technology which UCL still demands to be allowed to test on 60 more patients.
Now the most vile thing happened, as reported by The BMJ on July 12. Videregen, the Liverpool-based company which bought the trachea regeneration patent from UCL and engages Birchall’s services as advisor, deployed lawyers against Murray and Levy, precisely via their employer University of Liverpool. The main issue is the parliamentary submission by Levy and Murray, subject to absolute privilege. Yet Videregen also cites from the confidential notice of suspected research misconduct Murray and Levy submitted in good faith to UCL (which has not yet decided whether misrepresenting data and providing false information in applications for funding, ethics approval and regulatory permissions is serious enough to warrant an investigation). One wonders who forwarded Videregen this notice, which was confidential and absolutely none of their business? UCL, or their professor Birchall, or Birchall with permission from UCL? Another question is: is our tax money which the EU Commission gave Videregen for trachea transplanting now being used to threaten critics? Continue reading “UCL trachea transplants: Videregen sets lawyers on Liverpool academics Murray and Levy”→
French science revolution is happening, and the corrupt elites are scared. As the daily Le Monde started brought into the public light the Catherine Jessus affair with its whitewashed data manipulation and the growing academic protest against such institutional endorsement of research misconduct, a counter-revolution put its foot in. A signature list in the worst Stalinist tradition was published, organised by the very elite of French academia (mostly members of Academie de Sciences), and signed by hundreds, mostly professors and CNRS group leaders, including the former CNRS president Alain Fuchs, the one who in 2015 oversaw the secret Olivier Voinnet investigation. The Stalinists demand: to uncover the identities of the 10 anonymous authors of the counter-report, which exposed the corruption and incompetence of the Jessus investigation by the Sorbonne University, and to have them as well as the Le Monde journalist David Larousserie punished. Those demands were endorsed in a secret press release (sic!) by CNRS president Antoine Petit and Sorbonne University president Jean Chambaz.
Other newspapers might have been intimidated against such massive and organised pushback from the elites of society. But the Pravda-esque denunciation of traitors and enemies of the people is unlikely to lead to an intended purge. It appears to have already now backfired badly, and the Stalinists who signed it already started regretting it. Indeed, many names were removed, and the list was closed to further signing, left standing at 503 shameful sycophantic signatures. Another main French daily, Le Figaro, brought its own Jessus-critical article, while Le Monde hit CNRS and Sorbonne University back where it hurts. The newspaper exposed the enormous conflict of interest behind the Jessus investigation and made clear who the man behind that whitewashing farce was and still is: the Sorbonne professor of biochemistry and cell biology,Francis-Andre Wollman, Academie de Sciences member and Knight of the Honour Legion. Wollman was defending Jessus and attacking her critics long before he was tasked with investigating her, and as Le Monde indicated, the investigative report was written by or at least together with Jessus herself. Finally, Le Monde reported that the Stalinist signature collection was published on a web platform hosted by Wollman and Chambaz. From another source we learned the investigative report lied that the journals involved accepted the explanations and agreed not to do anything: the journal editors actually are still deliberating what to do about the data manipulations in Jessus papers.
Here I publish the English version of the counter-report, together with a statement forwarded to me by its 10 authors, so that also the international community can see what disreputable deed Wollmann and his CNRS Politburo pulled off and now defend tooth and nail.
The revolution in French science has begun, and its target is the corrupt elite who betrayed against basic principles of research integrity and conspired to protect one of their own, the CNRS chief biologist Catherine Jessus. French scientists seem to finally have enough of watching fraudsters eat cake and now storm the Bastille.
Much of evidence of data manipulation in papers from Jessus’ lab was originally forwarded to me by my readers and reported on my site, I then posted it also on PubPeer. Under mounting pressure from her peers, Jessus started to correct some of her papers, and eventually her employer CNRS, Europe-largest network of research institutes, decided to switch to attack mode of defence. Sorbonne University in Paris, where Jessus holds a professorship, delivered an outrageous whitewashing report about Jessus’s data manipulations, which were either declared to be minor errors, or denied outright, or even declared to be actually good scientific practice, all despite absence of original data. The authors of that opus hid their identity, but one was eventually exposed by my sources: Francis-André Wollman, an elite CNRS and Sorbonne biologist. I was personally accused of libellous slander in a CNRS press release, which also announced to persecute those raising misconduct allegations, while urging French researchers to “collective vigilance” against such traitors. CNRS new president Antoine Petit, whose predecessor Anne Peyroche was deposed after my reporting about data manipulations in her own papers, then announced to smoke out anonymous PubPeer commenters using IT tools of deep surveillance.
Yesterday, an Open Letter has been published on the website Sauvons l’Université ! , authored by around 10 unnamed French biologists. It plucks apart the Sorbonne report of Jessus papers and declares:
“We, geneticists, biochemists, cell and molecular biologists, have read this report, have analysed, criticised it point by point and can conclude that all the arguments of the Inquiry Commission are against all common rules of good scientific practice and of the interpretation of results, which form the basis of research integrity. Worse, and that is the reason that led us to react (see our open letter), it encourages image manipulations which are nevertheless recognized as fabrications and falsifications of results”.
This is an Open Letter I sent today by email to the Italian Senate and its Health Committee, appealing for an investigation into the trachea transplants of the scandal surgeon Paolo Macchiarini.
It is published below bilingually, in Italian and in English. After the earlier Open Letter by Prof Rafael Cantera was signed by over 220 academics and thus led the University of Würzburg in Germany to investigate the trachea transplants of Macchiarini’s former colleagues, Heike and Thorsten Walles, I invite now
all Italian clinicians and researchers, in Italy and abroad, as well as their international colleagues working in Italy, to sign this letter in the comment section below. Please use your full affiliation.
The signed Open Letter will be then forwarded to both chambers of Italian parliament and other state authorities.
Appello per un’inchiesta sui trapianti di trachea eseguiti a Firenze da Paolo Macchiarini
Gentili Senatrici, Egregi Senatori membri della 12ª Commissione permanente Igiene e sanità,
questo appello è indirizzato a Voi affinché vogliate considerare l’opportunità di investigare uno dei più gravi casi internazionali di abuso ai danni di pazienti, che è avvenuto e si sta ancora oggi verificando, in grandissima parte anche in Italia.
Chi vi scrive è un giornalista scientifico indipendente, il cui sito web (in lingua inglese) è diventato la più completa fonte di informazioni oggi disponibile a livello globale sul caso di Paolo Macchiarini e della sua “medicina rigenerativa”.
Here I republish the written evidence submitted to by two UK scientists to the Science and Technology Committee of the British House of Commons and its inquiry into Research Integrity, as originally published on November 21st 2017. It deals with the trachea transplants performed by the surgeons Paolo Macchiarini and his former parter at UCL, Martin Birchall. The report’s lead author is Patricia Murray, professor in stem cell biology and regenerative medicine, previously a nurse on a Head and Neck unit. She generously invited me in May 2017 to give a seminar at her department at the University of Liverpool on this topic. Her coauthor is Raphael Lévy, senior lecturer in nanotechnology and imaging at the same university. I wrote about his reproducibility studies on the topic of nanoparticles in this article.
UCL recently investigated Birchall’s past trachea transplants, and recommended to continue with his two current clinical trials to transplant cadaveric decellurised trachea and larynx, regenerated with bone marrow cells, as I reported here. For some reason, UCL Registrar Wendy Appleby, when speaking as witness on November 21st in front of the Parliament Inqury, found herself unable to answer the rather straightforward question whether the UCL investigative commission advised to continue transplanting trachea or not (watch here, from 11:50 on). Appleby and her UCL were instructed by the Inquiry to address the concerns by Murray and Levy in writing.
Both clinical trials Inspire and RegenVox were already placed by the supervising authorities on hold, Murray and Levy now call to stop the dangerous and science-unsupported experimenting on misinformed human patients and to return back to the lab.
Below a support letter by Rafael Cantera, professor of zoology at the University of Stockholm in Sweden, addressed to the leadership of the University Clinic Würzburg. This is because two professors of this German university, Thorsten Walles and Heike Mertsching (now Walles) chose to respond to my inquiries about their earlier trachea transplants made from pig intestine (see my detailed report here) with lawyers’ financial blackmail and right after, with court actions, which had me sentenced guilty with a threat of a prison term of 6 months, without my prior knowledge (see case description here). Such are the peculiarities of German law: internet bloggers are basically legally defined here by default as criminals, and professors as infallible and divine beings (in fact, even Walleses’ former boss and collaborator Paolo Macchiarini is still a protected adjunct professor at their former common place of work, the Medical University Hannover). I received lots of support from my readers, and was also invited to give an interview with the French magazine Mediapart (German version here). Now, I am deeply grateful to Prof. Cantera for his support, and hope other international and maybe even German academics join in and sign below. Continue reading “Open Letter in support of my investigation of trachea transplants in Germany, by Rafael Cantera”→
“Research misconduct is rare, but when it occurs it is usually individuals or small research teams working under the strong influence of a dishonest research leader. Such a closed environment makes it more difficult to quickly detect cheating. […]
The main responsibility for combating scientific fraud through preventive measures and for investigating suspected fraud and taking action is the responsibility of the country’s universities and colleges – the research organizations. […]
Of course it is also crucial to handle the matter properly, when suspicions of scientific misconduct occur. The Swedish Research Council has repeatedly argued that this should be done in a manner that guarantees independence from the influence of personal connections and other conflicts of interest, research misconduct should be investigated by an independent body”.