Science journalism by Leonid Schneider, on research integrity and academic publishing in life sciences and biomedicine
A decision was announced by the Swedish Prosecution Authority in Gothenburg on the Paolo Macchiarini case today. The issue are plastic trachea transplants the scandal surgeon performed at the hospital of the Karolinska Institutet (KI) in Stockholm, Sweden. The earlier decision by state prosecutor was changed in part and the preliminary investigation will be reopened
Paediatric surgeon Paolo De Coppi claims to grow all possible internal organs in his lab at UCL. Though his career started with his association with Macchiarini, and their regenerative medicine ideas sound strangely similar, De Coppi is celebrated as a modest genius poised to save lives of uncounted children, and the funding money flows.
A “defamation Complaint” was lodged with Google, against 6 of my articles and one cartoon. Each of them affects to some degree the British laryngologist Martin Birchall, professor at UCL and former close associate of scandal surgeon Paolo Macchiarini. I also show that Birchall and UCL even now continue researching plastic tracheas on pigs, for future use in humans patients. This grant is presently funded by UK government.
This is my review of the Russian book “Megagrant”, which tells of Macchiarini’s adventures with the plastic trachea, much of it played out in Russia, funded by a state Megagrant of €4.5mn. Some books are namely only good as court evidence.
Elite journal Nature Cell Biology (NCB) requests deposition of raw data, in particular original scans of western blots and other gel analyses. Spanish star cancer researcher Carlos López-Otín, winner of 2017 Nature Mentoring Award, instead deposited whatever odd gel picture his lab had available, counting that nobody will bother to check. Yet readers did.
In September 2010, trachea transplant surgeon Paolo Macchiarini was basically at the end of his career of fraud and patient abuse, unwanted by everyone. Except by Karolinska Institutet in Sweden, which pushed the recruitment process through in just 3 weeks, despite warnings from colleagues in Florence, Barcelona and Hannover not to employ someone who was basically a lying psychopath. Yet Karolinska leadership was desperate for some positive reviews for Macchiarini. They finally got them from London, from UCL and GOSH.
Videregen, the Liverpool-based company which bought the trachea regeneration patent from UCL, deployed lawyers against the academics Patricia Murray and Raphael Levy, precisely via their employer University of Liverpool. Main issue is the parliamentary submission by Levy and Murray, subject to absolute privilege. Yet Videregen also cites from the confidential notice of suspected research misconduct Murray and Levy submitted in good faith to UCL.
Another one of Paolo Macchiarini’s past trachea transplant patients has died on 9 July 2018. She received from Macchiarini a cadaveric decellurised trachea in December 2010. By 2018, Zhadyra’s situation critically deteriorated, the dying patient was used for another experiment. On June 5th 2018, Zhadyra received in Moscow another trachea transplant. Responsible was same Parshin who performed the first trachea transplant together with Macchiarini.
The travesty around the data faking regenerative medicine enthusiast Suchitra Sumitran-Holgersson is finally over. Her Swedish employer University of Gotheburg announced to sack her as university professor. Retractions of 7 papers were requested
Paloma was supposed to the second trachea transplant patient of Paolo Macchiarini’s in Barcelona, in summer 2008. The scandal surgeon gave her a fake diagnosis of a lethal tracheal cancer which she never had, and also “accidentally” mislocated her stent during a enforced bronchoscopy. All to coerce his patient to agree to a trachea transpalnt. Paloma had a lucky escape, twice. She namely also encountered Thorsten Walles.
