Macchiarini’s trachea transplant patients: the full list

Macchiarini’s trachea transplant patients: the full list

This article lists all known (including those not officially declared) patients of the scandal surgeon Paolo Macchiarini, who received from his a cadaveric or plastic trachea. All received grafts “regenerated” with bone marrow and epithelial cells, in some cases bioreactor was used to incubate cells on the trachea carcass, in some cases a “bionic” method was applied,  where cells were brought straight into open patient, together with growth factors like EPO. Not all patients are named in my list, though names of all are available, certainly at the hospitals where they were treated. One of my sources is a patients list from the Careggi Hospital in Florence, Italy, which the Corriere Fiorentino journalist Alessio Gaggioli sent me.  Some of the patients I already described in an earlier article.

This now is a full list, and it will be updated whenever I receive any new evidence. All Macchiarini trachea transplant patients are listed in the chronological order of their operation. The 2003 operated patient (story here), who received from Macchiarini (together with Heike and Thorsten Walles) a small “regenerated” tracheal patch of pig intestine, is not included here, as it was not a trachea transplant as such. There is a total of 17 patients, at least 11 are dead, the rest, if alive, were left mutilated.

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Keziah’s deadly trachea transplant: UCL hospital’s secret

Keziah’s deadly trachea transplant: UCL hospital’s secret

Keziah Shorten was a 19-year old teenager from England and officially Paolo Macchiarini 3rd patient receiving a cadaveric trachea transplant. She suffered from a slow growing form of cancer and received a cadaveric trachea transplant from Macchiarini at the Careggi hospital in Florence. After life-threatening complications ensued, her second transplant, a plastic trachea made and implanted at UCL and its UCL hospital (UCLH) in London, failed also. Keziah died one and a half years after her first operation. With new evidence provided to me by a source close to the patient, I present here a version of Keziah’s story which is very much different from the official one. This makes UCL and UCLH at least in part responsible for her death, from the very beginning. It was their decision to treat Keziah with the first cadaveric transplant, which sealed her fate.  Next to the UCL honorary professor Macchiarini himself, the British doctors, who according to my source promised Keziah a complete cure and initiated this transplant, were UCL professors and surgeons Martin Birchall and Paul O’Flynn. Keziah was even supposed to be operated at UCLH, but once Macchiarini got an ethics permit in Italy, she was moved there. O’Flynn followed her and joined Macchiarini in the transplant operation. Afterwards, it was an ongoing catastrophe which was exacerbated by an apparent botched intervention at UCL Hospital. Death seemed a relief after terrible suffering imposed on Keziah by fame-seeking doctors worshipping their own magic of regenerative medicine. Continue reading “Keziah’s deadly trachea transplant: UCL hospital’s secret”

Ciaran’s success story

Ciaran’s success story

Trachea is a very difficult organ to transplant, because its blood supply happens through many tiny blood vessels and it is practically impossible to connect them all (same is true also for the oesophagus). An organ transplanted without blood supply will die, and this is where the regenerative medicine of Paolo Macchiarini and Martin Birchall comes in: a treatment with stem cells and growth factors will somehow magically ensure quick vascularization and bring the dead tissue to life. There is no independent evidence for this, and most patients died as the consequence or became dangerously ill when their new tracheas, made from plastic or from dead, decellurised cadaveric organs predictably failed.  One boy has survived: Ciaran Lynch. His current clinical state is not too rosy, even by Birchall’s own admittance, but nevertheless the sole fact that Ciaran (unlike almost all other trachea transplant patients) is alive, sufficed for Birchall to have one or two more patients operated (both dead) and to push through a clinical trial in UK with a much larger follow-up trial EU-wide. The difference though: that boy never had much choice anyway, since he had no real trachea in the first place. He received very early on a pickled trachea homograft from dead human donor tissue which functioned very well for many years, but at some point urgently needed replacement in order to save his life. Now Birchall however wishes to remove the live airways of stable patients outside any life danger, who suffer from tracheal stenosis, and replace them with his regenerated dead ones (see this report). Noone seems to wonder why these tracheas are to be prepared in a radically different way from that of the sole success, Ciaran Lynch: Birchall’s bioreactor vs so-called “bionic” method of Macchiarini.

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Susana Rivas: a new research integrity scandal in French plant sciences

Susana Rivas: a new research integrity scandal in French plant sciences

Susana Rivas, a CNRS research group leader from the French National Institute for Agricultural Research (INRA) in Toulouse is now at the epicenter of a new research integrity scandal in plant sciences. In the last two years, France was shaken by the Olivier Voinnet scandal, when their former star researcher was found guilty of data manipulation throughout his entire career, from his PhD at The Sainsbury Laboratory in Norwich, UK, over his position of many years as research director at CNRS plant science institute in Strasbourg up to his current professorship at the ETH Zürich in Switzerland. Before she became CNRS group leader in 2003, the Spanish plant scientist Rivas worked as postdoc at The Sainsbury Laboratory, in the lab of Jonathan Jones, at around the same time when Voinnet was finishing his PhD there under David Baulcombe. Now, Jones retracted a paper authored by Rivas from the journal The Plant Cell, he also requested the retraction of another paper from his lab with Rivas as first author, in The Plant Journal. Meanwhile, I share here new evidence of suspected data manipulations from Rivas’ own lab in Toulouse, in her 5 publications which include PNAS, PLOS One, The Plant Cell and Nature Communications. Continue reading “Susana Rivas: a new research integrity scandal in French plant sciences”

The vexatious life-saving question of cadaveric tracheas

The vexatious life-saving question of cadaveric tracheas

As we learned it from the Swedish documentary „Experimenten“, the scandal trachea surgeon Paolo Macchiarini didn’t much like to operate on sick cancer patients: they died too quickly after receiving a trachea transplant. This is why Macchiarini was said to have moved on to patients outside of any life-threatening conditions, like the Russian car accident victim Yulia Tuulik. She died because of the plastic trachea which Macchiarini implanted into her. Yesim Cetir, young victim of a botched operation, was slightly luckier to survive the plastic trachea, but only because it was removed and because of constant emergency care and multiple organ transplants (she is presently in very grave state). However, it seems that even Macchiarini’s cancer patients could have led a relatively long life, had they not agreed to receive his trachea transplants. And I am not speaking about the lethal plastic ones. In fact, the “biological” grafts made of decellurised dead donor tracheas were not such a great success either, and seem to have brought suffering and have shortened lives instead of prolonging them. The British UCL and its hospital UCLH are preparing their own clinical trial with cadaveric tracheas, while busily covering up their role in the Macchiarini scandal.

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Ryan’s mentor Dow pretends copyright to combat my reporting

Ryan’s mentor Dow pretends copyright to combat my reporting

The academic career of the Irish microbiologist Robert Ryan is apparently over. Following an internal misconduct investigation at the University of Dundee, Ryan had to resign from his position as group leader and lost the prestigious funding from the Wellcome Trust. Prior to this, he was suspended by his employer, while the European molecular biology society EMBO terminated his participation in the EMBO Young Investigator programme. Peculiarly, there never were any press releases or official communications. The University of Dundee apparently chose instead to leak internal emails to media (for details see my reporting here and here), the most recent announcement about Ryan’s “resignation” was no exception.

Ryan’s however is not the only name crowning all those papers now under suspicion of misconduct. Another recurrent name belongs to his former mentor of many years, the leading plant pathogen researcher Maxwell Dow, from the University College Cork (UCC) in Ireland. The PubPeer evidence is quite heavy against Ryan and Dow papers, and in fact UCC once suggested to me that they would initiate an investigation. Other media never even mentioned Dow’s name. Only on my site was his most obvious responsibility for Ryan’s research discussed, nowhere else. Now Dow decided to act against this unwelcome reporting. He submitted a DMCA takedown request to my website host WordPress and LinkedIn’s Slideshare, targeting my article and my teaching presentation from a research integrity workshop in Catania, Italy. Dow’s copyright claim concerned a photograph of his together with Ryan which was made publicly available by their university in this UCC press release.   Continue reading “Ryan’s mentor Dow pretends copyright to combat my reporting”

Birchall’s trachea transplant trial at UCL suspended by health authorities

Birchall’s trachea transplant trial at UCL suspended by health authorities

The British laryngologist and UCL professor Martin Birchall is in trouble now, despite all his constant attempts to turn claims into facts and declare the “stem cell”-based cadaveric trachea transplant technology (which he initially developed together with Paolo Macchiarini) a full success. Birchall’s own little trachea transplant trial INSPIRE (see background here), where the method was about to be applied once again, and on four patients outside of any life-threatening conditions, has been now suspended indefinitely by the NHS Health Research Authority and its South Central – Oxford A Research Ethics Committee (REC), as I report exclusively below. Meanwhile, the Information Commissioner’s Office (ICO) is investigating Birchall’s employer UCL Hospital for providing me with inappropriate and misleading information about that trial under Freedom of Information Act (see email here). Also, the Human Tissue Authority (HTA) is investigating a suspected loss of laboratory documentation at the veterinary department of Bristol University, where their former professor, his Bristol colleagues and Macchiarini’s student Philipp Jungebluth generated in 2008 a trachea transplant for Macchiarini’s patient Claudia Castillo in Barcelona (for background, see my report here). Continue reading “Birchall’s trachea transplant trial at UCL suspended by health authorities”