The irony is rich. Just last month, the Swedish Karolinska Institutet (KI) announced the results of the investigation into papers by their former guest professor Paolo Macchiarini and his right-hand man Philipp Jungebluth. The two were found guilty of research misconduct and their plastic trachea transplant papers were set for retraction, where at least the journal The Lancet finally obliged (read here). Exemplary decision, but there is a snag: next to the ruthless trachea transplanters, other scientists were found guilty of misconduct, among them Karl-Henrik Grinnemo, one of the four original KI whistleblowers without whose brave actions there would have been no Macchiarini scandal. Two more whistleblowers were found “blameworthy” of negligence. Also KI professor Katarina Le Blanc was found guilty of misconduct, incidentally a whistleblower herself who reported severe ethics breaches in a different case of regenerative medicine and human research at KI two years ago. Finally, KI fingered the sacked UCL nanotechnologist Alexander Seifalian for research misconduct, using the very same shaky arguments the London university pulled off in its investigative report in 2017 (read here). The bizarre thing: back then UCL did not allow Seifalian to defend himself or to appeal against the accusations, and KI now did exactly same. He was served a misconduct verdict, but was denied by KI a right to testimony or appeal, which Macchiarini and his gang were granted generously and made ample use of.
The Macchiarini investigation was initiated in 2016 by the interim KI Vice-Chancellor (rector) Karin Dahlman-Wright and was completed this year by the newly installed Vice-Chancellor Ole Petter Ottersen. The promised irony is that several Dahlman-Wright papers were now scrutinised by the pseudonymous data integrity sleuth Clare Francis with the result that one wonders if Dahlman-Wright was the right person to supervise a research misconduct investigation. Here comes namely even more irony: that former interim rector and her successor Ottersen previously absolved the notorious KI group leader Helin Vakifahmetoglu-Norberg and her former PhD mentor, the KI professor Boris Zhivotovsky (read here), despite heavy evidence of manipulated data. Nine more professors were under misconduct investigation during Dahlman-Wright’s tenure (read here), and since we heard nothing yet, one can assume that all the duplicated and photoshopped data in their papers was also a misunderstanding which bears no relevance on the quality of their research. The Dahlman-Wright evidence I present below is heavy, but also Ottersen himself might be tainted: he is co-author on an old paper with a likely image duplication. Continue reading “Former KI rector Dahlman-Wright: stones in a glass house”
English version below
Умерла еще одна жертва Маккиарини – Жадыра Игликова
Еще одна из пациенток, которым Маккиарини в прошлом проводил трансплантацию трахеи, умерла 9 июля 2018. Об этом сообщила российский медицинский журналист Алла Астахова, упомнув в качестве источника аккаунт в Instagram одного из членов семьи пациентки. Аккаунт содержит много ценной информации. Жадыра Игликова получила от Маккиарини обесклеченную трахею посмертного донора в декабре 2010 года. Эта операция была шоу своего рода и должна была привлечь чудо-хирурга в российский проект мегагрантов. Результатом стали до 6 смертельных трансплантаций пластиковой трахеи . Трансплантат был получен в больнице Careggi во Флоренции, где Маккиарини работал в то время, и доставлен в Россию. Операция была проведена в московской Национальном научном центре хирургии имени Петровского. Ведущим хирургом наряду с Маккиарини был Владимир Паршин . Сразу же после этого последовали осложнения, трансплантат развалился и сгнил, как сообщает Дземешкевич 2015 .
К 2018 году состояние Жадыры критически ухудшилось, у нее была хроническая пневмония, трахеопищеводный свищ и весила она менее 39 кг. В феврале 2018 ее семья отправилась с ней из Казахстана в Москву искать помощи в клинике МГМУ имени Сеченова. Совпадение или нет, но руководит отделением торакальной хирургии в этой клинике Паршин, выполнивший первую операцию по пересадке трахеи Жадыре в 2010 году. Continue reading “Macchiarini victim Zhadyra Iglikova is dead”
English version, and a secret of yet another dead trachea transplant patient below.
Me llamo Paloma Cabeza Jiménez,
tengo 43 años y vivo en Alicante aunque nací en Madrid (España)
Con tan solo 10 años, tuve un accidente doméstico con un caustico.
En aquella época (1986) no se manejaban con buen acierto ni criterio las lesiones traqueales.
Mi lesión primaria era de tan solo dos centímetros de longitud y a causa de malas decisiones médicas y pocos recursos… aquellos dos centímetros degeneraron en una lesión que abarcaba la longitud total de la tráquea, lo cual me obligó a la colocación de una prótesis de silicona tipo “T” llamada Montgomery en 1992 (el verano que cumplía 18 años)
Tras años de múltiples recambios de Mongomerys para evitar la colonización por bacterias, se dieron cuenta que esas mismas manipulaciones (cada 3-6 meses) en quirófano estaban favoreciendo y provocando la aparición de nuevas bacterias por contaminación y sumada a esta realidad la propia manipulación destrozaba la regeneración natural de la mucosa traqueal.
Asi mismo, las reiteradas manipulaciones con fibrobroncoscopio rigido y aspiraciones…dañaron parcialmente mi bronquio principal izquierdo, quedándose con una estenosis estable de diámetro entre 6-7mm. Calibre compatible con una calidad de vida normal si no pretendes ser deportista profesional. Continue reading ““Me llamo Paloma Cabeza Jiménez”: Macchiarini victim speaks out”
Today the Swedish Karolinska Institutet (KI) will announce its decision about 6 papers of their former professor and surgeon, Paolo Macchiarini. This article will be updated accordingly. Update 14:00: a decision was published, all 6 papers are to be retracted, 7 scientists found guilty of misconduct.
The background: On 30 October 2017, Swedish Central Ethics Review Board (CEPN) requested that 6 publications by Macchiarini and co-authors, all authored while at KI, are to be retracted, in a press release and a statement I received, in English original. The decision was based on the expert review by Martin Björck, professor of surgery at University of Uppsala, and Detlev Ganten, professor emeritus of pharmacology and former CEO of the Charité university hospital in Berlin, Germany, their report is available here on my site. The two experts found Macchiarini and his former acolyte and right-hand man Philipp Jungebluth guilty of breaching the Nuremberg Code of 1947 and Helsinki declaration, which forbid unethical and dangerous medical research on humans. One of those papers set for retraction is Jungebluth et al Lancet 2011, where a patient from Iceland was tricked to subject himself to a deadly experiment with a never before tested plastic trachea (that issue lead to a major investigation in Iceland and now is even about to be addressed by the Icelandic parliament).
Judging from last week’s email by Jungebluth to KI which I quote below, a call for retraction is expected.
Continue reading “Karolinska requests retraction of Macchiarini and Jungebluth papers”
A most bizarre thing happened. In the aftermath of the scandal around the thoracic surgeon and regenerative medicine enthusiast Paolo Macchiarini, which left many patients dead, his former employer Karolinska Institutet (KI) in Stockholm, Sweden, requested a retraction of one of his papers. It was not about a trachea transplant, but about unethical and painful medical experiments on a dying patient (actually, two of them). KI’s decision to request a retraction of the paper Jungebluth et al, “Autologous peripheral blood mononuclear cells as treatment in refractory acute respiratory distress syndrome”, Respiration, 2015 was based on the investigation commissioned by Swedish Central Ethics Review Board (CEPN). The Swiss-German and family-owned medical publisher Karger and its journal Respiration however categorically refused to retract the paper and ordered KI not “to patronize the readers of the journal ‘Respiration’.”
It gets much worse. The German Editor-in-Chief of this journal has a huge conflict of interest. It is better you just read on, because if I try to summarize it here, I might get sued by Macchiarini’s German friends and associates once again, and next time it might even be prison for me. In Germany, doctors have a very special status. Journalists or even patients do not, as I learned in court.
Continue reading “Karolinska gets taught German medical ethics”
In 2017, the great London university UCL invited an external expert commission to investigate its role into the deadly trachea transplants performed by the former UCL honorary professor and scandal surgeon Paolo Macchiarini. An already sacked UCL nanotechnology professor, Alexander Seifalian, whose lab made the two UCL plastic POSS-PCU tracheas in 2011, was announced as the main culprit on UCL side for all the suffering of these two patients Andemariam Beyene and Keziah Shorten, as well as some recipients of vascular grafts. All this despite Seifalian’s having had no clinical role, training or ambitions, as he professed in his interview to the investigative committee, which I now obtained.
The interview also makes perfectly clear that the investigative committee’s surprise finding, namely that the nanotechnology specialist fabricated non-GMP certified plastic grafts for clinical use behind everyone’s back, was actually slanderous. Not only did UCL know very well that the product, which their own business branch UCLB approved for clinical use in Iran, Switzerland and India, was not GMP-certified, they even used it on their own patient at UCL hospital UCLH, in an attempt to grow a plastic nose. Even the UK regulatory authority MHRA was informed, and apparently did not mind or interfere. All this did not stop UCL investigators from publicly fingering cancer survivor Seifalian as the only culprit for that GMP-non-compliance.
Finally, the committee had information that Birchall allegedly proposed to make a plastic trachea for the child patient Ciaran Lynch in December 2009. Seifalian refused, for technical reasons, but this definitely and literally saved the boy’s life. Ciaran, presently one of just 3 known survivors of ~20 trachea transplants performed by Macchiarini and his former close associate, the UCL laryngologist Martin Birchall, was operated in London in March 2010 with a freshly decellurised cadaveric trachea graft supplied from Italy; Macchiarini was the surgeon. That clever Birchall-attributed idea, of being the first one to implant the utterly untested plastic trachea, and into a child no less, was somehow dropped from the final UCL report. Sod knows why. Continue reading “UCL trachea transplant inquiry: scapegoating, obfuscation and a lost nose”
The German justice has spoken on trachea transplants again, in the appeal hearing at Kammergericht Berlin, and found the problem to lie with the journalists and press freedom. Good news first: I might have won the first injunction case against Philipp Jungebluth, or at least in large part, so I will probably get most of my money refunded there (Update 30.05.2018: the court tricked me and rejected my appeal on that injunction too. It remains valid to 1/3 just as before, see below). This only happened because the judges regarded how exactly Jungebluth left his job in Heidelberg being a minor enough issue (they did advice him to sue a Swedish newspaper for interviewing him about his sacking in Sweden (sic!)). This money I then will pay back to Paolo Macchiarini‘s acolyte and the court, and much, much more on top, because the three appeal court judges announced to uphold the second injunction in full. These are their oral arguments from yesterday summarised: Continue reading “No good news, instead a major disaster in appeal court re: Macchiarini affair”