Research integrity University Affairs

The English science supremacy

England leads the world in science, any fule kno. Meet some more of the star jesters: Nick Lemoine, Peter St George-Hyslop and Xin Lu. They are curing cancer and Alzheimer with Photoshop.

England. A world superpower. Not just in everything else, but also in science, which is world-beating. English spitfire pluckiness destroyed the Huns in two world wars and in Brexit, but also in scientific performance, both impact-factor and money-wise. Brexit Britain will be free of all diseases, because whatever an English scientist does, conclusions remain not affected.

The secret to English science supremacy is not just the limitless capacity of certain English researchers to fabricate exciting results and phony cures, anyone can do that. It is the unique arrogance and corruption of English universities and of British health authorities who regularly decree all data fakeries to be quality science, outside statute of limitations, and verified independently by many citations, while telling whistleblowers to get lost.

It is a game only the crooks can win. And tax payers, charity donors and patients pay the price.

Not matter what you hear from Brexit, it’s not like England is not tolerant and welcoming. Clean of foreign detritus, free Britain can now freely choose what kind of foreigner it will let it. The foreigner must bring the right skill, like Amato Giaccia did, when he arrived to Oxford from Stanford in USA, trailed by a string of questionable research. Brexit and the COVID-19 pandemic showcased what the English ruling elites value most: defrauding and bullshitting the public. Science is just another coffer to plunder in this scam.

I previously celebrated the English science genius, with superior English minds like regenerative medicine enthusiast Martin Birchall, who took over Paolo Macchiarini‘s deadly technology to run some trachea transplants of his own. Birchall was acquitted in full by his own UCL, including for data irregularities, foreign scapegoats were assigned. Also Master of Birkbeck Sir David Latchman, CBE, was saved by UCL from unruly investigators whose reports were overruled by officials to determine no misconduct. Dame Kay Davies, DBE, was defended by her University of Oxford thanks to statute of limitations of 3 years for research misconduct charges, and by the publisher Oxford University Press where she as Editor-in-Chief retaliated against a fraud whistleblower. Paul Workman and Alan Ashworth, current and former director of ICR London, were both absolved in full, nothing at all worth retracting was found, while minor characters (not their protegees though) got the blame. Richard Marais of Cancer Research UK in Manchester weathered a research fraud scandal in his lab and a mountain of bullying accusations, he is still director of the institute.

Now, I shall celebrate more such talents, based on the sleuthing of Clare Francis. Cancer is cured, brain diseases vanquished, all thanks to the English scholars I want you to admire. Please raise, tuck in your shirt and comb your hair. The honour is all yours:

Nick Lemoine, FRCPath FMedSci

We shall start with Nicholas Lemoine. This cancer researcher is professor at the Queen Mary University of London and director of the Cancer Research UK Barts Centre. He is also an extremely high-ranking expert at the MRC (Medical Research Council), which means Dr Nick decides which biomedical researchers in UK gets funded and which don’t:

He has served as Chair of the Clinical Training and Career Development Panel at the Medical Research Council, and as Vice-Chair of the MRC Stratified Medicine Expert Panel. He has previously served as Chair of the MRC Stem Cell Strategic Grant and Fellowship Panels, and has been a member of the MRC’s Molecular & Cellular Medicine Board.

As medical director of NIHR Clinical Research Network, Dr Nick is now in charge of UK’s COVID-19 response:

So what kind of science are you, a humble British scientist seeking to eke out a meagre grant from MRC or NIHR, expected to deliver in order to impress Professor Lemoine? Well, you could study from his own papers, here is one:

Iman El-Hariry, Massimo Pignatelli, Nicholas R. Lemoine FGF-1 and FGF-2 regulate the expression of E-cadherin and catenins in pancreatic adenocarcinoma International Journal of Cancer (2001)  DOI: 10.1002/ijc.1515

As you see, the Figure 4 is fake, it has 3 cloned bands. Which means, the conclusions are not affected. A correction was issued by the publisher Wiley in 2019:

There is an error in the experimental conditions reported for the data presented in Figure 4 panel B. We apologize for these circumstances, which required clarification of the data.”

As it happens, Ashworth’s mentee and first author on a bunch of hilariously fake papers, Sarah Martin, is presently faculty member and Deputy Centre Lead at the Lemoine-ruled Bart’s and, this is really cruel: director of the graduate school. Now you see which qualifications you need to get employed at Barts, plus they probably sack PhD students for refusing to fake data there.

Maybe they use this paper by Limoine and his Barts colleagues to teach the students how to do cancer research properly:

Nothing was done. The Editor-in-Chief of this Nature Research Group journal is another professor in England, Georgios Giamas, owner of his own PubPeer record, and protege of the controversial, yet perfectly safe in his job, Imperial College professor Justin Stebbing. Giamas also holds a visiting professorship at Imperial, and he will definitely never do anything about the following paper by Limoine in Cancer Gene Therapy:

I A McNeish, T Tenev, S Bell, M Marani, G Vassaux, N Lemoine Herpes simplex virus thymidine kinase/ganciclovir–induced cell death is enhanced by co-expression of caspase-3 in ovarian carcinoma cells Cancer Gene Therapy (2001) doi: 10.1038/sj.cgt.7700305

In November 2018, the first author and another Imperial College professor Ian McNeish posted on PubPeer the full investigative report by Limoine’s employer, Barts College, which was also approved by Imperial. McNeish, Limoine and the unnamed investigator agree that the raw data doesn’t exist (anymore, they say), that the two papers were submitted and reviewed simultaneously and that the gel bands are indeed duplicated. The investigator’s conclusions, as quoted by McNeish:

None of these issues in my opinion change the conclusions made in the papers. I see no merit in retracting these important publications or publishing an erratum at this late stage, although agree that there have been errors made in producing the figures. […] The investigation stated that the conclusions made from the published studies were valid and important, even accounting for these reporting errors.

This is the standard attitude of all English and in fact British universities. The wording is typical English passive-aggressiveness towards whistleblowers warning them never to waste the university’s time ever again or meet their due fate.

Below some more of Limoine papers, the rest is on PubPeer. The following is 7 years old, when it was posted the raw data was rather fresh, sometimes even piping hot. A key coauthor on all these papers is Yaohe Wang, another professor at Barts.

J R Tysome, A Briat, G Alusi, F Cao, D Gao, J Yu, P Wang, S Yang, Z Dong, S Wang, L Deng, J Francis, T Timiryasova, I Fodor, N R Lemoine, Y Wang Lister strain of vaccinia virus armed with endostatin–angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancer Gene Therapy (2009) doi: 10.1038/gt.2009.74
Yaohe Wang, Rathi Gangeswaran, Xingbo Zhao, Pengju Wang, James Tysome, Vipul Bhakta, Ming Yuan, C.P. Chikkanna-Gowda, Guozhong Jiang, Dongling Gao, Fengyu Cao, Jennelle Francis, Jinxia Yu, Kangdong Liu, Hongyan Yang, Yunhan Zhang, Weidong Zang, Claude Chelala, Ziming Dong, Nick Lemoine CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells The Journal of clinical investigation (2009) doi: 10.1172/jci37905
Emma Spurrell, Rathi Gangeswaran, Pengju Wang, Fengyu Cao, Dongling Gao, Baisui Feng, William Wold, Ann Tollefson, Nicholas R Lemoine, Yaohe Wang STAT1 interaction with E3-14.7K in monocytes affects the efficacy of oncolytic adenovirus Journal of Virology (2014) doi: 10.1128/jvi.02829-13 
Han Hsi Wong, Guozhong Jiang, Rathi Gangeswaran, Pengju Wang, Jiwei Wang, Ming Yuan, Hexiao Wang, Vipul Bhakta, Heike Müller, Nicholas R Lemoine, Yaohe Wang Modification of the early gene enhancer-promoter improves the oncolytic potency of adenovirus 11 Molecular therapy (2012) doi: 10.1038/mt.2011.242

Barts College apparently decided instead to wait until this Photoshop travesty passes the 10 year statute of limitations. Expect another passive-aggressive investigative report in 2025, declaring Limoine and Wang innocent and all conclusions valid and not affected.

Peter St George-Hyslop, OC, FRS, FRSC, FRCPC

I think this name is so impressive, you can’t be more of English upper class, both in science and in society with a name like this. Of course Professor Peter St George-Hyslop is located in Cambridge, where he works on clinical neuroscience, previously he was in Canada where he was proclaimed “one of the most cited authors in the field of Alzheimer’s disease research”.

There are a number of papers coauthored by St George-Hyslop on PubPeer, here is one from his old lab at the University of Toronto:

Fusheng Chen, Gang Yu, Shigeki Arawaka, Masaki Nishimura, Toshitaka Kawarai, Haung Yu, Anurag Tandon, Agnes Supala, You Qiang Song, Ekaterina Rogaeva, Paul Milman, Christine Sato, Cong Yu, Christopher Janus, Julie Lee, Lixin Song, Lili Zhang, Paul E. Fraser, P. H. St George-Hyslop Nicastrin binds to membrane-tethered Notch Nature Cell Biology (2001) doi: 10.1038/35087069 

Cloned gel bands, spotted by Clare Francis. No action at all form that elite Nature-themed journal. Another St George-Hyslop fabrication, also done with Toronto colleagues:

Sonya Brijbassi, Zareen Amtul, Susan Newbigging, David Westaway, Peter St George-Hyslop, Richard F. Rozmahel Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo Neurobiology of Disease (2007) doi: 10.1016/j.nbd.2006.09.013

But the worst ones were done in collaboration with Frederic Checler, professor of neuroscience at CNRS in France. Like this, where the authors shamelessly double-published to increase their publication record:

Julie Dunys, Toshitaka Kawarai, Emilie Giaime, Sherwin Wilk, M. Herrant, P. Auberger, Peter St George-Hyslop, Cristine Alves Da Costa, Frédéric Checler Study on the putative contribution of caspases and the proteasome to the degradation of Aph-1a and Pen-2 Neuro-degenerative diseases (2007) doi: 10.1159/000101840

There was more data recycling, basically that paper in Neurodeg Dis is a copy of the previously published paper Dunys et al Biochemical J 2006, with all other authors the same. Neither journal, one by Portland Press, one by Karger, cares, never mind for research integrity, not even for their own infringed copyright.

Here more by St George-Hylop and his French ally, some gel band copy-pasting:


Bruno Vincent, Claire Sunyach, Hans-Dieter Orzechowski, Peter St George-Hyslop, Frédéric Checler p53-Dependent transcriptional control of cellular prion by presenilins The Journal of neuroscience (2009) doi: 10.1523/jneurosci.0789-09.2009
Raphaëlle Pardossi-Piquard, Agnès Petit, Toshitaka Kawarai, Claire Sunyach, Cristine Alves Da Costa, Bruno Vincent, Sabine Ring, Luciano D’Adamio, Jie Shen, Ulrike Müller, Peter St. George-Hyslop, Frédéric Checler Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP Neuron (2005) doi: 10.1016/j.neuron.2005.04.008

Here another interesting collaboration of our esteemed English upper class scientist, this time with Masaya Tohyama in Japan:

Naoya Sato, Kazunori Imaizumi, Takayuki Manabe, Manabu Taniguchi, Junichi Hitomi, Taiichi Katayama, Takunari Yoneda, Takashi Morihara, Yuichi Yasuda, Tsutomu Takagi, Takashi Kudo, Takehide Tsuda, Yasuto Itoyama, Takao Makifuchi, Paul E. Fraser, Peter St George-Hyslop, Masaya Tohyama Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2 The Journal of biological chemistry (2001) doi: 10.1074/jbc.m006886200
Taiichi Katayama, Kazunori Imaizumi, Akiko Honda, Takunari Yoneda, Takashi Kudo, Masatoshi Takeda, Kazutoshi Mori, Richard Rozmahel, Paul Fraser, Peter St. George-Hyslop, Masaya Tohyama Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer’s disease-linked presenilin-1 mutations The Journal of biological chemistry (2001) doi: 10.1074/jbc.m104096200 
Taiichi Katayama, Kazunori Imaizumi, Naoya Sato, Ko Miyoshi, Takashi Kudo, Junichi Hitomi, Takashi Morihara, Takunari Yoneda, Fumi Gomi, Yasutake Mori, Yuka Nakano, Junji Takeda, Takehide Tsuda, Yasuto Itoyama, Ohoshi Murayama, Akihiko Takashima, Peter St George-Hyslop, Masatoshi Takeda, Masaya Tohyama Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response Nature Cell Biology (1999) doi: 10.1038/70265

The evidence is years old, but nothing has happened so far. Yet one St George-Hyslop coauthored publication was retracted in 2020. Its first author Sabine Wislet is professor in Belgium and has a number of other papers questioned on PubPeer, including another retraction.

Sabine Wislet-Gendebien, Cheryl D’Souza, Toshitaka Kawarai, Peter St George-Hyslop, David Westaway, Paul Fraser, Anurag Tandon Cytosolic proteins regulate alpha-synuclein dissociation from presynaptic membranes The Journal of biological chemistry (2006) doi: 10.1074/jbc.m605965200

Now the fun starts. Clare Francis of course notified the University of Cambridge and the Wellcome Trust (which funds St Seorge-Hyslop’s research). This was their decision, as penned to Clare Francis by the Policies & Governance Officer of Wellcome Trust, Lucy Douch, in February 2017:

Further to your email of 17 August 2016, we raised your concerns about Professor Peter St George-Hyslop with the University of Cambridge, the employing institution.

The University conducted an investigation under its Misconduct in Research policy. The investigation concluded that the allegations made are entirely unfounded.”

This is not even passive aggressive, it sounds almost like a legal threat from Wellcome Trust. In fact, this is a proud English Fuck You to every single whistleblower who dares to impugn the greatness of English science genius.

Although, to be fair, I suspect the Cambridge University probably has same statute of limitations on research fraud as Oxford, of 3 years. Because there was nothing for them to investigate in those older paper, they declared the allegations as “entirely unfounded”.

If you enjoyed St George-Hyslop’s aristocratic antics, you should also have a look at the PubPeer record of another Cambridge professor, Dame Carol Mary Black, DBE, FRCP, BSD, Principal of the Newnham College. Here a sample, with the Dame Commander of the Order of the British Empire as last author, Denton et al JBC 2005:

Xin Lu, FRS

Britain is open to foreigners, as we know. Not the lowly kind who don’t know how to get rich quick. If you know how to play the game, you can become part of the English science elite. Xin Lu studied in her home land China, and in UK she eventually arrived to the Ludwig Cancer Centre, first at its London branch and later to take over the directorship of the central seat in Oxford.

Yes, Oxford is the university with 3 year statute of limitation for research misconduct. Nothing to see here at all:

Daniele Bergamaschi, Yardena Samuels, Alexandra Sullivan, Marketa Zvelebil, Hilde Breyssens, Andrea Bisso, Giannino Del Sal, Nelofer Syed, Paul Smith, Milena Gasco, Tim Crook, Xin Lu iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72–polymorphic p53 Nature Genetics (2006) doi: 10.1038/ng1879

So many cloned gel bands, and yes, Clare Francis informed the University of Oxford of this and other masterpieces. The first author on that paper, Daniele Bergamaschi is now lecturer at the Queen Mary University of London, his lab is at Barts. You see again which kind of talents Barts boss Lemoine expects from his principal investigators. Bergamaschi also authored this work of art with Lu:

Daniele Bergamaschi, Yardena Samuels, Boquan Jin, Sai Duraisingham, Tim Crook, Xin Lu ASPP1 and ASPP2: common activators of p53 family members Molecular and Cellular Biology (2004) doi: 10.1128/mcb.24.3.1341-1350.2004

And this one by Bergamaschi and Lu, in Oncogene (remember the Editor-in-Chief Justin Stebbing?):

Daniele Bergamaschi, Yardena Samuels, Shan Zhong, Xin Lu Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation Oncogene (2005) doi: 10.1038/sj.onc.1208535

I hope you are learning from Bergamaschi and Lu how to make career in English science. It’s not that difficult, all you need is the will to succeed. Another common author on all these papers is Yardena Samuels. She went back to Israel where she is now professor at the Weizmann Institute. Here more by Bergamaschi (and Samuels):


Daniele Bergamaschi, Yardena Samuels, Nigel J. O’Neil, Giuseppe Trigiante, Tim Crook, Jung-Kuang Hsieh, Daniel J. O’Connor, Shan Zhong, Isabelle Campargue, Matthew L. Tomlinson, Patricia E. Kuwabara, Xin Lu iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human Nature Genetics (2003) doi: 10.1038/ng1070
Caroline Gubser, Daniele Bergamaschi, Michael Hollinshead, Xin Lu, Frank J. M. Van Kuppeveld, Geoffrey L. Smith A new inhibitor of apoptosis from vaccinia virus and eukaryotes PLoS Pathogens (2007) doi: 10.1371/journal.ppat.0030017

The last author on one of those papers is Geoffrey Smith, head of Pathology Department at University of Cambridge and member of all possible learned societies including the German Leopoldina. People of this calibre can’t be associated with bad science, so don’t expect even a correction.

But the next two papers from Lu lab doesn’t have Bergamaschi among its authors. Here one:

Damian B. S. Yap, Jung-Kuang Hsieh, Shan Zhong, Vicky Heath, Barry Gusterson, Tim Crook, Xin Lu Ser392 phosphorylation regulates the oncogenic function of mutant p53 Cancer Research (2004) doi: 10.1158/0008-5472.can-1305-2 

These are two very fraudulent figures, bands were erased in one version by a rascal. But this paper, like others, is too old for anyone to give a toss about. Here something more recent:

Min Lu, Hilde Breyssens, Victoria Salter, Shan Zhong, Ying Hu, Caroline Baer, Indrika Ratnayaka, Alex Sullivan, Nicholas R. Brown, Jane Endicott, Stefan Knapp, Benedikt M. Kessler, Mark R. Middleton, Christian Siebold, E. Yvonne Jones, Elena V. Sviderskaya, Jonathan Cebon, Thomas John, Otavia L. Caballero, Colin R. Goding, Xin Lu Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP Cancer Cell (2013) doi: 10.1016/j.ccr.2013.03.013 

An Erratum was issued by Cell Press in 2016 and declared:

“This error does not affect any of the findings reported in the paper.”

With English research fabrications it is just like with Brexit: get over it, they won. Science is an English colony and the rotten upper classes are busy plundering it.


If you are interested to support my work, you can leave here a small tip of $5. Or several of small tips, just increase the amount as you like (2x=€10; 5x=€25). Or you can donate to Barts or Ludwig centres for cancer research!


166 comments on “The English science supremacy

  1. J Immunol. 2006 Nov 15;177(10):7173-83. doi: 10.4049/jimmunol.177.10.7173.
    IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kappa B binding to the proximal promoter
    Silvana Morello 1, Kazuhiro Ito, Satoshi Yamamura, Kang-Yun Lee, Elen Jazrawi, Patricia Desouza, Peter Barnes, Carla Cicala, Ian M Adcock

    1Airways Disease Section, NHLI Imperial College London, London, United Kingdom.
    PMID: 17082635 DOI: 10.4049/jimmunol.177.10.7173

    Am J Respir Crit Care Med. 2006 Feb 15;173(4):398-406. doi: 10.1164/rccm.200506-869OC. Epub 2005 Dec 1.
    Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease
    Katia Varani 1, Gaetano Caramori, Fabrizio Vincenzi, Ian Adcock, Paolo Casolari, Edward Leung, Stephen Maclennan, Stefania Gessi, Silvana Morello, Peter J Barnes, Kazuhiro Ito, Kian Fan Chung, Giorgio Cavallesco, Gianfranco Azzena, Alberto Papi, Pier Andrea Borea
    Affiliations collapse
    1Department of Clinical and Experimental Medicine, Pharmacology Unit, Via Fossato di Mortara 17-19, 44100 Ferrara, Italy.
    PMID: 16322645 DOI: 10.1164/rccm.200506-869OC

    Figure 3a J Immunol. 2006 Nov 15;177(10):7173-83 much more similar to figure 8B Am J Respir Crit Care Med. 2006 Feb 15;173(4):398-406 than expected.


  2. Am J Respir Crit Care Med. 2002 Sep 1;166(5):724-31. doi: 10.1164/rccm.2104010.
    Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression and reduced apoptosis in alveolar macrophages from smokers
    Katsuyuki Tomita 1, Gaetano Caramori, Sam Lim, Kazuhiro Ito, Toyoyuki Hanazawa, Timothy Oates, Irena Chiselita, Elen Jazrawi, K Fan Chung, Peter J Barnes, Ian M Adcock

    1Department of Thoracic Medicine, National Heart and Lung Institute at Imperial College School of Science, Technology and Medicine, London, United Kingdom.
    PMID: 12204872 DOI: 10.1164/rccm.2104010

    Figure 8A.
    Position of cell nuclei in Control and Ozone (300ppb) panels much more similar than expected.


  3. Am J Respir Crit Care Med. 2005 Sep 15;172(6):704-12. doi: 10.1164/rccm.200408-1041OC. Epub 2005 Apr 28.
    Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy
    Omar S Usmani 1, Kazuhiro Ito, Kittipong Maneechotesuwan, Misako Ito, Malcolm Johnson, Peter J Barnes, Ian M Adcock

    1Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK.
    PMID: 15860753 DOI: 10.1164/rccm.200408-1041OC

    Figure 8B. Much more similar than expected.


  4. FASEB J. 2013 Nov;27(11):4510-9. doi: 10.1096/fj.12-222604. Epub 2013 Aug 9.
    Importin-7 mediates glucocorticoid receptor nuclear import and is impaired by oxidative stress, leading to glucocorticoid insensitivity
    Amir Hakim 1, Peter J Barnes, Ian M Adcock, Omar S Usmani

    11National Heart and Lung Institute, Airway Disease Section, Imperial College London and Royal Brompton Hospital, Dovehouse St., London, SW3 6LY, UK.
    PMID: 23934279 DOI: 10.1096/fj.12-222604

    Figure 4. Much more similar than expected.


  5. Genes Dev. 2009 May 15;23(10):1207-20. doi: 10.1101/gad.516509.
    Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes
    Ian R Powley 1, Alexander Kondrashov, Lucy A Young, Helen C Dobbyn, Kirsti Hill, Ian G Cannell, Mark Stoneley, Yi-Wen Kong, Julia A Cotes, Graeme C M Smith, Ron Wek, Christopher Hayes, Timothy W Gant, Keith A Spriggs, Martin Bushell, Anne E Willis

    1Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.
    PMID: 19451221 PMCID: PMC2685536 DOI: 10.1101/gad.516509

    Figures 1C, 2Bii) and supplementary 1c.Much more similar than expected.

    Figure 2A. Much more similar than expected.

    Figures 2A and 2Bii) much more similar than expected.


  6. Mol Cell Biol. 2008 Jan;28(1):40-9. doi: 10.1128/MCB.01298-07. Epub 2007 Oct 29.
    Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs
    Laura C Cobbold 1, Keith A Spriggs, Stephen J Haines, Helen C Dobbyn, Christopher Hayes, Cornelia H de Moor, Kathryn S Lilley, Martin Bushell, Anne E Willis
    Affiliations collapse
    1School of Pharmacy, Pharmacy Building, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.
    PMID: 17967896
    PMCID: PMC2223313 DOI: 10.1128/MCB.01298-07


  7. Nucleic Acids Res. 2009 Sep;37(17):5881-93. doi: 10.1093/nar/gkp623. Epub 2009 Aug 4.
    The human insulin receptor mRNA contains a functional internal ribosome entry segment
    Keith A Spriggs 1, Laura C Cobbold, Simon H Ridley, Mark Coldwell, Andrew Bottley, Martin Bushell, Anne E Willis, Kenneth Siddle
    Affiliations collapse
    1University of Nottingham, School of Pharmacy, University Park, Nottingham NG7 2RD, UK.
    PMID: 19654240
    PMCID: PMC2761284
    DOI: 10.1093/nar/gkp623

    Figure 4B.


  8. Biochem J. 2014 Mar 1;458(2):213-24. doi: 10.1042/BJ20130979.
    The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h
    Anne Roobol 1, Jo Roobol 1, Martin J Carden 1, Matthew E Smith 1, John W B Hershey 2, Amandine Bastide 3, John R P Knight 3, Anne E Willis 3, C Mark Smales 1

    1*Centre for Molecular Processing, School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, U.K.
    2†Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA 95616, U.S.A.
    3‡MRC Toxicology Unit, Hodgkin Building, P.O. Box 138, University of Leicester, Lancaster Road, Leicester LE1 9HN, U.K.
    PMID: 24320561
    DOI: 10.1042/BJ20130979


  9. Problematic data Cancer Res. 2013 Nov 1;73(21):6435-47. doi: 10.1158/0008-5472.CAN-12-3308. Epub 2013 Aug 15.

    miR-153 supports colorectal cancer progression via pleiotropic effects that enhance invasion and chemotherapeutic resistance

    Lei Zhang 1, Karen Pickard, Veronika Jenei, Marc D Bullock, Amanda Bruce, Richard Mitter, Gavin Kelly, Christos Paraskeva, John Strefford, John Primrose, Gareth J Thomas, Graham Packham, Alex H Mirnezami

    Authors’ Affiliations:

    University of Southampton Cancer Sciences Division, Somers Cancer Research Building; Department of Colorectal Surgery, Southampton University Hospital NHS Trust, Southampton; Bioinformatics Unit, London Research Institute, Cancer Research UK, London; and School of Cellular and Molecular Medicine, University of Bristol, Medical Sciences Building, Bristol, United Kingdom.PMID: 23950211 PMCID: PMC3818136 DOI: 10.1158/0008-5472.CAN-12-3308

    Problematic data figure 2F. Much more similar than expected.


  10. Cell Death Dis. 2013 Jun 20;4(6):e684. doi: 10.1038/cddis.2013.213.

    Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression
    M D Bullock 1, K M Pickard, B S Nielsen, A E Sayan, V Jenei, M Mellone, R Mitter, J N Primrose, G J Thomas, G K Packham, A H Mirnezami
    Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, UK.

    PMID: 23788041 PMCID: PMC3702298
    DOI: 10.1038/cddis.2013.213

    Problematic data figure 4C. Much more similar than expected.


  11. J Biol Chem. 2004 Mar 26;279(13):12005-8. doi: 10.1074/jbc.C300557200. Epub 2004 Jan 23.
    AMP-activated protein kinase plays a role in the control of food intake
    Ulrika Andersson 1, Karin Filipsson, Caroline R Abbott, Angela Woods, Kirsty Smith, Stephen R Bloom, David Carling, Caroline J Small
    Affiliations collapse
    1Medical Research Council Clinical Sciences Centre, Cellular Stress Group and Endocrine Unit, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, United Kingdom.
    PMID: 14742438 DOI: 10.1074/jbc.C300557200

    Figures 2b and 2d. Splicing in one panel, but not in others.


  12. 2021 correction for:

    Proc Natl Acad Sci U S A. 2004 May 11;101(19):7341-6. doi: 10.1073/pnas.0308195101. Epub 2004 Apr 30.
    Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies
    Juan Li*, Anthony J. Bench*, George S. Vassiliou*, Nasios Fourouclas*, Anne C. Ferguson-Smith†,
    and Anthony R. Green*‡
    *Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 2XY, United Kingdom; and
    †Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
    *Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 2XY, United Kingdom; and †Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
    PMID: 15123827 PMCID: PMC409920 DOI: 10.1073/pnas.0308195101

    2021 correction notice.
    “The authors note that a mistake occurred during the preparation of Fig. 1B. Three control lanes (6, 7, and 8) were inadvertently duplicated and also shown as lanes 3, 4, and 5. This resulted from a technical error during preparation of the figure and does not alter any of the conclusions of the paper. The corrected figure and the unaltered figure legend appear below.”

    Figure 1B.


  13. Vascul Pharmacol. 2017 Jan;88:11-20. doi: 10.1016/j.vph.2016.11.007. Epub 2016 Nov 22.
    Heterodimerisation between VEGFR-1 and VEGFR-2 and not the homodimers of VEGFR-1 inhibit VEGFR-2 activity
    Meng Cai 1, Keqing Wang 1, Colin E Murdoch 1, Yuchun Gu 2, Asif Ahmed 3
    Affiliations collapse
    1Aston Medical Research Institute, Aston Medical School, Aston University, Aston Triangle, Birmingham B4 7ET, United Kingdom.
    2Aston Medical Research Institute, Aston Medical School, Aston University, Aston Triangle, Birmingham B4 7ET, United Kingdom; Institute of Molecular Medicine, Peking University, Beijing 100871, China.
    3Aston Medical Research Institute, Aston Medical School, Aston University, Aston Triangle, Birmingham B4 7ET, United Kingdom. Electronic address:

    Figure 1C and 2B. Much more similar and different than expected.



    Activation of Vascular Endothelial Growth Factor Receptor-1 Sustains Angiogenesis and Bcl-2 Expression Via the Phosphatidylinositol 3-Kinase Pathway in Endothelial Cells
    Jun Cai1, Shakil Ahmad2, Wen G. Jiang3, Jianhua Huang4, Christopher D. Kontos4, Mike Boulton1 and Asif Ahmed2
    +Author Affiliations

    Address correspondence and reprint requests to Professor Asif Ahmed, Department of Reproductive and Vascular Biology, University of Birmingham, the Medical School, Edgbaston, Birmingham B15 2TG, U.K. E-mail:
    Diabetes 2003 Dec; 52(12): 2959-2968.

    Figure 4.



  15. Circ Res. 2006 Sep 29;99(7):715-22. doi: 10.1161/01.RES.0000243989.46006.b9. Epub 2006 Aug 31.
    Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis
    Shakil Ahmad 1, Peter W Hewett, Ping Wang, Bahjat Al-Ani, Melissa Cudmore, Takeshi Fujisawa, Jody J Haigh, Ferdinand le Noble, Ling Wang, Debabrata Mukhopadhyay, Asif Ahmed

    1Department of Reproductive and Vascular Biology, Institute for Biomedical Research, The Medical School, University of Birmingham, Birmingham B15 2TT, UK.
    PMID: 16946136

    1 comment on PubPeer (by: Trechus Barii)
    DOI: 10.1161/01.RES.0000243989.46006.b9

    Click to access Professor%20Asif%20Ahmed%20CV.pdf


  16. 2019 retraction for:

    PLoS One. 2011 Mar 25;6(3):e18076. doi: 10.1371/journal.pone.0018076.
    Placenta growth factor-1 exerts time-dependent stabilization of adherens junctions following VEGF-induced vascular permeability
    Jun Cai 1, Lin Wu, Xiaoping Qi, Lynn Shaw, Sergio Li Calzi, Sergio Caballero, Wen G Jiang, Stanley A Vinores, David Antonetti, Asif Ahmed, Maria B Grant, Michael E Boulton
    Jun Cai
    AFFILIATION Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America

    Lin Wu
    AFFILIATION Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America

    Xiaoping Qi
    AFFILIATION Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America

    Lynn Shaw
    AFFILIATION Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, United States of America

    Sergio Li Calzi
    AFFILIATION Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, United States of America

    Sergio Caballero
    AFFILIATION Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, United States of America

    Wen G. Jiang
    AFFILIATION Department of Surgery, School of Medicine, Cardiff University, Cardiff, United Kingdom

    Stanley A. Vinores
    AFFILIATION Ophthalmology, Johns Hopkins University, Wilmer Eye Institute, Baltimore, Maryland, United States of America

    David Antonetti
    AFFILIATION Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania, United States of America

    Asif Ahmed
    AFFILIATION BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, United Kingdom

    Maria B. Grant
    AFFILIATION Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida, United States of America

    Michael E. Boulton
    * E-mail:

    AFFILIATION Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America

    2019 retraction notice.

    Figure 8a. Much more similar than expected.


  17. Hypertension. 2008 Apr;51(4):1010-9. doi: 10.1161/HYPERTENSIONAHA.107.097790. Epub 2008 Feb 7.
    Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling
    Cissy Chenyi Zhou 1, Shakil Ahmad, Tiejuan Mi, Shahrzad Abbasi, Lingwei Xia, Mary-Clare Day, Susan M Ramin, Asif Ahmed, Rodney E Kellems, Yang Xia

    1Department of Biochemistry and Molecular Biology, Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands, United Kingdom.
    PMID: 18259044

    2 comments on PubPeer (by: Trechus Barii, Clypeadon Haigi)
    PMCID: PMC3261612 DOI: 10.1161/HYPERTENSIONAHA.107.097790

    Figure 6B.


  18. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9396-400. doi: 10.1073/pnas.161288698.
    Distinct mechanisms of cell cycle arrest control the decision between differentiation and senescence in human neuroblastoma cells
    Linda J. Wainwright, Anna Lasorella, and Antonio Iavarone
    Affiliations collapse
    1Department of Neurology, Developmental and Molecular Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
    PMID: 11481496 PMCID: PMC55432 DOI: 10.1073/pnas.161288698

    Figure 3.

    First author presently.

    Senior Biologist
    Unilever R&D
    Mar 2000 – Present21 years 1 month

    Unilever R&D, Sharnbrook, Beds

    Project Leader for Beauty From Within, Strategic Science Group, Unilever Colworth

    Under publications:
    “Distinct mechanisms of cell cycle arrest control the decision between differentiation and senescence in human neuroblastoma cells
    Proceedings of the National Academy of Sciences of the United States of America July 31, 2001
    Retinoic acid (RA) induces cell cycle arrest and differentiation of human neuroblastoma (NB) cells. Typically, NB cells differentiate along the neuronal lineage, but quiescent, “flat” cell types frequently have been described after treatment with differentiating agents. Two indistinguishable subclones of the cell line SK-N-SH, SK-N-SH-N (SH-N) and SK-N-SH-F (SH-F), display dramatically different responses to RA. In SH-N, RA induces neuronal differentiation, but in SH-F it transforms the small…”

    and here:

    Senior Biologist

    Beauty & Personal Care
    Unilever R&D


    • Additional problematic data Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9396-400.

      Figure 4B. Much more similar than expected.



      Distinct mechanisms of cell cycle arrest control the decision between differentiation and senescence in human neuroblastoma cells
      LJ Wainwright, A Lasorella… – Proceedings of the …, 2001 – National Acad Sciences
      Retinoic acid (RA) induces cell cycle arrest and differentiation of human neuroblastoma (NB)
      cells. Typically, NB cells differentiate along the neuronal lineage, but quiescent,“flat” cell
      types frequently have been described after treatment with differentiating agents. Two …

      Cited by 120 Related articles All 8 versions

      120 blind bats!


  19. The U.K: how it works.

    Biotechnology and Biological Sciences Research Council
    Research Grants

    Award winner: Neil Perkins
    Institution: Newcastle University
    Value: £384,474
    DNA damage induced phosphorylation and regulation of NF-kappaB


  20. Oncogene . 2005 Aug 25;24(36):5543-51. doi: 10.1038/sj.onc.1208735.
    CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus
    David Bernard1CBX7 controls the growth of normal and tumor-derived prostate cells
    by repressing the Ink4a/Arf locus
    David Bernard1, Juan F Martinez-Leal2 , Sian Rizzo3 , Dolores Martinez4 , David Hudson3 ,
    Tapio Visakorpi5, Gordon Peters6 , Amancio Carnero2 , David Beach7 and Jesus Gil*,6

    1 Laboratory of Molecular Virology, Faculty of Medicine, Free University of Brussels, Brussels, Belgium;
    2 Experimental Therapeutics Program, Centro Nacional de Investigaciones Oncolo´gicas, Melchor Ferna´ndez Almagro
    3, 28029 Madrid, Spain; 3 Prostate Stem Cell Laboratory, Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, UK;
    4 Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK;
    5 Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, FIN-33014 University of Tampere, Tampere, Finland;
    6 Molecular Oncology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln’s Inn Fields, WC2A 3PX London, UK; 7 Center for Cutaneous Biology,
    Institute for Cell and Molecular Sciences, 2 Newark St, Whitechapel, E1 2AT London, UK.

    Figure 1f. Much more similar than expected.

    Figure 5a. Much more similar than expected.


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