Yuletide greetings from Jungebluth’s lawyer

Yuletide greetings from Jungebluth’s lawyer

On December 22nd, I received some Christmas mail. It was a letter from a famous media lawyer, Prof. Dr. Jan Hegemann, recruited by Philipp Jungebluth to deal with my unwelcome reporting. This is the third time a German clinician set lawyers upon me (here and here are the previous two), and the second time it is about  trachea transplants. This lawyer, whose offices are at Potsdamer Platz at the business heart of Berlin and who represented the biggest stars of German media landscape, is certainly not cheap.

Jungebluth was the closest assistant of the scandal surgeon of Paolo Macchiarini, many of their trachea transplant patients have died. Through his lawyer, Jungebluth (who is an unfinished surgeon) denied any responsibility for any of these operations, insisting against a huge mountain of evidence that he was solely contributing academically, as a scientist. The lawyer also insists that Jungebluth’s medical dissertation, completed under Macchiarini’s supervision at the Medical University Hannover (MHH) in Germany, was equivalent to a PhD degree and that his employer Karolinska Institutet (KI) officially recognized this (for some reason, same lawyer apparently deems my own PhD degree as null and void). Interestingly, the lawyer did not deny my earlier report that his client’s dissertation is being investigated by the MHH right now, which may result in the revocation of Jungebluth’s medical doctorate and of all its alleged equivalences.

The lawyer’s main assertion is that his client quit his job at the University Clinic Heidelberg utterly voluntarily, thus abandoning all his research and training as thorax surgeon, to become a junior doctor at some provincial communal hospital near Hannover. Yet the loss of his job in research was what Jungebluth actually profusely lamented just now in an interview with Swedish newspaper.

Continue reading “Yuletide greetings from Jungebluth’s lawyer”

Macchiarini, Jungebluth guilty of research fraud, KI demands retraction of Nature Communications paper

Macchiarini, Jungebluth guilty of research fraud, KI demands retraction of Nature Communications paper

The scandal surgeon Paolo Macchiarini, now professor at Federal University of Kazan in Russia, is preparing to experiment on monkeys using plastic oesophagus. He proclaims previous success in rats, yet today’s decision of his former employer, the Karolinska Institutet (KI) in Stockholm declared that very paper as fraudulent and found Macchiarini and his acolyte Philipp Jungebluth guilty of research misconduct. An earlier decision of the Swedish Central Ethical Review Board (CEPN, read decision here) came on September 6th 2016 to a similar conclusion, with one minor difference. Back then, all senior authors were found “guilty of scientific misconduct”, thus also including Macchiarini’s American collaborator Doris Taylor (who in 2014 almost made him a professor at her University of Texas). Now, all authors except of Macchiarini and Jungebluth have been virtually absolved, while the junior co-authors, the graduate student Sebastian Sjöqvist and the assistant professor Mei Ling Lim received an admonition.

KI now demands the retraction of this 2014 Nature Communications paper:

Sebastian Sjöqvist, Philipp Jungebluth, Mei Ling Lim, Johannes C. Haag, Ylva Gustafsson, Greg Lemon, Silvia Baiguera, Miguel Angel Burguillos, Costantino Del Gaudio, Antonio Beltrán Rodríguez, Alexander Sotnichenko, Karolina Kublickiene, Henrik Ullman, Heike Kielstein, Peter Damberg, Alessandra Bianco, Rainer Heuchel, Ying Zhao, Domenico Ribatti, Cristián Ibarra, Bertrand Joseph, Doris A. Taylor & Paolo Macchiarini

Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats Continue reading “Macchiarini, Jungebluth guilty of research fraud, KI demands retraction of Nature Communications paper”

Karolinska in denial, by Johan Thyberg

Karolinska in denial, by Johan Thyberg

This is a guest post by Johan Thyberg, a 1947-born Swedish biologist and a well-known activist against science fraud. His 2009 published book “Scientific Fraud or Legal Scandal?” meticulously narrates several fraud scandals in Swedish science, one of which I referred to when introducing a guest post of another concerned Swedish academic. Until his academic retirement, Thyberg used to be professor for cell and molecular biology at Karolinska Institutet (KI) in Stockholm, the showplace of probably the biggest medicine scandal of recent times, that of the trachea transplant surgeon Paolo Macchiarini. Continue reading “Karolinska in denial, by Johan Thyberg”

Collapse of Biotrachea, or how Macchiarini’s greed saved human lives

Collapse of Biotrachea, or how Macchiarini’s greed saved human lives

The trachea transplant experiments by Paolo Macchiarini left many of his trusting patients dead or mutilated. His €5.5 Million EU-funded research project Biotrachea started in April 2012 and was specifically designed to treat even more human beings with lethal plastic tracheas (and with the slightly less lethal cadaveric ones). The consortium was terminated in 2014 (see some background here), but not because the Biotrachea scientists or EU officials suddenly had second thoughts when the Macchiarini scandal unraveled and when his misconduct, ethics breaches as well as painful deaths and suffering of his plastic trachea recipients became known. Unlike an EU spokesperson previously insisted, there were no ethics concerns at all regarding Biotrachea. In fact, all ethics approvals were in place, human Guinea pigs were supposed to be lured en masse using a highly inappropriate patient consent form towards their likely deaths for the sake of EU-funded mega-science.

In truth, Biotrachea collapsed only because of Macchiarini’s greed for money. His financial conflict about patent revenues with the British university UCL drove the star surgeon to seek another plastic transplant manufacturer and then to destroy the entire multinational research consortium which he was presiding over, after the EU rejected his new plastic provider. Not because that one was also deemed unsafe, but as the EU negotiators mentioned, it was because that new type of plastic trachea lacked novelty. All this only became known after the original Biotrachea documents, which the EU and all consortium participants refused to grant me any insight into, were fully legally obtained by Jonas Malmstedt under Swedish transparency from Macchiarini’s ex-employer, the Karolinska Institutet (KI). Thanks to this brave and decent surgeon, I make all that secret documentation available below.

Continue reading “Collapse of Biotrachea, or how Macchiarini’s greed saved human lives”

Mass investigation of 9 senior scientists at Karolinska Institutet

Mass investigation of 9 senior scientists at Karolinska Institutet

The scandal-shaken Swedish Karolinska Institutet (KI) invited nine of their research group leaders and professors to explain themselves about data integrity concerns raised in regard to their publications. They have time until November 24th 2016 to address of the suspicions of image duplications which were posted on PubPeer by anonymous watchdogs and subsequently reported to Karolinska by a whistleblower. This was the email the 9 scientists received on November 10th from Lisen Samuelsson of KI’s legal department:

“Karolinska Institutet (KI) has been notified about inaccuracies in one or more scientific articles according to comments on the website PubPeer. You are named as the main author of the article (s) in question.

KI therefore requests that you provide a statement regarding whether the alleged inaccuracies are correct or not. If there are inaccuracies in the article (s), KI requests that you specify whether they have been corrected, or if they will be corrected, and if so, how. Please submit your statement to KI at registrator@ki.se regarding this matter by November 24, 2016”.

dear-scientist

The email was complemented by a list of these scientists’ respective PubPeer-flagged publications. Most of these 9 addressees are very senior KI researchers, like Ulla Stenius and Boris Zhivotovsky. Here is the list, with some background information:

Continue reading “Mass investigation of 9 senior scientists at Karolinska Institutet”

Helin Vakifahmetoglu and Nobel-prized autophagy research of Karolinska

The Nobel Assembly at the Karolinska Institutet (KI) in Sweden awarded this week the Nobel Prize in Physiology or Medicine 2016 to the Japanese scientist Yoshinori Ohsumi “for his discoveries of mechanisms for autophagy”. Autophagy is a physiologically highly relevant intracellular process of protein and organelle recycling, when these are misfolded or damaged or when the cell lacks nutrients. Possibly, KI Nobel Assembly’s decision might have been inspired by the success of their own excellent young autophagy researcher: Helin Vakifahmetoglu-Norberg, see also this press release. The following is to raise concerns about hers and KI’s achievements in the Nobel-awarded research field of autophagy, which are somewhat marred by recurrent image duplications. The copious new evidence I was given by a certain sleuth team suggests a possibly bigger problem than KI previously decreed.

The young group leader started her career in the field of apoptosis (cell death) research and authored many publications in highly respectable journals, both as PhD student of Karolinska in the lab of cell biologist Boris Zhivotovsky, as well as postdoctoral scientist in Harvard, with another apoptosis specialist, Junying Yian.  Vakifahmetoglu-Norberg then returned to KI to start her own cell biology research group, not on apoptosis, but on autophagy. At her institutional website she lists research funding from top-sources like the Swedish Research Council (VR), the Ragnar Söderberg Foundation, the Swedish Society for Medical Research and several others.  “Highly enthusiastic and hardworking postdocs and undergraduate students” are invited to join the “protein degradation pathways“ lab, while also discretely asked to bring their own financial support. Funding money plays a big role at KI, as we all recently learned during the Paolo Macchiarini scandal.

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Mild criticism only for Sumitran-Holgersson and Olausson from Gothenburg University Hospital investigation

The indestructible Swedish regenerative medicine researcher Suchitra Sumitran-Holgersson could have been stopped early on, and a patient of hers could have been alive still. The former professor at the Karolinska Institutet (KI) was caught faking data in 2009. A paper had to be retracted as consequence (Elsheikh  et al, Blood, 2005) , but in 2011 the entire external investigation and its results was declared nil and void by the Swedish Research Council Vetenskapsrådet (VR) which had originally commissioned it. The reasons used back then were rather incomprehensible, it boiled down to the accusations against the two investigators themselves, of having found research misconduct where they were not supposed to find research misconduct (for details, see my earlier report). To top it off, all frozen funding of this cheater professor was reinstituted and the University of Gothenburg together with its Sahlgrenska University Hospital welcomed Sumitran-Holgersson as a “genius”. There, at the Department of Surgery at the Sahlgrenska Academy she established a hub of regenerative medicine, helped by her husband Jan Holgersson (whose company had been threatening his wife’s investigators, silently condoned by VR), and by the head surgeon Michael Olausson. Together, Sumitran-Holgersson and Olausson produced a string of regenerative medicine papers of which the University of Gothenburg and Sahlgrenska used to be very proud. Maybe less so these days, since a rich evidence of fresh data manipulations surfaced on PubPeer several months ago (see examples here). Meanwhile, part of Sumitran-Holgersson’s tremendous funding has been frozen, though VR still maintains their trust in her research. Apparently, also the Sahlgrenska Academy of Gothenburg.

Continue reading “Mild criticism only for Sumitran-Holgersson and Olausson from Gothenburg University Hospital investigation”