Sonia Melo is back, and not to be messed with. The Portuguese zombie scientist is responsible for a number of papers with manipulated data (only one was retracted, Melo et al, Nature Genetics, 2009), saw her EMBO Young Investigator funding withdrawn in 2016, but was whitewashed and reinstalled by her employing institute Instituto de Investigação e Inovação em Saúde (I3S) in Porto. Her key publication in Nature with MD Anderson professor Raghu Kalluri, Melo et al, 2015, which raised obscene money in industrial and public investment for Kalluri’s spin-off Codyak Biosciences to market exosome-based liquid biopsy for pancreatic cancer detection, was disproven as an artefact at best, the authors even admitted in a follow-up preprint to have intentionally manipulated flow cytometry data to achieve results they needed. Collaborators were instructed never to work with her again. All in all, Melo is as toxic as a zombie scientist can be. But apparently not in her home country Portugal.
In March 2018, Melo received a Prémio FAZ Ciênciaaward from Fundação AstraZeneca (FAZ) and Sociedade Portuguesa de Oncologia (Portuguese Society of Oncology, SPO). Which means, not just Portuguese academia, also international Big Pharma industry trusts her Photoshop skills. The award comes with €35k cash, and this is how much or how little was needed for the University of Porto to drop all pretence at research integrity and celebrate their zombie scientist as a genius researcher about to cure cancer. Continue reading “Zombie scientist Sonia Melo awarded by AstraZeneca”→
The cell biologist Maria Pia Cosma, top-funded and prize-winning professor in Barcelona, is either an indestructible zombie scientist or a martyred saint. Her name means in Italian Mary the Pious, so it is probably the latter. So the following post is written in the style of a canonical satire.
Holy Mary Pia was accused by evil tongues on PubPeer of research misconduct in several of her publications. Philistines pointed crooked fingers and cast stones at duplicated western blot bands in papers published by St. Maria Pia in exalted scriptures like Cell. The accusers, envious of such impact factors, wished those gospels of scientific truth crucified on the cross of retraction and demanded for Our Lady of Barcelona to be judged and investigated. Yet Lord took mercy upon the tortured saint and sent His angels to defend her.
The Portuguese cancer researcher Sonia Melo has been cleared of all suspicions of scientific misconduct by her employer Instituto de Investigação e Inovação em Saúde (I3S) in Porto. She is now re-installed as research group leader, despite of an earlier EMBO investigation which stripped Melo of her start-up funding and the title of EMBO Young Investigator. Previously, PubPeer users raised strong suspicions of data manipulations as well as concerns about irreproducibility and artefactual results based on questionable reagents. The affected publications were authored by Sonia Melo during her stays in the laboratories of Manel Esteller in the Spanish city Barcelona (see my report here) and Raghu Kalluri at MD Anderson in Texas, USA.
Neither of her former supervisors has been investigated by his respective host institution in connection to PubPeer-posted concerns about their publications with or without Melo. Aside of the EMBO investigation (the findings of which were only made available to Melo’s former and current employers), I3S was the only institution to initiate their own investigation. Unfortunately, its report is not available to the public either. All we now receive is a press release, in which I3S admits to the existence of data manipulations (interpreted as cases of “negligence” which “do not compromise the scientific content”) in 3 of Melo’s papers: the now retracted Melo et al, Nature Genetics, 2009, plus Melo et al, PNAS 2011 and Melo et al, Nature 2015. Both papers will be corrected; the latter was seminal in the fundraising of at least $80 Million for the purpose of developing a commercial cancer diagnostics test. No further Melo publications were investigated, including this one: Continue reading “Sonia Melo fully exonerated and reinstalled as PI by her Portuguese employer I3S”→
Only days after, on August 28th, big news broke out in Scottish and Irish media. The Scotsman brought the headline: “Leading scientist suspended amid ‘research misconduct’ investigation”. The newspaper then indicated that Ryan has to answer for suspected image manipulations in his papers:
“It is alleged he used identical images across multiple papers, claiming they were different strains. In some cases, it is alleged the evidence was flipped or rotated, which could indicate an “intent to deceive”, according to one source. The extent of the alleged misconduct is unclear, but the source indicated it is alleged to have spanned “a number of years” and involved numerous prestigious journals”.
One dishonest scientist sacked, another one is welcomed. At least this is what it looks like at the Spanish National Centre for Cardiovascular Research, CNIC, which seems to be recruiting their principal investigators through the whistleblower platform PubPeer, as the scientist who alerted me to this development quipped half-jokingly. The new recruitment at the Madrid institute is the regenerative medicine researcherPura Muñoz-Cánoves, whose papers contain evidence of data manipulation in form of band and lane duplications in western blots and gels.
CNIC only recently sacked the ERC-funded heart regeneration researcher Susana Gonzalez. Their investigative report is confidential and not available to public, though one can safely assume misconduct was in play. Gonzalez quickly found another job, at a different Madrid research institute, her €2 Million ERC funding is not terminated, but suspended while ERC investigates (see my brief report here). Gonzalez’ research specialization is cardiac muscle ageing and regeneration (or the data manipulation therein), that of Muñoz-Cánoves is just the same, but for the skeletal muscle. The latter is therefore a suitable replacement for the former in every respect. Continue reading “Does Spanish Research recruit its Leaders from PubPeer?”→
Sonia Melo, the Portuguese scientist accused of data manipulation and misconduct, now loses her EMBO Installation Grant funding by the European research agency EMBO. The EMBO funding was of ”50,000 Euros annually for three to five years” for her research lab at the Instituto de Patologia e Imunologia Molecular da Universidade do Porto (Ipatimup) in Portugal, as well as “benefits similar to those of the EMBO Young Investigator Programme“. EMBO has began their investigation into Melo’s publications in January 2016 after they were made aware of the accusations of data manipulation raised against Melo on PubPeer (see details here).
As I was informed by Tilmann Kiessling, Head of Communications at EMBO:
“as a follow up to your reporting on Sonia Melo, this is to confirm that EMBO has withdrawn the installation grant awarded to her. After EMBO had become aware of the allegations against papers authored by her we set up a committee to investigate these allegations. After a thorough analysis of all papers that had formed the basis for her application for the grant, the committee concluded that the body of work upon which the selection for an installation grant was made contained evidence of a level of negligence in handling and presenting data that would have precluded a recommendation for an award. The committee therefore decided that Sonia Melo should not become a member of the EMBO network of Young Investigators and Installation Grantees, and that the installation grant will be revoked. This has been communicated to Sonia Melo and her home institution on February 29.”.
Sonia Melo, Portuguese cancer researcher and recipient of the prestigious EMBO Installation Grant, now has her publications investigated by EMBO for suspected image manipulations. Her current and former research institutions are apparently actively avoiding any attempts to scrutinise her papers, some due to very heavy financial conflicts of interest. Yet my information suggests that Melo’s former PhD advisor and co-author, Manel Esteller, is being presently investigated by his research centre in Barcelona.
Melo already had to retract a first-author publication from her PhD period with Esteller from the journal Nature Genetics. The retraction notice admits image duplications:
“We have recently become aware of the presence of duplicated images in the Figures 3 and 4 and Supplementary Figures 5 and 6 in our publication Nat. Genet. 41, 365–370, 2009, that were assembled according to the specified author contributions. We therefore retract the publication for the sake of the high standards we expect for research and scientific journals. All the authors have signed this statement”.