In Spain, there seems to be a tradition of reacting to emerging evidence of data manipulation with handing out prestigious awards to authors of these papers. This is how we were all taught that all the PubPeer evidence matters nothing whatsoever, as Pura Munoz-Canoves, Maria Pia Cosma and Manel Esteller were celebrated with prizes and grants for their research achievements (read here , here and here). Now there is a new popular academic hero in Spain, Carlos López-Otín, Professor of Biochemistry and Molecular Biology at the University of Oviedo, and EMBO member. Lopez-Otin was now awarded a 2017 Mentoring Award, presented to him by Sir Philip Campbell, on behalf of his journal Nature, which Editor-in-Chief Sir Philip has been for the last 22 years.
The journal Nature remains the highest authority in science, this Mentoring Award is Sir Philip’s parting present to the Nature-reading scientific community, as he is being promoted inside Springer Nature’s publishing hierarchy. It is in this way a statement of what Nature and its publisher think of research integrity. Lopez-Otin’s evidence record on PubPeer is telling enough, however most of the evidence of digitally manipulated gel images there was posted around 2-3 months ago, by the pseudonymous Claire Francis. Maybe the evidence appeared too late, and the award decision couldn’t be stopped anymore. Which would explain why Nature deleted their own tweet announcing the mentorship awards after I replied to it with PubPeer evidence on Lopez-Otin’s papers. According to another Nature website, which was for some reason also deleted, the closing date for nominations was Monday 31 July 2017. So I share some examples below, all are from papers where Lopez-Otin is last and corresponding author.

Nature tweeted the article about mentorship awards in Spain, to which I replied. Unlike with other social media, you cannot remove replies to your tweets if you disagree with those. Pop, the original Nature tweet was deleted, Nature followers on Twitter were then spared reading this filth:
The Nature site which invited award nomination from Spain, was gone as well. This was the awarding committee, according to residues that site left Google search and this source:
Chair of the judges: Josep Penuelas, Center for Ecological Research and Forestry Applications (CREAF) – National Research Council (CSIC), Barcelona
Judging panel:
Alison Abbott, Nature, Munich, Germany
Emilia R. Solano, CIEMAT, Madrid, Spain
Juan Lerma, Instituto de Neurociencias de Alicante – UMH, Alicante, Spain
Mariano Barbacid, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain
Pilar Ruiz Lapuente, Institute of Cosmos Sciences, University of Barcelona, Barcelona, Spain

For some reason, jury member Alison Abbot failed to mention her decisive role in her follow-up Nature article, while the past one listing her as member of the judging panel was deleted.

When issuing the award, Sir Philip said about Lopez-Otin:
“Spain’s great examples are no exception – they are extraordinary in their ability to nurture emerging scientists of great diversity.”
Extraordinary re-use of a loading control indeed, in this paper from Lopez-Otin lab:

Alison Abbot, who was one of the judges, later wrote in this Nature article:
“López-Otín’s mentees praised his ability to draw out and encourage even the shyest lab member. “Carlos gave me the strength to pursue an independent career as a principal investigator,” one wrote. “He made me feel that my career was a priority for him, and it is thanks to him that my career has advanced further than I would ever have imagined.” Another noted how López-Otín had encouraged trainees to read widely and think big. “Carlos told me that ground-breaking work comes from broad scientific knowledge, while overspecialization is the path to small science.”
Nominators said that López-Otín insisted on celebrating every accepted paper or project in the lab and was widely generous with advice”.
One wonders, how was this copy-pasting on the background, apparently required in order to get this paper accepted, celebrated?

Another quote from the Nature article by Alison Abbot:
“Carlos has been a constant catalyst of scientific activities in Asturias, a region marked by decades of economic and social distress,” wrote one of his mentees”.
In this vein, was prompting people to clone gel bands part of those catalytic activities of the mentorship award-winner Lopez-Otin?

Even Sir Philip’s own Nature family wasn’t spared of Lopez-Otis irregularities. This PubPeer post discusses Soria-Valles et al, Nature Cell Biology, 2015, and how the provided original blot images in the supplementary data do not match their published figure counterparts.

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For sure artistic creativity must be compensated….indeed a good part of a PhD in Spain is dedicated how to do the best Adobe Photoshop artistic jobs….
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Well Ana,
Sounds like you speak from experience, as, to the best of my knowldege, you are supporting such an UNTRUE statement by no evidence appart from your own PhD (and perhaps someone else’s in your environment?) in Spain.
Bottom line: you are just fabricating the data on which you based your conclusions. Therefore, in the light of your affirmation, I could probably say that you did a great PhD in Spain, right?. Good for you then!!
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Dear Manuel
Indeed I did a great, fair and clean PhD in Spain and I am truly thankful to a couple of Spanish who helped me in their painful crusade against their own system
Everybody knows about how the system works in Spain and most of the academics are afraid of talking fearing represalies
In Portugal the system is similar, fortunately we have an research fellows association who intends to defend their rights, ABIC with many difficulties
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Dear Ana,
I cannot do other thing that support Manuel and feel sorry for the pathetic environment you had on your PhD, mine, also in Spain, was full of amazing scientists, that were able to publish in very good journal with much less support than other countries. I learnt very good science, how to be a good scientist, and testimony of that is the good job I am doing outside Spain. I’m super proud, and it was here in UK the first time I faced lies in science and had to live with it. You are an arrogant and an ignorant by thinking that you were the only honest scientist in Spain or one of the “few”…keep doing that thinking you are the best, that kind of humility and respect to others is exactly what a good scientist should be…
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Yes, they should replicate the Portuguese system.
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You have to congratulate Nature on bringing the data manipulation to public attention.
Nature may be unwitting, but it does have high impact.
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In reply to Isabel January 10, 2018 at 18:05
“Spain, was full of amazing scientists”
Care to name a few?
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With that question you don’t even deserve an answer…
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Dear Isabel,
I am still waiting you to name 20 “amazing scientists” in Spain.
It should not be difficult as you wrote that “Spain, was full of amazing scientists”.
If you cannot name 20 where have they gone?
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I hope we could end this debate by agreeing there are in fact quite a lot of very good scientists in Spain, but under current conditions they must live in fear of their dishonest peers who accumulate power, grants and awards. An award given to these cheaters is not just a meaningless cup or a medal. It is a sign who enjoys protection from the very top. Spain as a former oppressive dictatorship surely knows how this works.
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“Spain as a former oppressive dictatorship surely knows how this works.” If I had any interest in this blog, this kind of bigoted and scientific statement unveils who you really are.
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No, you wrote that “Spain was full, of amazing scientists”. Name 20.
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You know there are 20 and more. Yes, those that you mention are not part of that group. What else do you need?
What is your plan to improve the scientific environment in Spain? Write helpful stuff that can be applied, hopefully without prejudice and racism. Don’t let your anger take the best of you.
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Dear Angela,
Many feel that scrutiny is not nice.
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Yolanda Revilla.
http://www.cbm.uam.es/joomla-rl/index.php/en/research/scientific-departments/virology-and-microbiology?id=691
https://pubpeer.com/publications/D5D1F1DCC207C82E0888E921627AA5
https://pubpeer.com/publications/86A3C0F9F2D138C79192A527730EEA
https://pubpeer.com/publications/3F53F9301766DAA28FA092AC1832CC
https://pubpeer.com/publications/C6177B50409C1846E07202A052F590
https://pubpeer.com/publications/6BDB25D8179779C2F176CF22776952
https://pubpeer.com/publications/468C9F2FEC0C12762A4469269BC6C7
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Maria Gasset.
Instituto Química-Física Rocasolano, Consejo Superior de Investigaciones Científicas, Serrano 119, 28006 Madrid, Spain.
https://pubpeer.com/search?q=gasset
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Manuel Benito.
https://www.ucm.es/biomol2/directorio?id=2663
https://pubpeer.com/search?q=manuel+benito
http://retractionwatch.com/2017/04/25/harvard-diabetes-researcher-retracts-third-paper/
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Mireia Dunach.
http://uab.academia.edu/MireiaDuñach
https://pubpeer.com/search?q=+dunach
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Antonio Celada.
https://www.researchgate.net/profile/Antonio_Celada
https://pubpeer.com/search?q=celada
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Susana Gonzalez.
http://retractionwatch.com/2017/09/18/stem-cell-scientist-appealing-dismissal-loses-another-paper/
http://retractionwatch.com/2016/03/07/stem-cell-researcher-in-spain-dismissed-following-investigation/
https://elpais.com/elpais/2016/03/04/ciencia/1457090679_248492.html
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Jose M Rojas.
http://www.isciii.es/ISCIII/es/contenidos/fd-el-instituto/fd-organizacion/fd-estructura-directiva/fd-subdireccion-general-servicios-aplicados-formacion-investigacion/fd-centros-unidades/fd-unidad-funcional-de-investigacion-de-enfermedades-cronicas/fd-areas-y-unidades-UFIEC/unidad-de-biologia-celular.shtml
https://pubpeer.com/publications/89582C2164A1D9F4764540B7A83E2B
https://pubpeer.com/publications/C20FE9AAE2120DFC44CFCB7DFDB6F2
https://pubpeer.com/publications/F0E03F9AD1B066658E1605341A3D4E
https://pubpeer.com/publications/E37EB191FB71797127BF586EBDCC11
https://pubpeer.com/publications/D6ABBDA2D87FF215C2083F2C9EC576
https://pubpeer.com/publications/A18472472618ADF24C65BD6BF010DC
https://pubpeer.com/publications/86B96C3D8A46010B7DF4E7D25CB4DD
https://pubpeer.com/publications/36548E08E70595A39B3D2A79BBB852
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Margarita Lorenzo.
Dead, but they should clear up the problematic data,
https://elpais.com/diario/2010/04/17/necrologicas/1271455201_850215.html
and not do virtue signalling
https://www.fundacionlilly.com/es/actividades/premios-fundacion-lilly/premio-margarita-lorenzo.aspx
https://pubpeer.com/search?q=margarita+lorenzo
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Felix Bonilla.
https://www.pubfacts.com/author/Felix+Bonilla
Hospital Universitario Puerta de Hierro
https://pubpeer.com/search?q=felix+bonilla
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Antonio Garcia de Herreros.
https://www.imim.cat/programesrecerca/cancer/en_ubcm.html
https://pubpeer.com/publications/BDEB1BEC0F27AC6D5AFDD0D0E980F7
https://pubpeer.com/publications/D9AB005FB5B07483BC12C2C0DFB454
https://pubpeer.com/publications/5A785B0CF23403E24C25D3C43111FB
https://pubpeer.com/publications/981BDA5DB6DFD80DCC41AEF1808BE9
https://pubpeer.com/publications/BEB69B48326037191631A1B13D607C
https://pubpeer.com/publications/4166CB88F57104A834DDEF71515EEC
https://pubpeer.com/publications/A8F3E69DACCF638411E66257F47A9F
https://pubpeer.com/publications/447EC5BFD11D3D1D947100DAB271F9
https://pubpeer.com/publications/2EB431B880F997FBCDB5A4E48927FD
https://pubpeer.com/publications/034CC3FA793059AD615B5A5D80BD84
https://pubpeer.com/publications/95D7EDC45C43706AB46E45AE03F1A1
https://pubpeer.com/publications/7A2D9BBDCE85623CB4824CA04077E0
https://pubpeer.com/publications/07643B5654697153BE6504D2C3F966
https://pubpeer.com/publications/2F0AF28466D2E1D31510ACC72794F1
https://pubpeer.com/publications/8A9B324060E1673639C5114CC0F3C5
https://pubpeer.com/publications/77ACF5E0CB3F2BB5DEAF2019B0CCE3
https://pubpeer.com/publications/C82AD606E1FE4DE152DA1D1796DE7B
https://pubpeer.com/publications/AE72300768ECE0EA987B4842EB30CA
https://pubpeer.com/publications/0E155718533A0156BBEAD8E8D59A0C
https://pubpeer.com/publications/0A32B29DEA2D2B0A10F4F362F55CD4
https://pubpeer.com/publications/E2D2996937DCDDAF9559725FDFDC95
https://pubpeer.com/publications/0E99B1B3B43B7D6917347AAA23EE7B
https://pubpeer.com/publications/42E81CC060E1BEA09DB2F7AAC9E484
https://pubpeer.com/publications/A62C2A767B8A9A60229DD116BCBB0D
https://pubpeer.com/publications/03C59A9C6383C9E70C9EEA7E056336
https://pubpeer.com/publications/DD8A003880FB4B4E2CE5218FD971D8
https://pubpeer.com/publications/7B8A5F590BF1468283CC3FE7D6BBCA
https://pubpeer.com/publications/E3471375942FBF3B5CBA8C3AC0C551
https://pubpeer.com/publications/7D64B99471B2AE86604500FC8D6569
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J Biol Chem. 2004 Jun 18;279(25):26627-34. Epub 2004 Apr 15.
Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish.
Quesada V1, Sánchez LM, Alvarez J, López-Otín C.
Author information
1
Departamento de Bioquimica y Biologia Molecular and Morfologia y Biologia Celular, Facultad de Medicina, Instituto Universitario de Oncologia, Universidad de Oviedo, 33006-Oviedo, Spain.
Figure 4. https://imgur.com/ZzWbrk5
Figure 3, see: https://pubpeer.com/publications/A2392B5A5FD19456E8AD74A68FCF80
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NF-κB activation impairs somatic cell reprogramming in ageing
Nature Cell Biology (2015) – 4 Comments
doi: 10.1038/ncb3207 issn: 1465-7392 issn: 1476-4679 pubmed: 26214134
Clara Soria-Valles , Fernando G. Osorio , Ana Gutiérrez-Fernández , Alejandro De Los Angeles , Clara Bueno , Pablo Menéndez , José I. Martín-Subero , George Q. Daley , José M. P. Freije , Carlos López-Otín
https://pubpeer.com/publications/836AB3A8AB4FD562A2D4CBFBF8ED18
Figure 2, 6, 7.
https://pubpeer.com/publications/836AB3A8AB4FD562A2D4CBFBF8ED18#1
Figure 3.
https://pubpeer.com/publications/836AB3A8AB4FD562A2D4CBFBF8ED18#3
Figure 7.
https://pubpeer.com/publications/836AB3A8AB4FD562A2D4CBFBF8ED18#2
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Still arguments continue on the paper of Soria-Valles et al…
NF-κB activation impairs somatic cell reprogramming in ageing
Nature Cell Biology (2015) – 4 Comments
doi: 10.1038/ncb3207 issn: 1465-7392 issn: 1476-4679 pubmed: 26214134
Clara Soria-Valles , Fernando G. Osorio , Ana Gutiérrez-Fernández , Alejandro De Los Angeles , Clara Bueno , Pablo Menéndez , José I. Martín-Subero , George Q. Daley , José M. P. Freije , Carlos López-Otín
https://pubpeer.com/publications/836AB3A8AB4FD562A2D4CBFBF8ED18#10
Figure 6

Supplementary figure 6
https://pubpeer.com/publications/836AB3A8AB4FD562A2D4CBFBF8ED18#9
Supplementary figure 8
https://pubpeer.com/publications/836AB3A8AB4FD562A2D4CBFBF8ED18#5
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Similarities between three Lopez-Otin papers:-
Cancer Res. 2000 Feb 15;60(4):877-82.
Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors.
Velasco G1, Cal S, Merlos-Suárez A, Ferrando AA, Alvarez S, Nakano A, Arribas J, López-Otín C.
Author information
Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Oviedo, Spain.
J Biol Chem. 2002 Oct 4;277(40):37637-46. Epub 2002 Jul 30.
Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins.
Velasco G1, Cal S, Quesada V, Sánchez LM, López-Otín C.
Author information
Departamento de Bioquimica y Biologia Molecular, Instituto Universitario de Oncologia, Universidad de Oviedo, 33006 Oviedo, Spain.
J Biol Chem. 2003 Feb 7;278(6):3671-8. Epub 2002 Nov 21.
Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy.
Mariño G1, Uría JA, Puente XS, Quesada V, Bordallo J, López-Otín C.
Author information
Departamento de Bioquimíca y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, Spain.
See: https://i.imgur.com/PEdywou.png
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J Biol Chem. 2005 Jan 21;280(3):1953-61. Epub 2004 Nov 9.
Human polyserase-2, a novel enzyme with three tandem serine protease domains in a single polypeptide chain.
Cal S1, Quesada V, Llamazares M, Díaz-Perales A, Garabaya C, López-Otín C.
Author information
1
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.
Sample order differences between other papers and this one outlined in orange.
There are examples of re-use with sample order same.
See: https://imgur.com/D25yKrt
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