The misconduct-tainted paper on oesophagus transplants in rats (Sjöqvist et al 2014) by the fallen star of regenerative medicine Paolo Macchiarini is finally retracted by the journal Nature Communications. This happens after Swedish investigations found the authors (primarily the scandal thorax surgeon and his right-hand man Philipp Jungebluth) guilty of data manipulation and research misconduct in September 2016 and after the Karolinska Institutet (KI) shortly before Christmas publicly demanded a retraction (see my report here). Today’s retraction is a major setback for Macchiarini, since his current employment and funding at the Federal University of Kazan (KFU) in Russia depend on his experiments with oesophageal transplants in primates (see my reports here and here). That Russian project was in turn only possible because of Macchiarini’s allegedly successful experiments in rats, published in a prestige journal with “Nature” in its title. This paper’s retraction is therefore probably only the beginning of a whole looming avalanche of bad news for Macchiarini and his acolyte Jungebluth (who currently sues me in court). An expert review of their publication Jungebluth et al 2015 declares the findings of misconduct, ethics breach and patient abuse. The report however has yet to be confirmed by a commission at the Swedish Central Ethics Review Board (CEPN) and then formulated as an official decree by the KI. I publish the expert reviewer report below. Continue reading “Retraction, and another looming misconduct finding for Macchiarini and Jungebluth”
This is a new guest post from Johan Thyberg, a retired professor for cell and molecular biology from Sweden, a known activist against science fraud and author of the 2009 book “Scientific Fraud or Legal Scandal?”. Thyberg played a key role in uncovering the research misconduct and horrendous patient abuse around the trachea transplant surgeon Paolo Macchiarini, which took place at Alma Mater, the Karolinska Institutet (KI) in Stockholm, and left at KI alone 3 patients dead (his last plastic trachea recipient there, Yesim Cetir, died yesterday after years of suffering).
After a previous guest post by Thyberg, which criticised KI’s handling of the Macchiarini scandal, it is an honour for me to present his new article on my site. It deals with another international star of regenerative medicine whom KI recruited soon after Macchiarini: Kenneth Chien. The people who recruited Chien were also the same who made Macchiarini’s professorship at KI possible: the then-chancellor Harriet Wallberg and the cell biology professor Urban Lendahl. Both had to resign from their positions with the KI’s Nobel Committee in the wake of Macchiarini scandal (see my report here).
This is what Chien’s 20-head strong lab is working on at KI, according to its website:
“The central scientific interest of the Chien lab is to understand heart development at the molecular and cellular level, with the ultimate goal of applying the developmental principles, logic, pathways, technology, and model systems to unravel human heart disease”.
According to Thyberg, Chien’s engagement at KI is less about his actual scientific achievements, which seem objectively rather modest relative to his elite status there, but more about personal networks and money, which include pharma industry and a certain Chinese investor. One of these Chien-related businesses is Moderna Therapeutics, a biotech start-up which STAT News brought a critical special report on.
Below I am publishing Thyberg’s own English version article, a Swedish version appeared on March 17th on NewsVoice.
My attempt recently to inform the readers of the journal Tissue Engineering Part A about grave omissions and factual inconsistencies in the Steinke et al 2015 publication by Heike and Thorsten Walles failed spectacularly. Not because the concerns I raised about their tracheal transplants where deemed is irrelevant, far from it. It was the messenger who was seen as disreputable. The editor chose to send my letter out for peer review, despite the fact that I was never addressing the science of the paper, but the omitted, yet verified medical complications and deaths of the patients, as well as non-existent animal tests. Two of three peer reviewers simply chose not to believe me and my evidence, one of the reasons was: my blog site where I published it is not peer reviewed. I was also decreed to be scientifically incompetent, driven by personal vendetta against poor Walles (who are presently suing me at court for reporting about these transplants) and simply as a liar, who made all these things up. At the same time, the notorious third reviewer warns the editor that the journal’s readers must never see or hear of my accusations. Continue reading “My Walles trachea transplant reporting fails peer review”
s we learned it from the Swedish documentary „Experimenten“, the scandal trachea surgeon Paolo Macchiarini didn’t much like to operate on sick cancer patients: they died too quickly after receiving a trachea transplant. This is why Macchiarini was said to have moved on to patients outside of any life-threatening conditions, like the Russian car accident victim Yulia Tuulik. She died because of the plastic trachea which Macchiarini implanted into her. Yesim Cetir, young victim of a botched operation, was slightly luckier to survive the plastic trachea, but only because it was removed and because of constant emergency care and multiple organ transplants (she is presently in very grave state). However, it seems that even Macchiarini’s cancer patients could have led a relatively long life, had they not agreed to receive his trachea transplants. And I am not speaking about the lethal plastic ones. In fact, the “biological” grafts made of decellurised dead donor tracheas were not such a great success either, and seem to have brought suffering and have shortened lives instead of prolonging them. The British UCL and its hospital UCLH are preparing their own clinical trial with cadaveric tracheas, while busily covering up their role in the Macchiarini scandal.
The trachea transplant doctor and acolyte of Paolo Macchiarini, Philipp Jungebluth, followed up on his previous legal threat to me and used his star lawyer to issue an injunction against me by a court in Berlin. The plaintiffs even declared to have started their legal action following a similar move against me by other former collaborators of the scandal surgeon Paolo Macchiarini, Heike and Thorsten Walles. Here, however, Macchiarini and Jungebluth are proclaimed being “renowned in Germany and world-wide”, no, not how you know them from the more recent Swedish and also British media. Jungebluth is portrayed as an excellent, most-sought for, doctor and top scientist whose only career dent came from what I wrote about him on my site. Once again, I was not invited or informed of the trial, and sentenced never again to assume that Jungebluth might have left his research surgeon employment with the University Clinic of Heidelberg in any other way but entirely of his own accord. The usual threat: €250,000 fine or 6 months in prison.
The lawyer didn’t really have to bother claiming any urgency to have this injunction passed, since Jungebluth is happily employed as junior doctor at a small communal hospital outside Braunschweig, in northern Germany. It sufficed to assert that he felt bothered by my reporting after no less than 35 colleagues asked him about it, and the other side of story became immediately irrelevant for now. Once again, German justice created legal facts out of accusations, without allowing the accused to bring any evidence to defend himself. The alleged eminence of Dr. Jungebluth, scientist and physician, made all evidence obsolete. Except that to all those who ever followed the Macchiarini scandal, the young doctor is not as renowned and respected as the court trusted his lawyer. Conveniently though, in Germany this media reporting never really happened. Continue reading “Jungebluth achieves court injunction against me, because he published in The Lancet”
Below I am publishing the most recent dossier authored by the four whistle-blowers from the Karolinska Institutet (KI) in Sweden: Oscar Simonson, Karl-Henrik Grinnemo, Matthias Corbascio and Thomas Fux. Two of their earlier notifications of research misconduct to KI by their former colleague Paolo Macchiarini are available in full on my site, here and here.
This time it is about Macchiarini’s trachea transplants in Russia, and the so-called Megagrant funding he received from the Russian government for his work at the Kuban State Medical University in Krasnodar. The accusation goes that the KI star surgeon misrepresented the true outcomes of his two first disastrous human experiments with a plastic trachea, performed at KI on the patients Andemariam Beyene and Chris Lyles, both of who died. Also, the whistle-blowers criticise that KI failed to investigate these failed transplants and patient deaths and did not report those to the Russian authorities, which might have helped avoid the unnecessary deaths of at least two Russian patients, Yulia Tuulik and Alexander Zozulya. Continue reading “Macchiarini and his Russian megagrant”
On December 22nd, I received some Christmas mail. It was a letter from a famous media lawyer, Prof. Dr. Jan Hegemann, recruited by Philipp Jungebluth to deal with my unwelcome reporting. This is the third time a German clinician set lawyers upon me (here and here are the previous two), and the second time it is about trachea transplants. This lawyer, whose offices are at Potsdamer Platz at the business heart of Berlin and who represented the biggest stars of German media landscape, is certainly not cheap.
Jungebluth was the closest assistant of the scandal surgeon of Paolo Macchiarini, many of their trachea transplant patients have died. Through his lawyer, Jungebluth (who is an unfinished surgeon) denied any responsibility for any of these operations, insisting against a huge mountain of evidence that he was solely contributing academically, as a scientist. The lawyer also insists that Jungebluth’s medical dissertation, completed under Macchiarini’s supervision at the Medical University Hannover (MHH) in Germany, was equivalent to a PhD degree and that his employer Karolinska Institutet (KI) officially recognized this (for some reason, same lawyer apparently deems my own PhD degree as null and void). Interestingly, the lawyer did not deny my earlier report that his client’s dissertation is being investigated by the MHH right now, which may result in the revocation of Jungebluth’s medical doctorate and of all its alleged equivalences.
The lawyer’s main assertion is that his client quit his job at the University Clinic Heidelberg utterly voluntarily, thus abandoning all his research and training as thorax surgeon, to become a junior doctor at some provincial communal hospital near Hannover. Yet the loss of his job in research was what Jungebluth actually profusely lamented just now in an interview with Swedish newspaper.