French Biologists: CNRS-Sorbonne investigators “totally incompetent”, data manipulations in Jessus papers “intentionally fraudulent forgeries”

French Biologists: CNRS-Sorbonne investigators “totally incompetent”, data manipulations in Jessus papers “intentionally fraudulent forgeries”

The revolution in French science has begun, and its target is the corrupt elite who betrayed against basic principles of research integrity and conspired to protect one of their own, the CNRS chief biologist Catherine Jessus. French scientists seem to finally have enough of watching fraudsters eat cake and now storm the Bastille.

Much of evidence of data manipulation in papers from Jessus’ lab was originally forwarded to me by my readers and reported on my site, I then posted it also on PubPeer. Under mounting pressure from her peers, Jessus started to correct some of her papers, and eventually her employer CNRS, Europe-largest network of research institutes, decided to switch to attack mode of defence. Sorbonne University in Paris, where Jessus holds a professorship, delivered an outrageous whitewashing report about Jessus’s data manipulations, which were either declared to be minor errors, or denied outright, or even declared to be actually good scientific practice, all despite absence of original data. The authors of that opus hid their identity, but one was eventually exposed by my sources: Francis-André Wollman, an elite CNRS and Sorbonne biologist. I was personally accused of libellous slander in a CNRS press release, which also announced to persecute those raising misconduct allegations, while urging French researchers to “collective vigilance” against such traitors. CNRS new president Antoine Petit, whose predecessor Anne Peyroche was deposed after my reporting about data manipulations in her own papers, then announced to smoke out anonymous PubPeer commenters using IT tools of deep surveillance.

Yesterday, an Open Letter has been published on the website Sauvons l’Université ! , authored by around 10 unnamed French biologists. It plucks apart the Sorbonne report of Jessus papers and declares:

“We, geneticists, biochemists, cell and molecular biologists, have read this report, have analysed, criticised it point by point and can conclude that all the arguments of the Inquiry Commission are against all common rules of good scientific practice and of the interpretation of results, which form the basis of research integrity. Worse, and that is the reason that led us to react (see our open letter), it encourages image manipulations which are nevertheless recognized as fabrications and falsifications of results”.

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Flawed cytometry of Rector Giorgio Zauli

Flawed cytometry of Rector Giorgio Zauli

Giorgio Zauli is Italian clinical haematologist and cancer researcher, who used to be director of Burlo Garofolo Pediatric Institute in Trieste, till in 2015 he was appointed Rector of the respected University of Ferrara. In this position he might soon be investigating his own papers, because given the massive evidence uncovered by the pseudonymous data integrity sleuth Clare Francis and others, Zauli seems to become a second Alfredo Fusco, and given his Rector status, probably just as unshakable. In Italy, science and politics are unhealthily interconnected, as demonstrated by the deadly scandal of Paolo Macchiarini in Florence. In any case, the list of gross irregularities in Zauli’s papers on PubPeer grows daily.

Zauli’s impressive publishing record consists of almost 200 first- and last-author papers in prestigious journals and his h-index bears the impressive size of 57. Some of this academic output, largely co-authored by his close associate and head of his department in Ferrara, Paola Secchiero (h-index 41), was achieved by their rather questionable attitude to data integrity. Of course we have the usual: western blots with duplicated gel lanes and bands re-appearing in several figures and papers, standing in for different experiments and even different patients. This article however will focus on Zauli’s flow cytometry studies, and how such data in his publications apparently got manipulated in a way which is supposed to provide deniability should the authors ever be caught.

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Macchiarini victim’s family sues trachea makers for wrongful death

Macchiarini victim’s family sues trachea makers for wrongful death

Yesim Cetir was a young woman from Turkey, whose vulnerability the scandal surgeon used to test his plastic trachea (twice), a third such operation he performed at the hospital of the Karolinska Institutet in Sweden, and his fifth plastic trachea recipient. Like almost all the at least 17 patients whom Paolo Macchiarini experimented upon with either cadaveric or plastic trachea, Yesim died. Her suffering was long and horrible, her father Hayrullah Cetir dedicated all his waking hours to caring for his daughter. He died himself soon after her, from a neglected cancer.

Since April 2017, Yesim’s family (or in US legalese, the Estate of Yasim Cetir) is suing the company Harvard Bioscience, which spin-off Biostage (in turn formerly known as Harvard Apparatus) produced the bioreactors and the second plastic trachea graft used by Macchiarini on Yesim. Also the manufacturer of her first plastic trachea, Nanofiber Solutions, is being sued at the Suffolk County Superior Court in Massachusetts, USA, case number 1784CV01174. An article in Boston Business Journal indicated that even Macchiarini himself might be subject to the wrongful death lawsuit:

“Now, the estate of one of the deceased patients is pursuing wrongful death claims against both Biostage and Macchiarini”

Continue reading “Macchiarini victim’s family sues trachea makers for wrongful death”

The Perennial Northern Blot of Lopez-Otin

The Perennial Northern Blot of Lopez-Otin

On the Iberian peninsula, there seems to be a tradition to give well-connected scientists suspected (or even convinced) of data fudging an award. In Spain, Carlos López-Otín, Professor of Biochemistry and Molecular Biology at the University of Oviedo, was given a Mentoring Award from the elite journal Nature, on recommendation from Spanish academia and despite evidence of data irregularities in his papers. This prompted my readers, in particular the famous pseudonymous data integrity sleuth Clare Francis, to comment on on PubPeer and on my site (as “Zebedee”) with additional evidence, which made Lopez-Otin’s scientific credibility look progressively worse and worse, with each new post.

Eventually, an image of a Northern blot (showing expression of mRNAs which code for proteins) was found to appear recurrently across several papers from that Oviedo lab, where the authors pretended it was a newly produced analysis. In reality, it was a “library” loading control reused so the authors could re-run same RNA gel of human tissue lysates over the years and never check ever again what they have actually loaded on their gels. Eventually Lopez-Otin et al even stopped caring what order of samples that original loading control had.

Clare Francis was soon joined on his quest for the Perennial Northern Blot of Oviedo by Elisabeth Bik, famous microbiology blogger and image duplication detective, and my regular contributor (also pseudonymous) Smut Clyde, who now presents you the findings of no less than 23 appearances of that same northern blot in 23 publications from Lopez-Otin’s lab in the guest post below. It is just as convincing as if the Spanish actor Antonio Banderas appeared in 23 different films still dressed in same costume from his 1995 hit Desperado, carrying same guitar case. Incidentally, also Lopez-Otin’s Perennial Northern Blot made its first appearance at around that year.
Continue reading “The Perennial Northern Blot of Lopez-Otin”

Zombie scientist Sonia Melo awarded by AstraZeneca

Zombie scientist Sonia Melo awarded by AstraZeneca

Sonia Melo is back, and not to be messed with. The Portuguese zombie scientist is responsible for a number of papers with manipulated data (only one was retracted, Melo et al, Nature Genetics, 2009), saw her EMBO Young Investigator funding withdrawn in 2016, but was whitewashed and reinstalled by her employing institute Instituto de Investigação e Inovação em Saúde (I3S) in Porto. Her key publication in Nature with MD Anderson professor Raghu Kalluri, Melo et al, 2015, which raised obscene money in industrial and public investment for Kalluri’s spin-off Codyak Biosciences to market exosome-based liquid biopsy for pancreatic cancer detection, was disproven as an artefact at best, the authors even admitted in a follow-up preprint to have intentionally manipulated flow cytometry data to achieve results they needed. Collaborators were instructed never to work with her again. All in all, Melo is as toxic as a zombie scientist can be. But apparently not in her home country Portugal.

In March 2018, Melo received a Prémio FAZ Ciência award from Fundação AstraZeneca (FAZ) and Sociedade Portuguesa de Oncologia (Portuguese Society of Oncology, SPO). Which means, not just Portuguese academia, also international Big Pharma industry trusts her Photoshop skills. The award comes with €35k cash, and this is how much or how little was needed for the University of Porto to drop all pretence at research integrity and celebrate their zombie scientist as a genius researcher about to cure cancer. Continue reading “Zombie scientist Sonia Melo awarded by AstraZeneca”

Trachea transplanters without borders

Trachea transplanters without borders

News from the trachea transplant entrepreneurs. What with the UK authorities having officially suspended both phase 1 clinical trials Inspire and RegenVox, and the EU phase 2 clinical trial TETRA going nowhere, the technology’s owner, Liverpool-based company Videregen decided to seek new clinical partners. Surgeons and universities from outside the EU, especially from US, China and Japan are invited to test Videregen’s trachea transplant technology, which was originally developed together with Paolo Macchiarini by the UCL laryngologist and paid Videregen advisor Martin Birchall.

While tracheal stenosis was the indication sought to treat with trachea transplants in UK and EU (as the authorities drew curtains before the show even started), Videregen now goes for bronchopleural fistula, while pretending (quite dishonestly) that “all required regulatory and ethical approvals necessary to commence clinical trials in the UK” would exist.

The other bit of news is that UCL finally published the 2015 PhD thesis of Birchall’s student Claire Crowley (now postdoctoral scientist in charge of clinical research on oesophagus replacement with UCL professor and another trachea transplanter Paolo De Coppi). It reads as if certain parts of the thesis were edited or even written by UCL’s legal department. Not what thesis says, but what is omitted is worrisome. Crowley was namely responsible for the production of 3 trachea replacements requested by Birchall, which all proved deadly to their human recipients. One was a decellurised cadaveric graft, and two were POSS-PCU plastic tracheas, which Crowley made herself, in the lab of her other advisor, the (now sacked) UCL nanotechnologist Alexander Seifalian. Yet the thesis only mentions one graft, in a brief one-page statement, simply because Crowley could not deny her role there. She is co-author on the Macchiarini paper Jungebluth et al Lancet 2011 telling the alleged success story of the very first plastic trachea transplant performed in Sweden on the patient Andemariam Beyene. Otherwise, Crowley never mentions in her thesis the cases of Keziah Shorten or Shauna Davison, whose lethal trachea grafts she also made herself, as part of her PhD studies. Continue reading “Trachea transplanters without borders”

Linköping University and Tiwari’s predatory conferences

Linköping University and Tiwari’s predatory conferences

The predatory conferences organised by the team around Ashutosh Tiwari, fake professor of Linköping University (LiU) in Sweden, became now a comparatively modest affair, after my reporting set several misconduct investigations at LiU in motion and even alerted Swedish and international media. Tiwari stopped pretending being a LiU professor and even ceased signing his conference invitations. Internet announcements for his conference scams became rather minimalistic, while conference programmes or lists of speakers are not released to participants and are apparently arranged on the spot.

Since my last reporting on the Tiwari case, several things happened. Tiwari’s patron, LiU professor Anthony “Tony” Turner retired from this faculty position, his former division at LiU’s Department of Physics, Chemistry and Biology (IFM) is has a new head. Turner now works with a biotech start-up Innovosens, in Malmö, Sweden, and remains Editor-in-Chief of his Elsevier journal, Biosensors and Bioelectronics. And it was in this journal that his former protégé Tiwari suffered two retractions, from a 2017 journal issue which he himself edited, no less. Even Turner’s boasting of full support by Elsevier against troll accusations didn’t protect Tiwari. All thanks to his data-faking friend from Allahabad, Prashant Sharma, whose seven papers were now mass-retracted just from Biosensors and Bioelectronics alone, following the guest post on my site by Smut Clyde.

LiU issued two press releases (here and here) to announce investigations and that Tiwari was never their professor, yet the university proved unable to dissociate itself from Tiwari’s predatory conferences as of yet. Mikael Syväjärvi, Tiwari’s probably closest business associate, was permitted to continue run their predatory conference and publishing business while officially at his work place as LiU employee. At least Syväjärvi doesn’t present himself as professor anymore, as he occasionally used to. Continue reading “Linköping University and Tiwari’s predatory conferences”