Will words or actual evidence count in the Walles case?

Will words or actual evidence count in the Walles case?

On March 16th I stood a court trial by the trachea transplanters and University of Würzburg professors  Heike and Thorsten Walles against myself. The judge (it was the same who passed the injunction against me) will announce his decision on April 6th, just as I will stand trial in Berlin against their trachea transplant colleague Philipp Jungebluth (see this report). I publish here an extended memory-based protocol which I first published on Facebook. Meanwhile, several large institutions built a protective wall of silence around Walles and their tracheal transplants. The German Medical Association refused investigation in a bizarre letter which I also publish below.

The court hearing

It was the so-called speed trial, so instead of examining evidence, everyone was free to tell the judge their views. Mostly, Walles and their lawyer spoke, occasionally, my lawyer and I were able to squeeze a word in to reject the outlandish or false claims. For example, while her lawyer insisted the tracheal transplants were full success despite dead patients, Heike Walles challenged me to compare her transplants with the first heart transplant which failed. I pointed out that this is exactly the same argument Paolo Macchiarini uses to defend his own failed trachea transplants (for example, here). Continue reading “Will words or actual evidence count in the Walles case?”

Retraction, and another looming misconduct finding for Macchiarini and Jungebluth

Retraction, and another looming misconduct finding for Macchiarini and Jungebluth

The misconduct-tainted paper on oesophagus transplants in rats (Sjöqvist et al 2014) by the fallen star of regenerative medicine Paolo Macchiarini is finally retracted by the journal Nature Communications. This happens after Swedish investigations found the authors (primarily the scandal thorax surgeon and his right-hand man Philipp Jungebluth) guilty of data manipulation and research misconduct in September 2016 and after the Karolinska Institutet (KI) shortly before Christmas publicly demanded a retraction (see my report here). Today’s retraction is a major setback for Macchiarini, since his current employment and funding at the Federal University of Kazan (KFU) in Russia depend on his experiments with oesophageal transplants in primates (see my reports here and here). That Russian project was in turn only possible because of Macchiarini’s allegedly successful experiments in rats, published in a prestige journal with “Nature” in its title. This paper’s retraction is therefore probably only the beginning of a whole looming avalanche of bad news for Macchiarini and his acolyte Jungebluth (who currently sues me in court). An expert review of their publication Jungebluth et al 2015 declares the findings of misconduct, ethics breach and patient abuse. The report however has yet to be confirmed by a commission at the Swedish Central Ethics Review Board (CEPN) and then formulated as an official decree by the KI. I publish the expert reviewer report below. Continue reading “Retraction, and another looming misconduct finding for Macchiarini and Jungebluth”

Walles tracheal transplant patients: secrets and lies

Walles tracheal transplant patients: secrets and lies

The German trachea transplanters Heike and Thorsten Walles fitted three patients with pig-intestine-based airway grafts. They responded to my inquisitive reporting about these with a court injunction, the trial takes place this week, on March 16th. A commission of their Unversity of Würzburg initially absolved Walles of all suspicions of research misconduct, only to start the investigation anew as evidence of heavy data manipulation in their papers emerged (see my previous report). Roland Jahns, specially recruited as medical expert from the same University Clinic Würzburg where both Walleses work, was dismissed after he insulted me as “pseudoscientist” to defend his colleagues’ questionable attitude to data integrity, medical ethics and patient welfare. A new expert will be recruited, but Jahns did reveal some clues to what happened to the two last Walles patients operated in Stuttgart in 2007 and 2009, just before they received their professorships in Würzburg.

It appears Thorsten Walles issued two radically opposing versions of the 2007 patient’s state. In his publications, he presented the intervention as “compassionate use” case and the patient as stable, but in need of innovative strategies to cure his condition. In the medical file however, Walles described the patient as terminally ill and dying from cancer. The intervention to replace his airways with a never-before-tested pig-intestine large patch was presented as a palliative approach, which however turns the entire concept of either palliative care or compassionate use care on its head. In any case, the graft had to be removed after only 2 weeks, the patient died four weeks later due to massive bleeding and multi-organ failure. Walles decided that this disastrous incident had nothing to do with the transplant, so when they recruited their next patient to sign an informed consent in 2009, they simply didn’t tell him what happened to his predecessor. That last patient was also post-suicidal and in psychiatric treatment (though not yet officially of unsound mind, his mental state further deteriorated later on). Continue reading “Walles tracheal transplant patients: secrets and lies”

My Walles trachea transplant reporting fails peer review

My Walles trachea transplant reporting fails peer review

My attempt recently to inform the readers of the journal Tissue Engineering Part A about grave omissions and factual inconsistencies in the Steinke et al 2015 publication by Heike and Thorsten Walles failed spectacularly. Not because the concerns I raised about their tracheal transplants where deemed is irrelevant, far from it. It was the messenger who was seen as disreputable. The editor chose to send my letter out for peer review, despite the fact that I was never addressing the science of the paper, but the omitted, yet verified medical complications and deaths of the patients, as well as non-existent animal tests. Two of three peer reviewers simply chose not to believe me and my evidence, one of the reasons was: my blog site where I published it is not peer reviewed. I was also decreed to be scientifically incompetent, driven by personal vendetta against poor Walles (who are presently suing me at court for reporting about these transplants) and simply as a liar, who made all these things up. At the same time, the notorious third reviewer warns the editor that the journal’s readers must never see or hear of my accusations. Continue reading “My Walles trachea transplant reporting fails peer review”

DFG decision: Antonia Joussen innocent victim of co-authors’ data manipulations

DFG decision: Antonia Joussen innocent victim of co-authors’ data manipulations

Antonia Joussen, German professor and head of the ophthalmology clinic at the Berlin university hospital Charite, is innocent of research misconduct in any form, despite of all the evidence of data irregularities in her publications which emerged in 2015 on PubPeer (see my detailed report here). This is at least what the German Research Foundation (DFG) decided two weeks ago, despite never disputing the PubPeer evidence and even admitting that some of Joussen’s publications do contain manipulated figures. There however, DFG decided that it was Joussen’s co-authors who secretly manipulated the data without her knowing, while her authorship on these problematic papers was anyway accidental and attributed to her behind her back as well. With such argumentation, even as a senior researcher Joussen was not supposed to ensure the data integrity in her own papers. Continue reading “DFG decision: Antonia Joussen innocent victim of co-authors’ data manipulations”

The vexatious life-saving question of cadaveric tracheas

The vexatious life-saving question of cadaveric tracheas

s we learned it from the Swedish documentary „Experimenten“, the scandal trachea surgeon Paolo Macchiarini didn’t much like to operate on sick cancer patients: they died too quickly after receiving a trachea transplant. This is why Macchiarini was said to have moved on to patients outside of any life-threatening conditions, like the Russian car accident victim Yulia Tuulik. She died because of the plastic trachea which Macchiarini implanted into her. Yesim Cetir, young victim of a botched operation, was slightly luckier to survive the plastic trachea, but only because it was removed and because of constant emergency care and multiple organ transplants (she is presently in very grave state). However, it seems that even Macchiarini’s cancer patients could have led a relatively long life, had they not agreed to receive his trachea transplants. And I am not speaking about the lethal plastic ones. In fact, the “biological” grafts made of decellurised dead donor tracheas were not such a great success either, and seem to have brought suffering and have shortened lives instead of prolonging them. The British UCL and its hospital UCLH are preparing their own clinical trial with cadaveric tracheas, while busily covering up their role in the Macchiarini scandal.

Continue reading “The vexatious life-saving question of cadaveric tracheas”

Image duplication and other irregularities of Heike and Thorsten Walles

Image duplication and other irregularities of Heike and Thorsten Walles

More inconsistencies arise in publications and statements of the litigation-happy professors of the University of Würzburg, Heike and Thorsten Walles. These regenerative medicine scientists turned the entire might of German justice system against my reporting, while their academic employer remains shamefully silent.  Their elusive animal experiments with the pig intestine-based tracheal transplants seem to be very real when Heike Walles speaks about them and become non-existent when her husband and research partner Thorsten does. While the University of Würzburg and the federal watchdog Paul-Ehrlich-Institute (PEI) protect the surgeon by asserting that no ethics vote was needed to perform his tracheal transplants on 3 patients, his wife claimed that he actually needed and obtained an ethics approval to do this.  Thorsten Walles himself in fact indicated that his last transplant in 2009 might have broken the German Tissue Law from 2007, i.e., if he indeed failed to obtain an ethics vote, while operating under compassionate use. In any case, no German institution was willing to discuss with me the existence or non-existence of these ethics approvals. Despite the simple fact that none of these 3 patients is alive today (one died in fact very soon after operation), it is none of public’s business.

Now, a seemingly duplicated image was spotted in two Walles publications (Linke et al 2007 and Schanz et al 2010). They describe the creation of an “artificial liver”, made from decellurised pig intestine (just like the tracheal transplants), seeded with endothelial and liver cells. These two publications are 3 years apart, the methodology description is also slightly different (e.g., decellurisation process and the speed and kind of perfusion). A minor aspect may be that the Linke et al 2007 paper described the use of pig cellular material, and Schanz et al 2010 employed primary human cells from patient biopsies. Finally, the image seems not just duplicated, but one looks actually brighter and like a zoom-in of the other.

Continue reading “Image duplication and other irregularities of Heike and Thorsten Walles”