Academic Publishing Csaba Szabó Open Letter

The Fribourg Declaration

"The papermill crisis is not an external attack on science but a mirror held up to its dysfunctional ecosystem. The for-profit publishing industry, posing as a newly found saviour of research integrity, is in fact its chief beneficiary and enabler." - Csaba Szabo

Csaba Szabo is not convinced with all those announcements, manifestos, white papers and declarations on how to fix scholarly publishing. Therefore, he offers a more radical solution.

Here some past declarations:

Many more declarations on scholarly publishing here. And because Csaba is professor at the University of Fribourg in Switzerland, I decided to call this “The Fribourg Declaration”. Needless to say, the following views are Csaba’s own and most likely not of his employer.


Beyond Papermills: Why Scientific Publishing Must Be Rebuilt from the Ground Up

By Csaba Szabo

The papermill crisis is not an external attack on science but a mirror held up to its dysfunctional ecosystem. The for-profit publishing industry, posing as a newly found saviour of research integrity, is in fact its chief beneficiary and enabler. If science is to recover its credibility, the system that feeds on its dysfunction must be dismantled. Not repaired, not polished: dismantled.

The existence of papermills — shady operations that fabricate scientific papers for paying “authors” and guarantee their publication — has been known for years (STM & COPE report 2022, Bishop & Abalkina 2023. Abalkina et al 2025). What’s new is the attention they are getting in the mainstream scientific literature. People who hear about them for the first time are amazed when they realize the sheer volume of papermills’ activity. The brazen arrogance of their operations. Their infiltration into every layer of academia. The staggering sums of money flowing through their networks. While it is not difficult to infiltrate their circles to expose their modus operandi (as I did, see here and here), the criminals behind the papermills remain untouched, hiding in plain sight — protected, intentionally or not, by the very system that pretends to fight them. 

A Sting Inside a Papermill

“It’s clear that any academically corrupt individual — particularly one with editorial connections — could easily “place” dozens of these Anzen products into indexed journals and collect a handsome side income in the process.” – Csaba Szabo

The Publishers’ “War” on Papermills: Virtue-Signaling and Hypocrisy

The publishing establishment “declared war” on papermills. United2Act, as they announce with banners and hashtags and zoom presentations. Their newest invention, the Trust Marker,” promises to flag “authentic” work, based on certain characteristics of the authors and institutions — unconnected to whether the paper’s claims are true or reproducible. The Lancet has just assembled a new committee, in conjunction with the so-called “World Conferences on Research Integrity (WCRI) Foundation”; they will meet at their upcoming meeting in Vancouver in May 2026. Even the controversial publisher MDPI announced to start using “AI-powered image proofing” to identify fake images. Most recently, the “Stockholm Declaration” by Bernhard Sabel and Dan Larhammar alerted everybody that “paper mills’ increasingly pollute the scientific literature with fake articles reporting fake data” and called on everyone to “implement legislations, regulations and policies to increase publishing quality and integrity”.

These campaigns look righteous at first glance. But they are hollow, hypocritical, and self-serving. It is marketing, not reform. WRCI conferences have been going on since 2007, without any visible impact. There is an endless supply of integrity and metascience conferences, workshops and a similarly never-ending list of studies, guidelines, checklists and concordances –– some of them academia-initiated, many of them supported by the publishing industry. But let’s be clear: this industry is not the victim in the story of papermills — it is an accomplice.

Ticket to Tianjin

“So here is a novelty in the annals of fictional research: a nomadic digital caliper. It visited a series of laboratories, accompanied by a backing troupe of mouse-mined xenograft tumours for it to measure” – Smut Clyde

Based on the massive volume of fake articles published every day, papermills represent a significant revenue stream for the publishing industry. The “top” journals can afford to be selective, but even the publishers of the most reputable journals have established lower-tier journals, to beef up their income. In other words, every publisher which relies on a revenue, benefits from the flood of garbage science.

The gray-zone and predatory journals have always happily taken papermill submissions to collect the publication fees, and the whitelisted Open Access journals are not much better. And, of course, closed-access journals need to fill their pages with something in order to collect the subscription money from academic libraries. Unless something drastic happens, the publishers will continue with their current practices –– while applauding their own “anti-papermill” initiatives.

At least in part based on information from For Better Science, a recent analysis published in PNAS (Richardson et al 2025) shows that papermills operate hand in hand with corrupt editors — even in supposedly reputable journals. A few names were recently exposed in Nature, again based in part on information from For Better Science. Some editors quietly resigned –– or were removed. For every corrupt editor caught, dozens more remain. The system tolerates them because large parts of it depend on them.

As I have discussed in my book, while the amount of grant funding for research has stagnated over the last decade, the number of published papers has increased dramatically. I am afraid, the most plausible explanation is this: a lot of these publications are not based on actual research.

 

Papermills Are a Symptom, Not the Disease

Every time a new detection tool appears, papermills adapt. They moved from copy-paste fabrications to AI-generated text and images, and now to algorithmic exploitation of open-access databases. Each crackdown simply drives evolution. 

There will be always plenty of publishers ready to take the papermill money. This feels like a never-ending process. And pursuing the papermillers themselves? Bound to fail – they operate offshore and in the dark web. The US FTC “won” its case against the OMICS Group years ago — and OMICS is still alive and profitable. 

Papermills exist because the academic system demands them. They are not the disease — they are a symptom.

The real problem is the demand. The desperate, constant demand from people — let’s stop pretending they’re scientists — inside universities who need papers to survive, advance, or impress. Why do they buy fake science? Because their institutions reward publication volume and citation metrics above everything else. Until these perverse incentives are dismantled, papermills will thrive. When the demand dies, the supply will die also. Everything else is virtue signalling.  

Beyond Papermills: The Deeper Rot

Papermills are just a visible fungus growing on a rotten tree. Systematic replication studies have already shown that 80% of biomedical papers (or more!) — even those in “top” journals, even when repeated with assistance from the original authors — fail to replicate (Szabo 2025a, Szabo 2025b). Most of this irreproducibility cannot be blamed on papermills.

Irreproducible papers come from mainstream labs, with grants, prestige, and institutional blessing. The empirical truth is that the biomedical scientific literature, as a whole, is profoundly unreliable.  Papermills are merely the black-market version of the same sickness: a culture that rewards output, not validity; novelty, not truth; publication, not knowledge. Fixing this requires a total systemic reform — of training, funding, data analysis, and quality control. Until that happens, we are not curing the disease.  

BMJ invaded by Iranian papermill

“Patients with weak heart function who receive stem cell therapy shortly after a heart attack are at lower risk of developing heart failure and related hospital stays compared with standard care, finds a clinical trial published by The BMJ today.”

Why the For-Profit Publishing System Must Go

The for-profit publishing industry does a great job in presenting itself as the only possible mechanism for the communication and distribution of scientific results. However, historically, scholarly communication and the publication of scientific and academic work did not rely on a shareholder-owned, for-profit business model (Stephen Buranyi in Guardian, 2017). University presses, learned societies and academic communities took responsibility for dissemination and quality control. For much of the twentieth century journals were owned or managed by academic societies (often non-profit) and libraries subscribed to them; the service model was part of the academic infrastructure rather than a commercial venture. For-profit intermediaries gradually gained dominance, but there is no intrinsic reason why the publication of scholarship must be structured as a profit-maximising business rather than as a public good.

An attractive and “natural” target for fraudsters

“In the various excellent texts on paper mills the question is discussed why Naunyn-Schmiedebergs Archives of Pharmacology has become a target for fake papers. I oppose the assumption that we simply want to fill pages with pseudo-scientific content. We actually look for quality and good science.” – Prof Dr Roland Seifert, Editor-in-Chief

The latest “papermill crisis” and the self-serving and inefficient “declaration of war” on them is just the latest proof for the obvious mismatch between the logic of profit and the logic of scholarship. The system today imposes high costs, exhibits growth in volume rather than demonstrable improvement in quality, fails to guarantee the reliability of the published claims, and shows no evidence of genuine self-reform. The economics of current academic publishing is a staggering waste of public resources.

Despite the fact that public and charities pay for most research, peer-reviewing is carried out largely by unpaid academics (Aczel et al 2021), and the final product is then sold back to institutions (and indirectly governments) via subscriptions or article processing charges (APCs). Publishers are consistently making profit margins of 30–40%. The academic sector (i.e., ultimately, the taxpayers) ends up paying dearly, and largely for a system that redistributes publicly-funded knowledge through a commercial intermediary whose margins are high and whose value added is questionable. 

The “brand” value of journals is increasingly inflated; the journal impact factor and prestige hierarchy drive researcher behaviour (to publish in high-impact titles) rather than the intrinsic value of the published work. Which, by the way, keeps decreasing, in terms of each published paper’s real-word impact. But when the system incentivises volume and prestige rather than replication, rigour and quality, what is achieved is rather an expansion of output, not an expansion of trusted validated knowledge.

This is the only reason why papermills exist: to fill the growing gap between the amount of available real research output and the virtual pages that an ever-growing number of for-profit journals must fill up with something. Almost anything. 

Gradual Improvements Are Hopeless

There is a lot of talk about making various improvements of the current system. Improving the peer review system (Waltman et al 2023, Margalida & Colomer 2016. Pinfield et al 2014, Aczel et al 2025). Awarding trust markers (COS 2025, Butler 2025) and other distinguishing features to “legitimate” groups of scientists. Improving the policing of fake images and AI-generated text. The list goes on. As long as the for-profit industry can pay lip service to such improvements, they will be embraced.

An often proposed and rather popular alternative suggests that scientists should “reclaim the ownership of journals” and place them in the hands of academic societies or universities. This suggestion, while made in good faith, would never succeed, because it would leave the underlying incentives, such as the metrics-heavy academic evaluation system, and the overall hypercompetitive publish-or-perish mentality, untouched. “Society journals” are in the money-making business, too: in this case the money is being generated for the society which owns them.

If a system –– any system –– does not work, if it does not serve its original purpose, it must be drastically reformed, or, better yet, it should eliminated and replaced. Stopgap measures will not work: the only solution is the urgent and complete abolition of scientific journals in their current form.

The papers are coming from inside the house!

“It feels like half the higher-echelon professors at Jilin University have built their careers on these fairy-tales, with successions of papers itemising the interactions of ADAM10 or GRIM-19. […] if only they had published instead about the Tooth-Fairy circ-RNA and how it targets the Easter-Bunny Pathway…”, – Smut Clyde

The Way Forward: We Must Put Scientific Publishing in the Hands of Funders 

In a new system, the current journal-based model of scientific result dissemination would be completely abolished (or, better said, it would cease to exist, on its own, because it would no longer be fuelled by the endless stream of manuscript submissions). Instead, funders would take direct responsibility for scholarly communication and data dissemination. They would establish an open infrastructure — preprint servers, community-managed peer review platforms, data-code repositories — and decouple certification (peer review, replication) from branding and business. In this model:

  1. When an investigator (or group of investigators) is funded, they would have to agree that the funders’ platform will be the sole means of data dissemination and publication.
  2. The funders would provide quality assurance, quality control and data integrity support: in other words, they would become active stakeholders, partners in the actual research.
  3. Once a significant project component is completed, the grantees would post their findings (all raw data and their analysis) on a funder-mandated open archive. The data would be accompanied by an abstract and a manuscript, which is then immediately made public and collated by abstracting systems (e.g. PubMed)
  4. Post-publication commenting (we don’t even need to call it peer review) would only begin at this point; both by funder-appointed panels and by direct input from the scientific community; comments would be open, signed or transparent.
  5. Independent replication studies by third-party investigators must be encouraged, and performed in a blinded and controlled (industry-standard) manner. Independent replications would have to be part of the condition of each grant: separate funds would have to be reserved for this sole purpose. The results of the replication efforts would be posted on the funders’ server –– linked to the original body of data and manuscript. Studies that pass independent replication would receive a “stamp” of certified reliability.
  6. Only those investigators who produce valid and reliable data would receive further funding. Institutions whose investigators generate large amounts of irreproducible or fraudulent data will be banned from further grant support, forcing them to improve their quality control processes.

Wellcoming the samizdat publishing revolution

The British research funder Wellcome Trust (now just Wellcome) is about to launch its own journal, where the funding recipients and their collaborators are invited to published their research free of charge (since Wellcome will be covering those costs). Wellcome Open Research will be open access (OA) and offer fully transparent post-publication peer review, i.e. all reviewer…

This approach aligns publishing with the public-funded nature of research, removes the profit layer, and ties the system to community governance. This system, by the way, is not new. A decade ago the Wellcome Foundation has attempted to come up with something similar (“Wellcome Open Research”), but it failed, because –– after a public uproar –– it did not mandate its grantees to publish in its own journal.

The reform suggested above will only work if it is mandatory. The benefits would be massive: reduced costs, increased access, stronger quality control (via replication), realignment of incentives toward reliability rather than novelty.

Conclusion: Papermills Are Not the Problem — The System Is

The for-profit scholarly-publishing system with its self-serving and vacuous declarations to “fight” papermills has outlived its usefulness and lacks a credible mechanism for self-reform, because its structure is founded on profit rather than scholarship. It must go. Gradual improvements at the edges of the system do not work, otherwise they would have worked by now. 

The Citation Payola

“The proposition that a niche of citation brokers exists, opens our eyes to other transaction options..” . Smut Clyde

Dismantling the current system and shifting publishing control to funders and research institutions is the only route to a more sustainable, scholarly-centric, transparent and cost-effective scientific ecosystem. Needless to say, any reform along the suggested lines will be difficult, because the publication industry, which is deeply entangled with the current academic system, controls much of the public discourse and is very good at self-preservation. Also, the current granting agencies are typically led by academic scientists who are also embedded in the current, dysfunctional scientific and publication ecosystem. So they must go as well. The management of the granting bodies should be replaced with a new crop of government administrators and reform-minded scientists whose sole interests are quality, reproducibility, validation, and the eventual translation of the findings for public benefit. 

It will be very hard to force a true reform. But it must be done. There is no other way forward.  


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27 comments on “The Fribourg Declaration

  1. Zebedee's avatar

    “The for-profit publishing industry, posing as a newly found saviour of research integrity, is in fact its chief beneficiary and enabler”

    Why shouldn’t the mainstream publishers be extremely happy with the way things are? Why will any of them fundamentally change anything?

    A leading example.

    For the financial year 2024.

    Springer Nature profits up 7 per cent to €512 million – Research Information

    €1,853 million and adjusted operating profit was €511 million
    511/1853 = 27.57% profit for Springer Nature

    Like

    • C Szabo's avatar

      Because they don’t control the distribution of the research money. The funders do. Which is why what I suggest in the post is the only way their oligopoly can be broken.

      Like

      • Just My Imagination's avatar
        Just My Imagination

        The logistics of starting a diamond open access journal are simple, and the computing infrastructure required for serving up static PDF files costs peanuts. We could move to a diamond open access system overnight. The main stumbling block is the academics themselves, who will fight tooth and nail to preserve the current system. These academics have made their careers in marketing themselves as most prestigious, and they need their prestigious publication venues. They squealed like pigs back in 2018 when the funders in Europe suggested introducing open access publishing mandates with publication fee caps. “We need to be able to publish in Nature!”. It was also unfortunate to see For Better Science promoting some of the self-serving academics back then who unfortunately succeeded in defending the current system.

        Like

  2. Assprof's avatar

    There’s a community-run peer-reviewed journal, JOSS.
    Publishes ~100-200 papers per year.
    Reviews are open & fully transparent, as they are posted on github, see eg. https://github.com/openjournals/joss-reviews/issues/7945

    The current cost of running this journal: ~1000 USD/year https://joss.theoj.org/about#costs
    see also the discussion https://blog.joss.theoj.org/2019/06/cost-models-for-running-an-online-open-journal
    Meanwhile, APC in any Elsevier, SN, Wiley journal is usually at least 2-3 times that much PER PAPER.

    Liked by 2 people

  3. Gabor Lente's avatar

    To the part “The Way Forward”:

    What happens to a scientist who publishes papers without any specific funding? It may be a tiny, but existing minority. Like myself. I am a researcher specializing in mathematical chemistry. For the past 15 years, I have never even applied for dedicated funding because my research can be done with the resources I already have access to as part of my university job. A full success of the ‘mandatory open access’ model would be the end of my research career, but so would ‘the funder publishes’ model proposed here. For at least some scientists, science is still mainly intellectual stuff and not financial.

    Like

    • C Szabo's avatar

      Since –– considering the lobby power of the publishing industry, the majority of the academia embedded in the current system, and the overall incompetence of politicians and decisionmakers –– there is almost no chance that the proposed model would be implemented, if I were you, I would not lose too much sleep over the scenario you ask about. (And by some miracle it would be comprenehsively implemented, there could be still various university-run or society-run journals for manuscripts like the one you outline.)

      Like

  4. kenrodmelrocity's avatar
    kenrodmelrocity

    “Instead, funders would take direct responsibility for scholarly communication and data dissemination.”

    I’m a US National Science Foundation program officer, just returned to work after being furloughed due to the federal government shutdown. Apologies for my knee-jerk reaction to this idea, but there is no chance in hell that something like this is going to happen within US federal funding agencies.

    Like

    • C Szabo's avatar

      I am curious if you refer to THIS NIH or ANY NIH when you say no chance. You know what Mandela said: “It always seems impossible until it’s done”. Somebody in some administration (this one or a future one) will say: enough money is wasted, we cannot let the publishing industry suck out all this money from the system and we cannot allow further funding of largely unreproducible research. And then it will happen. Maybe it will not be driven from the moral angle, but from the financial/efficiency angle.

      Like

      • kenrodmelrocity's avatar
        kenrodmelrocity

        I’m referring to NSF. The situation in NIH is far more dire than where I am in NSF. In the last 10 months NSF as a whole has lost 40-50% of its program officers and, so far, proposal submissions are up relative to last year. It’s going to take a lot of hiring just to get back to where we were, let alone the increases required to turn the agency into a scientific publisher.

        Like

    • Michael Jones's avatar
      Michael Jones

      I think, kenrodmelrocity, that to your point below regarding “the last 10 months” is a bit apples-and-oranges. The problem being discussed here well predated the current United States presidential administration, and while layoffs and funding cuts would certainly hamper such and endeavor (as you rightly point out), it’s at cross-purposes to presuppose that the current situation caused the problem or that its particular contribution to the problem is an etiological agent. Regardless of who’d been elected, the problem would have continued though I won’t conjecture about the rate of acceleration of it (which is outside the scope of the present discussion, I think; though certainly relevant).

      I see an interesting parallel to healthcare in the United States and other countries with single payer healthcare. As you point out, funding agencies are vested in the quality of the research that they fund and thus would make an obvious agent of oversight for reproducibility and transparency. The motivations and entities outwith comprise something analogous to the “health insurance industry” which for various reasons has proven rather difficult to break free from in this country. I would envision it would take something akin to a massive labor movement or embargo to force such a change through.

      An additional, interesting point regards funding and replication studies. I know firsthand that there are groups of researchers that agree to replicate each others’ bogus findings, who serve on study sections, and who fund each others’ research. The aging research field is an example of this. An entity such as the Interventions Testing Program serves as an independent agent whose function it is to evaluate reproducibility concerning claims of lifespan extention of various compounds and yet research into many of these compounds whose erstwhile function has been debunked continues to be funded (just searched “resveratrol” in PubMed to see if it has “died” yet … still going strong).

      In any case, I certainly endorse your ideas but I think that these changes will require quite revolutionary changes in terms of people’s expectations of the system that put them into positions of authority, and vice-versa, and many of the levers of power are not wielded by individuals who value honesty and transparency in practice.

      Like

      • Hubert Wojtasek's avatar
        Hubert Wojtasek

        Let me again cite a comment I placed somewhere else:

        “If nothing changes, then in a couple of years there will be no just papermilling but no science. Therefore we have to try to convince decision makers that something has to be done. Unfortunately, this means mostly politicians who usually are too busy with their political fighting to notice science and don’t understand the problem (at least in Poland, I don’t follow the rest of the world too closely). But if we don’t succeed, we can pack up.”

        We have to get the attention of people who distribute research money (in Poland the Minister of Science and Higher Education). One idea I just received from a researcher at Gdansk Tech is to involve members of the Polish and European parliaments. I know it won’t be easy, just like fighting papermills isn’t easy, but if this revolution is to succeed, it has to be global, not local.

        Liked by 2 people

  5. forsdyke's avatar

    So a great FBS article ends with the granting agencies being dysfunctional and needing a sole interest in quality, etc.. This was the position I arrived at decades ago (bicameral review). Many papers and a dedicated website (updated regularly) and a book (Tomorrows Cures Today? How to Reform the Health Research System, 2000).

    home page [Main navigation page for these webpages]

    Like

  6. Albert Varonov's avatar
    Albert Varonov

    The global corporate model infiltrated science with the metrics and the only important thing is how many. It doesn’t matter the quality, only the quantity. And we have come to the situation these how many to be actually zero many, since nobody cares about the quality, just show’em a polished turd (more and more frequently we see that even the polishing is absent) and on to the next one…

    Any system built on this foundation is doomed to fail again like this one has, the restart should come from above.

    Like

    • C Szabo's avatar

      Agreed. Maybe society, in general, or through some sort of grassroots or pressure groups (if informed about the situation) could put some pressure on these people you call ‘above’.

      Like

      • Albert Varonov's avatar
        Albert Varonov

        Yes, even I am not sure who these ‘above’ are but they’re surely the ones that define the whole funding process and the scientists that deserve receiving it. Using logic, some of these are most probably the largest scientific publishers and we all read about their stance on this topic here in the blog.

        Like

  7. Realtiv's avatar

    PhD students in my (all countries?) country are required to publish in a journal the University deems “esteemed”. This ist nonnegotiable. Any advice as to what a PhD Student can realisticly do to contribute to change?

    Like

    • C Szabo's avatar

      Not much I am afraid. The system is not set up that way. As I wrote in an earlier response,
      maybe society, in general, or through some sort of grassroots or pressure groups (if informed about the situation) could put some pressure on the people ‘above’ (i.e. politicians who control the appointment, funding and regulation of most grant-giving bodies). Maybe students or lab workers could set up some such group at some point and try to hear their voices heard. I am sorry I have no idea how community organizing works.

      Like

  8. Hubert Wojtasek's avatar
    Hubert Wojtasek

    On October 21 Forum Akademickie published an article by Prof. Adam Liebert, Romuald Zabielski, and Michał Mrozowski, members of the Polish Academy of Sciences.

    Promować rzetelność badań, eliminować zachowania nieetyczne

    “Promote research integrity, eliminate unethical behavior”

    Here is a fragment:

    “Maybe it’s time to build our own independent publishers, where reviewers and editors are held accountable for quality rather than the number of publications? Could the Polish Academy of Sciences, which currently maintains several dozen journals published by institutes and scientific committees, take on the task of creating such a publisher? Could the funds directed from the Polish science system to finance publications in the open access system, including in so-called predatory journals, be redirected to finance it?”

    Ad here is one of my comments to that article.

    “I think this is a step in the right direction, but the idea is too conservative. I believe the situation has matured enough to radically change the model of publishing results of scientific research. Scientific journals have become commercial entities whose primary goal is profit. For the largest publishers, this amounts to billions of dollars annually. Reducing the number of publications is not in their interest, so they certainly will not do it voluntarily. It should be remembered that “funds directed from the Polish science system to finance publications in the open access system, including in so-called predatory journals” are just part of the problem. Much larger costs are incurred for access to journals through subscriptions and to databases (Scopus, WoS, etc.). These amount to hundreds of millions of zlotys annually. It is similar in other countries. Currently, articles are mostly published only in electronic form anyway. Anyone can do this. Printing houses are not needed. So why not create an international repository (or possibly discipline-specific repositories) operating on the principles of journals (editors, peer review), but managed by public institutions? Of course, the resistance from major publishers will be enormous, because this would threaten their existence, but in my opinion, this is the only way to limit the current flood of scientific junk, for the publication of which taxpayers around the world pay publishers. Unfortunately, as I have written before, it would also require a change in the mentality of a significant portion of scientists, who conduct research ‘for credentials’ rather than to solve an important problem or gain new knowledge.”

    Liked by 1 person

    • C Szabo's avatar

      In the article, I pointed out that countries of small size, such as Poland, would not be ideal to initiate this reform, because their universities and research institutes would inevitably fall behind in international competition. If the Polish research network, as an early adopter, were to switch to publishing through a domestic server system and this new (and therefore impact-factor-less) scientific results–dissemination platform, it would find itself at a disadvantage compared to every other researcher in the world who remains within the traditional publication system. From that point on, the CVs of researchers who have switched to the new system would no longer contain papers published in well-known journals, and international research funders would not view this favourably; in other words, external grant funding would dry up. Thus, the way I see it, a large-scale reform would only be possible if the biggest players—namely the United States and the European Union—were the ones to initiate it.

      Like

  9. onip's avatar

    I don’t know about material science or other fields, but in biomedical research there is still a small minority who truly understands the urgency for change and actually puts meaningful effort into it. The rest either remain focused on short-term goals such as keeping their jobs, securing a Blau Karte or Green Karte, or climbing the academic ladder to provide better opportunities for their families, or they are too preoccupied with gaining then maintaining their high status. They fail to (or can’t afford to) grasp how deeply flawed research will ultimately affect their lives (or already did) and the lives of their loved ones. The same short-sightedness is shared by many within the funding agencies, unfortunately.

    Part of the problem is that too much media attention is directed at the profits of publishers, wasted money, metrics and the unmerited promotions, rather than how certain problematic basic science papers, including some of those identified as papermill products, directly and ultimately impact human health. Somehow wasted money receives more attention than wasted lives. But alright, at this stage, any attention helps.

    I believe the people who would be most motivated to convey the urgency of this issue to policymakers/funding agencies are the ones sitting at the doctor’s office waiting room for their follow-up appointment or ones participating in clinical trials without being aware that some of those may have been built on unsound foundations. Their lives and/or their quality of life depend on the integrity of the science behind those drugs or interventions.

    This is why we must put more effort into explaining, clearly and repeatedly, how a single flawed basic-science article that passed through a substandard peer-review of a for-profit journal can cascade into patient harm, and why those directly affected (sometimes thousands and definitely more than those who are here and want a change) must understand the problem and make this case to the people who can change the system. I wonder what percent of patient support groups are even aware of the problems in the publishing system and their direct consequences or know about FBS (which is one of the few that mentions the consequences to patients and one of the few that is sometimes too bitter : ). Here the physician scientists have a responsibility to better trace and explain the transnational relevance and given the limited resources, those finding errors have a responsibility to triage and focus more on papers that found their way to drug development and guidelines. Reddit and Quora are both full of posts written by patients asking if any of the recently identified research problems had any affect on the clinical trials they are participating at those institutions or the therapy they are receiving. And the answers are often misleading because they are based on the limited information available in the media.

    Cardiac stem cell research is the perfect example to this, and even in Anversa case, few reported on its direct impact on patients: https://www.reuters.com/investigates/special-report/health-hearts-stem-cells/

    One needs to be heard to be understood. I don’t think funding agencies nor (self-destructive) publishers (who may be patients one day) are hearing, and patients have the loudest voice in this – in my very very humble opinion.

    Like

  10. C Szabo's avatar

    100% agree. In fact I wrote a lot of the same already in my book “Unreliable” (including the stem cell disaster; I even cite the Reuters report).

    Like

  11. onip's avatar

    Here is a perfect example from a comment written on Andrew Gelman’s blog from last year. I don’t know if any of the studies of this case found their way to clinical practice, but this comment shows how some (including those doing the research itself) perceive basic science research as ‘something nobody reads’ and cannot understand that some of this research shows up as a medical device in the OR or as a drug in the treatment plan. That it is not only a ‘harm to taxpayers’.

    https://statmodeling.stat.columbia.edu/2024/07/03/a-columbia-surgeons-study-was-pulled-he-kept-publishing-flawed-data/#comment-2381515

    ‘’ I actually would like to know if there’s data available on his surgical outcomes. The bogus “engineering” papers coming out of the University of Nevada may be completely worthless, but we can also assume nobody is actually reading them and thus no harm is done (except to taxpayers). Whether this guy is a competent surgeon seems like a more important issue than such paper…’’

    I arrived to the link above yesterday while reading his very recent blog from Nov 15th, and here are a few quotes from him:

    https://statmodeling.stat.columbia.edu/2025/11/15/the-density-of-fraud/

    ‘’ Following the link at Sholto David’s comment let me to a website called For Better Science, and . . . wow. There’s a lot of corruption out there by medical researchers at top universities. Columbia included…’’

    ‘’ Until looking at that For Better Science, I just hadn’t thought hard about the sheer prevalence of scientific fraud at major university medical centers.’’

    If even faculty like him who seem to genuinely care about research, work under the same roof as those creating the problems, and are in the system themselves (even in a different field), are unaware of the extent of these issues, it’s hard to expect much from funding agencies. This once more shows how little awareness there is at the patients’ and patient support groups’ end.

    Here is the flattering part for Leonid that I left to the end : )

    ‘’ I read Retraction Watch and I know about fraud—but just the level of this, it’s stunning.’’

    ‘’ Seeing the occasional story in Retraction Watch hadn’t given me the sense of the sheer density of fraud in the system.’’

    Joking aside, this is a little bit of a problem that something so serious can only be learned through a blog written from someone’s home (I guess) in Germany, not from New York Times, medical societies or the faculty’s well known institution in the US. It is ‘wow !’.

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  12. blatnoi's avatar

    Thanks for the link to the conference in May with Elisabeth Bik and Brandon Stell. I’m seriously thinking of going now; maybe I’ll get to talk to them. I’m thinking of creating some sort of scientific integrity small course in the future. Anyone else going?

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