Swedish Central Ethics Review Board finds Macchiarini guilty of misconduct, requests retraction of 6 papers

Swedish Central Ethics Review Board finds Macchiarini guilty of misconduct, requests retraction of 6 papers

Breaking news, Central Ethics Review Board (CEPN) decided today on the case of trachea transplant surgeon Paolo Macchiarini. The expert review by Martin Björck, professor of surgery at University of Uppsala, and Detlev Ganten, professor emeritus of pharmacology and former CEO of the Charité, on which this decision is based, is available here on my site.

Here the press release I received:

The Expert Group on Scientific Misconduct has on request from the Karolinska Institut (KI) delivered a Statement in a case where Paolo Macchiarini is one of the researchers accused of scientific misconduct.
The case comprises six articles which mainly deals with transplantation of synthetic tracheas. These articles have previously been reviewed by Professor Bengt Gerdin, who found scientific misconduct in all six articles. Despite that, KI choose to clear Paolo Macchiarini and the co-authors. KI have thereafter opened the case again.
The Expert Group have appointed two external experts, Professor Martin Björck, Uppsala and Professor Detlev Ganten, Berlin. They have similarly to Bengt Gerdin, founded that there arescientific misconduct in the articles in question.
The Expert Group state that the transplantations are described successfully in the articles, which is not the fact. The Expert Group also establish that the information in the articles are misleading and beautifying regarding the patients conditions and furthermore that information has been withhold in this purpose and that this constitutes scientific misconduct. In addition,there is false information of ethical approval, which also constitute scientific misconduct.
The Expert Group finds that all co-authors to the six articles are guilty of scientific misconduct. The responsibility is however different amongst the authors. The main responsibility lies on Paolo Macchiarini as the main author and research-leader and others who have had a more prominent role in the research and the authorship. The more detailed responsibility and the future consequences for the respective authors is up to their employers to decide.
The Expert Group request the different publications to withdraw all six articles.

Continue reading “Swedish Central Ethics Review Board finds Macchiarini guilty of misconduct, requests retraction of 6 papers”

Swedish police investigation acquitted Macchiarini on advice of misconduct-tainted trachea transplanters

Swedish police investigation acquitted Macchiarini on advice of misconduct-tainted trachea transplanters

On October 12th 2017, the Swedish prosecutor Jennie Nordin  gave a long-awaited press conference about the case of the scandal surgeon Paolo Macchiarini. The surprise hardly anyone expected was: all manslaughter charges were dropped, the case closed. The operations on three patients, whom Macchiarini gave a plastic trachea at the hospital of the Karolinska Institutet (KI), and who died as the result, were declared  mere negligence. Andemariam Beyene, Chris Lyles and Yesim Cetir (details of their cases here) were considered as dying anyway and without any other possibility to help, in fact the prosecution decreed that there was no way to prove if they would have lived longer had Macchiarini not experimented on them without ethics permits or any previous animal testing.

While Sweden and the world listened in disbelief at the words of Nordin, everyone wondered how could the police investigators come to such radically different conclusion about the medical aspects of these trachea transplant operations than the experts in Sweden and worldwide, who clearly see Macchiarini’s trachea transplants as unethical human experimenting and misconduct (see here). The prosecution refused to divulge which experts advised them though, also their assessments remain confidential. Now, thanks to KI’s emeritus professor and whistleblower Johan Thyberg, I found out what the Chairman of the Judicial Council Camilla Olsson, and her rapporteur Robert Grundin wrote to the prosecution:

“The Board has obtained the opinion of Professor Hasse Ejnell and Professor Michael Olausson”

Update 27.10.2017: Prosecutor Nordin confirmed to Thyberg by email that the experts appointed by the National Board of Health and Welfare (Socialstyrelsen) were indeed Hasse Ejnell and Michael Olausson.

These are the two clinical professors from the University of Gothenburg who themselves transplanted a cadaveric trachea, without obtaining a proper ethics vote or an approval of authorities on the treatment and its medication. The patient died soon afterwards and the publication describing that operation  (Berg et al, Tissue Eng Part A. 2014) was retracted for data manipulations. The scientist behind this was the notorious Gothenburg regenerative medicine researcher Suchitra Sumitran-Holgersson. She and Olausson were both found guilty of misconduct and ethics breach by the University of Gothenburg, regarding that trachea transplantation as well as transplants of “regenerated” veins into three child patients.

On top of this, Olausson was involved into the case of Yesim Cetir, Macchiarini’s third patient. Unlike previous two patients Yesim had no slow-growing or any kind of cancer, all she had was a tracheostomy due to damaged trachea after a botched operation in her home country Turkey. With such a defect alone, she was in no life danger at all, as long as she did not try to swim. It was Macchiarini who declared her in his recent television interview as “bleeding a glass of blood” daily, or the Swedish prosecution claiming she was suffering of “life-threatening” chest infection, without explaining how this can be cured with a plastic trachea transplant. Olausson, who helped the prosecution form this diagnosis, has made together with Sumitran-Holgersson a cadaveric trachea which was supposed to save Yesim’s life after her first plastic trachea transplant failed. Macchiarini’s acolyte Philipp Jungebluth (the one who keeps suing me in court in Germany) travelled to Gothenburg to pick up that trachea in 2013.  Macchiarini then changed his mind, sent Olausson his necro-trachea back and implanted another plastic graft into Yesim. Which wade matters even worse, Yesim died in March of this year in the hospital of the Temple University, USA. Her father Hayrullah, who dedicated all his time and attention to trying to save her, died soon after Yesim, on untreated cancer.

Continue reading “Swedish police investigation acquitted Macchiarini on advice of misconduct-tainted trachea transplanters”

After misconduct investigation, Irina Stancheva left Edinburgh, in secret

After misconduct investigation, Irina Stancheva left Edinburgh, in secret

A scientist was “dismissed” by the Department of Biological Sciences at the University of Edinburgh, UK. All evidence points towards that it was the cell biologist Irina Stancheva who specialises on the epigenetics and regulatory methylation of DNA, and who departed from the university recently, after a forced leave. She also has an impressive record on PubPeer, where her publications were flagged for suspected data manipulations around 2 years ago. The suspicions were mostly of western blot band re-use and duplication. Around same time, an investigation started about these PubPeer issues, and by now Stancheva’s name does not feature of the Department’s list of academic staff. A archived version from December 2016 does feature Stancheva, but not that of August 2017. Her institutional website was deleted just hours after I sent my email inquiries to her former faculty colleagues. Continue reading “After misconduct investigation, Irina Stancheva left Edinburgh, in secret”

Karolinska embarrasses itself to save two professors

Karolinska embarrasses itself to save two professors

The Swedish Karolinska Institutet (KI) is going through turbulent times. The Paolo Macchiarini scandal sensitised the European elite biomedical research centre and home of the Nobel Prize not just to patient abuse, but also to research misconduct and data manipulations, which its past professor Macchiarini was found guilty of. The misconduct and patient abuse investigations are ongoing. In parallel, several non-clinical KI professors were or still are under KI investigation, because of PubPeer evidence against their publications, as I reported before on my site. Two of them, as I wrote in a separate article, were the autophagy researcher Helin Vakifahmetoglu-Norberg and her former PhD supervisor, the apoptosis specialist  Boris Zhivotovsky. Both are now finally and irrevocably acquitted by KI of all suspicions of data manipulations in their common publications. The case is closed, there will be no external investigation.

In a previous decision regarding 9 of her papers, KI performed an amazing show of contortionism to absolve Vakifahmetoglu-Norberg from all suspicions of data manipulation (see this report). In one case, manipulated data was declared as non-existent because the paper containing it (Shen et al, Oncogene 2008) was retracted, and hence non-existent itself. No papers from Vakifahmetoglu-Norberg’s postdoctoral period in the US in the lab of Junying Yuan in Harvard were scrutinised by KI, despite the fact that KI originally based their decision to recruit Vakifahmetoglu-Norberg as assistant professor in no small part on these very publications. For example, western blot images from Vakifahmetoglu-Norberg et al, Genes & Dev 2013 were apparently re-used in her new lab’s paper in KI, Xia et al JCB 2015, see this PubPeer evidence: Continue reading “Karolinska embarrasses itself to save two professors”

Paul-Ehrlich Institute admits to have approved Walles tracheal transplant over phone, without questions

Paul-Ehrlich Institute admits to have approved Walles tracheal transplant over phone, without questions

The German trachea transplanters Heike and Thorsten Walles treated the 3 patients with their pig-intestine-based tracheal transplants (one of them performed with Paolo Macchiarini). They are currently suing me in court for reporting about those, while their employer, the University of Würzburg, investigates these tracheal transplants together with the evidence for blatant data manipulations in several Walles publications on suspicion of misconduct. None of those 3 patients is alive today, yet Walles insist that neither of their transplant operations was in any way related to the patients deaths or that it might have reduced their quality of life. They keep declaring those operations as resounding successes, free from any evidence, though the last transplant was performed in 2009 and never again. A corresponding clinical trial, financed by the German Ministry of Education and Research with €1.5 Million between 2009 and 2015 (and briefly mentioned at the beginning of the PEI letter), did not achieve even a single milestone. Not even animal experiments were permitted by the responsible watchdog institution, the Paul Ehrlich Institute (PEI). For almost 7 months, PEI refused to answer my Freedom of Information inquiry. It seems however, my complaints to authorities and the Federal Ministry of Health, finally had an effect.

Continue reading “Paul-Ehrlich Institute admits to have approved Walles tracheal transplant over phone, without questions”

Data manipulation evidence in Helin Vakifahmetoglu papers “warrants no further consideration”

Data manipulation evidence in Helin Vakifahmetoglu papers “warrants no further consideration”

The Swedish Karolinska Institutet (KI) has investigated its own cell biologist and well-funded autophagy researcher Helin Vakifahmetoglu-Norberg, following my publishing of a dossier with evidence for data manipulations in her papers. Also PubPeer evidence was considered. This was a second investigation of Vakifahmetoglu-Norberg, who was fully acquitted by KI already in 2016. While the new KI investigation progressed, one of Vakifahmetoglu-Norberg’s publications was retracted (Shen et al, Oncogene 2008), due to image duplications and unavailability of original data. With their second decision, KI again exonerated  Vakifahmetoglu-Norberg from all suspicions. One of the reasons was: since the Shen et al 2008 is retracted, it ceases to exist. Hence, all image duplications it shares with other Vakifahmetoglu-Norberg papers cease existing also. Other arguments were the author’s assertions to have reproduced more than 10 year old results faithfully (since the original data was unavailable), or her presenting evidence that similar looking images were in fact dissimilar. Unfortunately, where such original data could be recovered, it was shown only to internal investigators at KI, noone else. The case is closed, no appeal is possible. There will be no corrections even, unless journals do the unlikely thing and decide not to accept the KI decision.

Another Vakifahmetoglu paper (Imreh et al, J Cell Biol. 2011) is still under KI investigation but she has officially nothing to do with it. KI announced to follow this through with her former boss and the paper’s last author, Boris Zhivotovsky. He is under another KI investigation already, together with several of his colleagues including the  department’s prefect Ulla Stenius (see my report here), who received the KI letter about  Vakifahmetoglu whitewashing in cc.  Continue reading “Data manipulation evidence in Helin Vakifahmetoglu papers “warrants no further consideration””

German Leibniz institute director Karl Lenhard Rudolph guilty of misconduct

German Leibniz institute director Karl Lenhard Rudolph guilty of misconduct

A major misconduct finding hits German life sciences. Karl Lenhard Rudolph, stem cell and ageing researcher, director of the Fritz-Lippmann-Institute (FLI) of the Leibniz Society, was found guilty of research misconduct by an investigation of the Leibniz Society, in a decision published on June 15th. 11 papers in total were investigated, going back as far as 2001. One paper is to be retracted, seven Errata were requested. The investigation confirmed duplications of image parts, inappropriate splicing, rigged loading controls etc. No original data or lab books were available.

Just in Mai 2016, Rudolph’s FLI was raided by the police “on  suspected breaches of the animal welfare and drug law, as well as embezzlement” . All animal experimenting was stopped till present day, according to Radio Jena, other sources quoted Rudolph in May 2017 that mouse experiments were approved again, though the police investigation continued. Rudolph also admitted that his own lab was also part of the problem and that 13,000 mice were killed unnecessarily. Was Leibniz Society’s recent tough and public disciplinary action upon FLI director Rudolph the consequence?

The translated report on Rudolph’s research misconduct (my own version) is published below, the German original is here. I have not yet determined which publications from Rudolph lab were investigated, but 5 Rudolph papers were previously flagged on PubPeer. His institute, located in the Eastern German town of Jena, is now banned from Leibniz funding for 3 years, FLI now must report back to the Leibniz Executive Board until November 1st 2017 on the improvements regarding data documentation, quality control as well as tutoring and supervision of employees. Continue reading “German Leibniz institute director Karl Lenhard Rudolph guilty of misconduct”