The Science and Technology Committee of the British House of Commons is now dealing with the trachea transplants performed by the scandal surgeon Paolo Macchiarini and his former parter at UCL, Martin Birchall as part of its inquiry into Research Integrity. Two UK scientists from Liverpool initiated this with their written submission from November 21st 2017 which I previously re-published: Patricia Murray, professor in stem cell biology and regenerative medicine, previously a nurse on a Head and Neck unit, and Raphael Lévy, senior lecturer in nanotechnology. Their concerns were not just the past trachea transplants, but also the present clinical trials with bioengineered trachea and larynx which UCL is most keen to start with, following the recommendation of an investigative commission from last year. UCL’s problem is however, that the two phase 1 UK trials are suspended by the UK authorities, and the big phase 2 EU-sponsored trial cannot begin recruiting patients without the results from phase 1.
By now it looks like UCL and their laryngology professor Birchall are in a pickle. Their own reply to the letter by Murray and Levy was not really honest when describing past UCL trachea transplant patients to the Parliament committee. On top of it, it turned out Birchall was reusing data from same old experiments on 16 pigs across different publications which were meant to show separate studies. This, and many more inconsistencies of UCL’s reply to the House of Commons are addressed in the re-published new letter by Murray and Levy from January 30th 2018 below. Continue reading “Trachea transplanters: Round 2 at UK Parliament”→
I previously reported about numerous cases of suspected (or even blatantly obvious) data manipulation at the Weizmann Institute of Science in Israel (here, here and here). Initially I wrongly assumed that the institute does not investigate misconduct evidence on principle. It turned out they do, but these investigations “are not public” as Michal Neeman, Vice President of the Weizmann Institute, told me in an email.
Below I present the documents from one such investigation from 2012, regarding two papers by the Weizmann cell biologist, apoptosis researcher and keen dancerAtan Gross. The original report was filed in July 2012 by a peer of Gross, David Vaux, deputy director of The Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia. The Weizmann investigation ended just one month later with data manipulations confirmed, original raw data absent, but with the conclusion that it all was only an “unfortunate decision about presentation of the data” with “no evidence for falsification with an intent to deceive”. The case was closed with the request of two corrections, one to Journal of Biological Chemistry (JBC), and another one to Cell, with the manipulated data replaced by newly generated Ersatz. While the former journal duly issued a correction, Cell‘s Editor-in-Chief and Cell Press CEO Emilie Marcus declared that she will do nothing at all. Continue reading “How Emilie Marcus and Cell covered up misconduct at Weizmann”→
The Linköping University (LiU) in Sweden is quite busy these days with the affair around their fake professor Ashutosh Tiwari, trying to figure out what actually happened inside their own Department of Physics, Chemistry and Biology (IFM). How could a person with some very shady claims to a doctorate, a publication list consisting mostly of papers in his own private predatory journal, titles and awards from his own fake research institutions and predatory conferences fool the system for years in this way? How could he get the prestigious Marie-Curie fellowship, which in turn delivered him a habilitation degree of Docent at LiU and grant money from Swedish public? In this regard, how could he have just last year been awarded funding from the Swedish Research Council, Vetenskapsrådet (VR) if he wasn’t even employed at LiU or anywhere else since early 2015?
The answer is: with bold chutzpah and even bolder support from certain Swedish professors. First and foremost, from his mentor, the LiU bioelectronics professor Anthony “Tony” Turner, who conveniently accepted a large number of Tiwari-coauthored papers in his Elsevier journal Bionsensors and Bioelectronics, and played a key role in Tiwari being awarded the Marie-Curie fellowship and the docent degree. Others helped along, a recommendation letter from a Malmö biochemistry professor proves a particularly bizarre piece of evidence of how Tiwari’s fraud was interpreted as superhuman genius achievements. Continue reading “How scam artist Ashutosh Tiwari played Linköping University”→
The esteemed London university UCL seems to live in its own world. There, the regenerative medicine magic thrives, living organs miraculously grow in labs, while stem cell-made trachea transplants proved a blessing for humanity, despite the negative vibes from UCL’s former honorary professor Paolo Macchiarini. UCL’s own laryngology professor and regenerative medicine enthusiast Martin Birchall cured several patients already, and it is imperative that he is allowed to save more lives with his tracheas and voiceboxes, regenerated from dead decellurised carcasses using patient’s own bone marrow cells. Scientific evidence and research integrity are nothing but cumbersome bureaucracy, which restrain the genius of Birchall, whose educated guess alone should suffice as solid proof.
This is basically how UCL replied to the to request from the Science and Technology Committee of the British House of Commons, following a critique of Birchall’s trachea transplants submitted as RES0022 on November 21st 2017 by the Liverpool scientists Patricia Murray and Raphael Lévy. The undated UCL reply appeared online around the New Year and is a staunch defence of Birchall’s endeavours, while calling the two Liverpool researchers “emotive” and dismissing the evidence on my site as inaccurate. It is authored by UCL Registrar Wendy Appleby, who incidentally was now appointed by UCL to investigate Birchall’s data re-use, where he apparently resurrected long-dead pigs twice, by turning some ancient animal experiment data with regenerated larynx into two fresh and very distinct studies.
The biggest inaccuracy, or barefaced lie (as you prefer), is UCL’s pretence that they had nothing at all to do with a certain lethal transplant of a cadeveric trachea, performed by Macchiarini on July 13th 2010 in Italy on the young British patient Keziah Shorten. I have been protesting to UCL Hospital (UCLH) and the British information authorities for a whole year against the refusal of UCLH to release the information about their involvement into that trachea transplant, and eventually UCLH was forced to reply to me. Even then they only admitted what I already knew, and now they hide this information from the UK Parliament inquiry. I will share it here then. Continue reading “UCL fibs Parliament about trachea transplants”→
This is an Open Letter I sent today by email to the Italian Senate and its Health Committee, appealing for an investigation into the trachea transplants of the scandal surgeon Paolo Macchiarini.
It is published below bilingually, in Italian and in English. After the earlier Open Letter by Prof Rafael Cantera was signed by over 220 academics and thus led the University of Würzburg in Germany to investigate the trachea transplants of Macchiarini’s former colleagues, Heike and Thorsten Walles, I invite now
all Italian clinicians and researchers, in Italy and abroad, as well as their international colleagues working in Italy, to sign this letter in the comment section below. Please use your full affiliation.
The signed Open Letter will be then forwarded to both chambers of Italian parliament and other state authorities.
Appello per un’inchiesta sui trapianti di trachea eseguiti a Firenze da Paolo Macchiarini
Gentili Senatrici, Egregi Senatori membri della 12ª Commissione permanente Igiene e sanità,
questo appello è indirizzato a Voi affinché vogliate considerare l’opportunità di investigare uno dei più gravi casi internazionali di abuso ai danni di pazienti, che è avvenuto e si sta ancora oggi verificando, in grandissima parte anche in Italia.
Chi vi scrive è un giornalista scientifico indipendente, il cui sito web (in lingua inglese) è diventato la più completa fonte di informazioni oggi disponibile a livello globale sul caso di Paolo Macchiarini e della sua “medicina rigenerativa”.
Here I republish the written evidence submitted to by two UK scientists to the Science and Technology Committee of the British House of Commons and its inquiry into Research Integrity, as originally published on November 21st 2017. It deals with the trachea transplants performed by the surgeons Paolo Macchiarini and his former parter at UCL, Martin Birchall. The report’s lead author is Patricia Murray, professor in stem cell biology and regenerative medicine, previously a nurse on a Head and Neck unit. She generously invited me in May 2017 to give a seminar at her department at the University of Liverpool on this topic. Her coauthor is Raphael Lévy, senior lecturer in nanotechnology and imaging at the same university. I wrote about his reproducibility studies on the topic of nanoparticles in this article.
UCL recently investigated Birchall’s past trachea transplants, and recommended to continue with his two current clinical trials to transplant cadaveric decellurised trachea and larynx, regenerated with bone marrow cells, as I reported here. For some reason, UCL Registrar Wendy Appleby, when speaking as witness on November 21st in front of the Parliament Inqury, found herself unable to answer the rather straightforward question whether the UCL investigative commission advised to continue transplanting trachea or not (watch here, from 11:50 on). Appleby and her UCL were instructed by the Inquiry to address the concerns by Murray and Levy in writing.
Both clinical trials Inspire and RegenVox were already placed by the supervising authorities on hold, Murray and Levy now call to stop the dangerous and science-unsupported experimenting on misinformed human patients and to return back to the lab.
The British laryngologist and UCL professor Martin Birchall is one of the two founding fathers of “bioengineered” trachea, the other one being his former partner, the scandal surgeon Paolo Macchiarini. Birchall presently runs three trachea transplant trials clinical trials, two in the UK and one EU-wide. His patients must however wait to be cured, because the two UK trials, Inspire and RegenVox (with the latter primarily about larynx and upper trachea transplant) were both placed on hold, and the EU funded phase 2 trial TETRA is still far from getting an ethics approval and just now lost one potential trial site after the Medical University Vienna jumped ship. The EU Commission refuses to tell me anything about TETRA, except that it has not applied for ethics approval yet. EU’s Transparence department still evade commenting on how to put this scheduled 48 patient clinical trial in context of the 11 cadaveric trachea transplants by Macchiarini and Birchall, most or maybe even all of which left the patients either dead or mutilated.