Susana Rivas: a new research integrity scandal in French plant sciences

Susana Rivas: a new research integrity scandal in French plant sciences

Susana Rivas, a CNRS research group leader from the French National Institute for Agricultural Research (INRA) in Toulouse is now at the epicenter of a new research integrity scandal in plant sciences. In the last two years, France was shaken by the Olivier Voinnet scandal, when their former star researcher was found guilty of data manipulation throughout his entire career, from his PhD at The Sainsbury Laboratory in Norwich, UK, over his position of many years as research director at CNRS plant science institute in Strasbourg up to his current professorship at the ETH Zürich in Switzerland. Before she became CNRS group leader in 2003, the Spanish plant scientist Rivas worked as postdoc at The Sainsbury Laboratory, in the lab of Jonathan Jones, at around the same time when Voinnet was finishing his PhD there under David Baulcombe. Now, Jones retracted a paper authored by Rivas from the journal The Plant Cell, he also requested the retraction of another paper from his lab with Rivas as first author, in The Plant Journal. Meanwhile, I share here new evidence of suspected data manipulations from Rivas’ own lab in Toulouse, in her 5 publications which include PNAS, PLOS One, The Plant Cell and Nature Communications. Continue reading “Susana Rivas: a new research integrity scandal in French plant sciences”

Human Brain Project: bureaucratic success despite scientific failure

Human Brain Project: bureaucratic success despite scientific failure

The EU €1-Billion-Flagship Human Brain Project (HBP) has passed its midterm evaluation with flying colours. Noone knows exactly what the objectives of this bombastic project is, as members of the evaluation panel indicated to me, while others refused to answer this question. The HBP leadership sure keeps the exact definition of these objectives secret, or maybe they don’t know them themselves. Which is easy to understand, because given the leniency HBP keeps receiving from those supposed to evaluate it, its real objective becomes perfectly clear: to secure the public funding. There, HBP succeeded indeed, the €1 Billion seems rather safe. It is none of the public’s business where the money will go, but it can rest assured it will certainly go somewhere. The public should also not expect any deliverables or return on its research investment, this the HBP leadership already made perfectly clear. I am showing below what a farce the recent HBP evaluations were, while the positive outcome was much hailed as evidence for excellent scientific performance.  Continue reading “Human Brain Project: bureaucratic success despite scientific failure”

The vexatious life-saving question of cadaveric tracheas

The vexatious life-saving question of cadaveric tracheas

As we learned it from the Swedish documentary „Experimenten“, the scandal trachea surgeon Paolo Macchiarini didn’t much like to operate on sick cancer patients: they died too quickly after receiving a trachea transplant. This is why Macchiarini was said to have moved on to patients outside of any life-threatening conditions, like the Russian car accident victim Yulia Tuulik. She died because of the plastic trachea which Macchiarini implanted into her. Yesim Cetir, young victim of a botched operation, was slightly luckier to survive the plastic trachea, but only because it was removed and because of constant emergency care and multiple organ transplants (she is presently in very grave state). However, it seems that even Macchiarini’s cancer patients could have led a relatively long life, had they not agreed to receive his trachea transplants. And I am not speaking about the lethal plastic ones. In fact, the “biological” grafts made of decellurised dead donor tracheas were not such a great success either, and seem to have brought suffering and have shortened lives instead of prolonging them. The British UCL and its hospital UCLH are preparing their own clinical trial with cadaveric tracheas, while busily covering up their role in the Macchiarini scandal.

Continue reading “The vexatious life-saving question of cadaveric tracheas”

The travelling circus of research integrity in Strasbourg

The travelling circus of research integrity in Strasbourg

On March 8, an international scientific review board will be evaluating the research at the French CNRS Institut de Biologie Moléculaire des Plantes (IBMP) in Strasbourg. This is the place where the former star (and now misconduct-tainted pariah) of plant sciences Olivier Voinnet shot to fame, where his main lab operated since 2002 until he was taken away control over it in 2015, after found guilty of massive data manipulations in many papers by his employers CNRS and ETH Zürich (see my various reports here). The Voinnet lab in Strasbourg had since been led by his right-hand man, Patrice Dunoyer, first author on 3 retracted papers, who also admitted his own data manipulations in several more instances (most recent Voinnet/Dunoyer retraction and correction list here). A serious institute might have reconsidered collaborating with such a questionable scientist as Dunoyer, not so CNRS and its IBMP (which is actually just as fair, because also the Swiss ETH kept his boss Voinnet as their professor). Dunoyer was only punished by a one-month suspension back then in 2015, to CNRS leadership he seems to be a perfect scientist to lead a research lab in this plant science institute. Indeed, Dunoyer is apparently well integrated at IBMP: on March 8th the review board will not only be judging his scientific performance, but also that of his several IBMP colleagues whose publications were also flagged for data integrity concerns on PubPeer, e.g. Christophe Ritzenthaler, Véronique Ziegler-Graff and Pascal Genschik. Incidentally, IBMP invited as review committee members such international scientists who will be well able to understand this delicate matter, because, like for example Martin Crespi, director of the Institute of Plant Sciences in Paris-Saclay, or Serge Delrot, professor at University of Bordeaux, their own publications were reported on PubPeer for serious data integrity concerns as well. One could quip here: it takes one to know one. Continue reading “The travelling circus of research integrity in Strasbourg”

Image duplication and other irregularities of Heike and Thorsten Walles

Image duplication and other irregularities of Heike and Thorsten Walles

More inconsistencies arise in publications and statements of the litigation-happy professors of the University of Würzburg, Heike and Thorsten Walles. These regenerative medicine scientists turned the entire might of German justice system against my reporting, while their academic employer remains shamefully silent.  Their elusive animal experiments with the pig intestine-based tracheal transplants seem to be very real when Heike Walles speaks about them and become non-existent when her husband and research partner Thorsten does. While the University of Würzburg and the federal watchdog Paul-Ehrlich-Institute (PEI) protect the surgeon by asserting that no ethics vote was needed to perform his tracheal transplants on 3 patients, his wife claimed that he actually needed and obtained an ethics approval to do this.  Thorsten Walles himself in fact indicated that his last transplant in 2009 might have broken the German Tissue Law from 2007, i.e., if he indeed failed to obtain an ethics vote, while operating under compassionate use. In any case, no German institution was willing to discuss with me the existence or non-existence of these ethics approvals. Despite the simple fact that none of these 3 patients is alive today (one died in fact very soon after operation), it is none of public’s business.

Now, a seemingly duplicated image was spotted in two Walles publications (Linke et al 2007 and Schanz et al 2010). They describe the creation of an “artificial liver”, made from decellurised pig intestine (just like the tracheal transplants), seeded with endothelial and liver cells. These two publications are 3 years apart, the methodology description is also slightly different (e.g., decellurisation process and the speed and kind of perfusion). A minor aspect may be that the Linke et al 2007 paper described the use of pig cellular material, and Schanz et al 2010 employed primary human cells from patient biopsies. Finally, the image seems not just duplicated, but one looks actually brighter and like a zoom-in of the other.

Continue reading “Image duplication and other irregularities of Heike and Thorsten Walles”

Evidence is a lie, listen to our authority, say Walles to scientists

Evidence is a lie, listen to our authority, say Walles to scientists

The Würzburg regenerative medicine researchers Heike and Thorsten Walles, joined by their colleague Jan Hansmann, are now hitting back at the evidence I presented, which all clearly suggests that no animal testing was performed on their tracheal transplants made of pig intestine before those were tested on 3 patients, coincidently none of whom is alive today. The first test was performed in 2003 at the Hannover Medical School (MHH) in Germany, and led by none other than the scandal surgeon Paolo Macchiarini, Walleses’ former superior. Two more tests were performed on two patients in Stuttgart, where Walleses moved to in 2004 (see details here). About the last tracheal transplant in 2009, an analysis of Thorsten Walles’ own words raise new questions about its legality in regard to German Tissue Law from 2007.  The University Clinic Würzburg shamefully continues to refuse to share any information with me, despite the protests of many international scientists. In fact, it even refuses to say if Walleses were given persmission to use their institutional affiliation to achieve that court injunction against me. Continue reading “Evidence is a lie, listen to our authority, say Walles to scientists”