The aftermath of the Paolo Macchiarini scandal: many dead or mutilated trachea transplant patients, many stellar academic careers destroyed or damaged beyond repair, the reputation of the once world leading Karolinska Institutet (KI) in shatters and even the Nobel Prize itself is dented. The latter is because several members of the 50-head strong committee of the Nobel Prize in Physiology or Medicine were forced to resign:
- Urban Lendahl, KI professor of genetics, quit his postas Nobel Committee Secretary General already in February, due to his involvement into Macchiarini recruitment. Lendahl also used to be Macchiarini’s superior, as director of three research centres in stem cell research and regenerative medicine: DBRM, StratRegen and WIRM(the Wallenberg Institute for Regenerative Medicine).
- Hans-Gustaf Ljunggren, former KI Dean of Research resigned from this post and Nobel Committee in February 2016. Ljunggren decreedin August 2015 together with the then-Rector Anders Hamsten that Macchiarini did not commit any misconduct, and trashed the results of the Bengt Gerdin investigation.
- Katarina Le Blanc, immunology professor and Macchiarini co-author, who is apparently herself under investigation on suspicion of misconduct and data manipulation.
- Anders Hamsten and Harriet Wallberg-Henriksson were asked to resign by the new Secretary of the Nobel Assembly, Thomas Perlmann, after the KI report was published. Both ex-Rectors played a crucial role in the Macchiarini recruitment and the cover-up of his patient abuse and misconduct.
Two more members of the Committee were possibly asked to step down, but this information is not confirmed. Bo Risberg, emeritus professor of surgery at the University of Gothenburg and longstanding Macchiarini critic (see his earlier guest post for my website), proposed “a moratorium for two years to the Nobel prize” and for the award money to be donated to Macchiarini’s victims and their families.
The corrupt Ethics Council of KI was dissolved by the new Rector Karin Dahlman-Wright, other heads rolled as well. Two investigations, one by KI and one by Karolinska University Hospital revealed a culture of cover-up and disregard for basic research integrity and medical ethics. Meanwhile, the entire KI University Board was dismissed by a governmental decision.
What drove so many scientists and doctors to support Macchiarini and his outrageous visions? It seems, the driving force was, just as elsewhere in science, greed. Greed for research funding and the fame and power it brings. And Macchiarini attracted many millions of Kronen, Euros, Dollars and even Roubels, and he kept promising even more. It seems the lust for money and fame made everyone at Karolinska switch off their brains. As the result, innocent people have died.
Continue reading “Macchiarini and the bonfire of greed”
On August 24th I received an anonymous email over my website from a „Concerned Microbiologist”:
“I would like to bring the following to your attention on Robert P Ryan at the University of Dundee. https://pubpeer.com/search?q=Robert+P.+Ryan
He holds several high profile research grants and has won several awards. He is under investigation at the University of Dundee.
He has also featured in articles signing his praises in terms of his research achievements.
Only days after, on August 28th, big news broke out in Scottish and Irish media. The Scotsman brought the headline: “Leading scientist suspended amid ‘research misconduct’ investigation”. The newspaper then indicated that Ryan has to answer for suspected image manipulations in his papers:
“It is alleged he used identical images across multiple papers, claiming they were different strains. In some cases, it is alleged the evidence was flipped or rotated, which could indicate an “intent to deceive”, according to one source. The extent of the alleged misconduct is unclear, but the source indicated it is alleged to have spanned “a number of years” and involved numerous prestigious journals”.
Similar reports appeared on the same day in The Irish Times, The Courier and Herald Scotland, the latter also wrote:
“It is understood his research group at the university has been dissolved, with PhD students and staff scientists reallocated elsewhere while a formal investigation takes place”.
Continue reading “The mysterious public career execution of Robert Ryan”
This is a new instalment of my investigation into UK and EU funded clinical trials on trachea replacement by the throat surgeon Martin Birchall at UCL. The method of using bone marrow cells to regenerate a dead decellurised donor trachea was developed by Birchall together with Paolo Macchiarini, and tested since 2008 on several human patients, with catastrophic results. Macchiarini by now is a pariah sacked by his formerly proud employer, the Karolinska Institute in Sweden, but Birchall was given further millions in British and EU money for his human trachea transplant experiments.
I finally obtained the patient information brochure for such phase 1 clinical trial INSPIRE, which was consistently denied to me by all participants. The information therein, or rather the strategic lack of it and the consequential wilful misleading of prospective patients, is truly scandalous. There is no mention whatsoever of any of the previous trachea transplant experiments Birchall performed and the clinical outcome of which he likely misrepresented in order to obtain this very funding and even his current full professorship at UCL (with the help of Macchiarini, see page 43 of his CV). His described strategy of transplant preparation and implantation seems scientifically nonsensical, while suggestive of medical obfuscation and even deceit. Now that I finally received the INSPIRE patient information sheet, I understand why the consortium partners preferred in to be hidden from public scrutiny.
For the scientific and medical ethics background of this complicated case, please refer to my earlier reporting (in chronological order):
Did you ever wonder why certain zombie scientists were still in academic jobs? Despite having been caught on data manipulation or biomedical ethics breach?
It seems the answer is simpler than you thought. They are paying for their protection, by giving pizzo to their crooked research institutions, just as in some unoriginal mafia film. Well, actually YOU are paying their pizzo, through your taxes, which in turn are awarded to these zombie scientists as public research funding, from the national, international and European funding agencies. In fact, the most prestigious and self-important European funding agency ERC is completely unprepared or maybe just unwilling to respond to evidence of research misconduct by their elite grant recipients.
My understanding is provocative, and I may be utterly wrong. But absent of any reasonable alternative explanations, let us for a moment go with this one. I will provide you with examples where questionable European scientists surprisingly retained their European funding unquestioned (or even received fresh millions of Euros), and coincidently or not, many institutions did not at all mind to keep them in their jobs. Continue reading “Does ERC help cheaters pay protection money?”
The science of the fallen star of regenerative medicine Paulo Macchiarini was simple: take a dead organ, strip it of its cells and seed the carcass with stem cells (usually the magic cells from bone marrow). After some days in a “bioreactor”, you take out a living trachea, esophagus, even heart, and implant it into a patient. Another human life saved, and not only media, even scientist colleagues fell for this outrageous quackery. As the result of this hubris, several patients died, others remained in permanent critical care. Macchiarini and his partners Philipp Jungebluth, Martin Birchall and others had to fake ethics approvals as well as to lie and cheat about medical records in their publications in The Lancet, all in order to present a miserably suffering recipient of a ”regenerated” trachea as fully recovered. Animal experiments were performed only after Macchiarini’s team operated their first human patient, as indirectly evidenced by Jungebluth’s own doctorate thesis at the Medical University Hannover (MHH) in Germany.
Macchiarini began to develop his “decell-recell” method of organ regeneration while working in Hannover, close to the renowned heart surgeon and MHH clinic director, Axel Haverich (see Part 1 for the background). In 2009, the Italian cheater then moved on to a professorship at the Karolinska Institute in Stockholm, where he was showered in funding money and received best institutional protection, despite his patient abuse and his lies about his qualifications. Continue reading “Regenerating in Hannover, Part 2: Axel Haverich’s “growing” heart valves”
The European multimillion research project Human Brain Project is under fresh leadership, its visionary founder Henry Markram ousted from power. Worse, both life-and-blood projects of the neuroscience professor at the Swiss elite university EPFL are not performing as he envisioned them to. His open access publishing house Frontiers was dumped by the Nature Publishing Group and ended up with the German publisher Holtzbrinck, with neither them nor Frontiers particularly keen on boasting this property relationship. Editors and reviewers ran away or refused duty in droves, Frontiers was even fingered as a possible predatory publisher. On top of everything, Markram’s outlet stands accused of being an employee-abusing spam factory.
So much for Markram the Entrepreneur and Inventor. But he is first and foremost a scientist, whose research proposal received the biggest research funding grant in history: one billion Euros from the European Union, for his “brainchild” (as journalists dubbed it), the Human Brain Project. The modest promise Markram originally made to secure this mind-boggling mountain of cash: he intended to simulate the entire human brain in his supercomputer by 2023, the possibility of artificial consciousness specifically not excluded. Now however, his consortium partners took over, Markram was dethroned in a scientists’ coup and pushed aside to tinker on his seemingly less ambitious, but just as science-fictionary mouse Blue Brain simulation. Once in control of almost everything and everyone, with all the big money going through his hands, Markram is now only one of 12 project leaders and far from being the boss. The Human Brain Project (HBP) became instead a kind of funding network without any properly defined orientation, not even the new leaders could convincingly describe any defined goals. Instead, its main purpose seems to be now set on keeping the EU funding of almost €50 Million per year flowing. Remarkably, all this was achieved after an allegedly independent mediation by the director of an HBP-consortium partner institute; coincidentally a member scientist from this Jülich Research Centre (Forschungszentrum Jülich, located in a rural triangle between German cities Düsseldorf, Cologne and Aachen) is now the new scientific director of HBP.
This is how the dream of the brain-in-the-box grew, prospered and imploded. Continue reading “The laborious delivery of Markram’s brainchild”
The British research funder Wellcome Trust (now just Wellcome) is about to launch its own journal, where the funding recipients and their collaborators are invited to published their research free of charge (since Wellcome will be covering those costs). Wellcome Open Research will be open access (OA) and offer fully transparent post-publication peer review, i.e. all reviewer reports, manuscript versions as well as reviewer identities will be posted alongside the final articles. Manuscripts which received peer review approval will become proper research papers and feature accordingly on PubMed and other databases. Wellcome specifically invites scientists to publish negative and null results as well as databases. Importantly, the funder also promotes data sharing through “inclusion of supporting data”. The platform on which Wellcome Open Research will operate is that of F1000Research, a post-publication peer review journal which prides itself of its open science approach.
This sounds like excellent news for science, which is plagued by irreproducibility and misconduct crises, and many welcomed the Wellcome initiative, hoping that other national funding agencies in Europe, North America and elsewhere might follow. It is indeed the first serious attempt by a major western funder to move away from publisher-dependence towards a “samizdat”, a self-publishing service run exclusively for own researchers and their partners. However, a similar model of university press proved unsuccessful before and never became accepted by the scientific community. Therefore, some are sceptical that this Wellcome publishing enterprise may ever take off. Continue reading “Wellcoming the samizdat publishing revolution”