Cardiff University is very proud of its collaboration with manufacturer of Traditional Chinese Medicine Yiling Pharmaceuticals, while the money it brings in is largely a private issue between the two business partners. Unfortunately Cardiff’s surgery and tumour biology professor Wen Jiang, Fellow of Royal Society of Medicine, is at the centre of an affair about data manipulation in his papers, and about criticisms of peddling Yiling’s TCM concoction of ginseng, dried fungus, chicken gizzard and crushed cockroach as a Cardiff University-certified cancer cure, all involuntarily sponsored by the Welsh public and charity Cancer Research Wales. This is why the university threw their own damning internal investigative report out of the window, and had three poorly qualified experts declare Jiang innocent of any data manipulation in his cell biology papers. Cardiff University issued then a press release accusing me personally of having slandered Jiang with false allegations of misconduct.
After having mulled another one of my Freedom of Information (FOI) inquiries for a month, this time a request for the investigative report, Cardiff University declared that their whitewashing opus is secret, because:
“the formal investigation has not upheld the allegations of misconduct and to further distribute this report would be an unnecessary invasion of the privacy of the individual involved”.
The European Commission now admits to me, through European Ombudsman, that their €6.8 mn phase 2 clinical trial TETRA with cadaveric tracheas, led by the UCL laryngologist Martin Birchallis unlikely to ever recruit any patients, because “the current delay to the INSPIRE project therefore makes the prospects for the commencement and completion of the TETRA project uncertain“.
INSPIRE is a phase 1 clinical trial in UK, suspended since December 2016, which was about to recruit 4 patients for trachea transplants using the technology of cadaveric tracheas Birchall developed together with his former partner, the scandal surgeon Paolo Macchiarini. The UK trial was suspended by UK authorities because of my reporting, its funding ran out and it is unlikely to be ever resumed. Even the official sponsor of both INSPIRE and TETRA, Cell & Gene Therapy Catapult, sulkily announced to change the status of the former trial from “active, not recruiting” to “suspended” at the Clinicaltrials.gov website. And without INSPIRE (which EU Commission prefers to see as “delayed“, not as suspended) the phase 2 clinical trial TETRA becomes just a grave for tax money, but luckily not for patients. This is something however EU Commission sees no problem with, and these are their views declared to me in the nutshell, via a letter from European Ombudsman to whom I complained after my Freedom of Information request was rejected by EU Commission twice (here and here):
EU Commission refuses access to TETRA documentation because this could be “potentially causing reputational damage to the consortium and individuals linked to it“.
EU Commission sees no imminent “public health concerns or public benefits” because “the TETRA clinical trial is dependent on the successful completion of the INSPIRE project“
The trial will not be terminated, and will simply trudge on until the end of its funding period on 31 December 2019.
EU Commission maintains that Macchiarini only transplanted plastic tracheas and had no contribution to the cadaveric trachea technology of INSPIRE and TETRA: “the scientific research involved in TETRA is pursuing a different method than the one developed by the doctor who has been subject to misconduct investigations“
EU commission maintains that cadaveric trachea transplants, including those principal investigator Birchall was involved in, were either full successes (where patients survived) or they never happened (where patients died). The list of dead and mutilated patients who received cadaveric tracheas, which I specifically sent to EU Commission, was dismissed as not relevant for the current clinical trial
The Science and Technology Committee of the British House of Commons is now dealing with the trachea transplants performed by the scandal surgeon Paolo Macchiarini and his former parter at UCL, Martin Birchall as part of its inquiry into Research Integrity. Two UK scientists from Liverpool initiated this with their written submission from November 21st 2017 which I previously re-published: Patricia Murray, professor in stem cell biology and regenerative medicine, previously a nurse on a Head and Neck unit, and Raphael Lévy, senior lecturer in nanotechnology. Their concerns were not just the past trachea transplants, but also the present clinical trials with bioengineered trachea and larynx which UCL is most keen to start with, following the recommendation of an investigative commission from last year. UCL’s problem is however, that the two phase 1 UK trials are suspended by the UK authorities, and the big phase 2 EU-sponsored trial cannot begin recruiting patients without the results from phase 1.
By now it looks like UCL and their laryngology professor Birchall are in a pickle. Their own reply to the letter by Murray and Levy was not really honest when describing past UCL trachea transplant patients to the Parliament committee. On top of it, it turned out Birchall was reusing data from same old experiments on 16 pigs across different publications which were meant to show separate studies. This, and many more inconsistencies of UCL’s reply to the House of Commons are addressed in the re-published new letter by Murray and Levy from January 30th 2018 below. Continue reading “Trachea transplanters: Round 2 at UK Parliament”→
I previously reported about numerous cases of suspected (or even blatantly obvious) data manipulation at the Weizmann Institute of Science in Israel (here, here and here). Initially I wrongly assumed that the institute does not investigate misconduct evidence on principle. It turned out they do, but these investigations “are not public” as Michal Neeman, Vice President of the Weizmann Institute, told me in an email.
Below I present the documents from one such investigation from 2012, regarding two papers by the Weizmann cell biologist, apoptosis researcher and keen dancerAtan Gross. The original report was filed in July 2012 by a peer of Gross, David Vaux, deputy director of The Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia. The Weizmann investigation ended just one month later with data manipulations confirmed, original raw data absent, but with the conclusion that it all was only an “unfortunate decision about presentation of the data” with “no evidence for falsification with an intent to deceive”. The case was closed with the request of two corrections, one to Journal of Biological Chemistry (JBC), and another one to Cell, with the manipulated data replaced by newly generated Ersatz. While the former journal duly issued a correction, Cell‘s Editor-in-Chief and Cell Press CEO Emilie Marcus declared that she will do nothing at all. Continue reading “How Emilie Marcus and Cell covered up misconduct at Weizmann”→
The Linköping University (LiU) in Sweden is quite busy these days with the affair around their fake professor Ashutosh Tiwari, trying to figure out what actually happened inside their own Department of Physics, Chemistry and Biology (IFM). How could a person with some very shady claims to a doctorate, a publication list consisting mostly of papers in his own private predatory journal, titles and awards from his own fake research institutions and predatory conferences fool the system for years in this way? How could he get the prestigious Marie-Curie fellowship, which in turn delivered him a habilitation degree of Docent at LiU and grant money from Swedish public? In this regard, how could he have just last year been awarded funding from the Swedish Research Council, Vetenskapsrådet (VR) if he wasn’t even employed at LiU or anywhere else since early 2015?
The answer is: with bold chutzpah and even bolder support from certain Swedish professors. First and foremost, from his mentor, the LiU bioelectronics professor Anthony “Tony” Turner, who conveniently accepted a large number of Tiwari-coauthored papers in his Elsevier journal Bionsensors and Bioelectronics, and played a key role in Tiwari being awarded the Marie-Curie fellowship and the docent degree. Others helped along, a recommendation letter from a Malmö biochemistry professor proves a particularly bizarre piece of evidence of how Tiwari’s fraud was interpreted as superhuman genius achievements. Continue reading “How scam artist Ashutosh Tiwari played Linköping University”→
The esteemed London university UCL seems to live in its own world. There, the regenerative medicine magic thrives, living organs miraculously grow in labs, while stem cell-made trachea transplants proved a blessing for humanity, despite the negative vibes from UCL’s former honorary professor Paolo Macchiarini. UCL’s own laryngology professor and regenerative medicine enthusiast Martin Birchall cured several patients already, and it is imperative that he is allowed to save more lives with his tracheas and voiceboxes, regenerated from dead decellurised carcasses using patient’s own bone marrow cells. Scientific evidence and research integrity are nothing but cumbersome bureaucracy, which restrain the genius of Birchall, whose educated guess alone should suffice as solid proof.
This is basically how UCL replied to the to request from the Science and Technology Committee of the British House of Commons, following a critique of Birchall’s trachea transplants submitted as RES0022 on November 21st 2017 by the Liverpool scientists Patricia Murray and Raphael Lévy. The undated UCL reply appeared online around the New Year and is a staunch defence of Birchall’s endeavours, while calling the two Liverpool researchers “emotive” and dismissing the evidence on my site as inaccurate. It is authored by UCL Registrar Wendy Appleby, who incidentally was now appointed by UCL to investigate Birchall’s data re-use, where he apparently resurrected long-dead pigs twice, by turning some ancient animal experiment data with regenerated larynx into two fresh and very distinct studies.
The biggest inaccuracy, or barefaced lie (as you prefer), is UCL’s pretence that they had nothing at all to do with a certain lethal transplant of a cadeveric trachea, performed by Macchiarini on July 13th 2010 in Italy on the young British patient Keziah Shorten. I have been protesting to UCL Hospital (UCLH) and the British information authorities for a whole year against the refusal of UCLH to release the information about their involvement into that trachea transplant, and eventually UCLH was forced to reply to me. Even then they only admitted what I already knew, and now they hide this information from the UK Parliament inquiry. I will share it here then. Continue reading “UCL fibs Parliament about trachea transplants”→
This is an Open Letter I sent today by email to the Italian Senate and its Health Committee, appealing for an investigation into the trachea transplants of the scandal surgeon Paolo Macchiarini.
It is published below bilingually, in Italian and in English. After the earlier Open Letter by Prof Rafael Cantera was signed by over 220 academics and thus led the University of Würzburg in Germany to investigate the trachea transplants of Macchiarini’s former colleagues, Heike and Thorsten Walles, I invite now
all Italian clinicians and researchers, in Italy and abroad, as well as their international colleagues working in Italy, to sign this letter in the comment section below. Please use your full affiliation.
The signed Open Letter will be then forwarded to both chambers of Italian parliament and other state authorities.
Appello per un’inchiesta sui trapianti di trachea eseguiti a Firenze da Paolo Macchiarini
Gentili Senatrici, Egregi Senatori membri della 12ª Commissione permanente Igiene e sanità,
questo appello è indirizzato a Voi affinché vogliate considerare l’opportunità di investigare uno dei più gravi casi internazionali di abuso ai danni di pazienti, che è avvenuto e si sta ancora oggi verificando, in grandissima parte anche in Italia.
Chi vi scrive è un giornalista scientifico indipendente, il cui sito web (in lingua inglese) è diventato la più completa fonte di informazioni oggi disponibile a livello globale sul caso di Paolo Macchiarini e della sua “medicina rigenerativa”.