Expert review: Macchiarini papers on plastic trachea transplants are misconduct

Expert review: Macchiarini papers on plastic trachea transplants are misconduct

Bad times for the scandal surgeon Paolo Macchiarini and his acolyte Philipp Jungebluth. Misconduct findings led previously to retraction of an oesophagus transplant paper, with more soon to be expected, their employments in academia seem to be definitely a thing of a past. Macchiarini’s big plans of world-shattering trachea and oesophagus transplants in Russia went bust, when his grant funding was not extended and the Federal University of Kazan waved him goodbye. The master’s acolyte Jungebluth is currently suing me in court about my reporting on his own past employment, because he managed to convince the Berlin judge when passing the injunction that all his now proven research misconduct and patient abuse, which led to deaths of several patients, plus several other dishonest deeds of his, had in fact perfectly qualified him for an academic research career at the University of Heidelberg in Germany. A career he claims to have aborted entirely on his own accord, hence his (now only 1/3 successful) court injunction against me. Jungebluth, after having said farewell to his 8 years of thorax surgery training in vain, even claimed in court to be desperately wanted as thoracic surgeon by all Berlin hospitals, including the huge university hospital Charité.

Which brings us to the recent setback for the two trachea transplanters. Their publications regarding the plastic trachea operations at the Karolinska Institutet (KI) in Stockholm, which left three patients dead, were investigated by two external experts. One of the experts was Martin Björck, professor of surgery at University of Uppsala, the other was Detlev Ganten, professor emeritus of pharmacology and former CEO of the Charité. And their fresh report, submitted to the Swedish Central Ethics Review Board (CEPN), does not read like the Berlin Charité or any other medical research institution in Germany, or anywhere else for that matter, might ever consider employing Jungebluth. The central Lancet publication, describing the first plastic trachea transplant performed on Andemariam Beyene (Jungebluth et al, 2011), was slammed as based on misconduct, both ethical as well as research misconduct. It is the same Lancet paper Jungebluth presented to Berlin court as evidence of his scientific fame and excellence.

Continue reading “Expert review: Macchiarini papers on plastic trachea transplants are misconduct”

Macchiarini’s trachea transplant patients: the full list

Macchiarini’s trachea transplant patients: the full list

This article lists all known (including those not officially declared) patients of the scandal surgeon Paolo Macchiarini, who received from his a cadaveric or plastic trachea. All received grafts “regenerated” with bone marrow and epithelial cells, in some cases bioreactor was used to incubate cells on the trachea carcass, in some cases a “bionic” method was applied,  where cells were brought straight into open patient, together with growth factors like EPO. Not all patients are named in my list, though names of all are available, certainly at the hospitals where they were treated. One of my sources is a patients list from the Careggi Hospital in Florence, Italy, which the Corriere Fiorentino journalist Alessio Gaggioli sent me.  Some of the patients I already described in an earlier article.

This now is a full list, and it will be updated whenever I receive any new evidence. All Macchiarini trachea transplant patients are listed in the chronological order of their operation. The 2003 operated patient (story here), who received from Macchiarini (together with Heike and Thorsten Walles) a small “regenerated” tracheal patch of pig intestine, is not included here, as it was not a trachea transplant as such. There is a total of 17 patients, at least 11 are dead, the rest, if alive, were left mutilated.

Continue reading “Macchiarini’s trachea transplant patients: the full list”

Sumitran-Holgersson and Olausson guilty of misconduct and unethical experiments on children

Sumitran-Holgersson and Olausson  guilty of misconduct and unethical experiments on children

Game over apparently near for the indestructible Swedish regenerative medicine researcher Suchitra Sumitran-Holgersson, after investigations at her University of Gothenburg  draw to an end. It is about experimental transplants of decellurised veins “regenerated” with the patient’s own bone marrow cells into three child patients, all of whom ended up in life-long medical care, one patient received  a liver transplant after her graft failed, another child suffered severe complications (see this earlier report about an external investigation by Bengt Gerdin into that matter). The University of Gothenburg then established an investigative committee, which followed up on the Gerdin report and specific concerns voiced by a journal editor and a colleague. I publish below the two decisions which revealed that Sumitran-Holgersson and her surgeon partner Michael Olausson never performed any animal testing before recruiting their human patients, they also failed to obtain ethics permits for these operations. Instead the two lied in their publications (Olausson et al, Lancet, 2012; Olausson et al EBioMedicine, 2014) about having obtained ethics votes (something I already uncovered before). During the investigation, Olausson and Sumitran-Holgersson were caught submitting false information to the committee. They were now found guilty of misconduct and ethics breach in both these publications. Continue reading “Sumitran-Holgersson and Olausson guilty of misconduct and unethical experiments on children”

Retraction, and another looming misconduct finding for Macchiarini and Jungebluth

Retraction, and another looming misconduct finding for Macchiarini and Jungebluth

The misconduct-tainted paper on oesophagus transplants in rats (Sjöqvist et al 2014) by the fallen star of regenerative medicine Paolo Macchiarini is finally retracted by the journal Nature Communications. This happens after Swedish investigations found the authors (primarily the scandal thorax surgeon and his right-hand man Philipp Jungebluth) guilty of data manipulation and research misconduct in September 2016 and after the Karolinska Institutet (KI) shortly before Christmas publicly demanded a retraction (see my report here). Today’s retraction is a major setback for Macchiarini, since his current employment and funding at the Federal University of Kazan (KFU) in Russia depend on his experiments with oesophageal transplants in primates (see my reports here and here). That Russian project was in turn only possible because of Macchiarini’s allegedly successful experiments in rats, published in a prestige journal with “Nature” in its title. This paper’s retraction is therefore probably only the beginning of a whole looming avalanche of bad news for Macchiarini and his acolyte Jungebluth (who currently sues me in court). An expert review of their publication Jungebluth et al 2015 declares the findings of misconduct, ethics breach and patient abuse. The report however has yet to be confirmed by a commission at the Swedish Central Ethics Review Board (CEPN) and then formulated as an official decree by the KI. I publish the expert reviewer report below. Continue reading “Retraction, and another looming misconduct finding for Macchiarini and Jungebluth”

The Kenneth Chien Case at Karolinska, by Johan Thyberg

The Kenneth Chien Case at Karolinska, by Johan Thyberg

This is a new guest post from Johan Thyberg, a retired professor for cell and molecular biology from Sweden, a known activist against science fraud and author of the 2009 book “Scientific Fraud or Legal Scandal?”. Thyberg played a key role in uncovering the research misconduct and horrendous patient abuse around the trachea transplant surgeon Paolo Macchiarini, which took place at Alma Mater, the Karolinska Institutet (KI) in Stockholm, and left at KI alone 3 patients dead (his last plastic trachea recipient there, Yesim Cetir, died yesterday after years of suffering).

After a previous guest post by Thyberg, which criticised KI’s handling of the Macchiarini scandal, it is an honour for me to present his new article on my site. It deals with another international star of regenerative medicine whom KI recruited soon after Macchiarini: Kenneth Chien. The people who recruited Chien were also the same who made Macchiarini’s professorship at KI possible: the then-chancellor Harriet Wallberg and the cell biology professor Urban Lendahl. Both had to resign from their positions with the KI’s Nobel Committee in the wake of Macchiarini scandal (see my report here).

This is what Chien’s 20-head strong lab is working on at KI, according to its website:

“The central scientific interest of the Chien lab is to understand heart development at the molecular and cellular level, with the ultimate goal of applying the developmental principles, logic, pathways, technology, and model systems to unravel human heart disease”.

According to Thyberg, Chien’s engagement at KI is less about his actual scientific achievements, which seem objectively rather modest relative to his elite status there, but more about personal networks and money, which include pharma industry and a certain Chinese investor. One of these Chien-related businesses is Moderna Therapeutics, a biotech start-up which STAT News brought a critical special report on.

Below I am publishing Thyberg’s own English version article, a Swedish version appeared on March 17th on NewsVoice.

Continue reading “The Kenneth Chien Case at Karolinska, by Johan Thyberg”

Yuletide greetings from Jungebluth’s lawyer

Yuletide greetings from Jungebluth’s lawyer

On December 22nd, I received some Christmas mail. It was a letter from a famous media lawyer, Prof. Dr. Jan Hegemann, recruited by Philipp Jungebluth to deal with my unwelcome reporting. This is the third time a German clinician set lawyers upon me (here and here are the previous two), and the second time it is about  trachea transplants. This lawyer, whose offices are at Potsdamer Platz at the business heart of Berlin and who represented the biggest stars of German media landscape, is certainly not cheap.

Jungebluth was the closest assistant of the scandal surgeon of Paolo Macchiarini, many of their trachea transplant patients have died. Through his lawyer, Jungebluth (who is an unfinished surgeon) denied any responsibility for any of these operations, insisting against a huge mountain of evidence that he was solely contributing academically, as a scientist. The lawyer also insists that Jungebluth’s medical dissertation, completed under Macchiarini’s supervision at the Medical University Hannover (MHH) in Germany, was equivalent to a PhD degree and that his employer Karolinska Institutet (KI) officially recognized this (for some reason, same lawyer apparently deems my own PhD degree as null and void). Interestingly, the lawyer did not deny my earlier report that his client’s dissertation is being investigated by the MHH right now, which may result in the revocation of Jungebluth’s medical doctorate and of all its alleged equivalences.

The lawyer’s main assertion is that his client quit his job at the University Clinic Heidelberg utterly voluntarily, thus abandoning all his research and training as thorax surgeon, to become a junior doctor at some provincial communal hospital near Hannover. Yet the loss of his job in research was what Jungebluth actually profusely lamented just now in an interview with Swedish newspaper.

Continue reading “Yuletide greetings from Jungebluth’s lawyer”

Macchiarini, Jungebluth guilty of research fraud, KI demands retraction of Nature Communications paper

Macchiarini, Jungebluth guilty of research fraud, KI demands retraction of Nature Communications paper

The scandal surgeon Paolo Macchiarini, now professor at Federal University of Kazan in Russia, is preparing to experiment on monkeys using plastic oesophagus. He proclaims previous success in rats, yet today’s decision of his former employer, the Karolinska Institutet (KI) in Stockholm declared that very paper as fraudulent and found Macchiarini and his acolyte Philipp Jungebluth guilty of research misconduct. An earlier decision of the Swedish Central Ethical Review Board (CEPN, read decision here) came on September 6th 2016 to a similar conclusion, with one minor difference. Back then, all senior authors were found “guilty of scientific misconduct”, thus also including Macchiarini’s American collaborator Doris Taylor (who in 2014 almost made him a professor at her University of Texas). Now, all authors except of Macchiarini and Jungebluth have been virtually absolved, while the junior co-authors, the graduate student Sebastian Sjöqvist and the assistant professor Mei Ling Lim received an admonition.

KI now demands the retraction of this 2014 Nature Communications paper:

Sebastian Sjöqvist, Philipp Jungebluth, Mei Ling Lim, Johannes C. Haag, Ylva Gustafsson, Greg Lemon, Silvia Baiguera, Miguel Angel Burguillos, Costantino Del Gaudio, Antonio Beltrán Rodríguez, Alexander Sotnichenko, Karolina Kublickiene, Henrik Ullman, Heike Kielstein, Peter Damberg, Alessandra Bianco, Rainer Heuchel, Ying Zhao, Domenico Ribatti, Cristián Ibarra, Bertrand Joseph, Doris A. Taylor & Paolo Macchiarini

Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats Continue reading “Macchiarini, Jungebluth guilty of research fraud, KI demands retraction of Nature Communications paper”