Will words or actual evidence count in the Walles case?

Will words or actual evidence count in the Walles case?

On March 16th I stood a court trial by the trachea transplanters and University of Würzburg professors  Heike and Thorsten Walles against myself. The judge (it was the same who passed the injunction against me) will announce his decision on April 6th, just as I will stand trial in Berlin against their trachea transplant colleague Philipp Jungebluth (see this report). I publish here an extended memory-based protocol which I first published on Facebook. Meanwhile, several large institutions built a protective wall of silence around Walles and their tracheal transplants. The German Medical Association refused investigation in a bizarre letter which I also publish below.

The court hearing

It was the so-called speed trial, so instead of examining evidence, everyone was free to tell the judge their views. Mostly, Walles and their lawyer spoke, occasionally, my lawyer and I were able to squeeze a word in to reject the outlandish or false claims. For example, while her lawyer insisted the tracheal transplants were full success despite dead patients, Heike Walles challenged me to compare her transplants with the first heart transplant which failed. I pointed out that this is exactly the same argument Paolo Macchiarini uses to defend his own failed trachea transplants (for example, here). Continue reading “Will words or actual evidence count in the Walles case?”

Retraction, and another looming misconduct finding for Macchiarini and Jungebluth

Retraction, and another looming misconduct finding for Macchiarini and Jungebluth

The misconduct-tainted paper on oesophagus transplants in rats (Sjöqvist et al 2014) by the fallen star of regenerative medicine Paolo Macchiarini is finally retracted by the journal Nature Communications. This happens after Swedish investigations found the authors (primarily the scandal thorax surgeon and his right-hand man Philipp Jungebluth) guilty of data manipulation and research misconduct in September 2016 and after the Karolinska Institutet (KI) shortly before Christmas publicly demanded a retraction (see my report here). Today’s retraction is a major setback for Macchiarini, since his current employment and funding at the Federal University of Kazan (KFU) in Russia depend on his experiments with oesophageal transplants in primates (see my reports here and here). That Russian project was in turn only possible because of Macchiarini’s allegedly successful experiments in rats, published in a prestige journal with “Nature” in its title. This paper’s retraction is therefore probably only the beginning of a whole looming avalanche of bad news for Macchiarini and his acolyte Jungebluth (who currently sues me in court). An expert review of their publication Jungebluth et al 2015 declares the findings of misconduct, ethics breach and patient abuse. The report however has yet to be confirmed by a commission at the Swedish Central Ethics Review Board (CEPN) and then formulated as an official decree by the KI. I publish the expert reviewer report below. Continue reading “Retraction, and another looming misconduct finding for Macchiarini and Jungebluth”

The Kenneth Chien Case at Karolinska, by Johan Thyberg

The Kenneth Chien Case at Karolinska, by Johan Thyberg

This is a new guest post from Johan Thyberg, a retired professor for cell and molecular biology from Sweden, a known activist against science fraud and author of the 2009 book “Scientific Fraud or Legal Scandal?”. Thyberg played a key role in uncovering the research misconduct and horrendous patient abuse around the trachea transplant surgeon Paolo Macchiarini, which took place at Alma Mater, the Karolinska Institutet (KI) in Stockholm, and left at KI alone 3 patients dead (his last plastic trachea recipient there, Yesim Cetir, died yesterday after years of suffering).

After a previous guest post by Thyberg, which criticised KI’s handling of the Macchiarini scandal, it is an honour for me to present his new article on my site. It deals with another international star of regenerative medicine whom KI recruited soon after Macchiarini: Kenneth Chien. The people who recruited Chien were also the same who made Macchiarini’s professorship at KI possible: the then-chancellor Harriet Wallberg and the cell biology professor Urban Lendahl. Both had to resign from their positions with the KI’s Nobel Committee in the wake of Macchiarini scandal (see my report here).

This is what Chien’s 20-head strong lab is working on at KI, according to its website:

“The central scientific interest of the Chien lab is to understand heart development at the molecular and cellular level, with the ultimate goal of applying the developmental principles, logic, pathways, technology, and model systems to unravel human heart disease”.

According to Thyberg, Chien’s engagement at KI is less about his actual scientific achievements, which seem objectively rather modest relative to his elite status there, but more about personal networks and money, which include pharma industry and a certain Chinese investor. One of these Chien-related businesses is Moderna Therapeutics, a biotech start-up which STAT News brought a critical special report on.

Below I am publishing Thyberg’s own English version article, a Swedish version appeared on March 17th on NewsVoice.

Continue reading “The Kenneth Chien Case at Karolinska, by Johan Thyberg”

Walles tracheal transplant patients: secrets and lies

Walles tracheal transplant patients: secrets and lies

The German trachea transplanters Heike and Thorsten Walles fitted three patients with pig-intestine-based airway grafts. They responded to my inquisitive reporting about these with a court injunction, the trial takes place this week, on March 16th. A commission of their Unversity of Würzburg initially absolved Walles of all suspicions of research misconduct, only to start the investigation anew as evidence of heavy data manipulation in their papers emerged (see my previous report). Roland Jahns, specially recruited as medical expert from the same University Clinic Würzburg where both Walleses work, was dismissed after he insulted me as “pseudoscientist” to defend his colleagues’ questionable attitude to data integrity, medical ethics and patient welfare. A new expert will be recruited, but Jahns did reveal some clues to what happened to the two last Walles patients operated in Stuttgart in 2007 and 2009, just before they received their professorships in Würzburg.

It appears Thorsten Walles issued two radically opposing versions of the 2007 patient’s state. In his publications, he presented the intervention as “compassionate use” case and the patient as stable, but in need of innovative strategies to cure his condition. In the medical file however, Walles described the patient as terminally ill and dying from cancer. The intervention to replace his airways with a never-before-tested pig-intestine large patch was presented as a palliative approach, which however turns the entire concept of either palliative care or compassionate use care on its head. In any case, the graft had to be removed after only 2 weeks, the patient died four weeks later due to massive bleeding and multi-organ failure. Walles decided that this disastrous incident had nothing to do with the transplant, so when they recruited their next patient to sign an informed consent in 2009, they simply didn’t tell him what happened to his predecessor. That last patient was also post-suicidal and in psychiatric treatment (though not yet officially of unsound mind, his mental state further deteriorated later on). Continue reading “Walles tracheal transplant patients: secrets and lies”

Würzburg misconduct Commission acquits Walles, dismisses biased medical expert, restarts anew as data manipulations flood in

Würzburg misconduct Commission acquits Walles, dismisses biased medical expert, restarts anew as data manipulations flood in

The University of Würzburg did not ignore the Open Letter in support of my journalism, and has concluded its internal investigation into medical and scientific activities of their trachea transplanters Heike and Thorsten Walles, without finding any misconduct. This was however not the end of it. I was invited to appeal this decision in front of the commission, which I did on March 6th 2017. In the end, the medical “external consultant”, Roland Jahns (specialist in inner medicine from the University Clinic of Würzburg) was catapulted out of the commission after insulting me as “pseudoscientist” and the entire investigation will be re-opened, with a new consultant to be recruited. The main reason: a newly emerged wealth of evidence of gross data manipulations in the papers by Walles, which readers of my site posted on PubPeer just when I arrived in Würzburg to give evidence.

During my discussion with the Standing Commission for the Investigation of Scientific Misconduct of the University of Würzburg on March 6th, I was also told that the commission does not see my original text, for which I am facing a court trial on March 16th, as factually wrong. All information provided there was deemed correct except of one aspect: my readers were said to be led to misunderstand that the trachea transplant operations took place in Würzburg (while they happened in Stuttgart). The commission made clear that their university does not want to be associated with these transplants. They did however admit that the misunderstanding arose because Walles themselves have been placing such false information in media (including this recent article in the Siemens magazine), and even on the University of Würzburg website. The commission however assigned to me the responsibility of checking in advance the truthfulness of such obscure sources.  Continue reading “Würzburg misconduct Commission acquits Walles, dismisses biased medical expert, restarts anew as data manipulations flood in”

Three retractions and lost court case for zombie Susana Gonzalez

Three retractions and lost court case for zombie Susana Gonzalez

The Spanish zombie scientist Susana González, former star of regenerative medicine and ageing research, now retracts two papers in Nature Communications, after she only recently retracted a paper in Cell Cycle. The responsibility for the absence of original data and data manipulations is with her. She also recently lost her court case against her sacking with the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid, though this may go into the next court instance.  Her ERC research grant of €2 Million remains suspended. I previously reported about this and Gonzalez’s data integrity issues as well as her sacking from CNIC, and later on about her new job with Centro de Biología Molecular Severo Ochoa (CBMSO), also in Madrid. It seems at the present stage, Gonzalez is out on her ear of doing research, but certainly not out of being employed in academic research in Spain.  Continue reading “Three retractions and lost court case for zombie Susana Gonzalez”

The stinking fish of Strasbourg

The stinking fish of Strasbourg

There is a popular saying: “A fish stinks from the head down”. This is what the situation starts to look like for French CNRS Institut de Biologie Moléculaire des Plantes (IBMP) in Strasbourg, also unofficially known as “The Olivier Voinnet Institute for Research Integrity in Plant Sciences”, after its most famous former research director. A publication from the lab of the institute’s head, Laurence Maréchal-Drouard, seems to contain evidence of inappropriate data manipulation. The gel shown in Figure 1A of Salinas et al 2014, seems to have “no less than 4 copies of a background patch”, according to a concerned reader who contacted me with this evidence. Drouard herself did not reply to my email, possibly because she and her entire CNRS institute are banned from communicating with me.

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The IBMP director Laurence Drouard as now part of data integrity tumult herself. The background in this published gel lane from her lab seems to be duplicated four times. 

Continue reading “The stinking fish of Strasbourg”