Macchiarini, Jungebluth guilty of research fraud, KI demands retraction of Nature Communications paper

Macchiarini, Jungebluth guilty of research fraud, KI demands retraction of Nature Communications paper

The scandal surgeon Paolo Macchiarini, now professor at Federal University of Kazan in Russia, is preparing to experiment on monkeys using plastic oesophagus. He proclaims previous success in rats, yet today’s decision of his former employer, the Karolinska Institutet (KI) in Stockholm declared that very paper as fraudulent and found Macchiarini and his acolyte Philipp Jungebluth guilty of research misconduct. An earlier decision of the Swedish Central Ethical Review Board (CEPN, read decision here) came on September 6th 2016 to a similar conclusion, with one minor difference. Back then, all senior authors were found “guilty of scientific misconduct”, thus also including Macchiarini’s American collaborator Doris Taylor (who in 2014 almost made him a professor at her University of Texas). Now, all authors except of Macchiarini and Jungebluth have been virtually absolved, while the junior co-authors, the graduate student Sebastian Sjöqvist and the assistant professor Mei Ling Lim received an admonition.

KI now demands the retraction of this 2014 Nature Communications paper:

Sebastian Sjöqvist, Philipp Jungebluth, Mei Ling Lim, Johannes C. Haag, Ylva Gustafsson, Greg Lemon, Silvia Baiguera, Miguel Angel Burguillos, Costantino Del Gaudio, Antonio Beltrán Rodríguez, Alexander Sotnichenko, Karolina Kublickiene, Henrik Ullman, Heike Kielstein, Peter Damberg, Alessandra Bianco, Rainer Heuchel, Ying Zhao, Domenico Ribatti, Cristián Ibarra, Bertrand Joseph, Doris A. Taylor & Paolo Macchiarini

Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats Continue reading “Macchiarini, Jungebluth guilty of research fraud, KI demands retraction of Nature Communications paper”

Two EMBO corrections for the martyred saint Maria Pia Cosma

Two EMBO corrections for the martyred saint Maria Pia Cosma

The cell biologist Maria Pia Cosma, top-funded and prize-winning professor in Barcelona, is either an indestructible zombie scientist or a martyred saint. Her name means in Italian Mary the Pious, so it is probably the latter. So the following post is written in the style of a canonical satire.

Holy Mary Pia was accused by evil tongues on PubPeer of research misconduct in several of her publications. Philistines pointed crooked fingers and cast stones at duplicated western blot bands in papers published by St. Maria Pia in exalted scriptures like Cell. The accusers, envious of such impact factors, wished those gospels of scientific truth crucified on the cross of retraction and demanded for Our Lady of Barcelona to be judged and investigated. Yet Lord took mercy upon the tortured saint and sent His angels to defend her.

The martyr of research integrity, St. Maria Pia (right, standing) receives a sign for “Beatified”. Source: Cosma lab, under fair use

Continue reading “Two EMBO corrections for the martyred saint Maria Pia Cosma”

Kathrin Maedler loses Heisenberg Professorship, found guilty of misconduct by DFG

The German central research funding society DFG has issued a press release about two decisions on research misconduct. The main point concerns the Bremen University diabetes researcher Kathrin Maedler (see my story here) and strips her of the prestigious Heisenberg professorship awarded to her by DFG in 2014, after having found her guilty of misconduct and co-responsible for misrepresentation of research data in 6 publications. Today’s DFG decision stands in contrast to two previous investigations by the Universities of Bremen and Zürich, which acquitted Maedler of all suspicions of misconduct and upheld the validity of all her published research results. This is my Google-translate assisted English translation of the Mädler section of DFG press release.

Scientific misconduct: Decision in two DFG procedures

The General Committee decides to withdraw Heisenberg’s professorship […]

The German Research Foundation (DFG) is once again drawing conclusions from the scientific misconduct by the scientists it funded. In its meeting on 8 December 2016 in Bonn, the main committee of the largest research funding organization and central self-administration organization for science in Germany decided in two cases to implement measures in accordance with the DFG procedural rules for dealing with scientific misconduct. In doing so, it followed the recommendation of the DFG committee to investigate allegations of scientific misconduct. Continue reading “Kathrin Maedler loses Heisenberg Professorship, found guilty of misconduct by DFG”

Hannover thesis investigation and secret Heidelberg research of Philipp Jungebluth

Hannover thesis investigation and secret Heidelberg research of Philipp Jungebluth

The following article provoked a response by Philipp Jungebluth’s lawyer, presented here

The German surgeon-apprentice Philipp Jungebluth was student, most loyal acolyte and trusted right-hand man of the disgraced stem cell researcher Paolo Macchiarini. Jungebluth was part of most if not all trachea transplants performed by Macchiarini on their unlucky patients. Some new information I uncovered (despite best attempts at obfuscation) suggests that Jungebluth was recruited to the University Clinic Heidelberg from Sweden to develop a transplant technology of stem-cell regenerated 3D-printed plastic tracheas. The young surgeon-in-training and his Heidelberg host Hendrik Dienemann progressed to the stage of animal experiments, before Jungebluth lost his position in Heidelberg and left to whereabouts unknown.

The young German doctor started to work with trachea transplants in human patients under his mentor Macchiarini in Barcelona, in 2008. During this project, Jungebluth was part of the team which had been “regenerating” a cadaveric trachea (a section of a bronchus, precisely) with stem cell magic inside a veterinary lab of the University of Bristol, before the final product was flown to Barcelona and transplanted into Macchiarini’s young patient, Claudia Castillo. Not only were the British medical safety authorities not asked for permission, they were actually actively misled, as my earlier investigation revealed. The University of Bristol however simply declared all lab documentation as non-existent and sneakily deleted some press releases which contained uncomfortable information.

Continue reading “Hannover thesis investigation and secret Heidelberg research of Philipp Jungebluth”

Business interests trump patient safety, says EU about trachea transplant trial

The European Union (EU) is firmly determined to see dozens of patients transplanted with “regenerated” tracheas made by the method of Paolo Macchiarini.  Just as soon as one €5.5 Million-funded trial, Biotrachea, was terminated (because the replacement plastic material Macchiarini intended to use was not novel enough), EU gave fresh €7 Million to his former partner and now competitor, the UK throat surgeon Martin Birchall (see my report here). Birchall’s TETRA will be using decellurised cadaveric tracheas, “regenerated” with bone marrow and epithelial cells after the method he developed together with his thorax surgery colleague, Macchiarini. It is a phase II clinical trial, which is rapidly progressing while the Birchall’s corresponding phase I trial, INSPIRE (funded by the public funder Innovate UK), isn’t moving anywhere. In fact, it is about to receive a re-evaluation of its ethics approval on December 2nd 2016, possibly together with Birchall’s other regenerative trial, RegenVox. There, patients are being recruited to have their voice-box replaced with a lab-made one (using same methodology as with trachea); there is also some evidence that the UCL professor already transplanted 3 patients with plastic and cadaveric larynxes even before he applied to the British MRC for the funding of RegenVox in 2012.

I submitted a Freedom of Information (FOI)  inquiry to the EU, asking for the original research proposal of TETRA. My rationale was to compare its science and methodology to that of INSPIRE, which was decried as unscientific and dangerous by the throat surgery specialists I spoke with. The Director-General of the European Commission, Robert-Jan Smits denied my request on the grounds that it lacks an “overriding public interest”, despite the well-known fact that numerous patients have suffered tremendous damage to their health and even died previously when the very same technology was applied by Birchall and Macchiarini. Instead, the EU Commission declared that financial and business interests of the TETRA consortium participants trump all safety concerns about their human research subjects (the full letter can be read here). This is double as scary, also because I am well aware that among my readers are actual prospective patients of Birchall’s. At the same time, the patient information sheet Birchall is using to recruit patients to INSPIRE is highly misinformative (see my report here). Previously, EU ethics commission even approved a much more outrageous patient consent form for Macchiarini’s trachea transplant trial Biotrachea (see my report here). Bottom line: the patients are being duped by the trials’ own consent forms, while the EU has now officially denied these patients and their kin any right to learn from an independent source like my site about what their doctors intend to do to them. Continue reading “Business interests trump patient safety, says EU about trachea transplant trial”

Unveiling the mystery of fallen microbiologist Robert Ryan

Unveiling the mystery of fallen microbiologist Robert Ryan

The young star of microbiology Robert Ryan, rose to great heights only to be publicly shot down, without much of an explanation. Instead, newspapers were tipped-off underhand and internal emails discretely forwarded; the only half-way solid information we have is the evidence of image duplications in his papers as posted on PubPeer. Ryan now left the University of Dundee in Scotland; his institutional profile has been deleted. EMBO recently announced in a footnote that Ryan’s Young investigator Programme (YIP) funding was withdrawn.

Unlike the official news suggest though, Ryan did not resign. He was sacked, apparently after a half-a-year long external investigation organized by the University of Dundee and after appeals which involved lawyers on both sides. Unlike I previously assumed, there was no misconduct investigation by his main funder EMBO, the YIP funding was terminated upon unpublished notification forwarded to Ryan’s funders by the University of Dundee. The University College Cork (UCC) in Ireland claims to have initiated their own (also not officially announced) investigation which seems to involve Ryan’s former mentor and co-author on every single manipulations-tainted paper, Maxwell Dow. At least this is what I was told by direct sources, but again, there were no real official announcements whatsoever.

Continue reading “Unveiling the mystery of fallen microbiologist Robert Ryan”

Sonia Melo fully exonerated and reinstalled as PI by her Portuguese employer I3S

The Portuguese cancer researcher Sonia Melo has been cleared of all suspicions of scientific misconduct by her employer Instituto de Investigação e Inovação em Saúde (I3S) in Porto. She is now re-installed as research group leader, despite of an earlier EMBO investigation which stripped Melo of her start-up funding and the title of EMBO Young Investigator. Previously, PubPeer users raised strong suspicions of data manipulations as well as concerns about irreproducibility and artefactual results based on questionable reagents. The affected publications were authored by Sonia Melo during her stays in the laboratories of Manel Esteller in the Spanish city Barcelona (see my report here) and Raghu Kalluri at MD Anderson in Texas, USA.

Neither of her former supervisors has been investigated by his respective host institution in connection to PubPeer-posted concerns about their publications with or without Melo. Aside of the EMBO investigation (the findings of which were only made available to Melo’s former and current employers), I3S was the only institution to initiate their own investigation. Unfortunately, its report is not available to the public either. All we now receive is a press release, in which I3S admits to the existence of data manipulations (interpreted as cases of “negligence” which “do not compromise the scientific content”) in 3 of Melo’s papers: the now retracted Melo et al, Nature Genetics, 2009, plus Melo et al, PNAS 2011 and Melo et al, Nature 2015. Both papers will be corrected; the latter was seminal in the fundraising of at least $80 Million for the purpose of developing a commercial cancer diagnostics test. No further Melo publications were investigated, including this one: Continue reading “Sonia Melo fully exonerated and reinstalled as PI by her Portuguese employer I3S”