Academic Publishing Guest post medicine Research integrity Smut Clyde

The full-service paper mill and its Chinese customers

An investigation by Elisabeth Bik, Smut Clyde, Morty and Tiger BB8 reveals the workings of a paper mill. Its customers are Chinese doctors desperate for promotion. Apparently even journal editors are part of the scam, publishing fraudulent made-up science.

In China, clinicians are expected to publish a certain number of research papers in international journals if they want to be promoted. The easiest way is to pay a paper mill, which seem to provide a full service: an English-speaking research paper containing Photoshop-generated fake research data, in a respectable peer-reviewed journal, with your name on it. Entire journals published by Wiley or Elsevier succumb to such scams, presumably because certain corrupt editorial board members are part of it. This was uncovered in an investigation by Elisabeth Bik, as well as the pseudonymous Smut Clyde, Morty and Tiger BB8, and narrated below by Smut Clyde.

The presently almost 500 papers were traced to one specific paper mill not because of direct image reuse, but because the data showed same patterns of falsifications: same blot backgrounds, same shapes of bands, and similarly falsified flow cytometry plots.

The growing list of papers and affected journals is available here.

Apparently, the Chinese paper mills even handle submissions, peer review (if there is a peer review, that is) and sign the copyright consent forms while pretending to be the listed authors. This is evidenced by the fact that in some cases only bizarre Gmail addresses are provided for alleged corresponding authors in China. Gmail access, as all Google services, were blocked by the Great Chinese Firewall in 2014, on Party’s orders. It is theoretically possible to use Google via VPN, but the Party has criminalised this, so hardly anyone dares. Whoever answers the Gmail accounts like is definitely not some doctor in China listed as paper’s author, but the paper mill operator.

The papers mills churning out masses of 100% fabricated, never performed science which only exists in Photoshop, are the secret of Chinese science output supremacy which we in the West so admire and strive to keep up with. Reality is: nobody cares if the published research is real, slightly falsified or entirely made-up. Fraudsters face little consequences if they are well-connected, and one can always denounce a western conspiracy. The good scientific practice lessons preached by Chinese science elites do not even apply to themselves, as the case of Xuetao Cao demonstrated.

The extra joke on top is that many of these fake paper mill emissions tout the alleged powers of Traditional Chinese Medicine (TCM) to cure cancer and other maladies, all because the nation’s President Xi Jinping himself is such a big fan of TCM. The Communist Party of China is merely getting what it ordered, again and again.

Maybe we in the West also should impose such idiotic laws? In fact, also in the “western” university hospitals, promotions depend on the publication record. So far, US, German and other doctors got ahead by gift authorships, self-plagiarism, and where needed, with outright plagiarism and falsified data. But actually, can we really be so sure that paper mills are an Asian phenomenon only?

When the count was at 320 (now almost 500), more than half of the mill papers came from the Shandong province, almost a fifth from Jilin and one tenth from Henan. This message was sent to Tiger BB8 by such a Chinese paper mill customer:

Hello teacher, yesterday you disclosed that there were some doctors having fraudulent pictures in their papers. This has raised attention. As one of these doctors, I kindly ask you to please leave us alone as soon as possible.

Being as low as grains of dust of the world, countless junior doctors, including those younger me, look down upon the act of faking papers. But the system in China is just like that, you can’t really fight against it. Without papers, you don’t get promotion; without a promotion, you can hardly feed your family. I also want to have some time to do scientific research, but it’s impossible. During the day, I have outpatient surgeries; after work, I have to take care of my kids. I have only a little bit time to myself after 10 pm, but this is far from being enough because scientific research demands big trunks of time. The current environment in China is like that.

You expose us but there are thousands of other people doing the same. As long as the system remains the same and the rules of the game remain the same, similar acts of faking data are for sure to go on. This time you exposed us, probably costing us our job. For the sake of Chinese doctors as a whole, especially for us young doctors, please be considerate. We really have no choice, please!”

Tiger BB8 found out even more. There are actually even open online advertisement for authorships on artificially generated scientific papers:

Upper red box: “over 70 medical manuscripts for sale”.
Red box right, 1st bullet point: “multiple SCI manuscripts for sale. All written up. We will submit with your name on it.”
4th bullet point: “My lab has more SCI manuscripts for sale. Some have been reviewed and now under revision.”

But then again, not everyone buys fake papers from paper mills. What about these honest doctors who don’t, do their careers not count? And if doctors cheat in research, where else will they cheat to improve their performance statistics? Will fictional TCM papers lead to real patient therapies, a predictable public health disaster?

One journal particularly hit by an organised paper mill scam is the Journal of Cellular Biochemistry, published by Wiley. Its editorial board features many prominent US scientists, including the infamous Carlo Croce. For many years and up until mid-January 2020, the journal was run by an academic editor, the now 77-year-old Gary Stein. He stepped down, and the new temporary Editor-in-Chief is a Wiley employee Lucie Kalvodova. But when first concerns about falsified papers emerged, Stein wrote on 14 January 2020 to a whistleblower:

Thank you for bringing these concerns to our attention.  We will look further into the content of the article.

In September 2019, Wiley opened a search for a new Editor-in-Chief, as referenced by this Chinese website. It makes sense: in recent journal editions, around 90% of papers have Chinese authors, as if there was some kind of pattern. Now Wiley announced to me to be investigating the goings-on at Journal of Cellular Biochemistry, and asked to share the list compiled by Bik and Smut Clyde. Also a Taylor & Francis publishing ethics manager was thankful and added:

We’re looking into the affected articles as a matter of urgency.

Update 28.01 and 6.02.2020. It is possible the paper mill is creating dud ORCID profiles for their customers, since some journals, like Journal of Cellular Biochemistry apparently expect ORCID identification. Smut Clyde collected a number of suspect cases, here some examples: Zhang et al 2018 and Zhang & Liu 2019 contain next to utterly phony Gmail addresses also empty ORCID profiles, created after the manuscripts were submitted (here and here).

Further evidence to ORCID fraud is provided by the fact that certain actors and recurrent paper mill customers sport multiple ORCID entries. A certain Yang Wang of Jilin University purchased 3 papers from the mill (Nr 17, 18 and 31 in the list), for which 2 ORCID ID were created (here and here). The duo Dexin Yin and Dajun Sun, also of Jilin, purchased 6 papers (Nr 40, 41, 70, 265, 273, 279), for which two throwaway ORCID profiles were created for each gentlemen (Yin vs Yin, Sun vs Sun). There are even different throwaway email addresses for the alleged corresponding authors, different in each Journal of Cellular Biochemistry paper:

Here is the list again. There is also a pdf hosted by Elisabeth Bik, which is being regularly updated. The list presently contains

  • 59 papers in Journal of Cellular Biochemistry, 16 in BioFactors, 25 in Journal of Cellular Physiology, 8 in Phytotherapy Research (Wiley);
  • 52 in Biomedicine & Pharmacotherapy, 26 in Experimental and Molecular Pathology, 14 in Life Sciences, 9 in International Immunopharmacology, 4 in International Journal of Biological Macromolecules (Elsevier);
  • 27 in Cellular Physiology and Biochemistry (Karger, now self–published);
  • 5 in Molecular and Cellular Biochemistry, 4 in Journal of Physiology and Biochemistry, 8 in BMC Cancer (Springer Nature);
  • 31 in Brazilian Journal of Medical and Biological Research (SciELO);
  • 37 in Oncology Research (Ingenta);
  • 12 in International Journal of Immunopathology and Pharmacology (SAGE);
  • 5 in Cancer Biomarkers (IOS Press);
  • 7 in Neoplasma (AEPress);
  • 7 in European Review for Medical and Pharmacological Sciences (Verduci Editore)
  • whooping 78 papers in Artificial Cells Nanomedicine and Biotechnology (Taylor & Francis),
  • plus other journals and publishers. Judging by signature made-up gel and flow cytometry data, all stemming from the same paper mill.
That particular paper mill customers cluster around Jining. By Tiger BB8 using Google Maps

Thou shall not cavort like Zany Portuguese Sardines

By Smut Clyde

Here are some frames from a computer-animated version of Star Wars IV, plotted with an old line-printer (that’s what we did for entertainment in the late 1970s). The Death Star down in each frame’s quadrant Q3 is shooting out bolts of planet-smashing energy to the right through Quadrant Q4, while disciplined flotillas of Rebel Alliance X-Wing starfighters are swooping down through Q1 and Q2.

No, I made that up. These hairballs are purportedly FACS scatterplots where each dot is a cell, located by its surface-protein measurements: Figures from Tang et al. (2020) [11]. Surprisingly many cells yielded identical values in these independent experiments!

Other papers have reported further frames from the animation, overlapping in the same way. Fig 2 from Ren, Xu & Xu (2019) [6]:

Figures 2E and 2F from Xiao and Tian (2019) [8]:

What to make of this phenomenon? Perhaps these Western Blots from the same papers will assist in the search for an explanation.

When blobs of protein are formed on an electrophoresis gel, blotted onto a membrane and then picked out with antibodies, they can take many forms and shapes, depending on the distortions as they were force-marched across the gel… depending also on their shape when they were streaked out onto the starting-line. They can bunch up as they travel, or spread out sideways into neighbouring lanes, also the spaces between blobs vary. But they should not cavort like Zany Portuguese Sardines.

Thus skepticism is understandable when one encounters Figures where the lane spacing is constant and bands of all molecular weights are random but interchangeable morphological mixtures. Especially when the background texture is identical when emphasised by increasing the contrast; not only between bands but between Figures, and even between papers… manuscripts from non-overlapping teams of researchers, at unconnected hospitals and research centres from far-flung provinces in China.

Indigofera Tanganyikensis reported the first two instances of this phenomenon (Liu et al, 2019 [13]; Liu et al., 2020 [14]). Then Clone Ranger Elisabeth Bik (a.k.a. Obik-wan Kenobik) joined the chase. Currently they have flagged over 30 of these sardine scrapbooks in PubPeer threads, too many to list here so TigerBB8 and I scraped off the details and arranged them into a spreadsheet. Most author-names are unique although a few research teams have been back for a second bite of the cherry.

In theory the corresponding authors of each paper have been notified and invited to join the discussion of their work (an automagic feature of the PubPeer software), though no-one has shown up yet. In some cases the invitation may not have reached the authors, due to their choice of Gmail e-addresses, which are no longer accessible in mainland China.

Nancy Cook’s Fig 7 from [2] has the same band background as Brenda Willingham’s Fig 5C from [1]

Now I am in no position to criticise anyone for adopting a playful pseudonym for correspondence, but these are not as academic as I would expect. The sources of the nyms are not obvious, apart from Casey Peiffer, who is a 9/11 Truther of some renown. At any rate the journal has evidently managed to stay in contact with whoever submitted them. This is an improvement on another early example in this tradition, Liu et al. (2017) [3], which was retracted when the editors could not contact the authors for the final authorisation. Not because of this:

The topics of these studies tend to conform to a template, helpfully summarised by Dr Bik in Mad-Libs format.

Phytochemicals from the materia medica of Traditional Chinese Medicine are common — Astrogaloside, Baicalein, Salidroside. I begin to wonder if there are any TCM-approved phytochemicals which don’t inhibit the proliferation and migration of medulloblastoma Daoy cells, in the hands of staff from Jining #1 People’s Hospital.

The majority of papers appeared in the Journal of Cellular Biochemistry from the Wiley stable, though not exclusively so (Biomedicine & Pharmacotherapy features as well, and Artificial Cells Nanomedicine and Biotechnology, and a few others). This may change. I would not be surprised if the PubPeer commentariat simply focussed on recent issues of J.Cell.Biochem. first, so we should not succumb to Selection Bias.

J.Cell.Biochem. has become popular among China-based molecular-biology researchers as an outlet for their work, and has a respectable Citations Index of 3.448 (though how much of that citational credit flows in from other journals remains to be seen). Despite this, my initial hope that the editors would consult experts to review submissions has been dispelled by their blithe acceptance of the egregious images above. Perhaps the peer-reviewers and contributors are collectively engaged in a Post-Modern project of redefining what Western Blots and FACS plots should look like, forging new expectations and conventions.

Two papers featured what purport to be Transwell Invasion Assays, while more closely resembling exercises in fumage and collage; the reviewers also thought these were fine (Zhang et al, 2019 [7]; Zhuang, Liu & Wu, 2019 [9]). Despite non-overlapping author lists, the images of both papers were built from a single small repertoire of fumage motifs.

Notably, both papers included more frames from the Death Star animation, which is why they are included here despite the absence of zany-sardine Western Blots.

Elsewhere the reviewers signed off on this Declaration of Data Availability, puzzling in its uncertainty: “The data set(s) supporting the conclusions of this article is(are) included within the article” (Liu et al., 2020 [12]).

The article contained no raw data, lacking even the number of repetitions behind the graphs, though the statement could still be true if in fact the data sets don’t exist. Or if they exist but contradict the conclusions.

Setting the journal aside, the sources of these papers are not geographically diverse. The current list shows a concentration in Shandong Province, in Jining and Qingdao and a few other cities. Changchun, in Jilin Province, is a smaller hotspot. Those two groups trying TCM on medulloblastoma at the Department of Paediatrics, Jining No. 1 People’s Hospital seem to be working independently; they should get in touch and coordinate their efforts. [4], a.k.a. marildivisio25318, I’d like you to meet [5], a.k.a. RosettajKirkland3814… but maybe you have already met.

All this has a parsimonious explanation in a policy in China’s medical sector, whereby promotion for everyone — clinicians and researchers alike — depends on publishing academic papers. Of course the average overworked doctor has neither the time, the training nor the resources to apply transfection technology to the interaction between triptolide, microRNA-1462 and JNK pathways in osteosarcoma, then write it up for publication, so they pay someone else to make it all up. And if you were familiar with the conventions of the academic genre, and had the software for plotting made-up statistics, wouldn’t you take advantage of this market opportunity by setting up a papermill?

Presumably the persons behind this service are relying on word-of-mouth to advertise their service, hence the geographical concentration. They have friends or members outside the mainland, allowing them to access the bogus Gmail accounts and keep in touch with the journal. One can speculate that there is someone within the editorial structure of J.Cell.Biochem. who is in on the deal and has suborned the peer-review process to ensure that manuscripts are only sent to friendly or fictitious reviewers (the same deduction might also follow for other journals; we await further developments).

Are there any victims in this curious market-driven ecology, where the nominal authors get the CV-stuffers they need and the actual authors get paid? Opinions are divided. There is the danger that genuine biomedical researchers in China might be disadvantaged if they foolishly published in J.Cell.Biochem., only to have their work dismissed and ignored. It would be helpful if the journal introduced some sort of flag to let readers know which of their articles are based on real experiments and which ones are information-free fabrications, forged to meet contractual / promotional obligation.


  1. “ZIC2 promotes viability and invasion of human osteosarcoma cells by suppressing SHIP2 expression and activating PI3K/AKT pathways”, Shuaihao Huang, Anmin Jin. Journal of Cellular Biochemistry (2018), doi: 10.1002/jcb.26387 [PubPeer].
  2. “MicroRNA-29a inhibits proliferation and motility of schwannoma cells by targeting CDK6”, Ji Ma, Tengfei Li, Huifeng Yuan, Xinwei Han, Shaofeng Shui, Dong Guo, Lei Yan. Journal of Cellular Biochemistry (2018) doi: 10.1002/jcb.26426 [PubPeer].
  3. “Retraction : HCFU inhibits cervical cancer cells growth and metastasis by inactivating Wnt/β‐catenin pathway”, Ping Liu, Shuying Ma, Hua Liu, Huazhen Han, Shanshan Wang, Journal of Cellular Biochemistry (2017) doi: 10.1002/jcb.26570 [PubPeer].
  4. “Ginsenoside Rh2 inhibits proliferation and migration of medulloblastoma Daoy by down-regulation of microRNA-31”, Yan Chen, Hong Shang, Shunli Zhang, Xiaohong Zhang. Journal of Cellular Biochemistry (2018) doi: 10.1002/jcb.26716 [PubPeer].
  5. “Triptolide inhibits the proliferation and migration of medulloblastoma Daoy cells by upregulation of microRNA-138”, Haifang Zhang, Hui Li, Zhenguo Liu, Ang Ge, Enyu Guo, Shuxia Liu, Zhiping Chen. Journal of Cellular Biochemistry (2018) doi: 10.1002/jcb.27307 [PubPeer].
  6. “Salidroside represses proliferation, migration and invasion of human lung cancer cells through AKT and MEK/ERK signal pathway”, Mei Ren, Wenjing Xu, Tao Xu Artificial Cells Nanomedicine & Biotechnology (2019) doi: 10.1080/21691401.2019.1584566 [PubPeer].
  7. “Downregulation of microRNA-1469 promotes the development of breast cancer via targeting HOXA1 and activating PTEN/PI3K/AKT and Wnt/β-catenin pathways”, Yonghui Zhang, Jing Fang, Hongmeng Zhao, Yue Yu, Xuchen Cao, Bin Zhang. Journal of Cellular Biochemistry (2019) doi: 10.1002/jcb.27786 [PubPeer].
  8. “Knockdown of long noncoding RNA HOTAIR inhibits cell growth of human lymphoma cells by upregulation of miR‐148b”, Xianxian Zhao, Xiaoyan Tian Journal of Cellular Biochemistry (2019) doi: 10.1002/jcb.28500 [PubPeer].
  9. “Upregulation of long noncoding RNA TUG1 contributes to the development of laryngocarcinoma by targeting miR‐145‐5p/ROCK1 axis”, Shenfa Zhuang, Fengxian Liu, Pingping Wu. Journal of Cellular Biochemistry (2019) doi: 10.1002/jcb.28614 [PubPeer].
  10. “Sapylin inhibits lung cancer cell proliferation and promotes apoptosis by attenuating PI3K/AKT signaling”, Lin Zhang, Benhong Liu Journal of Cellular Biochemistry (2019) doi: 10.1002/jcb.28729 [PubPeer].
  11. “Long noncoding RNA MEG3 deteriorates inflammatory damage by downregulating microRNA‐101a”, Shouyi Tang, Junxia Han, Hui Jiao, Jingna Si, Yingying Liu, Jinlong Wang Journal of Cellular Biochemistry (2020) doi: 10.1002/jcb.29415 [PubPeer].
  12. “Silence of cZNF292 suppresses the growth, migration, and invasion of human esophageal cancer Eca‐109 cells via upregulating miR‐206”, Zengjia Liu, Guiju Hu, Yan Zhao, Zuorun Xiao, Mingzhe Yan, Mei Ren. Journal of Cellular Biochemistry (2020) doi: 10.1002/jcb.29458 [PubPeer].
  13. “Circular RNA ACR relieves high glucose‐aroused RSC96 cell apoptosis and autophagy via declining microRNA‐145‐3p”, Ying Liu, Xiaoqing Chen, Jingjing Yao, Jing Kang Journal of Cellular Biochemistry (2019) doi: 10.1002/jcb.29568 [PubPeer].
  14. “Intermedin attenuates cardiomyocytes hypoxia‐injury through upregulating long noncoding RNA MALAT1”, Long Liu, Haiming Xu, Jingze Zhang, Liquan Yin, Qini Zhao Journal of Cellular Biochemistry (2020) doi: 10.1002/jcb.29642 [PubPeer].


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84 comments on “The full-service paper mill and its Chinese customers

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