Schneider Shorts of 5 August 2022 – russia’s useful idiots, Dr Oz’ emails to Dr Birx about Dr Raoult, with Harvard’s undead pigs, Weizmann’s artificial baby mice, Neanderthals trapped in the metaphase, four humours of depression, punished fraudsters, papermills, retractions, and new cures for cancer and obesity.
Table of Discontent
Russia’s War on Ukraine
- Nuclear concerns – Is IAEA useful, or rather russia’s useful idiots?
- How Dr Oz got his chloroquine – by praising Raoult in emails to Birx
- Undead Pigs of Yale – after a measly brain, Nenad Sestan revives an entire dead pig
- Weizmann Genius – Jacob Hanna raises baby mice in his magic artificial womb
- The Neanderthal Metaphase – Svante Pääbo being his usual silly pushy old self
- Depression biomarkers – the four humours of Hikikomori
- Smirisin 2 – maresin follows irisin as the magic slimming molecule from Harvard
- Masked cancer drug – Cheshire finds other unexpectedly masked things
News in Tweets
Russia’s War on Ukraine
As you may know, russia occupied the Ukrainian nuclear power plant in Zaporizhzhia, the biggest in Europe with 6 reactors. The Ukrainian team is being held hostage and forced to follow orders from russian management from Rosatom, constantly under gunpoint from rascist occupiers ready to torture and kill.
AP now reports:
“The U.N. nuclear chief warned that Europe’s largest nuclear power plant in Ukraine “is completely out of control” and issued an urgent plea to Russia and Ukraine to quickly allow experts to visit the sprawling complex to stabilize the situation and avoid a nuclear accident.
Rafael Grossi, director general of the International Atomic Energy Agency, said in an interview Tuesday with The Associated Press that the situation is getting more perilous every day at the Zaporizhzhia plant in the southeastern city of Enerhodar, which Russian troops seized in early March, soon after their Feb. 24. invasion of Ukraine.”
I am not sure why Grossi blames Ukraine at least as much as russia, he even cynically berates the heroic hostage-held Ukrainian staff of the nuclear plant for their “faulty” and “patchy” communication with IAEA. What does he expect Ukraine to do? They most certainly don’t prevent IAEA from accessing the plant, the rascists do. But then again, the UN organisation IAEA is controlled by nuclear industry nations, of which russia is the second biggest. This is why Grossi seems grateful to russia for their act of good will, aka retreating from Chernobyl, and berates the uncooperative Ukrainians instead:
“Russian forces occupied the heavily contaminated site soon after the invasion but handed control back to the Ukrainians at the end of March. Grossi visited Chernobyl on April 27 and tweeted that the level of safety was “like a `red light’ blinking.” But he said Tuesday that the IAEA set up “an assistance mission” at Chernobyl at that time “that has been very, very successful so far.”
The IAEA needs to go to Zaporizhzhia, as it did to Chernobyl, to ascertain the facts of what is actually happening there, to carry out repairs and inspections, and “to prevent a nuclear accident from happening,” Grossi said.
The IAEA chief said he and his team need protection to get to the plant and the urgent cooperation of Russia and Ukraine.”
Yes, Ukraine is doing its best to kill those rascist orcs and make them retreat, no thanks to UN. Btw, IAEA declared back in 1980ies that the Chernobyl disaster was totally not dangerous, and those Ukrainian victims were just paranoid hysterical alcoholics.
Kate Brown’s “Manual for Survival”, a Chernobyl book review
This is what I learned from the new book by the historian Kate Brown, “Manual for Survival- A Chernobyl Guide to the Future”, a book which I strongly recommend.
Initially, russia’s plan was to steal the Zaporizhzhia electricity for its national purposes, but the existing grid doesn’t allow it. So the new plan is to use the nuclear facilities as storage space for troops and heavy weapons and to attack Ukrainian (mostly civil) targets from the plant’s perimeter. It’s a win-win situation for russia: if the cooling system or the reactors are hit, Ukraine and Europe which russia hates so much will receive an equivalent of a massive nuclear bomb explosion. Sure, russia will get badly radiated as well, but their rulers never cared about the lives of their slaves.
Empire of Slaves – Thoughts on Russia’s War on Ukraine
Russia is a warmongering, marauding, slave-holding racist tyranny which fell through the cracks of history straight from the times of ancient empires.
Grossi is either a russian agent, or a useful idiot. The Institute for the Study of War (ISW) noted on 3 August 2022:
“Russian forces are likely using Ukraine’s Zaporizhzhia Nuclear Power Plant (NPP) in Enerhodar to play on Western fears of a nuclear disaster in Ukraine, likely in an effort to degrade Western will to provide military support to a Ukrainian counteroffensive.”
Grossi eagerly plays his role in this dirty charade. ISW quotes the Ukrainian response to him:
“Russian Zaporizhia Occupation Administration Head Evgeniy Balitskyi responded that the IAEA was welcome at the plant: “We are ready to show how the Russian military guards it today, and how Ukraine, which receives weapons from the West, uses these weapons, including drones, to attack the nuclear plant, acting like a monkey with a grenade.” Russian officials are framing Ukraine as irresponsibly using Western-provided weapons and risking nuclear disaster to dissuade Western and other allied states from providing additional military support to Ukraine’s looming southern counteroffensive.
Russian forces based around the NPP have attacked Ukrainian positions in Nikopol and elsewhere in recent weeks, intentionally putting Ukraine in a difficult position—either Ukraine returns fire, risking international condemnation and a nuclear incident (which Ukrainian forces are unlikely to do), or Ukrainian forces allow Russian forces to continue firing on Ukrainian positions from an effective “safe zone.””
Every international forum and institution where russia has a controlling voice failed spectacularly. UNO, IAEA, even the Red Cross. The latter recently announced that if russia wants to cover up the torture of Azov prisoners of war by burning them alive (as rascists recently did in Olenivka): Red Cross never promised to protect them (not true) and washes its hands of it. Otherwise it might endanger the nice new Russian Red Cross centre about to open in Rostov!
And you probably heard of Amnesty International scandal, where the human rights organisation did what IAEA does, and blamed both sides for war crimes equally.
How Dr Oz got his chloroquine
Patient rights activist and regulatory expert Elizabeth Woeckner found something very interesting in the publicly available files of US government (“White House COVID Comms Pt. 1“, pages 163-169).
Specifically, emails sent on 22 March 2020 by the TV quack Dr Mehmet Oz to Trump’s Coronavirus Response Coordinator Deborah Birx, cc-ed former HHS drug pricing director Tyler McGuffee, subject:
Urgent Oz: Clinical Trial Drug Shortage
“I interviewed the respected Marseille Prof Dr Didier Raoult at 6am today. He authored the French hydroxychloroquine + azithromycin study and has very provocative un-published findings that are worth sharing. I shared his beliefs with my New York Presbyterian – Columbia team and we are writing IRBs for approval early this week but we need medications. However, in our massive hospital, we currently have enough hydroxychloroquine for 75 patients and azithromycin for 20 patients. I will personally fund the trial and committed $250,00 but nothing can progress without medications. The President should sequester these medications for clinical trials like ours. Can you help us? I am taping material for tomorrow and would appreciate any advice on how to phrase the Task Force’s efforts.
Mehmet Oz (917 648 8553)“
Chloroquine genius Didier Raoult to save the world from COVID-19
As COVID19 pandemic rages on, French microbiologist Didier Raoult offers a cure. President Trump is convinced, but is Raoult’s research reliable, here and in general?
The Chloroquine Elephant in the Room, by Christian Lehmann
“How I would have loved it if a brilliant genius, in the style of Jeff Goldblum, had discovered, on a corner of a grubby lab bench, THE miracle treatment for SARS-cov-2! But we’re not in a Hollywood style blockbuster.”
Woeckner explained to me:
But it is. IHU Marseille director, chloroquine quack, research fraudster, patient abuser and bully Didier Raoult has been obviously writing the results of his clinical trials before he even illegally ran those. And as it recently came out, his IHU colleague and newly appointer successor Pierre-Edouard Fournier wrote the illegal IRB approvals for Raoult’s chloroquine trials.
Some minutes later, Oz sent another email to Birx:
“If we cannot do trials, can we free US clinicians to start using this combo drug protocol. We cannot hide behind study protocols if we are not allowed to proceed. We should have started enrollment on Friday and I want to push brave Americans to join trials on my show tomorrow, but cannot without a game plan for accessing drugs.
P.S. The French physician Raoult argued that withholding access is unethical.“
Birx replied immediately:
This was posted yesterday on the CDC website and serves to address the issues you raised. Deb
Information for Clinicians on Therapeutic Options for COVID-19 Patients
It was this document. Oz was not satisfied:
“Thanks for sharing but this does not address the shortage issue. We already have an IRB for prophylaxis and applying for treatment trial today but don’t have drugs to complete so please share expectations that can inform our work. Can we
at least get batches of drugs for a hundred trial patients? If you don’t wish to put in writing, please call but I need guidance for my show and dozens of media interviews that I am doing tomorrow.
Also, the below summary correctly shares that no outcomes data is available from Marseille, but you should know that the French researcher confirmed clinical benefits but needs more data so will not release report for another 10 days.
These findings offer hope to our people.“
Birx forwarded Oz’ emails to Trump’s heads of FDA and CDC, Stephen Hahn and Robert Redfield, respectively. As you all know, Trump was a chloroquine fan very early on. According to the exchange, it was decided to do a task force and not go to press.
A few days later, on 28 March 2020, FDA infamously issued an Emergency Use Authorization (EUA) for chloroquine and hydroxychloroquine as COVID-19 therapy. It was eventually revoked, but FDA stood like a bunch of corrupt dorks.
Zelenko and Raoult fall in each other’s arms
The marriage of love between Didier Raoult and Vovka Zelenko is now official. It was ordained by the International Society for Microbial Chemotherapy. No COVID-19 restrictions apply, and there’s enough chloroquine for everyone.
Didier Raoult fraud: “Je ne regrette rien”
One year on: more fake data, financial fraud and illegal and falsified clinical trials by the chloroquine guru Didier Raoult.
Undead Pigs of Yale
A young genius scientist at Yale can revive dead pigs! Neuroscience professor Nenad Sestan was celebrated by Nature as one of “Ten people who mattered in science in 2019“.
Sestan reported to have revived the explanted brain of a dead pig from slaughterhouse in his machine called BrainEx:
“The researchers, at Yale School of Medicine in New Haven, Connecticut, had found electrical activity in brains taken from dead pigs. The team had painstakingly removed the organs shortly after death and infused them with oxygen and an ice-cold preservative, and in doing so, brought the brains at least partially back to life. With that shocking result, Sestan realized that what had started as a side project to find ways to better preserve brain tissue for research had morphed into a discovery that could redefine our understanding of life and death.
The excitement soon turned to concern, when the researchers thought they saw widespread, coordinated electrical activity — the type that can indicate consciousness. Sestan brought in a neurologist, who determined that the readout was actually an error, but the possibility had spooked them.”
This was published in Nature world was in awe, all the big media reported about the breakthrough.
Zvonimir Vrselja , Stefano G. Daniele , John Silbereis , Francesca Talpo , Yury M. Morozov , André M. M. Sousa , Brian S. Tanaka , Mario Skarica , Mihovil Pletikos , Navjot Kaur , Zhen W. Zhuang , Zhao Liu , Rafeed Alkawadri , Albert J. Sinusas , Stephen R. Latham , Stephen G. Waxman , Nenad Sestan Restoration of brain circulation and cellular functions hours post-mortem. Nature (2019). doi: 10.1038/s41586-019-1099-1
The BrainEx technology is proprietary, which is probably the real reason why nobody else picked up on this research. And now, another breakthrough! A new Nature paper and new press release from Yale:
“Using a new technology the scientists developed that delivers a specially designed cell-protective fluid to organs and tissues, the team restored blood circulation and other cellular functions in pigs a full hour after their deaths. They report their findings in the August 3 edition of the journal Nature.
Their results may help extend the health of human organs during surgery and expand the availability of donor organs, the authors said.”
The breakthrough paper:
David Andrijevic, Zvonimir Vrselja, Taras Lysyy, Shupei Zhang, Mario Skarica, Ana Spajic, David Dellal, Stephanie L. Thorn, Robert B. Duckrow, Shaojie Ma, Phan Q. Duy, Atagun U. Isiktas, Dan Liang, Mingfeng Li, Suel-Kee Kim, Stefano G. Daniele, Khadija Banu, Sudhir Perincheri, Madhav C. Menon, Anita Huttner, Kevin N. Sheth, Kevin T. Gobeske, Gregory T. Tietjen, Hitten P. Zaveri, Stephen R. Latham, Albert J. Sinusas and Nenad Sestan, Cellular recovery after prolonged warm ischaemia of the whole body Nature. (2012) DOI: 10.1038/s41586-022-05016-1
The old Nature paper merely revived a dead pig’s brain, but the new Nature paper revived the entire pig, in a new proprietary machine called OrganEx!
““If we were able to restore certain cellular functions in the dead brain, an organ known to be most susceptible to ischemia [inadequate blood supply], we hypothesized that something similar could also be achieved in other vital transplantable organs,” Sestan said.
In the new study, the scientists applied a modified version of BrainEx called OrganEx to the whole pig. The technology consists of a perfusion device similar to heart-lung machines — which do the work of the heart and lungs during surgery — and an experimental fluid containing compounds that can promote cellular health and suppress inflammation throughout the pig’s body. Cardiac arrest was induced in anesthetized pigs, which were treated with OrganEx an hour after death.
Six hours after treatment with OrganEx, the researchers found that certain key cellular functions were active in many areas of the pigs’ bodies — including the heart, liver, and kidneys. Additionally, some organ functions had been restored. For instance, they found evidence of electrical activity in the heart, which retained the ability to contract.
“We were also able to restore circulation throughout the body, which amazed us,” Sestan said.”
There are three sets of good news: first, the Croatian-born Yale professor Dr Sestan will become even more famous than Nikola Tesla, second, he is relatively young (merely 52) and will sure achieve a complete resurrection of a dead pig in yet another Nature paper soon, and third: Dr Sestan will live forever, resurrected by his own device by his trusty Balkan lab members.
As Yale titled: Cheating Death.
Also Israel’s greatest scientist, Jacob Hanna, achieved yet another miracle of stem cells and regenerative medicine, also using proprietary technology nobody else dares to master.
Washington Post is excited:
“Stem cell researchers in Israel have created synthetic mouse embryos without using a sperm or egg, then grown them in an artificial womb for eight days, a development that opens a window into a fascinating, potentially fraught realm of science that could one day be used to create replacement organs for humans.
The objective, scientists involved with the research said, is not to create mice or babies outside the womb, but to jump-start the understanding of how organs develop in embryos and to use that knowledge to develop new ways to heal people.
From a clump of embryonic stem cells, scientists at the Weizmann Institute of Science created synthetic embryos that closely resembled real mouse embryos, with rudimentary beating hearts, blood circulation, folded brain tissue and intestinal tracts. The mouse embryos grew in an artificial womb and stopped developing after eight days, about a third of a mouse pregnancy.”
The PubPeer Stars of Weizmann Institute
Rony Seger, Jacob Hanna, Ilana Kolodkin-Gal, Atan Gross, Sima Lev, Tsvee Lapidot, Moshe Oren, Varda Rotter and others. Let’s celebrate the Weizmann Science!
Does ERC help cheaters pay protection money?
Did you ever wonder why certain zombie scientists were still in academic jobs? Despite having been caught on data manipulation or biomedical ethics breach? It seems the answer is simpler than you thought. They are paying for their protection, by giving pizzo to their crooked research institutions, just as in some unoriginal mafia film. Well,…
Nobody talks about Hanna’s past troubles with research integrity anymore (well, to be fair hardly anyone ever did), he was made full professor at Weizmann, media loves him, and top journals fight over his discoveries. The recent breakthrough was published in Cell:
Shadi Tarazi , Alejandro Aguilera-Castrejon , Carine Joubran , Nadir Ghanem , Shahd Ashouokhi , Francesco Roncato , Emilie Wildschutz , Montaser Haddad , Bernardo Oldak , Elidet Gomez-Cesar , Nir Livnat , Sergey Viukov , Dmitry Lukshtanov , Segev Naveh-Tassa , Max Rose , Suhair Hanna , Calanit Raanan , Ori Brenner , Merav Kedmi , Hadas Keren-Shaul , Tsvee Lapidot, Itay Maza, Noa Novershtern, Jacob H. Hanna Post-Gastrulation Synthetic Embryos Generated Ex Utero from Mouse Naïve ESCs Cell (2022) doi: 10.1016/j.cell.2022.07.028
There is a caveat, for those who say, well, prove that those are actual embryos and not some crap you made up again, Jake:
“Although the synthetic mouse embryos bore a close resemblance to natural mouse embryos, they were not exactly the same and did not implant or result in pregnancies in real mice, according to Jacob Hanna, the stem cell scientist at the Weizmann Institute of Science who led the work.”
Hanna announced his artificial womb already in 2021, in a paper in Nature, done back then done with explanted mouse embryos. As MIT Technology Review informed:
“The photographs alone tell a fantastic story—a mouse embryo, complete with beating heart cells, a head, and the beginning of limbs, alive and growing in a glass jar.
According to a scientific group in Israel, which took the picture, the researchers have grown mice in an artificial womb for as long as 11 or 12 days, about half the animal’s natural gestation period.”
Alejandro Aguilera-Castrejon, Bernardo Oldak , Tom Shani , Nadir Ghanem , Chen Itzkovich , Sharon Slomovich , Shadi Tarazi , Jonathan Bayerl , Valeriya Chugaeva , Muneef Ayyash , Shahd Ashouokhi , Daoud Sheban , Nir Livnat , Lior Lasman , Sergey Viukov , Mirie Zerbib , Yoseph Addadi , Yoach Rais , Saifeng Cheng , Yonatan Stelzer , Hadas Keren-Shaul, Raanan Shlomo, Rada Massarwa, Noa Novershtern, Itay Maza, Jacob H. Hanna Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis Nature (2021) doi: 10.1038/s41586-021-03416-3
And a year later: living and developed mouse foetuses made from iPS cells, how amazing is that! The great thing about such science is that it only works in Hanna’s lab because only he has the proprietary skills.
As every self-respecting Israeli Scientist, Hanna founded a biotech company to monetise his genius discoveries, as Washington Post mentions:
“Our goal is not making pregnancy outside the uterus, whether it’s mice or any species,” Hanna said. “We are really facing difficulties making organs — and in order to make stem cells become organs, we need to learn how the embryo does that. We started with this because the uterus is a black box — it is not transparent.”
Hanna has founded a company, Renewal Bio, that plans to use the technology therapeutically. One possible use would be to take skin cells from a woman with fertility problems, reprogram those cells to create stem cells and then grow synthetic embryo models that could be used to produce eggs.”
Nobel Prize awaits!
The Neanderthal Metaphase
Well, there are geniuses in Germany, too. The evolutionary geneticist Svante Pääbo, director of the Max Planck Institute in Jena, may have done some important science in his youth (his lab decoded the Neanderthal genome), but in the last years he seems to abuse his power and status to publish utterly ridiculously silly nonsense in top journals. Who can’t say no because Pääbo is such a bigwig, and then all international media report his nonsense utterly uncritically because Pääbo is such a bigwig and because it was in Science or Nature.
Remember how Neanderthals were responsible for COVID-19?
Dirty diseased Neanderthals
Who brought us COVID-19? The Neanderthals. The susceptibility to the SARS-CoV2 coronavirus, but also to diabetes, obesity, allergies, skin diseases, smoking and autism all happened because your great-[…]-great-grandfather could not keep his todger in his trousers many thousands of years ago.
So here we go again, new silly stuff by Pääbo about poor maligned Neanderthals. An article on Science Alert:
“Scientists experimenting on mice have found evidence that key parts of the modern human brain take more time to develop than those of our long extinct cousin, the Neanderthal. […]
We know, for example, of around 100 amino acids – the compounds that make up proteins – that changed when modern humans diverged from the branch that gave rise to Neanderthals and another close cousin, the Denisovans.
Amino acid substitution can have significant effects, but it was unclear what functions these substitutions changed between humans and Neanderthals.
Six of the identified substitutions exist in proteins already known to play a role in the distribution of chromosomes during cell division. So a team of researchers led by geneticist Felipe Mora-Bermúdez of the Max Planck Institute of Molecular Cell Biology and Genetics in Germany conducted experiments to see if they could determine the role these amino acid changes might play in neocortex development.
The natural subject was laboratory mice, which happen to share with Neanderthals (and apes) those same six amino acids within the relevant proteins. Using CRISPR Cas-9, the researchers substituted those amino acids for those found in modern humans.
They also took the research in the opposite direction. They grew organoids of human brains from embryonic stem cells – lumps of brain tissue that are not alive or sentient – and replaced the modern human amino acids with the Neanderthal/mouse/ape variants.
The results were striking and fascinating.”
I am sure they were. Here is the paper, this time not quite in Science, unlike the article insists:
Felipe Mora-Bermúdez , Philipp Kanis , Dominik Macak , Jula Peters , Ronald Naumann , Lei Xing , Mihail Sarov , Sylke Winkler , Christina Eugster Oegema , Christiane Haffner , Pauline Wimberger , Stephan Riesenberg , Tomislav Maricic , Wieland B. Huttner , Svante Pääbo Longer metaphase and fewer chromosome segregation errors in modern human than Neanderthal brain development Science Advances (2022) doi: 10.1126/sciadv.abn7702
It uses the minibrain technology Pääbo and his Jena colleagues pioneered to “regrow your Neanderthal brain”:
The anti-social mini-brains of Neanderthals
Neanderthals colonised Europe and Middle East long before modern humans and went extinct less than 30,000 years ago, when our species has spread there. Their story inspired the fantasies of generation of scientists, some of whom still cannot accept the idea that Neanderthals were just another kind of humans very similar or maybe simply just…
The Science Advances abstract announces:
“When we introduce these modern human-specific substitutions in mice, three substitutions in two of these proteins, KIF18a and KNL1, cause metaphase prolongation and fewer chromosome segregation errors in apical progenitors of the developing neocortex. Conversely, the ancestral substitutions cause shorter metaphase length and more chromosome segregation errors in human brain organoids, similar to what we find in chimpanzee organoids. These results imply that the fidelity of chromosome segregation during neocortex development improved in modern humans after their divergence from Neanderthals.”
Basically, Max Planck professors are different from all other mammals, including other humans like Neanderthals and Denisovans, at the basic level of cellular mitosis already.
Can be worse. Alysson Muotri‘s minibrain papers for example, also on topic of Neanderthals.
Alysson Muotri, a minibrain
Autistic Neanderthal minibrains operating crab robots via brain waves of newborn babies are to be launched into outer space for the purpose of interstellar colonization. No, I am not insane. Science Has Spoken.
More amazing neuroscience, this time for the Japanese version of depression. A press release by Kyushu University in Japan:
“Researchers find multiple important biomarkers in people with Hikikomori (pathological social withdrawal), and they demonstrate their potential for predicting the severity of the disorder.
Key blood biomarkers for the pathological social withdrawal disorder called Hikikomori have been discovered by researchers at Kyushu University. The team’s research enabled them to distinguish between healthy people and hikikomori sufferers, as well as to gauge the severity of the disease.”
There’s a diagram:
Here is the paper:
Daiki Setoyamaa, Toshio Matsushima, Kohei Hayakawa, Tomohiro Nakao, Shigenobu Kanba, Dongchon Kang and Takahiro A. Kato, Blood metabolic signatures of hikikomori, pathological social withdrawal Dialogues in Clinical Neuroscience. (2022) DOI: 10.1080/19585969.2022.2046978
Apparently, the four humour balance model of well-being from the Middle Ages was correct after all, it just has to be adjusted from the somewhat unspecific references to phlegm, yellow bile, black bile and blood to the modern 4 factors of bodily fluids:
““Some of our key findings showed that in the blood of men with hikikomori, ornithine levels, and serum arginase activity were higher while bilirubin and arginine levels were lower,” states first author of the paper Daiki Setoyama. “In both men and women patients, long-chain acylcarnitine levels were higher. Moreover, when this data was further analyzed and categorized, we were able to distinguish between healthy and hikikomori individuals, and even predict its severity.””
Oh, and hikikomori is different from depression because of the different acylcarnitines chains.
In Harvard, scientists found the drug to treat obesity. Not, it’s not Irisin by Bruce Spiegelman and Pontus Böström again, but it sounds similar.
Pontus Boström: cheater carousel in Sweden
Sweden is a tolerant country, which is a very good thing. Unfortunately, sometimes this Swedish tolerance seems ill-advised. Dishonest scientists caught faking data are happily given another chance and fat funding, like the case of the diabetes researcher Pontus Boström shows. This scientist was found to have fabricated data during his PhD studies with late…
A press release by the Joslin Diabetes Center:
“Researchers from Brigham and Women’s Hospital and the Joslin Diabetes Center discovered that in diet-induced obese mice, exposure to cold temperatures improved insulin sensitivity and glucose tolerance while resolving obesity-induced inflammation. Their findings were reported in a new paper that was published in Nature Metabolism.
“We discovered that cold exposure reduced inflammation and improved metabolism in obesity, mediated at least in part by the activation of brown adipose tissue.” — Yu-Hua Tseng, Ph.D.
The research team also found that the mechanism was dependent on brown adipose tissue, which is commonly referred to as “good fat,” releasing a naturally occurring molecule called Maresin 2 in response to cold stimulation.”
This is the paper:
Satoru Sugimoto, Hebe Agustina Mena, Brian E. Sansbury, Shio Kobayashi, Tadataka Tsuji, Chih-Hao Wang, Xuanzhi Yin, Tian Lian Huang, Joji Kusuyama, Sean D. Kodani, Justin Darcy, Gerson Profeta, Nayara Pereira, Rudolph E. Tanzi, Can Zhang, Thomas Serwold, Efi Kokkotou, Laurie J. Goodyear, Aaron M. Cypess, Luiz Osório Leiria, Matthew Spite, and Yu-Hua Tseng Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation Nature Metabolism.(2022) DOI: 10.1038/s42255-022-00590-0
Irisin Maresin 2 drug has already been patented by the authors, we are told:
“Moreover, these findings also suggest that Maresin 2 could have clinical applications as a therapy for patients with obesity, metabolic disease, or other diseases linked to chronic inflammation; however, the molecule itself breaks down quickly in the body. Tseng and colleagues seek a more stable chemical analog for clinical use”
Pop-a-pill-and-eat-what-you-want obesity drugs are a hot competitive market. Good luck, folks!
PS: Guess where the Maresin 2 discoverer, the Harvard professor Yu-Hua Tseng trained as postdoc? The lab of the notorious C Ronald Kahn, also at Joslin Diabetes Center. Kahn has over 50 papers on PubPeer, 3 of those were retracted for fraud. Here two more which should have been retracted, you might recognise the first author:
Yu-Hua Tseng, Atul J. Butte, Efi Kokkotou , Vijay K. Yechoor , Cullen M. Taniguchi , Kristina M. Kriauciunas , Aaron M. Cypess , Michio Niinobe , Kazuaki Yoshikawa , Mary Elizabeth Patti , C. Ronald Kahn Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin Nature Cell Biology (2005) doi: 10.1038/ncb1259
There is more in that paper, but here another one:
Yu-Hua Tseng , Kristina M. Kriauciunas , Efi Kokkotou , C. Ronald Kahn Differential roles of insulin receptor substrates in brown adipocyte differentiation Molecular and Cellular Biology (2004) doi: 10.1128/mcb.24.5.1918-1929.2004
Dr Tseng has 5 papers on PubPeer, all with Kahn. Two were corrected, but in one case, residual forgery remained even after correction. Spiegelman’s and Boström’s Irisin was most likely fake. How real do you think Tseng’s Maresin 2 is?
Masked cancer drug
Cancer has been cured again, look, a press release by University of Chicago:
“Numerous cancer treatments are notoriously harsh on the body; they assault healthy cells simultaneously with tumor cells and result in a wide range of side effects. The Pritzker School of Molecular Engineering (PME) at the University of Chicago has now developed a strategy to prevent one potential cancer drug from causing such damage. Interleukin-12 has been modified by scientists into a new, “masked” form that is only activated when it comes into contact with a tumor. The study on the molecule, also known as IL-12, was published in the journal Nature Biomedical Engineering.“
This is the paper:
Aslan Mansurov, Peyman Hosseinchi, Kevin Chang, Abigail L. Lauterbach, Laura T. Gray, Aaron T. Alpar, Erica Budina, Anna J. Slezak, Seounghun Kang, Shijie Cao, Ani Solanki, Suzana Gomes, John-Michael Williford, Melody A. Swartz, Juan L. Mendoza, Jun Ishihara, and Jeffrey A. Hubbell, Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker Nature Biomedical Engineering. (2022) DOI: 10.1038/s41551-022-00888-0
The authors are quoted in the press release:
“For decades, the field has hoped that IL-12 could someday become a viable therapeutic in the fight against cancer and we’ve now shown that it is possible,” said Mansurov. “We’d like to translate this molecule to the clinic and are now talking to a number of potential partners to make that happen.”
Cheshire however found out it wasn’t just the cancer drug which the scientists masked. A gel lane was splcied also, and the really worrisome bit is that it was also spliced in the “raw” data the authors supplied with the manuscript (Hint: raw data can never be digitally spliced, or it is not real).
Here the journal’s chief editor Pep Pamies, it seems he and his team check for “degree of advance, broad implications, and breadth and depth of the work” (aka shmovelty) except for the actual data integrity:
News in Tweets
- Watchdog Ivan Oransky in Nature: “Retraction Watch has seen the retraction process change dramatically over the past decade. We’ve come to feel that the community is falling short.” Well, Ivan that’s because experts, in fact including you, suddenly don’t believe in research fraud when scientists you respect are concerned. Also Oransky: “Sleuths should be compensated and given access to tools to improve the hunt for errors and fraud — not face ridicule, harassment and legal action. Publishers could create a cash pool to pay them“. Since the sleuths are mostly anonymous, I assume some authority like Retraction Watch should manage the cash pool and oversee the sleuths? Btw, we learn that “I.O. is a volunteer member of the board of directors of the PubPeer Foundation.” Ivan watchdogs every debate, even that on PubPeer.
- Massimo Carafa, pharmacy professor in Rome, abuses Italian cliches after a recent retraction: “We didn’t mean to alter data or to publish false images. If so, we would have falsified images in a perfect way.“
- Also, Cheshire can’t leave poor old professor Paul Davis of Albany (the NY university, not the Balkan country) in peace. New fraud findings! (Lin et al 2007 and Shih et al 2022)
- Deepak Kaushal, director of the Southwest National Primate Research Center (SNPRC) at Texas Biomedical Research Institute is guilty of research misconduct. HHS-ORI released its findings: “ORI found that Respondent engaged in research misconduct by intentionally, knowingly, and/or recklessly falsifying and fabricating the experimental methodology to demonstrate results obtained under different experimental conditions that were included in the following one (1) published paper and two (2) grant applications submitted for PHS funds“. The paper (Foreman et al 2020), was already retracted. Maybe this is how much of primate biomedical research is done, let’s consider phasing it out or at least ban the fraudsters? Instead, Kaushal is sanctioned with being barred from participating at any “advisory committee, board, and/or peer review committee” of US Public Health Service for a year, but he is not barred from applying and receiving research funding. He is also sentenced to having “his research supervised for a period of one (1) year“, so he can learn to fake data better while abusing primates. This oversight system only pretends to work.
- HHS-ORI dispenses harsher punishments for junior fraudsters: “ORI found that Janina Jiang, M.D., Ph.D. (Respondent), former Assistant Researcher in the Department of Pathology & Laboratory Medicine at the David Geffen School of Medicine, University of California, Los Angeles (UCLA) engaged in research misconduct in research included in grant applications submitted for U.S. Public Health Service (PHS) funds“. Jiang left UCLA and now works in the lab of John Yu at Cedars Sinai, her past assistant professor stint at UCLA isn’t part of her CV anymore. Lu the sanctions: Jiang “will have her research supervised for a period of three (3) years” and is barred for this period from “service on any PHS advisory committee, board, and/or peer review committee“.
- Tobacco industry shill and antivax covidiocy peddler Konstantinos Farsalinos about my article about his activities: “…a ridiculous text that, as far as I’m concerned, deals with 3 of my 100 posts. I have that many in Toxicology Reports. How much more ridiculous can it get?“
- The journal Aging is sad about being infested by Chinese papermills:
Ruler of the Aging Papermill
Smut Clyde congratulates Aging: “This is bespoke tailoring, in contrast to the off-the-rack products cranked out by the average papermill […] no shame befalls the journals that accept these confections.”
Elsevier’s Pandemic Profiteering
Aristidis Tsatsakis, Konstantinos Poulas, Ronald Kostoff, Michael Aschner, Demetrios Spandidos, Konstantinos Farsalinos: you will need a disinfecting shower once you read their papers.
- Four different sets of Chinese authors ask for retractions using exactly identical text template in an email to the journals, blaming an unnamed first author for everything. Apparently, papermills manage not only fabrication, submission and peer review process these days, but also retractions. How much do they charge for that service, I wonder?
- “Pre-clod PBS“. Available at your local coordination polymer Chinese papermill.
Polymer Papermillers Taking the Piss
Papermill Industry enters its Logical Growth Phage. Smut Clyde explains what coordination polymer chemistry has to do with chickenshit.
- German surgeon and University of Cottbus professor Björn Brücher reminds everyone where the original papermill investigations are being published (For Better Science), clashing with the official version of record telling you to believe that all this work is really done by Byrne, Christopher, Oransky and some journal editors.
- An Erratum in Physical Review Letters for Braden et al 2019: “Inconsistency between Fig. 2 of the Letter and a similar plot in another publication  caused us to carefully re-examine all of our code. Closer inspection of the plotting routines revealed an inadvertent rescaling of the ϕ0 values by a factor of 1/2 for the orange dots (i.e., simulation results) in Fig. 2, which changes the plotted slope of lnΓ by a factor of 1/4. This has the same effect as artificially adjusting the fluctuation amplitudes, as suggested in Hertzberg et al. . […] With these changes, the importance of more work in this area is made even more evident.” Conclusions down the toilet, paper remains unaffected.
- Bennet, Olivieri et al 2022: “Twenty-six individuals who communicated safety, efficacy, or data integrity concerns were targets of threats and intimidation from corporate employees (twenty-three individuals) or regulatory personnel (three). […] Intimidation efforts by corporate personnel included threats of lawsuits (eighteen individuals), hiring private investigators (nine), and public disparagement at conferences (eleven). Related intimidation efforts carried out by academia or regulatory agency superiors included threats of: loss of positions (six), loss of grant funding (two), delays in decisions regarding tenure (two); or reassignment to a low-level position (one). Academic harms included lost: hospital or university appointments (nine and six, respectively), grant funding (two), chairperson title of an international clinical trial group (one), and journal editorial board position (one).“
Motherisk crook Gideon Koren now at Ariel University
The Israeli Ariel University recruited a doctor from hell to their newly established medical school: Gideon Koren, infamous for Motherisk and deferiprone scandals.
- Moss et al 2022: “Our cross-sectional global survey of targets of academic bullying indicates that bullying behavior depended strongly on the scientific discipline. Specifically, our comparison of the three major scientific categories, including Applied Sciences, Natural Sciences, and Social Sciences revealed significant differences (p < 0.05) in four (out of ten) of the contextual behaviors. Further comparison of the bullying behavior among specific disciplines (e.g., Chemistry, Engineering, Life Sciences, Neuroscience, and Social Sciences) revealed significant differences (p < 0.05) in five of the contextual behaviors. We also noticed that, among the top five disciplines analyzed, respondents in Engineering experienced the highest rate of bullying behaviors.” Published in Lancet‘s eClinicalMedicine, but my suggestion is to not even try to check for the extent of bullying in medicine, because your scale will break.
- Finally, some art.
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Happy Friday! Go for a walk. Nice work.
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For my Ukrainian readers (and those with Google translate), here a good explainer as to why Amnesty International is full of crap. https://www.radiosvoboda.org/a/amnesty-statement-army-ukraine/31974000.html
The Maresin 2 paper is what you get when someone with training on finding dubious molecules and mechanisms of metabolic regulation collaborates with someone (Dr Spite) who trained in the Serhan lab on finding dubious molecules that regulate inflammation. What could possibly go wrong?
Oh dear, they are all connected!
You should a link to your Serhan/Dalli story earlier in the year:
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The Kahn currently lab has its own pet class of lipid molecules called “fatty acid esters of hydroxyl fatty acids” that they are now pushing as magical anti diabetic/anti inflammatory cure-alls. I think the strategy is to propose a lot of these things, ideally molecules that are hard to measure and validate so you have a decent window of opportunity to rake in the papers and grants before people catch on. And at that point you just move on to the next molecule/pathway…
Do you know that Kahn and former Harvard Dean Jeffrey Flier are best friends since their youth or something? Which explains why Kahn is untouchable I guess.
Hot off the Flier press: https://muse.jhu.edu/article/839285/pdf
I wonder if he senses the irony, in light of what is going on in his best friend’s lab? LOL
It’s from last year, and it wasn’t funny even then. With research integrity champions like Flier, America is protected.
You confusing Barbara Kahn with Ronald Kahn?
Academia is all a big family!
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Both Kahn’s got Banting medals, which is awarded by the American Diabetes Association for great research. In light of the fact that I don’t think Ronnie-boy can prevent fraud in his lab, this is all the more evidence that labs should be limited two only 2 NIH ROI’s. Anything else will be waisted. But in light of fact the egos of faculty are generated by how much grant money they bring the school these egos will surely prevent this sensible limitation. Again, human ego will most certainly lead to human extinction. If there are space aliens casing us to take out planet from our idiotic, imbisillic hands, we are ready.
This website is full of good examples
Dr. Oz: https://nypost.com/2022/04/23/dr-oz-bought-2070-doses-of-hydroxychloroquine-during-pandemic/
“In March 2020, Oz spent $8,800.00 on 2070 tablets of the drug. The purchase came at a time when the TV doctor was heavily promoting the anti-Malaria drug as a possible treatment for the deadly virus.
His advocacy even reached the White House which confirmed Trump was taking the drug in May of that year.
Oz’s campaign confirmed the purchase and said the doctor had been trying to help Columbia University with a study.
“At the outset of the pandemic, Dr. Mehmet Oz spoke with health experts worldwide who were seeing hydroxychloroquine and azithromycin as viable treatment options for desperately ill COVID patients. He offered to fund the clinical trial at Columbia University,” Brittany Yanick, Oz’s Communications Director told The Post.
The campaign said Oz had been prepared to spend $250,000 to assist the school, but that the offer was rejected and Oz ended up donating the pills to a hospital which he refused to name.”
Good for Columbia. Someday Columbia can explain why long-term faculty don’t know what the IRB is or what it does.
Dr. Oz owns shares of companies that supply hydroxychloroquine, a drug he has backed as a Covid treatment
“Since he launched his campaign late last year, Oz has downplayed warnings by the FDA and other experts against using hydroxychloroquine as a Covid treatment. He suggested political animus against Trump, who endorsed the drug as a treatment and Oz in the Senate election, motivated criticism of the drug as a means to fight Covid.”
‘“Now, let me just say this real quick, I really don’t know if it works or not, we still to this day had not been able to prove if it [hydroxychloroquine] works or not, which is a shame, because we should have known by now if a cheap 70-year-old drug used by a billion people works or not,” Oz said at a campaign rally earlier this year. “But we don’t, which is a problem by itself. However, I mentioned it and then President Trump mentioned it in a press conference, and all of a sudden the entire world hated hydroxychloroquine without testing it, without knowing about it.”’
Comment: no controlled trial can prove a negative. Whenever you hear “we don’t know that drug X doesn’t work”, patients should run away and everyone else should grab their money and hide.
“Also in March 2020, Oz emailed Trump’s son in law and advisor Jared Kushner that “we must make completion of this study a national priority and insist on immediate enrollment,” according to the correspondence obtained and made public by the House committee. Kushner responded to Oz on the same day, “What do u recommend to speed it up?”
Email link: https://coronavirus.house.gov/sites/democrats.coronavirus.house.gov/files/2020.03.23_010P-R000014099_0001_Redacted.pdf
Comment: advertising and recruitment are the beginning of the process of informed consent and so require IRB review and approval, which Oz didn’t get. By insisting on immediate enrollment in a clinical trial without independent ethical review, Oz proposed to take Americans back to the good old days in Nazi Germany, to which the judges at Nuremberg so vehemently objected.
I REALLY want to know more about Columbia University School of Medicine’s human research protection education program.
OMG, I cannot believe this… dynamite-prize for Svante “from Svenska” Pääbo… is it by any chance April Fool’s Day?
Well he cured covid, so it’s well deserved. https://forbetterscience.com/2020/10/05/dirty-diseased-neanderthals/