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How Andrea Cerutti molested and defiled Journal of Immunology

Spain is where dishonest research gets rewarded, with awards, grants and media fame. No wonder the New York-based immunologist Andrea Cerutti opened a second lab in Barcelona.

Spanish science transitioned from being a provincial swamp of ignorant nepotism under Franco’s fascist dictatorship to an elitist swamp of arrogant nepotism with a choke-hold on European and international research funds. Young researchers, who once returned from abroad to reform the country’s bogged-down scientific system, have grown into the provincial greedy power-clutching tyrants they have dethroned. Faculty jobs once given to family members, now go to loyal members of your scientific family. Another difference: the new science oligarchs are international and speak more languages than just the local Spanish dialect. Some are even foreigners, like the Italians Maria Pia Cosma, or the central character of this story, Andrea Cerutti. One bizarre relic which remained: the fundamentalist Catholic order Opus Dei still seems to have its hand in Spanish academia, as the recent affair around Carlos Lopez-Otin revealed (see this article and especially the comment section). In the 1980ies, one Spanish medical fraudster saved his career by joining Opus Dei, he even underwent exorcism to expel the devil which made him commit research misconduct. Who knows if this still happens.

Many countries have a problem with cheaters in science, but in Spain those cheaters are celebrated, awarded with highest honours and biggest public and industrial grants. Spanish media seems to know its place and applauds each award to a dishonest data manipulator as if nothing was out of order. Lopez-Otin is back from his Paris exile to the University of Oviedo now, he wrote a book about his Passion, and he will very likely soon get the Princess of Asturias Prize he craves so much. 

The whole conspiracy farce around his 9 retractions, which culminated with an El Pais article showing Lopez-Otin with a 23-year-old progeria patient sitting on his lap wearing an Opus Dei crucifix, made one thing clear: any Spanish scientist opening their mouth about research integrity will be burnt at stake. Cancer and degenerative diseases are to be cured with massive investments into aggressive Photoshop fraud, Spanish elites of society have agreed. 

Here are some other examples of the bizarre cult of scientific dishonesty in Spanish academia:

Recently, certain French and Spanish newspapers established that I am a German racist, a terrorist, and a harasser of women in science, further facts in that regard were extensively elaborated on Twitter. 

In this regard, I will bring here a story about an Italian haematology and immunology researcher, Andrea Cerutti*, who holds transatlantic labs at Institut Hospital del Mar d’Investigacions Mèdiques (IMIM) in Barcelona, Spain, and at Icahn School of Medicine at Mount Sinai, New York, USA. Until recently, Cerutti used to swim in grant money, from 2011 to 2016 the Mount Sinai lab received from NIH $5 million for 4 projects, while the Barcelona lab frolicked from 2012 to 2017 in the €2.2 million ERC grant.

the graduates

I was alerted to the Cerutti case by the pseudonymous image integrity sleuth Clare Francis, who found recent irregularities in Cerutti’s papers, next to the already impressive PubPeer record. Like this, in Sintes et al Nature Communications 2017: it shares gel bands with a four year older paper from Cerutti lab in New York, Romberg et al J Clinical Investigation 2013.

9i7hffn

It is strange why same old blot from 2013 was rearranged so creatively in 2017, with same bands standing in for such diverse samples. Some might say, it was merely a loading control, but I personally feel those are kind of important and should not be faked. But again, others on Twitter proved me wrong, especially in this case.

In 2016, Cerutti had to correct a 10-year-old Qiao et al Nature Immunology 2006 paper, because of a palindromic gel, after evidence was posted on PubPeer:

The correction from summer 2016 went:

“In the version of the article originally published, in the top immunoblot (loading control) in Figure 5f, the right half was incorrectly a mirror-image duplication of the left half. The correct immunoblot from a replicate experiment is now presented (along with the corresponding bottom immunoblot).”

How can that kind of mirroring happen by mistake? It can’t, but do you think the publisher Nature used the occasion to screen the paper for other Easter eggs? Apparently not, but others did and posted it on PubPeer, the problem with Figure 2b already in October 2016:

Did Nature Immunology do anything about this new evidence of manipulated gels? No, the case was apparently closed. Maybe the journal was so shocked by what Cerutti is capable of, they decided not to mess with that immunologist from Photoshop hell. Because Cerutti also published this: He et al, Nature Immunology 2010:

One interesting collaborator of Cerutti’s is the fellow immunologist Paolo Casali, a compatriot from Italy and Cerutti’s former mentor from their common time back at Weill Medical College of Cornell University. Cerutti used to work in Casali’s lab from 1997 till 2003 when the latter left Weill Cornell for California, and then for the University of Texas in San Antonio, USA, where Casali is now Chair of Department of Microbiology. Cerutti stayed at Weill Cornell till 2009, the year when, according to this CV, the Italian blot fabricator was granted tenure. For some reason, Cerutti instead buggered off to Mount Sinai in New York. During that period, Cerutti and Casali polluted scientific literature with some highly toxic material. For example, they honoured Nature Immunology with this interesting collage in Cerutti et al 2001:

Not just that the pair of IgBeta bands are duplicated, one band makes an extra appearance in the gel below. It was obviously copy-pasted, just like its neighbours. The Italian couple published together also such Photoshop masterpieces like Zan et al J Immunology 2000 or Cerutti et al J Immunology 2002:

Or this Cerutti-Casali copro-duction, in the same journal, Litinskiy et al J Immunology 2002, with Cerutti as last author:

The poor Journal of Immunology, where Cerutti used to be associate editor until 2008, and which is published by The American Association of Immunologists of which Cerutti is a proud member. This appeared in He et al J Immunology 2004, last author Cerutti, just one of several manipulated figures in this paper:

imgur-ae0s7kw.jpg

Two years later, He et al J Immunology 2006, again from Cerutti lab in Cornell, and next to cloned gel bands there are also cloned FACS plots in that paper:

The following shows apparently how Cerutti and Casali started, back in 1998 there was not much Photoshop yet, you had to play glue, scissors, paper to get the right scientific result. A vintage artwork, from the olden times, Zan et al J Immunology 1998:

It is not like Cerutti stopped doing those naughty deeds once a successful academic career was fully established. It’s like with alcoholics, the temptation for recidivism is too strong and lurking everywhere. There are also these collaborative papers by Cerutti where same flow cytometry file appears twice. Examples are here, a paper from Cerutti’s collaborators at Karolinska Institutet in Stockholm, Sweden (Gutzeit et al J Immunology 2014) and at Icahn School of Medicine (Garcia-Carmona et al Frontiers in Immunology 2018). Duplicated flow cytometry (FACS) plots are labelled with colour squares.

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This might have been an honest mistake of oversight, but how come the quantified numbers are different? This means either the authors did it to obscure similarities, or they secretly changed measurement gates on each file to get the results they wanted (like Sonia Melo proudly admitted to having done). Neither constitutes good scientific practice. Cerutti actually published something similar with Casali before, guess where: Xu et al J Immunology 2008.

There is more material on PubPeer, but in Spain, its serves as a badge of honour, if anything.

*Andrea is a male name in Italy, but I don’t want to spoil the “harasser of women in STEM” story told about me online and offline. Also, I don’t want to miss the precious irony of Andrea Cerutti being possibly defended as a MeToo victim of harassment. 


 

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66 comments on “How Andrea Cerutti molested and defiled Journal of Immunology

  1. At first this was a difficult one, but after a while people “got their eye in”.

    Blood. 2007 Jan 15;109(2):729-39. Epub 2006 Sep 7.
    Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL.
    Chiu A1, Xu W, He B, Dillon SR, Gross JA, Sievers E, Qiao X, Santini P, Hyjek E, Lee JW, Cesarman E, Chadburn A, Knowles DM, Cerutti A.
    Author information
    1
    Department of Pathology and Laboratory Medicine, Weill Medical College, Cornell University, 1300 York Ave, Rm C-410, New York, NY 10021, USA.

    https://pubpeer.com/publications/6F8061D70C33EA7D14013FCF2015AB

    Figures 5A and 5C.
    https://pubpeer.com/publications/6F8061D70C33EA7D14013FCF2015AB#17

    Figure 5C
    https://pubpeer.com/publications/6F8061D70C33EA7D14013FCF2015AB#20

    Figure 3B.
    https://pubpeer.com/publications/6F8061D70C33EA7D14013FCF2015AB#21

    Like

    • Co-author on Blood. 2007 Jan 15;109(2):729-39, Ethel Cesarman, has another porblematic paper in Blood.

      Blood. 2006 Apr 15;107(8):3295-302. Epub 2005 Dec 27.
      NF-kappaB is essential for the progression of KSHV- and EBV-infected lymphomas in vivo.
      Keller SA1, Hernandez-Hopkins D, Vider J, Ponomarev V, Hyjek E, Schattner EJ, Cesarman E.
      Author information
      1
      Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA.

      https://pubpeer.com/publications/2CF0AD15767F7E22A39DEDC78E40D0#3

      Figure 3A.

      Like

  2. Some say that mirror images don’t matter, but then does any of it matter?

    Nature. 1998 Aug 6;394(6693):588-92.
    Transformation of primary human endothelial cells by Kaposi’s sarcoma-associated herpesvirus.
    Flore O1, Rafii S, Ely S, O’Leary JJ, Hyjek EM, Cesarman E.
    Author information
    1
    Department of Pathology, Cornell University Medical College, New York, New York 10021, USA.

    https://pubpeer.com/publications/C540D0FE29B0D75B4F44F6A0DF4DAC

    Figure 1a.

    Like

  3. Is it churlish to mention?

    J Virol. 2002 May;76(10):5208-19.
    Transcriptional downregulation of ORF50/Rta by methotrexate inhibits the switch of Kaposi’s sarcoma-associated herpesvirus/human herpesvirus 8 from latency to lytic replication.
    https://jvi.asm.org/content/76/10/5208/article-info
    AUTHOR INFORMATION
    Francesca Curreli1, Francesca Cerimele1,2, Sumitra Muralidhar3, Leonard J. Rosenthal3, Ethel Cesarman4, Alvin E. Friedman-Kien1,5, and Ornella Flore1,*
    1Departments of Microbiology
    5Dermatology, New York University School of Medicine, New York, New York 10016
    3Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, D.C. 20007
    4Department of Pathology, Weill Medical College of Cornell University, New York, New York 10021
    2Istituto di Microbiologia, Università Cattolica del Sacro Cuore, Rome, Italy.

    https://pubpeer.com/publications/1D6D2A500B9924A9E52BC9103E73EF

    Choose your own highlight.

    Something enigmatic about
    https://pubpeer.com/publications/1D6D2A500B9924A9E52BC9103E73EF#11
    Figure 5Ba.

    Like

  4. “Icahn School of Medicine at Mount Sinai, New York, USA”.

    Isn’t Andrea Cerutti going with the flow? Community standards?

    Cancer Res. 2007 Jun 15;67(12):5747-53.
    Androgen-induced Wnt signaling in preosteoblasts promotes the growth of MDA-PCa-2b human prostate cancer cells.
    Liu XH1, Kirschenbaum A, Yao S, Liu G, Aaronson SA, Levine AC.
    Author information
    1
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.

    Figure 2A.

    Figure 4B.

    Penultimate author: https://icahn.mssm.edu/profiles/stuart-a-aaronson

    Senior author: https://www.mountsinai.org/profiles/alice-c-levine

    First and corresponding author Xin-Hua Liu:

    https://pubpeer.com/publications/D1B1BC65C011425AA3C25130A7B668
    https://pubpeer.com/publications/DA0477687188B994267C61586360CE
    https://pubpeer.com/publications/0DB6F8386E1BA5B42BF2FDF8890070
    https://pubpeer.com/publications/146F5B5271CA00E45B8AD009626718
    https://pubpeer.com/publications/1E0EF245A7AD1BA04906CF25428667
    https://pubpeer.com/publications/3560F12FDEC90A1B6631F5278CAD48

    Andrea Cerutti’s works is not out of place with the above.

    Like

  5. Same institute at Mount Sinai (Immunology Institute).
    https://icahn.mssm.edu/profiles/huabao-xiong

    A lovely piece of work.

    J Biol Chem. 2006 Apr 14;281(15):10073-80. Epub 2006 Feb 16.
    IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways.
    Zhao J1, Kong HJ, Li H, Huang B, Yang M, Zhu C, Bogunovic M, Zheng F, Mayer L, Ozato K, Unkeless J, Xiong H.
    Author information
    1
    Immunobiology Center, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA.

    https://pubpeer.com/publications/B4E324371D7C9506837727C9BF0CFC

    Figure 4.

    Small detail figure 4B

    Parts of figure 4 are a reincarnation.

    Figures 4C and 5B

    Figures 4B and 6E

    Like

    • Another lovely piece of work, but with the senior author of J Biol Chem. 2006 Apr 14;281(15):10073-80 as first author.

      J Biol Chem. 2005 Jun 24;280(25):23531-9. Epub 2005 Apr 18.
      Ubiquitin-dependent degradation of interferon regulatory factor-8 mediated by Cbl down-regulates interleukin-12 expression.
      Xiong H1, Li H, Kong HJ, Chen Y, Zhao J, Xiong S, Huang B, Gu H, Mayer L, Ozato K, Unkeless JC.
      Author information
      1
      Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA.

      https://pubpeer.com/publications/1C17842D7B2BC1EA645410F7F23D49

      Figures 2 and 3B.

      Figure 5B

      Figures 1A and 3A.

      Like

      • To bring H Xiong’s J Biol Chem tally up to 3.

        J Biol Chem. 2009 Sep 4;284(36):24006-16. doi: 10.1074/jbc.M109.025528. Epub 2009 Jul 10.
        AP-1 activated by toll-like receptors regulates expression of IL-23 p19.
        Liu W1, Ouyang X, Yang J, Liu J, Li Q, Gu Y, Fukata M, Lin T, He JC, Abreu M, Unkeless JC, Mayer L, Xiong H.
        Author information
        1
        Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.

        Figures 1B and 8C.

        Like

    • Speaking of Huabao Xiong.
      Cancer Res. 2005 Jun 15;65(12):5009-14.
      Toll-like receptors on tumor cells facilitate evasion of immune surveillance.
      Huang B1, Zhao J, Li H, He KL, Chen Y, Chen SH, Mayer L, Unkeless JC, Xiong H.
      Department of Gene and Cell Medicine, Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.
      DOI: 10.1158/0008-5472.CAN-05-0784 Published June 2005

      2019 Editor’s Note.
      https://cancerres.aacrjournals.org/content/79/16/4305
      The editors were made aware of concerns by a reader regarding potential manipulation of data in this article (1). An internal review by the editors determined that lanes 2–4 of the β-actin Western blot image in Fig. 2C (MC26 cells) were rotated and duplicated in lanes 2–4 of the β-actin Western blot image in Fig. 2D. The editors are publishing this note to alert readers to these concerns.

      Reference
      1.↵Huang B, Zhao J, Li H, He KL, Chen Y, Mayer L, et al. Toll-like receptors on tumor cells facilitate evasion of immune surveillance. Cancer Res 2005;65:5009–14.

      Like

      • Huabao Xiong one of two corresponding authors. Editor’s note. See below citation.

        Cancer Res. 2007 May 1;67(9):4346-52.
        Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling.

        https://cancerres.aacrjournals.org/content/67/9/4346.article-info
        AUTHOR INFORMATION
        Bo Huang1, Jie Zhao2, Shiqian Shen3, Hongxing Li4, Kai-Li He5, Guan-Xin Shen3, Lloyd Mayer4, Jay Unkeless4, Dong Li1, Ye Yuan1, Gui-Mei Zhang1, Huabao Xiong4, and Zuo-Hua Feng1
        Departments of 1Biochemistry and Molecular Biology, 2Gynecology and Obstetrics, and 3Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, The People’s Republic of China; 4Immunobiology Center, Mount Sinai School of Medicine; and 5Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York
        Requests for reprints:
        Zuo-Hua Feng, Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, The People’s Republic of China. Phone: 86-27-83650754; Fax: 86-27-83650754; E-mail: fengzhg@public.wh.hb.cn or Huabao Xiong, Immunobiology Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6574. Phone: 212-659-9413; Fax: 212-849-2525; E-mail: Huabao.Xiong@mssm.edu.

        2019 Editor’s Note.
        https://cancerres.aacrjournals.org/content/79/16/4306

        The editors were made aware of concerns by a reader regarding potential manipulation of data in this article (1). An internal review by the editors determined that the same β-actin Western blot image was used in Fig. 4A of this article and in Fig. 2C of an article published earlier by the authors (2), yet the cell types are different. The editors are publishing this note to alert readers to these concerns.

        References
        1.↵Huang B, Zhao J, Shen S, Li H, He KL, Shen GX, et al. Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling. Cancer Res 2007;67:4346–52.
        2.↵Huang B, Zhao J, Li H, He KL, Chen Y, Mayer L, et al. Toll-like receptors on tumor cells facilitate evasion of immune surveillance. Cancer Res 2005;65:5009–14.

        Like

  6. To be fair to the Icahn School of Medicine at Mount Sinai, New York, USA, most of the problematic Andrea Cerutti papers come from his time at the Weill Cornell Medical School,
    which is 40 blocks, about 2 miles (3 km) down the road.

    Like

    • Weill Cornell Medical College breast cancer expert.
      http://vivo.med.cornell.edu/display/cwid-ajdannen

      The reality.
      https://pubpeer.com/search?q=Andrew+Dannenberg

      How come the governance of the Weill Cornell Medical College never noticed any of the problematic data?

      Like

      • Cancer Discov. 2012 Apr;2(4):356-65. doi: 10.1158/2159-8290.CD-11-0241. Epub 2012 Jan 27.
        Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women.
        Subbaramaiah K1, Morris PG, Zhou XK, Morrow M, Du B, Giri D, Kopelovich L, Hudis CA, Dannenberg AJ.
        Author information
        1
        Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA.

        https://pubpeer.com/publications/A0D814C531ABFB80B7E743422102A3

        Like

      • Cancer Prev Res (Phila). 2012 Oct;5(10):1183-94. doi: 10.1158/1940-6207.CAPR-12-0201. Epub 2012 Jul 10.
        Pioglitazone, a PPARγ agonist, suppresses CYP19 transcription: evidence for involvement of 15-hydroxyprostaglandin dehydrogenase and BRCA1.
        Subbaramaiah K1, Howe LR, Zhou XK, Yang P, Hudis CA, Kopelovich L, Dannenberg AJ.
        Author information
        1
        Department of Medicine, Weill Cornell Cancer Center, New York, NY 10065, USA.

        https://pubpeer.com/publications/35A01F5DB9F21CA8FC19CE4A95DD1B

        Like

      • Immunity. 2006 May;24(5):563-74.
        IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.
        Hu X1, Paik PK, Chen J, Yarilina A, Kockeritz L, Lu TT, Woodgett JR, Ivashkiv LB.
        Author information
        1
        Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021, USA.

        How to explain the same data appearing in another journal the previous year?

        https://pubpeer.com/publications/3B6B07303232FC776DD9A966FA3EB2

        Like

      • J Immunol. 2003 Nov 15;171(10):5034-41.
        Reprogramming of IL-10 activity and signaling by IFN-gamma.
        Herrero C1, Hu X, Li WP, Samuels S, Sharif MN, Kotenko S, Ivashkiv LB.
        Author information
        1
        Department of Medicine, Hospital for Special Surgery, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA.

        How to explain the duplication in this paper?

        https://pubpeer.com/publications/76685C1CD74576DA75194360EC9154

        Like

      • J Immunol. 2008 Jun 15;180(12):8057-65.
        IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways.
        Hu Y1, Hu X, Boumsell L, Ivashkiv LB.
        Author information
        1
        Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.

        How to eplain the same data appearing in 3 papers?

        https://pubpeer.com/publications/22158510422A7662F03042B8A8D864

        Like

      • https://www.bcrf.org/researchers/andrew-j-dannenberg

        Breast Cancer Research Foundation (Pink Ribbon)

        states: “He [Andrew J. Dannenberg, MD] has authored more than 150 scientific articles”.

        Has anybody in the Breast Cancer Research Foundation (Pink Ribbon) ever looked at any of these more than 150 scientific articles, and if so which ones?”.

        Here is a selection: https://pubpeer.com/search?q=Andrew+Dannenberg

        Like

      • 2019 Editor’s Note for:
        Cancer Discov. 2012 Apr;2(4):356-65. doi: 10.1158/2159-8290.CD-11-0241. Epub 2012 Jan 27.
        Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women.
        Subbaramaiah K1, Morris PG, Zhou XK, Morrow M, Du B, Giri D, Kopelovich L, Hudis CA, Dannenberg AJ.
        Author information
        1
        Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA. ksubba@med.cornell.edu

        2019 Editor’s Note.
        https://cancerdiscovery.aacrjournals.org/content/9/8/1142

        The editors are publishing this note to alert readers to concerns about this article (1). In Fig. 2B, the β-actin bands have similar features and it appears that lanes have been electronically spliced together. In Fig. 4C, the β-actin bands appear similar. In Fig. 5H, the β-actin bands for “SA CM,” “SA CM + Control siRNA,” and “SA CM + COX-2 siRNA” appear similar. In response to a query by the editors, the corresponding author, Andrew Dannenberg, stated that the original data were no longer available.

        Reference
        1.↵Subbaramaiah K, Morris PG, Zhou XK, Morrow M, Du B, Giri D, et al. Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer Discov 2012;2:356–65.

        Like

  7. Ann N Y Acad Sci. 2006 Apr;1068:225-33.
    Interactive effect of interleukin-6 and prostaglandin E2 on osteoclastogenesis via the OPG/RANKL/RANK system.
    Liu XH1, Kirschenbaum A, Yao S, Levine AC.
    Author information
    1
    Department of Medicine, Box 1055, Mount Sinai School of Medicine, New York, NY 10029.

    Figure 2.

    Like

  8. Ann N Y Acad Sci. 2007 Nov;1116:423-31. Epub 2007 Jul 23.
    Androgens promote preosteoblast differentiation via activation of the canonical Wnt signaling pathway.
    Liu XH1, Kirschenbaum A, Yao S, Levine AC.
    Author information
    1
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

    Figure 3.

    Like

  9. J Neurotrauma. 2017 Jun 15;34(12):2069-2074. doi: 10.1089/neu.2016.4763. Epub 2017 Feb 27.
    Spinal Cord Injury Leads to Hyperoxidation and Nitrosylation of Skeletal Muscle Ryanodine Receptor-1 Associated with Upregulation of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4.
    Liu XH1,2, Harlow L1, Graham ZA1,2, Bauman WA1,2,3, Cardozo C1,2,3,4.
    Author information
    1
    1 National Center for the Medical Consequences of Spinal Cord Injury, James J. Peter VA Medical Center , Bronx, New York.
    2
    2 Department of Medicine, Icahn School of Medicine at Mount Sinai , New York, New York.
    3
    3 Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai , New York, New York.
    4
    4 Department of Pharmacologic Science, Icahn School of Medicine at Mount Sinai , New York, New York.

    Figure 2A.

    Like

  10. It is highly likely that some senior authors will claim that they were victoms of young weasels. The problem with that argument is that there was a ruling in Ohio in November 2018 thanks to the pugnaciousness of Carlo Croce. You have to kiss dear old Carlo on both cheeks for that.

    https://retractionwatch.com/2018/11/08/judge-dismisses-most-of-carlo-croces-libel-case-against-the-new-york-times/

    “Defendants include in this tally of “Dr. Croce’s papers” manuscripts reporting research that (a) did not take place in Dr. Croce’s lab or under his supervision, (b) do not contain any figures prepared by Dr. Croce or anyone under his supervision, (c) were not written by Dr. Croce or anyone under his supervision, and (d) for which he is identified only as a middle author….

    Defendants falsely stated that papers on which Dr. Croce was only a middle author were “Dr. Croce’s papers.”

    In his 35-page opinion, Graham does not buy that argument:

    Dr. Croce contends that not all papers on which his name is listed were the product of research either conducted by him or under his supervision. But the Court believes that an ordinary reader would credit such a paper, on which Dr. Croce willingly allowed his name to appear as a co-author, to him.”

    The ruling in Ohio applies in New York State. The Behemoths of the the Corporate State, made fat by the public dole, Weill Cornell Medical College and the Icahn Medcial School at Mount Sinai, should be mindful of that ruling before trundling out their lawyers to defend the “reputations” of their faculty. How have these fat Behemoths failed to notice the problematic data? What do their research intergity officers, and their deans of reasearch actually do? Let these Behemoths be outraged by the true cause of the outrage, not by people pointing it out. Time they went on a diet.

    Like

    • “Spain is where dishonest research gets rewarded, with awards, grants ..”

      To be fair to Spain is the U.S.A. any better?

      Like

    • Virology. 2001 Aug 15;287(1):62-70.
      Expression of Kaposi’s sarcoma-associated herpesvirus G protein-coupled receptor monocistronic and bicistronic transcripts in primary effusion lymphomas.
      Nador RG1, Milligan LL, Flore O, Wang X, Arvanitakis L, Knowles DM, Cesarman E.
      Author information
      1
      Department of Pathology, Weill Medical College of Cornell University, New York, New York 10021, USA.

      Figure 3.

      Like

  11. https://pathology.weill.cornell.edu/about-us/news/weill-cornell-medicine-awarded-9-million-prestigious-grant-mantle-cell-lymphoma

    “Weill Cornell Medicine Awarded $9 Million Prestigious Grant for Mantle Cell Lymphoma Research
    December 9, 2018”

    “The team of Weill Cornell Medicine basic and clinical investigators includes: Drs. Jihye Paik, Giorgio Inghirami, Maurizio Di Liberto and Xiangao Huang in the Department of Pathology and Laboratory Medicine; Drs. Lewis Cantley, Peter Martin, John Leonard and Jia Ruan in the Weill Department of Medicine; Dr. Lorenzo Galluzzi in the Department of Radiation Oncology; Drs. Olivier Elemento and Christopher Mason in the Department of Physiology and Biophysics; and Drs. Karla Ballman and Zhengming Chen in the Department of Healthcare Policy and Research at Weill Cornell Medicine, all whom are members of the Sandra and Edward Meyer Cancer Center.”

    Giorgio Inghirami
    https://pubpeer.com/publications/69FA881264B9AE9BA24481755DED59#2
    https://pubpeer.com/publications/D715909FD7C4A4F8D67F11CCF9F62D#4
    https://pubpeer.com/publications/6EF6F248DE9275462F79FE67F48319#2
    https://pubpeer.com/publications/3686590C34E1C9C0F408043BD65EBA#7
    2016 correction for figure 5C.
    http://cancerres.aacrjournals.org/content/76/6/1669
    https://pubpeer.com/publications/3C3FF1636FF6F7CC508294CAB01B32#2

    Lewis Cantley (Cantley and Kahn)
    Retraction
    https://pubpeer.com/publications/A279FD58EA0B914A9A5BCF1BD3E79D
    https://pubpeer.com/publications/9D6AEC523F450355A90D0BD77630F2#1
    https://pubpeer.com/publications/4CAD00D54CCC445B7B6A5BA1451906
    https://pubpeer.com/publications/D22CAC8657772D65C46BABFC6A3036
    https://pubpeer.com/publications/B0EA4FA33389132689C60B149B2326
    https://pubpeer.com/publications/1FD3C89299910C1B9FE8711FAC1CDE
    https://pubpeer.com/publications/9BE3B0E66307C26F7AC68E5F5A866A
    https://pubpeer.com/publications/6709ED4F8F410BDAEA72B2668EA7B4
    https://pubpeer.com/publications/0751F554754C41076F40B466F76FC0
    https://pubpeer.com/publications/931161347C9AF2910BAAF650849963
    https://pubpeer.com/publications/71484B8879A7E765F7842C622C2D56
    https://pubpeer.com/publications/E79D474FF338A83052C690588F472B

    https://retractionwatch.com/2017/04/25/harvard-diabetes-researcher-retracts-third-paper/

    “One of the co-authors on the latest retraction is Lewis C. Cantley, a cancer biologist based at Weill Cornell Medical College. Cantley is credited with the discovery of a signaling pathway essential for the growth and survival of normal and cancerous cells, research which won him the coveted $3 million inaugural Breakthrough Prize in Life Sciences in 2013.”

    Bear in mind: https://retractionwatch.com/2018/11/08/judge-dismisses-most-of-carlo-croces-libel-case-against-the-new-york-times/

    “Dr. Croce contends that not all papers on which his name is listed were the product of research either conducted by him or under his supervision. But the Court believes that an ordinary reader would credit such a paper, on which Dr. Croce willingly allowed his name to appear as a co-author, to him.”

    Like

  12. https://pathology.weill.cornell.edu/about-us/news/weill-cornell-medicine-awarded-9-million-prestigious-grant-mantle-cell-lymphoma

    ““Currently we have a number of approved drugs and experimental therapies for MCL, yet we don’t precisely know how they work or why patients ultimately become resistant to them,” said principal investigator Dr. Selina Chen-Kiang…”

    Cancer Res. 2006 Aug 1;66(15):7661-7.
    A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6.
    Baughn LB1, Di Liberto M, Wu K, Toogood PL, Louie T, Gottschalk R, Niesvizky R, Cho H, Ely S, Moore MA, Chen-Kiang S.
    Author information
    1
    Department of Pathology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

    Figure 2A.

    Like

  13. https://pathology.weill.cornell.edu/about-us/news/weill-cornell-medicine-awarded-9-million-prestigious-grant-mantle-cell-lymphoma

    ““Currently we have a number of approved drugs and experimental therapies for MCL, yet we don’t precisely know how they work or why patients ultimately become resistant to them,” said principal investigator Dr. Selina Chen-Kiang…”

    Immunity. 1997 Jan;6(1):47-56.
    Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6.
    Morse L1, Chen D, Franklin D, Xiong Y, Chen-Kiang S.
    Author information
    1
    Department of Pathology, Cornell University Medical College, New York, New York 10021, USA.

    Figure 7B.

    Like

  14. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10640-5. Epub 2005 Jul 19.
    Investigation of antitumor effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo.
    Wu KD1, Cho YS, Katz J, Ponomarev V, Chen-Kiang S, Danishefsky SJ, Moore MA.
    Author information
    1
    James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

    Figure 3.

    Like

  15. J Immunol. 2009 Feb 15;182(4):1810-7. doi: 10.4049/jimmunol.0713726.
    CDK2 phosphorylation of Smad2 disrupts TGF-beta transcriptional regulation in resistant primary bone marrow myeloma cells.
    Baughn LB1, Di Liberto M, Niesvizky R, Cho HJ, Jayabalan D, Lane J, Liu F, Chen-Kiang S.
    Author information
    1
    Department of Pathology, Weill Medical College of Cornell University, New York, NY 10065, USA.

    Figure 2A.

    Figures 2A and 6B.

    Like

  16. Cancer Cell. 2012 Oct 16;22(4):506-523. doi: 10.1016/j.ccr.2012.09.003.
    Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomas.
    Zhang X#1,2, Zhao X#1, Fiskus W3, Lin J4, Lwin T1, Rao R3, Zhang Y2, Chan JC5, Fu K5, Marquez VE6, Chen-Kiang S7, Moscinski LC1, Seto E1, Dalton WS1, Wright KL1, Sotomayor E1, Bhalla K3, Tao J1.
    Author information
    1
    Departments of Malignant Hematology and Experimental Therapeutics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33613.
    2
    Department of Immunology and Malignant Hematology, Tianjin Cancer Hospital, Tianjin, China.
    3
    Experimental Therapeutics, University of Kansas Cancer Center, Kansas City, Kansas 66160.
    4
    Dana-Farber Cancer Institute, Boston, MA 02115.
    5
    Department of Pathology, University of Nebraska Medical Center, Omaha, NE 68198.
    6
    Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702.
    7
    Department of Pathology, Weill-Cornell Medical College, New York, NY 10065.
    #
    Contributed equally

    Figure 7B.

    Like

    • Correction.

      Additional problematic data Cancer Cell. 2012 Oct 16;22(4):506-523

      Figure 7A.

      Like

      • Same senior author as Cancer Cell. 2012 Oct 16;22(4):506-523.

        Blood. 2007 Sep 1;110(5):1631-8. Epub 2007 May 14.
        Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas.
        Lwin T1, Hazlehurst LA, Dessureault S, Lai R, Bai W, Sotomayor E, Moscinski LC, Dalton WS, Tao J.
        Author information
        1
        Department of Interdisciplinary Oncology and Experimental Therapeutics Program, H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, FL 33613, USA.

        Figure 4.

        Like

      • Same senior author as Cancer Cell. 2012 Oct 16;22(4):506-523.

        Leukemia. 2007 Jul;21(7):1521-31. Epub 2007 May 3.
        Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-kappaB (RelB/p52) in non-Hodgkin’s lymphoma cells.
        Lwin T1, Hazlehurst LA, Li Z, Dessureault S, Sotomayor E, Moscinski LC, Dalton WS, Tao J.
        Author information
        1
        Department of Interdisciplinary Oncology and Experimental Therapeutics Program, H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, FL 33613, USA.

        Figure 1b.

        Like

      • Same senior author as Cancer Cell. 2012 Oct 16;22(4):506-523.

        Oncogene. 2012 Jun 14;31(24):3002-3008. doi: 10.1038/onc.2011.470. Epub 2011 Oct 17.
        Myc represses miR-15a/miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell lymphomas.
        Zhang X#1,2, Chen X#1, Lin J1, Lwin T1, Wright G1, Moscinski LC1, Dalton WS1, Seto E1, Wright K1, Sotomayor E1, Tao J1.
        Author information

        1
        Department of Malignant Hematology, Molecular Oncology and Experimental Therapeutics Program, H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, FL, USA.
        2
        Department of Immunology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
        #
        Contributed equally

        Figure 2a.

        Same institute 2016.
        https://retractionwatch.com/2016/10/21/cancer-researcher-retracts-19-studies-at-once/

        Like

  17. Cell Cycle. 2013 Jun 15;12(12):1892-900. doi: 10.4161/cc.24928. Epub 2013 May 15.
    Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1.
    Chiron D1, Martin P, Di Liberto M, Huang X, Ely S, Lannutti BJ, Leonard JP, Mason CE, Chen-Kiang S.
    Author information
    1
    Department of Pathology and Laboratory Medicine, Weill-Cornell Medical College, New York, NY, USA.

    Figure 4A.

    Like

  18. Cancer Discov. 2014 Sep;4(9):1022-35. doi: 10.1158/2159-8290.CD-14-0098. Epub 2014 Jul 31.
    Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma.
    Chiron D1, Di Liberto M1, Martin P2, Huang X1, Sharman J3, Blecua P4, Mathew S1, Vijay P5, Eng K5, Ali S6, Johnson A7, Chang B8, Ely S1, Elemento O4, Mason CE4, Leonard JP2, Chen-Kiang S9.
    Author information
    1
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York.
    2
    Department of Medicine, Weill Cornell Medical College, New York, New York.
    3
    Willamette Valley Cancer Institute and Research Center/US Oncology Research, Springfield, Oregon.
    4
    Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York. Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York.
    5
    Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York. Tri-Institutional Training Program in Computational Biology and Medicine, Weill Cornell Medical College, New York, New York.
    6
    Foundation Medicine, Inc., Cambridge, Massachusetts.
    7
    Ohio State University, Columbus, Ohio.
    8
    Pharmacyclics, Sunnyvale, California.
    9
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York. Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, New York.

    Figure 3A.

    Like

  19. Cancer Discov. 2014 Sep;4(9):1022-35 continued.

    Figures 3C and 4B.

    Like

  20. Pingback: The Redemption of Arturo Casadevall – For Better Science

  21. “Spain is where dishonest research gets rewarded, with awards, grants…”

    Is the U.S. any better than Spain?

    https://pathology.weill.cornell.edu/about-us/news/dr-selina-chen-kiang-be-honored-leukemia-lymphoma-society

    “Dr. Selina Chen-Kiang to be Honored by the Leukemia & Lymphoma Society
    February 17, 2019

    We are delighted to announce that the New York City Chapter of The Leukemia & Lymphoma Society (LLS) will be honoring Dr. Selina Chen-Kiang at the 2nd Annual Crimson Ball on Wednesday, April 24, 2019 at The Mandarin Oriental in New York City.”

    Like

    • Cancer Res. 2005 Dec 15;65(24):11345-53.
      Mutually exclusive cyclin-dependent kinase 4/cyclin D1 and cyclin-dependent kinase 6/cyclin D2 pairing inactivates retinoblastoma protein and promotes cell cycle dysregulation in multiple myeloma.
      Ely S1, Di Liberto M, Niesvizky R, Baughn LB, Cho HJ, Hatada EN, Knowles DM, Lane J, Chen-Kiang S.
      Author information
      1
      Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA.

      Figures 3B and 4B.

      Like

    • 2019 Expression concern for Massimo Loda, presently Chair Department of Pathology and Laboratory Medicine NewYork-Presbyterian/Weill Cornell Medicine, before that long time at Harvard.

      https://news.weill.cornell.edu/news/2018/11/dr-massimo-loda-appointed-chair-of-the-department-of-pathology-and-laboratory-medicine

      “Dr. Loda was recruited to Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center from Dana-Farber Cancer Institute in Boston, where he is currently chair of the Department of Oncologic Pathology. He is also a professor of pathology at Harvard Medical School and chief of the Division of Translational and Molecular Oncologic Pathology at Brigham and Women’s Hospital.2

      PLoS One. 2009 Jun 11;4(6):e5877. doi: 10.1371/journal.pone.0005877.
      p63 promotes cell survival through fatty acid synthase.
      Sabbisetti V1, Di Napoli A, Seeley A, Amato AM, O’Regan E, Ghebremichael M, Loda M, Signoretti S.
      Author information
      1
      Department of Pathology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

      2019 Expression of Concern.
      https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219869

      After publication, concerns were raised about several western blot results reported in this article [1].

      The β-actin panel in Fig 4 for iPrEC-Tp63 cells appears similar to the β-actin panel in Fig 5D for SCC9-Tp63, with different aspect ratio. The original blots supporting these figures are no longer available, and so the authors are unable to resolve the questions regarding these control blots.
      It appears as though the same β-actin panels are presented in Fig 2D and in S1 Fig for SCC9 cells, although the p63 data and experimental conditions are different. The authors provided available blots in support of FASN, p-Akt, and β-actin results shown in S1B Fig (S1 File), which clarify that the incorrect β-actin blot was included for this experiment in the published figure. The original blots underlying Fig 2D and the p63 blot in S1B Fig are no longer available.
      p63 and β-actin data were reported multiple times in the article:
      ○. p63 in Fig 1A, Fig 3B, and Fig 4 for SCC9 cells
      ○. β-actin panels in Fig 1A, Fig 3B for SCC9 cells
      ○. p63 and β-actin panels for SCC9-Tp63 and iPREC-Tp63 cell lines in Fig 3B and Fig 4
      The authors commented that they believe the western blots in Figs 1A, 3B and 4 were obtained by analyzing proteins from the same experiments, and that the p63 data were presented multiple times in the article to demonstrate that the changes in FASN, p-Akt and pS6 levels were observed in cells in which they had also documented knockdown of p63 expression. The original SCC9 blots for p63 in Figs 1A, 3B and 4 and for β-actin in Figs 1A and 3B are provided in S2 File. The underlying blots are no longer available for the SCC9 β-actin blot shown in Fig 4, for the other SCC9 experiments shown in these figures, or for the iPREC-Tp63 or SCC9-Tp63 experiments.
      The same p63 data are presented in Figs 3B and 4 for the SCC9 cell line, although the β-actin data are different. The authors commented that the β-actin blot shown for SCC9 cells in Figs 1A and 3B also applies to the p63 experiment in Fig 4. The original blots are not available to clarify whether the β-actin blot shown in Fig 4 is the matched loading control for Akt, p-Akt, and p-S6 blots shown in this figure.
      The authors are unable to confirm whether the β-actin blots shown in the article’s figures are matched loading controls obtained using the same protein samples as in the corresponding experimental panels.
      The PLOS ONE Editors post this Expression of Concern to notify readers of the unresolved issues pertaining to the control data reported in this article and the unavailability of primary data to support most of the western blot results.

      Reference
      1. Sabbisetti V, Di Napoli A, Seeley A, Amato AM, O’Regan E, Ghebremichael M, et al. (2009) p63 Promotes Cell Survival through Fatty Acid Synthase. PLoS ONE 4(6): e5877. https://doi.org/10.1371/journal.pone.0005877 pmid:19517019

      Like

    • 2019 Expression concern for Massimo Loda.
      https://news.weill.cornell.edu/news/2018/11/dr-massimo-loda-appointed-chair-of-the-department-of-pathology-and-laboratory-medicine

      “Dr. Loda was recruited to Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center from Dana-Farber Cancer Institute in Boston, where he is currently chair of the Department of Oncologic Pathology. He is also a professor of pathology at Harvard Medical School and chief of the Division of Translational and Molecular Oncologic Pathology at Brigham and Women’s Hospital.”

      PLoS One. 2009 Jun 11;4(6):e5877. doi: 10.1371/journal.pone.0005877.
      p63 promotes cell survival through fatty acid synthase.
      Sabbisetti V1, Di Napoli A, Seeley A, Amato AM, O’Regan E, Ghebremichael M, Loda M, Signoretti S.
      Author information
      1
      Department of Pathology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

      2019 Expression of Concern.
      https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219869

      After publication, concerns were raised about several western blot results reported in this article [1].

      The β-actin panel in Fig 4 for iPrEC-Tp63 cells appears similar to the β-actin panel in Fig 5D for SCC9-Tp63, with different aspect ratio. The original blots supporting these figures are no longer available, and so the authors are unable to resolve the questions regarding these control blots.
      It appears as though the same β-actin panels are presented in Fig 2D and in S1 Fig for SCC9 cells, although the p63 data and experimental conditions are different. The authors provided available blots in support of FASN, p-Akt, and β-actin results shown in S1B Fig (S1 File), which clarify that the incorrect β-actin blot was included for this experiment in the published figure. The original blots underlying Fig 2D and the p63 blot in S1B Fig are no longer available.
      p63 and β-actin data were reported multiple times in the article:
      ○. p63 in Fig 1A, Fig 3B, and Fig 4 for SCC9 cells
      ○. β-actin panels in Fig 1A, Fig 3B for SCC9 cells
      ○. p63 and β-actin panels for SCC9-Tp63 and iPREC-Tp63 cell lines in Fig 3B and Fig 4
      The authors commented that they believe the western blots in Figs 1A, 3B and 4 were obtained by analyzing proteins from the same experiments, and that the p63 data were presented multiple times in the article to demonstrate that the changes in FASN, p-Akt and pS6 levels were observed in cells in which they had also documented knockdown of p63 expression. The original SCC9 blots for p63 in Figs 1A, 3B and 4 and for β-actin in Figs 1A and 3B are provided in S2 File. The underlying blots are no longer available for the SCC9 β-actin blot shown in Fig 4, for the other SCC9 experiments shown in these figures, or for the iPREC-Tp63 or SCC9-Tp63 experiments.
      The same p63 data are presented in Figs 3B and 4 for the SCC9 cell line, although the β-actin data are different. The authors commented that the β-actin blot shown for SCC9 cells in Figs 1A and 3B also applies to the p63 experiment in Fig 4. The original blots are not available to clarify whether the β-actin blot shown in Fig 4 is the matched loading control for Akt, p-Akt, and p-S6 blots shown in this figure.
      The authors are unable to confirm whether the β-actin blots shown in the article’s figures are matched loading controls obtained using the same protein samples as in the corresponding experimental panels.
      The PLOS ONE Editors post this Expression of Concern to notify readers of the unresolved issues pertaining to the control data reported in this article and the unavailability of primary data to support most of the western blot results.

      Reference
      1. Sabbisetti V, Di Napoli A, Seeley A, Amato AM, O’Regan E, Ghebremichael M, et al. (2009) p63 Promotes Cell Survival through Fatty Acid Synthase. PLoS ONE 4(6): e5877. https://doi.org/10.1371/journal.pone.0005877 pmid:19517019

      Like

  22. Mol Cell Biol. 1994 Jan;14(1):268-76.
    Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region.
    Hsu W1, Kerppola TK, Chen PL, Curran T, Chen-Kiang S.
    Author information
    1
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029.

    Figure 4.

    See: https://imgur.com/GVQamop

    Like

  23. Figure 4 Mol Cell Biol. 1994 Jan;14(1):268-76.

    The vertical, straight light strips on either side of the main F(1-380) G2 band do not seem natural.
    Given the low resolution the bands in the F(1-380) G2 and J(2-334) G2 lanes look very similar.

    Like

  24. Just so the Icahn Medical School at Mount Sinai does not feel left out.

    https://icahn.mssm.edu/profiles/stuart-a-aaronson

    2019 expression of concern for
    Mol Cell Biol. 2000 Mar;20(5):1723-32.
    Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression.
    Lee SW1, Reimer CL, Fang L, Iruela-Arispe ML, Aaronson SA.
    Author information
    1
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.

    https://pubpeer.com/publications/E182BF54F2EB5B4A748A2494B61AEF
    See comment#7.

    2019 Expression of concern
    https://mcb.asm.org/content/39/9/e00088-19
    Volume 20, no. 5, p. 1723–1732, 2000, https://doi.org/10.1128/MCB.20.5.1723-1732.2000. The American Society for Microbiology (ASM) and Molecular and Cellular Biology (MCB) are issuing this Expression of Concern to alert readers to questions that have been raised about the integrity of the data in this article. MCB has been notified by Harvard Medical School about potential image duplications affecting Fig. 5A. ASM has reviewed the figure and confirmed the suspected duplications. This figure was generated in the laboratory of the first author. This Expression of Concern is issued pending the outcome of an appeal to the Office of Research Integrity (ORI) and will be updated accordingly.

    Like

  25. Welcome to the world of Blood!

    Blood. 2000 Feb 1;95(3):1014-22.
    Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L).
    Perkins C1, Kim CN, Fang G, Bhalla KN.
    Author information
    1
    Division of Clinical and Translational Research, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA.

    Figure 3.

    Like

  26. Welcome to Cancer Research world!

    Cancer Res. 2000 Mar 15;60(6):1645-53.
    The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis.
    Perkins CL1, Fang G, Kim CN, Bhalla KN.
    Author information
    1
    Division of Clinical and Translational Research, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Florida 33136, USA.

    Figure 2B.

    Is it all part of community standards?

    Like

  27. SUCH an important niche you’re working on. People forget that scientists are people and THUS SUBJECT TO CORRUPTION!

    Like

  28. Pingback: The good life of Benjamin Bonavida – For Better Science

  29. “Example[s] are here, a paper from Cerutti’s collaborators at Karolinska Institutet in Stockholm, Sweden (Gutzeit et al J Immunology 2014)..”

    2019 correction.
    https://www.jimmunol.org/content/203/3/769.long

    “Correction: Exosomes Derived from Burkitt’s Lymphoma Cell Lines Induce Proliferation, Differentiation, and Class-Switch Recombination in B Cells
    Cindy Gutzeit, Noemi Nagy, Maurizio Gentile, Katarina Lyberg, Janine Gumz, Helen Vallhov, Irene Puga, Eva Klein, Susanne Gabrielsson, Andrea Cerutti and Annika Scheynius
    J Immunol August 1, 2019, 203 (3) 769-770; DOI: https://doi.org/10.4049/jimmunol.1900638

    In the published version of Fig. 6A, the FACS dotplot shown for the stimulation of DG75-COex at 25 μg in the presence of IL-21 was inadvertently duplicated from the 5 μg/IL-21 panel. The indicated frequency of 5% of CD38highCD20low B cells, however, is correct. This correct value of 5% was used in Fig. 6B, so the error in Fig. 6A did not influence the interpretation of the results and conclusions of this work. Fig. 6A has now been corrected with the correct dotplot for stimulation of DG75-COex at 25 μg in the presence of IL-21. The corrected version of Fig. 6 is shown below. The figure legend was correct as published and is shown below for reference. Fig. 6 has also been corrected in the online version of the article, which now differs from the print version originally published.”

    Like

  30. Cornell to the fore!

    J Exp Med. 2000 Feb 21;191(4):631-40.
    Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis.
    Zhong S1, Salomoni P, Ronchetti S, Guo A, Ruggero D, Pandolfi PP.
    Author information
    Department of Human Genetics and the Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA.
    Figure 4. See:

    Like

  31. http://www.jbc.org/content/278/14/12294.long
    Promyelocytic Leukemia Protein Sensitizes Tumor Necrosis Factor α-Induced Apoptosis by Inhibiting the NF-κB Survival Pathway*
    Wen-Shu Wu‡, Zhi-Xiang Xu‡, Walter N. Hittelman§, Paolo Salomoni¶, Pier Paolo Pandolfi¶ and Kun-Sang Chang‡‖
    – Author Affiliations

    From the Departments of ‡Molecular Pathology and §Clinical Investigation, the University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030 and the ¶Department of Human Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021

    First Published on
    January 22, 2003
    doi: 10.1074/jbc.M211849200
    April 4, 2003
    The Journal of Biological Chemistry
    278, 12294-12304.

    Figure 7c.

    Computer generated data?

    Like

  32. J Exp Med. 2004 Jun 7;199(11):1545-57.
    Ubiquitin-dependent degradation of p73 is inhibited by PML.
    Bernassola F1, Salomoni P, Oberst A, Di Como CJ, Pagano M, Melino G, Pandolfi PP.
    Author information
    1
    Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA.

    Figures 1 and 2. More similar than you would expect.

    Like

  33. Adv Immunol. 2010;107:31-69. doi: 10.1016/B978-0-12-381300-8.00002-2.
    Innate signaling networks in mucosal IgA class switching.
    Chorny A1, Puga I, Cerutti A.
    Author information
    1
    Department of Medicine, The Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA.

    and

    J Allergy Clin Immunol. 2010 Nov;126(5):889-95; quiz 896-7. doi: 10.1016/j.jaci.2010.09.026.
    Innate signals in mucosal immunoglobulin class switching.
    Puga I1, Cols M, Cerutti A.
    Author information
    1
    IMIM-Hospital del Mar, Barcelona Biomedical Research Park, Barcelona, Spain.

    Figures contain many of the same elements arranged in very similar patterns.

    Like

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