How Irun Cohen and Weizmann Institute almost cured diabetes

How Irun Cohen and Weizmann Institute almost cured diabetes

This is a new episode of the data manipulation affair around Weizmann Institute of Science in Rehovot, Israel (and another guest post by “Smut Clyde“), with the hope that Israeli researchers and their state officials finally step in and investigate what goes on in this institute, supported by external experts from the academic community. There are many good and honest researchers working at Weizmann, the dishonest deeds which used to happen (and maybe still happen at Weizmann) should never throw a shadow upon their work. This can only be achieved by an open debate in the scientific community worldwide and a large, independent investigation inside Weizmann.

My earlier article about Weizmann’s “stars” of research integrity, and the follow-up guest post by Smut Clyde, prompted a wider scrutiny by internet sleuths on PubPeer. One of them was the well-known pseudonymous Claire Francis. In this case presented below, while Ofer Lider, associate professor of Immunology at Weizmann, was dying from leukaemia, his dedicated colleagues were apparently secretly stuffing manipulated data into his publications. They continued to do so even after his death in 2004, and now Lider papers are being plucked apart on PubPeer. There are many co-authors, and the scientific narrative mostly circles around a “visionary” diabetes cure, the substance DiaPep277, a peptide fragment of the ubiquitous heatshock protein Hsp60.

What was done to the scientific and human legacy of the immunologist Ofer Lider, is the basically academic equivalent of urinating of someone’s literal grave. If this won’t make Weizmann leadership feel shame, I do not know what would. It was a travesty of two retracted papers and a meeting abstract of a DiaPep277 clinical trial by the trainwreck company Andromeda Biotech, and it made world news in 2014. What came out only now, thanks to the sleuths of PubPeer, is that this scandal of clinical trial statistics was supported by a preclinical cornucopia of rigged western blots made at Weizmann, which all served the purpose of delivering a promise of a diabetes “vaccine”.

Continue reading “How Irun Cohen and Weizmann Institute almost cured diabetes”

Yehiel Zick, Weizmann’s resident Western blot artist; by Smut Clyde

Yehiel Zick, Weizmann’s resident Western blot artist; by Smut Clyde

The  Weizmann Institute of Science in Rehovot, Israel, is not just a renowned biomedical research centre of world calibre. It is also home to many Israeli artists, who take mundane scientific tools like western blot and microscopy images and transform those into modern, or in fact postmodern art. I listed some of these artists in my previous article, after which one of these researchers wrote to me comparing me to “a “judge” in some totalitarian countries”, waving “a ready death sentence”. Now, I am presenting a guest post from the pseudonymous “Smut Clyde” (who honoured my site before), which extolls the artistic achievements of yet another Weizmann artist, an actual Wunderkind of postmodern Western blot collage, Yehiel Zick.

In his day job, the near-pensioner Zick is a humble diabetes researcher, still studying insulin resistance, but also mechanisms of cancer and bone remodelling. He also heads the Department of Molecular Cell Biology at Weizmann. Less known is Zick for his published Western blot collages, which are being honoured in the guest post below. No less than seven Zick publications are currently being admired on PubPeer, all appeared in the Journal Of Biological Chemistry (JBC). Which is likely soon to become a major problem, because this journal destroyed the career of Zick’s colleague and another famous Western blot artist at Weizmann, Rony Seger, after the editors retracted 9 of his papers in one go. Both Seger and Zick earned their PhD degrees in the same lab of the late biochemist Shmuel Shaltiel at Weizmann, both worked on a related project, the former in 1975-1980, the latter in 1983-1988. The two published also some papers together. Did their mentor Shaltiel fail to spot his two students’ artistic inclinations? And if he did, how did he react? We will never know.

I did learn however from one Weizmann professor that this institute has a strange approach to investigating suspected research misconduct. Seger was apparently under investigation for some time, yet not much happened until JBC pulled the plug on his nine papers. Then things happened pretty quickly, though Seger still keeps his tenured job. Is Zick facing some retractions, followed by an involuntary retirement? And are all others safe, because they mostly had the wise foresight to avoid publishing in JBC?

Continue reading “Yehiel Zick, Weizmann’s resident Western blot artist; by Smut Clyde”

The PubPeer Stars of Weizmann Institute

The PubPeer Stars of Weizmann Institute

Journals generally avoid acting on data manipulation, unless forced to by investigations from universities and research institutions. The Lancet‘s current stance on Macchiarini (and previously Wakefield) affair is probably the most dangerous example. Practically at every single research integrity conference (which are usually organised by major publishers like Elsevier), publishing executives preach that journals should never be asked to deal with data manipulations in papers they publish,  but only respond to the final results of institutional investigations.

Actually, even there journals prefer not to retract as requested, as Science did in the case of Olivier Voinnet. On the other hand, some publishers are ready to forgive all misconduct when a unrepentant cheater offers them a new hot paper. Nature Publishing group, EMBO Press and even the publisher lobby group COPE recently protested against journals’ cheater blacklists, in connection with the data-faking plant researcher Patrice Dunoyer, a past Voinnet associate (his story here). And some journals even openly take the side of cheater scientists, while attacking PubPeer whistleblowers, as F1000 Research seemingly did, see tweet below.

Scholarly journals mostly act like grocery shops, which despite better knowledge refuse to remove contaminated foods off the shelves until manufacturer’s official recall, regardless of how many glass shards were found inside. It therefore lies in the hands of research institutions when fraud and cheating continue unabated, while research community is fooled and robbed, left alone with futile attempts to reproduce dishonest papers full of secret data manipulations. Yet this is exactly what Weizmann Institute of Science in Israel is good at:

The Art of Not Investigating

The following article lists Weizmann scientists with some serious evidence on PubPeer against the trustworthiness of their research. Before this elite institution from Rehovot, that most famous biomedical research centre in Israel, dismisses my article as anti-Semitic slander of an obscure German Nazi blogger, they should first try it with declaring me an assimilation-corrupted, self-hating diaspora Jew. Continue reading “The PubPeer Stars of Weizmann Institute”

Does ERC help cheaters pay protection money?

Does ERC help cheaters pay protection money?

Did you ever wonder why certain zombie scientists were still in academic jobs? Despite having been caught on data manipulation or biomedical ethics breach?

It seems the answer is simpler than you thought. They are paying for their protection, by giving pizzo to their crooked research institutions, just as in some unoriginal mafia film. Well, actually YOU are paying their pizzo, through your taxes, which in turn are awarded to these zombie scientists as public research funding, from the national, international and European funding agencies. In fact, the most prestigious and self-important European funding agency ERC is completely unprepared or maybe just unwilling to respond to evidence of research misconduct by their elite grant recipients.  

My understanding is provocative, and I may be utterly wrong. But absent of any reasonable alternative explanations, let us for a moment go with this one. I will provide you with examples where questionable European scientists surprisingly retained their European funding unquestioned (or even received fresh millions of Euros), and coincidently or not,  many institutions did not at all mind to keep them in their jobs. Continue reading “Does ERC help cheaters pay protection money?”