Appeal to Italian Parliament for an investigation into trachea transplants in Florence by Paolo Macchiarini

Appeal to Italian Parliament for an investigation into trachea transplants in Florence by Paolo Macchiarini

This is an Open Letter I sent today by email to the Italian Senate and its Health Committee, appealing for an investigation into the trachea transplants of the scandal surgeon Paolo Macchiarini.

It is published below bilingually, in Italian and in English. After the earlier Open Letter by Prof Rafael Cantera was signed by over 220 academics and thus led the University of Würzburg in Germany to investigate the trachea transplants of Macchiarini’s former colleagues, Heike and Thorsten Walles, I invite now

  • all Italian clinicians and researchers, in Italy and abroad, as well as their international colleagues working in Italy, to sign this letter in the comment section below. Please use your full affiliation.

The signed Open Letter will be then forwarded to both chambers of Italian parliament and other state authorities.

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Paolo Macchiarini, with his supporter, Governor of Tuscany Enrico Rossi. Photo credit: Corriere Fiorentino

Versione italiana

Appello per un’inchiesta sui trapianti di trachea eseguiti a Firenze da Paolo Macchiarini

Gentili Senatrici, Egregi Senatori membri della 12ª Commissione permanente Igiene e sanità,

questo appello è indirizzato a Voi affinché vogliate considerare l’opportunità di investigare uno dei più gravi casi internazionali di abuso ai danni di pazienti, che è avvenuto e si sta ancora oggi verificando, in grandissima parte anche in Italia.

Chi vi scrive è un giornalista scientifico indipendente, il cui sito web (in lingua inglese) è diventato la più completa fonte di informazioni oggi disponibile a livello globale sul caso di Paolo Macchiarini e della sua “medicina rigenerativa”.

In breve, queste sono state fino a oggi le sue vittime: https://forbetterscience.com/2017/06/16/macchiarinis-trachea-transplant-patients-the-full-list/

Forse avete già avuto modo di apprendere di questa scandalosa vicenda, nella quale persone malate sono state utilizzate quali cavie per esperimenti con trachee artificiali. La maggior parte di essi ora è deceduta, mentre i pochi sopravvissuti soffrono di gravi mutilazioni. Continue reading “Appeal to Italian Parliament for an investigation into trachea transplants in Florence by Paolo Macchiarini”

Tissue-engineered tracheas: an assessment of the scientific, clinical and ethical implications

Tissue-engineered tracheas: an assessment of the scientific, clinical and ethical implications

Here I republish the written evidence submitted to by two UK scientists to the Science and Technology Committee of the British House of Commons and its inquiry into Research Integrity, as originally published on November 21st 2017. It deals with the trachea transplants performed by the surgeons Paolo Macchiarini and his former parter at UCL, Martin Birchall. The report’s lead author is Patricia Murray, professor in stem cell biology and regenerative medicine, previously a nurse on a Head and Neck unit. She generously invited me in May 2017 to give a seminar at her department at the University of Liverpool on this topic. Her coauthor is Raphael Lévy, senior lecturer in nanotechnology and imaging at the same university. I wrote about his reproducibility studies on the topic of nanoparticles in this article.

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Prof. Patricia Murray

UCL recently investigated Birchall’s past trachea transplants, and recommended to continue with his two current clinical trials to transplant cadaveric decellurised trachea and larynx, regenerated with bone marrow cells, as I reported here. For some reason, UCL Registrar Wendy Appleby, when speaking as witness on November 21st in front of the Parliament Inqury, found herself unable to answer the rather straightforward question whether the UCL investigative commission advised to continue transplanting trachea or not (watch here, from 11:50 on). Appleby and her UCL were instructed by the Inquiry to address the concerns by Murray and Levy in writing.

Both clinical trials  Inspire and RegenVox were already placed by the supervising authorities on hold, Murray and Levy now call to stop the dangerous and science-unsupported experimenting on misinformed human patients and to return back to the lab.

Following is a copy of the (originally published on the UK Parliament website), Continue reading “Tissue-engineered tracheas: an assessment of the scientific, clinical and ethical implications”

Open Letter in support of my investigation of trachea transplants in Germany, by Rafael Cantera

Open Letter in support of my investigation of trachea transplants in Germany, by Rafael Cantera

Below a support letter by Rafael Cantera, professor of zoology at the University of Stockholm in Sweden, addressed to the leadership of the University Clinic Würzburg. This is because two professors of this German university, Thorsten Walles and Heike Mertsching (now Walles) chose to respond to my inquiries about their earlier trachea transplants made from pig intestine (see my detailed report here) with lawyers’ financial blackmail and right after, with court actions, which had me sentenced guilty with a  threat of a prison term of 6 months, without my prior knowledge (see case description here). Such are the peculiarities of German law: internet bloggers are basically  legally defined here by default as criminals, and professors as infallible and divine beings (in fact, even Walleses’ former boss and collaborator Paolo Macchiarini is still a protected adjunct professor at their former common place of work, the Medical University Hannover). I received lots of support from my readers, and was also invited to give an interview with the French magazine Mediapart (German version here). Now, I am deeply grateful to Prof. Cantera for his support, and hope other international and maybe even German academics join in and sign below.  Continue reading “Open Letter in support of my investigation of trachea transplants in Germany, by Rafael Cantera”

Professors: innocent victims of snakes at their bosoms? A guest post from Sweden

Professors: innocent victims of snakes at their bosoms? A guest post from Sweden

The following guest post by a Swedish professor under the assumed name of ”Frank Nilsson” (his real identity is known  to me) is an open letter response to a recent article in Svenska Dagbladet by  Sven Stafström, Director General of the Swedish Research Council (Vetenskapsrådet, VR). There Straftröm wrote, in the wake of the Paolo Macchiarini scandal:

“Research misconduct is rare, but when it occurs it is usually individuals or small research teams working under the strong influence of a dishonest research leader. Such a closed environment makes it more difficult to quickly detect cheating. […]

The main responsibility for combating scientific fraud through preventive measures and for investigating suspected fraud and taking action is the responsibility of the country’s universities and colleges – the research organizations. […]

Of course it is also crucial to handle the matter properly, when suspicions of scientific misconduct occur. The Swedish Research Council has repeatedly argued that this should be done in a manner that guarantees independence from the influence of personal connections and other conflicts of interest, research misconduct should be investigated by an independent body”.

Continue reading “Professors: innocent victims of snakes at their bosoms? A guest post from Sweden”

Macchiarini and the tracheal regeneration scandal, by Pierre Delaere

Macchiarini and the tracheal regeneration scandal, by Pierre Delaere

This is an open letter to the academic community by Pierre Delaere, professor for respiratory surgery at KU Leuven, Belgium, and one of the earliest and fiercest critics of Paolo Macchiarini. Delaere recently published a paper explaining that “the engineered trachea is an example of blatant scientific deception” (Delaere and Van Raemdonck, J Thorac Dis. 2016). For the background of Macchiarini’s misconduct and patient deaths after his trachea transplants, as well as Delaere’s attempts to prevent those, please refer to my articles here, here and here. An earlier open letter by Bo Risberg, emeritus professor of surgery at the University of Gothenburg, is also available exclusively on my site Continue reading “Macchiarini and the tracheal regeneration scandal, by Pierre Delaere”