In Spain, there seems to be a tradition of reacting to emerging evidence of data manipulation with handing out prestigious awards to authors of these papers. This is how we were all taught that all the PubPeer evidence matters nothing whatsoever, as Pura Munoz-Canoves, Maria Pia Cosma and Manel Esteller were celebrated with prizes and grants for their research achievements (read here , here and here). Now there is a new popular academic hero in Spain, Carlos López-Otín, Professor of Biochemistry and Molecular Biology at the University of Oviedo, and EMBO member. Lopez-Otin was now awarded a 2017 Mentoring Award, presented to him by Sir Philip Campbell, on behalf of his journal Nature, which Editor-in-Chief Sir Philip has been for the last 22 years.
The journal Nature remains the highest authority in science, this Mentoring Award is Sir Philip’s parting present to the Nature-reading scientific community, as he is being promoted inside Springer Nature’s publishing hierarchy. It is in this way a statement of what Nature and its publisher think of research integrity. Lopez-Otin’s evidence record on PubPeer is telling enough, however most of the evidence of digitally manipulated gel images there was posted around 2-3 months ago, by the pseudonymous Claire Francis. Maybe the evidence appeared too late, and the award decision couldn’t be stopped anymore. Which would explain why Nature deleted their own tweet announcing the mentorship awards after I replied to it with PubPeer evidence on Lopez-Otin’s papers. According to another Nature website, which was for some reason also deleted, the closing date for nominations was Monday 31 July 2017. So I share some examples below, all are from papers where Lopez-Otin is last and corresponding author.
Nature tweeted the article about mentorship awards in Spain, to which I replied. Unlike with other social media, you cannot remove replies to your tweets if you disagree with those. Pop, the original Nature tweet was deleted, Nature followers on Twitter were then spared reading this filth:
The Nature site which invited award nomination from Spain, was gone as well. This was the awarding committee, according to residues that site left Google search and this source:
Chair of the judges: Josep Penuelas, Center for Ecological Research and Forestry Applications (CREAF) – National Research Council (CSIC), Barcelona
Judging panel:
Alison Abbott, Nature, Munich, Germany
Emilia R. Solano, CIEMAT, Madrid, Spain
Juan Lerma, Instituto de Neurociencias de Alicante – UMH, Alicante, Spain
Mariano Barbacid, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain
Pilar Ruiz Lapuente, Institute of Cosmos Sciences, University of Barcelona, Barcelona, Spain
For some reason, jury member Alison Abbot failed to mention her decisive role in her follow-up Nature article, while the past one listing her as member of the judging panel was deleted.
When issuing the award, Sir Philip said about Lopez-Otin:
“Spain’s great examples are no exception – they are extraordinary in their ability to nurture emerging scientists of great diversity.”
Extraordinary re-use of a loading control indeed, in this paper from Lopez-Otin lab:
Alison Abbot, who was one of the judges, later wrote in this Nature article:
“López-Otín’s mentees praised his ability to draw out and encourage even the shyest lab member. “Carlos gave me the strength to pursue an independent career as a principal investigator,” one wrote. “He made me feel that my career was a priority for him, and it is thanks to him that my career has advanced further than I would ever have imagined.” Another noted how López-Otín had encouraged trainees to read widely and think big. “Carlos told me that ground-breaking work comes from broad scientific knowledge, while overspecialization is the path to small science.”
Nominators said that López-Otín insisted on celebrating every accepted paper or project in the lab and was widely generous with advice”.
One wonders, how was this copy-pasting on the background, apparently required in order to get this paper accepted, celebrated?
Another quote from the Nature article by Alison Abbot:
“Carlos has been a constant catalyst of scientific activities in Asturias, a region marked by decades of economic and social distress,” wrote one of his mentees”.
In this vein, was prompting people to clone gel bands part of those catalytic activities of the mentorship award-winner Lopez-Otin?
Even Sir Philip’s own Nature family wasn’t spared of Lopez-Otis irregularities. This PubPeer post discusses Soria-Valles et al, Nature Cell Biology, 2015, and how the provided original blot images in the supplementary data do not match their published figure counterparts.
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http://www.primaciatv.es/actor-antonio-banderas-bioquimico-carlos-lopez-otin-abriran-la-ceremonia-los-premios-fundacion-princesa-girona/
“El actor Antonio Banderas y el bioquímico Carlos López-Otín abrirán la ceremonia de los Premios Fundación Princesa de Girona”.
You have to give credit to Carlos López-Otín, he is also an “actor”.
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J Biol Chem. 1999 Feb 19;274(8):4570-6.
Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members.
Velasco G1, Pendás AM, Fueyo A, Knäuper V, Murphy G, López-Otín C.
Author information
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain.
See: https://i.imgur.com/iQugL8A.png
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I had thought that “Wandering Western Blot Syndrome” was confined to Brazilian diabetes researchers, but evidently it is spreading!
https://pubpeer.com/publications/CD3325D6086BF005D1C72E75ED722D#11
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Treaty of Tordesillas divided the newly “discovered” lands outside Europe between the Portuguese Empire and the Crown of Castile (present day Spain), along a meridian 370 leagues west of the Cape Verde islands, off the west coast of Africa. In effect, Portugal colonized what is now Brazil, Spain colonized most of the rest of South America. In this case we are seeing Spain. The spreading goes from the East to West.
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J Biol Chem. 1994 Oct 28;269(43):27136-42.
Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues.
Velasco G1, Ferrando AA, Puente XS, Sánchez LM, López-Otín C.
Author information
Departamento de Biología Funcional, Universidad de Oviedo, Spain.
See: https://i.imgur.com/j4J7rJS.png
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My count so far (after following Zebedee’s lead) has the wandering Northern-blot Actin controls appearing in:
1. “Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues” (1994).
J Biol Chem. 1994 Oct 28;269(43):27136-42.
“Cloning and expression analysis of a novel human serine hydrolase with sequence similarity to prokaryotic enzymes involved in the degradation of aromatic compounds” (1995)
JBC 270, 12926-12932.
10.1074/jbc.270.21.12926
“Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution” (1997).
J Biol Chem. 1997 Feb 14;272(7):4281-6.
“Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location” (1998).
J Biol Chem. 1998 Jul 3;273(27):16816-23.
“Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members” (1999).
J Biol Chem. 1999 Feb 19;274(8):4570-6.
“Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain” (1999).
J Biol Chem. 1999 May 14;274(20):13800-9
“Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors”.
Cancer Research (2000).
“Identification, Characterization, and Intracellular Processing of ADAM-TS12, a Novel Human Disintegrin with a Complex Structural Organization Involving Multiple Thrombospondin-1 Repeats” (2001).
Journal of Biological Chemistry (2001) : 10.1074/jbc.M100534200
“Matriptase-2, a Membrane-bound Mosaic Serine Proteinase Predominantly Expressed in Human Liver and Showing Degrading Activity against Extracellular Matrix Proteins” (2002).
Journal of Biological Chemistry (2002) – 10.1074/jbc.M203007200
“Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product” (2003).
Proc Natl Acad Sci U S A. 2003 Aug 5; 100(16): 9185–9190.
“Human Autophagins, a Family of Cysteine Proteinases Potentially Implicated in Cell Degradation by Autophagy” (2003).
Journal of Biological Chemistry (2003) – 10.1074/jbc.M208247200
“Identification of Human Aminopeptidase O, a Novel Metalloprotease with Structural Similarity to Aminopeptidase B and Leukotriene A4 Hydrolase” (2005).
Journal of Biological Chemistry (2005) – 10.1074/jbc.M413222200
“Human Polyserase-2, a Novel Enzyme with Three Tandem Serine Protease Domains in a Single Polypeptide Chain” (2005).
Journal of Biological Chemistry (2005) – 10.1074/jbc.M409139200
“Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain” (2006).
BMC Biochemistry (2006) – 10.1186/1471-2091-7-9
More precisely, there are four versions of the Actin band… one for fetal tissues with four lanes; and two for adult tissues and one for tumor cell lanes, each with eight lanes. Lanes are sometimes labelled consistently. Not all of the bands always appear in a single paper. They undergo occasional horizontal or vertical flips and stretching, and sometimes lose lanes from the ends or even the middle.
Have I missed any?
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It would be informative to collect and put all the doubtful images of Lopez-Otin’s papers in a single place, so others could forsee the ‘impact’ of his study at a glance.
Gather images in a bundle of imgur links. Appreciate if one could check and re-put images in imgur links at pubpeer.
NF-κB activation impairs somatic cell reprogramming in ageing
Nature Cell Biology (2015) – 12 Comments
doi: 10.1038/ncb3207 issn: 1465-7392 issn: 1476-4679 pubmed: 26214134
Clara Soria-Valles , Fernando G. Osorio , Ana Gutiérrez-Fernández , Alejandro De Los Angeles , Clara Bueno , Pablo Menéndez , José I. Martín-Subero , George Q. Daley , José M. P. Freije , Carlos López-Otín
Figure 3.
Figure 6
Figure 6
Identification and Characterization of Human and Mouse Ovastacin
Journal of Biological Chemistry (2004) – 4 Comments
pubmed: 15087446 doi: 10.1074/jbc.M401588200 issn: 0021-9258 issn: 1083-351X
Víctor Quesada , Luis M. Sánchez , Jesús Alvarez , Carlos López-Otín
Figure 4.
Human Autophagins, a Family of Cysteine Proteinases Potentially Implicated in Cell Degradation by Autophagy
Journal of Biological Chemistry (2003) – 6 Comments
pubmed: 12446702 doi: 10.1074/jbc.M208247200 issn: 0021-9258 issn: 1083-351X
Guillermo Mariño , José A Uría , Xose S. Puente , Vı́ctor Quesada , Javier Bordallo , Carlos López-Otín
Figure 8
Figure 3 continued.
Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors
Cancer Research (2000) – 11 Comments
pubmed: 10706098 issn: 0008-5472
G Velasco , S Cal , A Merlos-Suárez , A A Ferrando , S Alvarez , A Nakano , J Arribas , C López-Otín
Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain
BMC Biochemistry (2006) – 5 Comments
pubmed: 16566820 doi: 10.1186/1471-2091-7-9 issn: 1471-2091
Santiago Cal , Juan R Peinado , María Llamazares , Víctor Quesada , Angela Moncada-Pazos , Cecilia Garabaya , Carlos López-Otín
To be continued.
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Identification of Human Aminopeptidase O, a Novel Metalloprotease with Structural Similarity to Aminopeptidase B and Leukotriene A Hydrolase
Journal of Biological Chemistry (2005) – 2 Comments
pubmed: 15687497 doi: 10.1074/jbc.M413222200 issn: 0021-9258 issn: 1083-351X
Araceli Díaz-Perales , Víctor Quesada , Luis M. Sánchez , Alejandro P. Ugalde , María F. Suárez , Antonio Fueyo , Carlos López-Otín
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Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain
Journal of Biological Chemistry (1999) – 3 Comments
pubmed: 10318784 issn: 0021-9258
I Santamaría , G Velasco , A M Pendás , A Paz , C López-Otín
Figure 5
Figure 6
bands are wandering to other papers.
Human Polyserase-2, a Novel Enzyme with Three Tandem Serine Protease Domains in a Single Polypeptide Chain
Journal of Biological Chemistry (2005) – 2 Comments
pubmed: 15536082 doi: 10.1074/jbc.M409139200 issn: 0021-9258 issn: 1083-351X
Santiago Cal , Víctor Quesada , María Llamazares , Araceli Díaz-Perales , Cecilia Garabaya , Carlos López-Otín
Figure 3
Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors
Cancer Research (2000) – 12 Comments
pubmed: 10706098 issn: 0008-5472
G Velasco , S Cal , A Merlos-Suárez , A A Ferrando , S Alvarez , A Nakano , J Arribas , C López-Otí
Figure 4
NF-κB activation impairs somatic cell reprogramming in ageing
Nature Cell Biology (2015) – 13 Comments
doi: 10.1038/ncb3207 issn: 1465-7392 issn: 1476-4679 pubmed: 26214134
Clara Soria-Valles , Fernando G. Osorio , Ana Gutiérrez-Fernández , Alejandro De Los Angeles , Clara Bueno , Pablo Menéndez , José I. Martín-Subero , George Q. Daley , José M. P. Freije , Carlos López-Otín
Supplementary figure 8.
Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members
Journal of Biological Chemistry (1999) – 1 Comment
pubmed: 9988691 issn: 0021-9258
G Velasco , A M Pendás , A Fueyo , V Knäuper , G Murphy , C López-Otín
Figure 6
Matriptase-2, a Membrane-bound Mosaic Serine Proteinase Predominantly Expressed in Human Liver and Showing Degrading Activity against Extracellular Matrix Proteins
Journal of Biological Chemistry (2002) – 7 Comments
pubmed: 12149247 doi: 10.1074/jbc.M203007200 issn: 0021-9258 issn: 1083-351X
Gloria Velasco , Santiago Cal , Victor Quesada , Luis M. Sánchez , Carlos López-Otín
Figure 8
Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location
Journal of Biological Chemistry (1998) – 1 Comment
pubmed: 9642240 issn: 0021-9258
I Santamaría , G Velasco , A M Pendás , A Fueyo , C López-Otín
Figure 5
Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues
Journal of Biological Chemistry (1994) – 1 Comment
pubmed: 7929457 issn: 0021-9258
G Velasco , A A Ferrando , X S Puente , L M Sánchez , C López-Otín
Figure 5
To be continued.
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Not just Nature rewards data manipulation, but the European Research Council also rewards data manipulation.
Click to access ERC-2016-AdG-results-all-domains.pdf
Page 8.
ERC Advanced Grants 2016
LOPEZ OTIN Carlos
Universidad de Oviedo
University of Oviedo ES DeAge
Deconstructing Ageing: from molecular mechanisms to intervention strategies
LS4
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J Immunol. 2012 Oct 15;189(8):4135-43. doi: 10.4049/jimmunol.1103739. Epub 2012 Sep 7.
Control of allergen-induced inflammation and hyperresponsiveness by the metalloproteinase ADAMTS-12.
Paulissen G1, El Hour M, Rocks N, Guéders MM, Bureau F, Foidart JM, Lopez-Otin C, Noel A, Cataldo DD.
Author information
Laboratory of Tumor and Developmental Biology, Interdisciplinary Group of Applied Genoproteomics-Cancer (GIGA-Cancer), University of Liège and University Hospital of Liège, 4000 Liège, Belgium.
Figure 3B. https://imgur.com/08ANZ5K
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Am J Respir Cell Mol Biol. 2010 Sep;43(3):286-95. doi: 10.1165/rcmb.2008-0426OC. Epub 2009 Oct 20.
Matrix metalloproteinase-19 deficiency promotes tenascin-C accumulation and allergen-induced airway inflammation.
Maud M. Gueders 1,2, Stuart J. Hirst 3, Florence Quesada-Calvo 1,2, Geneviève Paulissen 1,2, Jonathan Hacha 1,2, Christine Gilles 1, Philippe Gosset 4, Renaud Louis 2, Jean-Michel Foidart 1, Carlos Lopez-Otin 5, Agnes Noël 1, and Show All…
1Laboratory of Tumor Biology and Development, and 2Department of Respiratory Diseases, GIGA-I3 and GIGA Cancer, GIGA Research, University of Liege and Centre Hospitalier Universitaire, CHU-Liege, Liege, Belgium; 3Department of Physiology, Monash University, Melbourne, Australia; 4Unité INSERM U774, Institut Pasteur de Lille, Lille, France; and 5Departamento de Bioquimica y Biologia Molecular, Instituto Universitario de Oncologia, Universidad de Oviedo, Oviedo, Spain.
Figure 6A. https://imgur.com/mLTiYJu
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Expression of collagenase-3 in the rat ovary during the ovulatory process
Journal of Endocrinology (1996) – 1 Comment
pubmed: 8691099 issn: 0022-0795
M Balbín , A Fueyo , J M López , I Díez-Itza , G Velasco , C López-Otín
Hormonal regulation of the human pepsinogen C gene in breast cancer cells. Identification of a cis-acting element mediating its induction by androgens, glucocorticoids, and progesterone
Journal of Biological Chemistry (1996) – 1 Comment
pubmed: 8663058 issn: 0021-9258
M Balbín , C López-Otín
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Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
Nature (2005) – 1 Comment
pubmed: 16079796 doi: 10.1038/nature04019 issn: 1476-4687 issn: 0028-0836
Ignacio Varela , Juan Cadiñanos , Alberto M Pendás , Ana Gutiérrez-Fernández , Alicia R Folgueras , Luis M Sánchez , Zhongjun Zhou , Francisco J Rodríguez , Colin L Stewart , José A Vega , Karl Tryggvason , José M P Freije , Carlos López-Otín
Control of Allergen-Induced Inflammation and Hyperresponsiveness by the Metalloproteinase ADAMTS-12
The Journal of Immunology (2012) – 2 Comments
pubmed: 22962682 doi: 10.4049/jimmunol.1103739 issn: 1550-6606 issn: 0022-1767
Geneviève Paulissen , Mehdi El Hour , Natacha Rocks , Maud M Guéders , Fabrice Bureau , Jean-Michel Foidart , Carlos Lopez-Otin , Agnès Noel , Didier D Cataldo
Figure 3
Matrix Metalloproteinase-19 Deficiency Promotes Tenascin-C Accumulation and Allergen-Induced Airway Inflammation
American Journal of Respiratory Cell and Molecular Biology (2010) – 2 Comments
pubmed: 19843707 doi: 10.1165/rcmb.2008-0426OC issn: 1535-4989 issn: 1044-1549
Maud M. Gueders , Stuart J. Hirst , Florence Quesada-Calvo , Geneviève Paulissen , Jonathan Hacha , Christine Gilles , Philippe Gosset , Renaud Louis , Jean-Michel Foidart , Carlos Lopez-Otin , Agnes Noël , Didier D. Cataldo
Figure 6
Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors
Cancer Research (1999) – 5 Comments
pubmed: 10363975 issn: 0008-5472
E Llano , A M Pendás , J P Freije , A Nakano , V Knäuper , G Murphy , C López-Otin
Figure 5
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Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases
Biochemical and Biophysical Research Communications – 1 Comment
doi: 10.1016/j.bbrc.2003.12.050 issn: 0006-291X
Vı́ctor Quesada , Araceli Dı́az-Perales , Ana Gutiérrez-Fernández , Cecilia Garabaya , Santiago Cal , Carlos López-Otı́n
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Nature. 2005 Sep 22;437(7058):564-8. Epub 2005 Aug 3.
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.
Varela I1, Cadiñanos J, Pendás AM, Gutiérrez-Fernández A, Folgueras AR, Sánchez LM, Zhou Z, Rodríguez FJ, Stewart CL, Vega JA, Tryggvason K, Freije JM, López-Otín C.
Author information
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.
Much more similar than you would expect.
See: https://i.imgur.com/Ttj0XoS.png
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According to “Fundación GADEA por la Ciencia”, http://gadeaciencia.org/en/the-foundation/board/
of which the President Scientific Advisory Counsil (website’s typo), is the prominent scientist Mariano Barbacid, and the scientific advisory council http://gadeaciencia.org/en/scientific-advisory-council/includes of which includes such prominent members as:-
Out of Spain section.
1. Carlos Cordon-Cardo, (2017 retraction of 2003 paper http://mcb.asm.org/content/37/18/e00365-17.short “Digital experts have informed us that some of the published data in this paper were very likely digitally manipulated.”, but could not figure it out himself, which does suggest the question of his being about to advise anybody else about authenticity, or being able to judge data),
2. Salvador “4 retractions” Moncada, who had 3 retractions in his group at UCL, https://retractionwatch.com/2012/09/04/three-retractions-for-university-college-london-mitochondrial-biologist-for-inappropriate-figure-manipulations/, under somebody’s nose does not suggest competency at being a judge, and one retraction delayed 17 years at Harvard. https://retractionwatch.com/2012/09/10/ori-findings-lead-to-two-retractions-nearly-17-years-later/, this particular retraction: http://www.jimmunol.org/content/189/6/3260.full
In Spain section.
3. Manel Esteller, who is well documented at Pubpeer:
https://pubpeer.com/search?q=manel+estellerpubpeer
3. Pura Muñoz-Canoves, who is also well-documented at Pubpeer:
https://pubpeer.com/search?q=Mu%C3%B1oz-Canoves
Last, but not least. Carlos Lopez-Otin.
Carlos Lopez-Otin
http://gadeaciencia.org/teams/lopez-otin-carlos-2/
“The work of López-Otín’s laboratory has yielded the identification of more than 60 novel human proteases dysregulated in cancer and defined their functional role in cancer and in other pathological processes, including the devastating syndromes of accelerated aging.”
His data are in conflict with those claims.
It is not obvious if being a “Team” means that you are funded by “Fundación GADEA por la Ciencia”.
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Cancer Res. 1996 Apr 15;56(8):1746-50.
Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance.
Ferrando AA1, Velasco G, Campo E, Lopez-Otin C.
Author information
Departmento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Oviedo, Spain.
See: https://i.imgur.com/kBKnOAQ.png
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Blood. 1997 Jan 1;89(1):272-80.
Deletions and loss of expression of p16INK4a and p21Waf1 genes are associated with aggressive variants of mantle cell lymphomas.
Pinyol M1, Hernandez L, Cazorla M, Balbín M, Jares P, Fernandez PL, Montserrat E, Cardesa A, Lopez-Otín C, Campo E.
Author information
Department of Anatomic Pathology, Hospital Clinic Provincial, University of Barcelona, Spain.
Figure 1. Differential splicing between panels dilutes meaning.
See: https://i.imgur.com/znY6avC.png
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http://www.elmundo.es/ciencia/2016/07/24/579272dc268e3e8a788b4654.html
“Carlos López Otín: “España es una sociedad sin afición por la ciencia” “.
He should speak for himself.
Is it a plea for help?
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J Biol Chem. 2012 Nov 16;287(47):39554-63. doi: 10.1074/jbc.M112.408625. Epub 2012 Sep 27.
ADAMTS-12 metalloprotease is necessary for normal inflammatory response.
Moncada-Pazos A1, Obaya AJ, Llamazares M, Heljasvaara R, Suárez MF, Colado E, Noël A, Cal S, López-Otín C.
Author information
Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain.
2018 correction.
http://www.jbc.org/content/293/29/11648.short
Fig. 3C did not indicate the borders between different sections of the same gel for the calprotectin, S100A8, and S100A9 immunoblots from day 8. The actin immunoblots were electrophoresed on parallel gels. This error has now been corrected and does not affect the results or conclusions of this work.
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J Biol Chem. 2008 Apr 4;283(14):9465-74. doi: 10.1074/jbc.M709522200. Epub 2008 Feb 1.
Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice.
Folgueras AR1, Fueyo A, García-Suárez O, Cox J, Astudillo A, Tortorella P, Campestre C, Gutiérrez-Fernández A, Fanjul-Fernández M, Pennington CJ, Edwards DR, Overall CM, López-Otín C.
Author information
1
Departamento de Bioquímica y Biología Molecular, and Biología Funcional, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, and Servicio de Anatomía Patológica, Hospital Central de Asturias, Oviedo 33006, Spain.
2018 correction.
http://www.jbc.org/content/293/30/11968.short
For clarity, upon assembly of Figs. 4, 5A, and 8B, corresponding to a dissection of mouse spinal cords, torn fragments of adjacent tissue that were incompletely removed during manual dissection were eliminated digitally, leaving only the spinal cord tissue under study. The unprocessed versions of these figures are shown without this modification. Additionally, an incorrect image was shown in Fig. 4O. These errors have now been corrected and do not affect the results or conclusions of this work.
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The issues need MORE attension. Integrity of JBC could be in doubt. Unfortunate that Carlos Lopez-Otin escapes from his misconduct dealt doen with mere correction.
@jbiolchem
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