The team around the paediatric oncologist Nabil Ahmed at Baylor College of Medicine in Houston, Texas, discovered a way to engineer T-leukocytes to bypass the blood-brain barrier at attack otherwise untreatable brain cancers. Their amazing technology to get this published in Nature was brazenly insolent data fakery.
The 2015 Nature Cell Biology paper by the Spanish cancer researcher Carlos Lopez-Otin and his US partner George Q Daley, stem cell titan and dean of Harvard Medical School, is being retracted. First author and Lopez-Otin’s student Clara Soria-Valles caused Daley even more trouble: her next groundbreaking paper was meant to be already published, but it is not even submitted and might never be.
Too many scientists defend the practice of not probing for loading controls for each protein gel. They say a “library” method perfectly suffices, when one separate loading control gel is run once for reference. Such sloppiness can sometimes be a hint of even worse practices taking place.
Smut Clyde will take you on a meditative Ayurvedic trip where the most respectable of research institutions and their world-renowned academics were caught dancing with the Guru Deepak Chopra himself. Famous cardiologist and medical writer Eric Topol and the Nobel Prize winner Elizabeth Blackburn were just two most prominent US academics listed on Chopra’s Panchakarma clinical trial.
Louis J. Ignarro knew how to monetize his 1998 Nobel Prize for discovery of nitric oxide as molecular cell signalling agent. He made many millions selling dietary supplement for Herbalife and pomegranate juice for POM Wonderful Company. Some of that found its way (without proper conflict of interest declaration) into Ignarro’s peer reviewed papers. Those, done in collaboration with certain Photoshop artists like Claudio Napoli, contain clearly fabricated data.
Elite journal Nature Cell Biology (NCB) requests deposition of raw data, in particular original scans of western blots and other gel analyses. Spanish star cancer researcher Carlos López-Otín, winner of 2017 Nature Mentoring Award, instead deposited whatever odd gel picture his lab had available, counting that nobody will bother to check. Yet readers did.
Janine Erler is a star of Danish cancer research, funded by ERC. Her earlier research led to the discovery of the key role of the enzyme lysyl oxidase in cancer metastasis and brought the scientist and businesswoman very close to curing cancer. Until some sad envious bad-wishers found duplicated gel bands in Erler papers.