Hannover Medical School MHH: where doctor careers matter more than patient lives?

Hannover Medical School MHH: where doctor careers matter more than patient lives?

Philipp Jungebluth, formerly right-hand man and student of the lethal trachea transplant surgeon Paolo Macchiarini, is threatening another lawsuit against me. This time, he is unhappy about being associated with the 5 trachea transplant operations Macchiarini performed in Italy (only one of these five might still be alive, with a permanent brain damage). Jungebluth freely admits through his lawyer to have been part in the two operations in Barcelona: the very first trachea transplant on Claudia Castillo in 2008, and another one, performed in secret against an explicit ban issued by the Hospital Clinic Barcelona, in a neighbouring hospital on the Argentinian patient DD. Both patients Castillo and DD were previously unsuccessfully operated on their airways by Macchiarini, both were eventually offered a bronchus or trachea transplant, respectively.  I was informed how the 55-year old  DD fared after the operation, and it was a total disaster (it is all but clear if she is still alive, in fact even survivor Claudia Castillo can’t be found anymore).

These two operations were however according to Jungebluth part of his German medical education, the so-called “practical year”, as student of the Hannover Medical School (MHH). It seems that a past MHH professor, Heike Kielstein (nee Nave) was involved in the histological analyses of these trachea transplants. In 2010, Kielstein as part of award ceremony presented Jungebluth with a €2500 prize for his Macchiarini-supervised medical dissertation, which described only the first trachea transplant patient, but kept the second transplant operation on DD as a total secret. But MHH apparently knew about that highly unethical act, and did not mind at all.

Hence, MHH did not cease all trachea transplant research in 2006, as they once told to me untruthfully. The technology was simply outsourced in a good MHH tradition to poorer parts of Europe. To escape tough German regulations or legal responsibilities? Or maybe because the non-German patients abroad were seen as more suitable for medical experiments? MHH, whose rector just recently ordered its own university not to investigate Jungebluth’s dissertation, remains deadly silent. Herr Professor Macchiarini, whose German is near-native (the Italian grew up in Switzerland) and is much better than his English, remains adjunct professor at MHH, against state law.  Continue reading “Hannover Medical School MHH: where doctor careers matter more than patient lives?”

The Costs of Knowledge: scientists want their cut on the scam

The Costs of Knowledge: scientists want their cut on the scam

When the mathematician Timothy Gowers, with some co-signers, started in 2012 his initiative “The Costs of Knowledge” to boycott Elsevier for their business practices, he was hoping to release science from the grip of commercial publishers. His reasoning went: with academics boycotting Elsevier en masse as authors, reviewers and editors, the commercial publisher would be forced to change its greedy ways, or the universities would separate themselves from the blackmail-like practice of Elsevier subscriptions (not that NatureSpringer, Wiley or others are much better in that regard). Meanwhile only 16800 people signed The Cost of Knowledge pledge, and some renounced on it silently. Open Access (OA) movement gained speed at roughly the same time, originally with the goal of reducing publication costs. Exactly the opposite was achieved, in fact what subscription publishers did was to usurp the OA movement for their greedy purpose, by subsidising OA conferences and feeding the egos of or simply doing business with those most vocal OA proponents. By now, same megapublishers sell so-called Gold OA on top or in addition to subscriptions; NatureSpringer and Elsevier became world’s biggest and second -biggest OA publishers, respectively.

University library budgets are near breakpoint, in fact Germany just now cancelled Elsevier subscriptions, in a desperate attempt to negotiate a better deal which would include both subscriptions and OA article-processing charges (APC). But some academics seem to have a different viewpoint on how to respond to publishers ripping off their own research institutions. They want their cut on the scam, namely to be paid for their peer review services. The idea is: since peer reviewing duties are not directly specified as such in faculty employment contracts, they must be then not a part of research activities, but a kind of voluntary charity to your peers, or in fact to commercial publishers. As journals and their for-profit owners (because even academic society-run journals are for-profit) make such big money publishing peer reviewed research, the peer reviewers want their share. And they don’t seem to spare a thought if science gets damaged beyond repair in the process.

incompetent referee

Continue reading “The Costs of Knowledge: scientists want their cut on the scam”

The PubPeer Stars of Weizmann Institute

The PubPeer Stars of Weizmann Institute

Journals generally avoid acting on data manipulation, unless forced to by investigations from universities and research institutions. The Lancet‘s current stance on Macchiarini (and previously Wakefield) affair is probably the most dangerous example. Practically at every single research integrity conference (which are usually organised by major publishers like Elsevier), publishing executives preach that journals should never be asked to deal with data manipulations in papers they publish,  but only respond to the final results of institutional investigations.

Actually, even there journals prefer not to retract as requested, as Science did in the case of Olivier Voinnet. On the other hand, some publishers are ready to forgive all misconduct when a unrepentant cheater offers them a new hot paper. Nature Publishing group, EMBO Press and even the publisher lobby group COPE recently protested against journals’ cheater blacklists, in connection with the data-faking plant researcher Patrice Dunoyer, a past Voinnet associate (his story here). And some journals even openly take the side of cheater scientists, while attacking PubPeer whistleblowers, as F1000 Research seemingly did, see tweet below.

Scholarly journals mostly act like grocery shops, which despite better knowledge refuse to remove contaminated foods off the shelves until manufacturer’s official recall, regardless of how many glass shards were found inside. It therefore lies in the hands of research institutions when fraud and cheating continue unabated, while research community is fooled and robbed, left alone with futile attempts to reproduce dishonest papers full of secret data manipulations. Yet this is exactly what Weizmann Institute of Science in Israel is good at:

The Art of Not Investigating

The following article lists Weizmann scientists with some serious evidence on PubPeer against the trustworthiness of their research. Before this elite institution from Rehovot, that most famous biomedical research centre in Israel, dismisses my article as anti-Semitic slander of an obscure German Nazi blogger, they should first try it with declaring me an assimilation-corrupted, self-hating diaspora Jew. Continue reading “The PubPeer Stars of Weizmann Institute”

Yoshinori Watanabe data manipulations: much worse than officially presented

Yoshinori Watanabe data manipulations: much worse than officially presented

Earlier this months, a research misconduct scandal in molecular cell biology broke out in the big news. Yoshinori Watanabe, Japanese researcher of cell division and how cells separate their replicated DNA during mitosis and meiosis, was found guilty of scientific misconduct by his University of Tokyo (read the news here and here). This followed an investigation initiated in the fall of 2016, after anonymous whistleblowers submitted to the university a report accusing 6 Tokyo research groups of data manipulation, first and foremost, Watanabe (I managed to obtain this dossier, and publish it below).

As the outcome of the University of Tokyo investigations, which concluded on May 31st 2017, misconduct was determined in 5 publications from Watanabe’s lab, which appeared between 2008 and 2015 in the elite journals like Science, Nature and Nature Cell Biology. However, the whistleblower dossier lists 7 papers, one of them a paper in Cell from 2015 with duplicated gel images, and a 2011 EMBO Reports paper which contains a western blot which was obviously digitally retouched to remove unwanted bands. Watanabe’s assistant professor Yuji Tanno was also found guilty of misconduct, and indeed his 2015 Science paper with Watanabe looks like a total train wreck of data manipulations.  Yet it seems there is a tendency to present Watanabe’s deeds as mere mistakes (though grossly inappropriate ones) by a great genius scientist, who was confused by the complexity of rules on data acquisition and incidentally broke some while producing outstanding and absolutely reliable top-level research. Some of his peers seem to be calling for leniency or at least some understanding for Watanabe. The selected evidence from the whistleblower dossier which I post below suggests that Watanabe knew perfectly well what he was doing, and he did so in order to produce desirable results which his lab experiments failed to deliver, and which he needed in order to impress the choosy elite journals.

Continue reading “Yoshinori Watanabe data manipulations: much worse than officially presented”

The one who asked questions: interview with Johannes Wahlström, by Alla Astakhova

The one who asked questions: interview with Johannes Wahlström, by Alla Astakhova

Below I am re-publishing an interview which the Russian health journalist Alla Astakhova conducted with the Swedish journalist Johannes Wahlström. Wahlström’s work for the Swedish television SVT, together with Bosse Lindquist, was decisive in uncovering the patient abuse by the fallen star surgeon Paolo Macchiarini (see here the full list of trachea transplant patients). Without the dedicated work of the Swedish journalists, Macchiarini would probably still be experimenting on humans with his cadaveric and plastic tracheas, generating even more death and suffering in the process. In the interview with Astakhova, Wahlström tells about his research for the famous SVT film Experimenten, and how the SVT team found out about the four Karolinska Institutet whistleblowers Oscar SimonsonKarl-Henrik Grinnemo, Matthias Corbascio and Thomas Fux (see my reports about them here, here and here).

For Wahlström, the scandal is not just about Macchiarini. The central figures here are the abused patients, most, if not almost all of them no longer alive. And Macchiarini is not the only one guilty. Wahlström explains how everyone else orbiting that grandiose thorax surgeon was co-responsible, by looking away, covering things up or contributing their small share to the grand horror. The multilingual Swedish journalist specifically criticises the irresponsible dishonesty of Macchiarini’s Russian surgeon partners Vladimir Parshin and Igor Polyakov in the face of the catastrophe they participated in, or the bizarre attitude of Macchiarini’s biographer and Megagrant-manager Elena Kokurina, who seems to have been deliberately avoiding learning the real fate of his patients. Wahlström also questions the ethics of German TV producers who decided to air their Macchiarini-extolling documentary Supercells! in Germany and France despite knowing that its protagonist, Yulia Tuulik, was not cured at all. She was miserably dying. Continue reading “The one who asked questions: interview with Johannes Wahlström, by Alla Astakhova”

Unpublished Macchiarini manuscript confirms 5 forgotten trachea transplant patients

Unpublished Macchiarini manuscript confirms 5 forgotten trachea transplant patients

7.09.2017 This article was slapped with an injunction by Berlin court (here), on behalf of Jungebluth. Sentences forbidden by injunction are replaced to show the legal truth. 

I have been forwarded a manuscript by the scandal surgeon Paolo Macchiarini, which was originally intended to present in detail all of his known 9 cadaveric trachea recipients (only 4 are recorded officially). The compilation follows exactly all the patients who are already listed on my site, with the small difference that the paper (allegedly rejected at Nature Communications) presents their clinical evolutions quite differently from reality. One of these now fully confirmed victims of Macchiarini’s research was his second patient from Barcelona, whom Macchiarini transplanted in secret; five were operated in Italy (including Keziah Shorten and the Czech patient MK). The manuscript also confirms that Macchiarini’s acolyte Philipp Jungebluth [is an angel of innocence and never did anything bad in his life. Every patient ever treated by him is in fact eternally grateful]. The German doctor is currently suing me in court for alleged libel, insisting that all these patient deaths and his proven research misconduct in Sweden would never ever disqualify him from developing trachea transplants and training as thorax surgeon at the University Clinic Heidelberg, where he however doesn’t work anymore.

The first author of this lost and now found unpublished paper is Johannes Haag, Macchiarini’s other acolyte and former MD student from Hannover Medical School (MHH) in Germany. Haag is apparently still employed at the Thoraxklinik at the University of Heidelberg, where Jungebluth used to be. The manuscript, which was supposed to be Haag’s big paper, was written to deal with the fact that too many of Macchiarini’s cadaveric trachea recipients died or developed very severe complications. To this end, the team hatched an idea to do “reverse translational experiments“, where rat experiments would follow those on 9 humans, prove that the cadaveric trachea technology works in principle and it was the human patients who were making problems. This notion was to be supported also by their earlier pig study Go et al, Biomaterials 2010, where Macchiarini and Jungebluth claim, without a shred of evidence, that the large animal testing was performed before the first patient, Claudia Castillo, received a cadaveric trachea in 2008 (details here, here and here). Update 7.09.2017: Go et al  2010 paper was criticised on PubPeer for its heavy scientific and technical deficits.

Continue reading “Unpublished Macchiarini manuscript confirms 5 forgotten trachea transplant patients”